Advertisement
If you have a new account but are having problems posting or verifying your account, please email us on hello@boards.ie for help. Thanks :)
Hello all! Please ensure that you are posting a new thread or question in the appropriate forum. The Feedback forum is overwhelmed with questions that are having to be moved elsewhere. If you need help to verify your account contact hello@boards.ie
Good news everyone! The Boards.ie Subscription service is live. See here: https://subscriptions.boards.ie/

COVID-19: Vaccine and testing procedures Megathread Part 3 - Read OP

18081838586328

Comments

  • Registered Users, Registered Users 2 Posts: 32,132 ✭✭✭✭is_that_so


    https://www.reuters.com/article/reutersComService_2_MOLT/idUSKCN2AT1J0

    Fair play to AZ looks like they're going to fulfill their commitments. The government's vaccine forecast took in to account shortfalls from AZ so were in for a bumper Q2 if they follow through on this and the EU gets 180m in Q2 rather than 90m.

    Maybe the spotlight should be turned on Moderna now? Pitiful supplies from them thus far.
    Think from Q2-Q3 they'll be up to speed. I'd cut them some slack as they are a almost a one man band in comparison with the rest.


  • Registered Users, Registered Users 2 Posts: 2,027 ✭✭✭lbj666


    https://edition.cnn.com/2021/03/01/health/us-coronavirus-monday/index.html

    US begining to roll out J&J (Jansen) vaccine, yet we have to wait until April. I thought that the EU leaders were under pressure because of our slow roll out. Not enough to do anything it seems. Depressing.

    US have first dibs on anything funded under project Warp speed, same with Moderna. I know someone queried it today but Moderna have been cut some amount of slack compared to Astra Zeneca because they made clear their promises supply would be very slow to begin.


  • Registered Users, Registered Users 2 Posts: 6,617 ✭✭✭Charles Babbage


    This study suggests that there is little benefit in the second Pfizer vaccine, that it reaches 90%+ after the first shot.
    If this data holds up then it would seem that there is little need for the second shot immediately, we could inject everyone once and then have a booster tweaked for new variants to ensure longevity of the protection.

    https://www.medrxiv.org/content/10.1101/2021.02.23.21252315v1


  • Registered Users, Registered Users 2 Posts: 11,789 ✭✭✭✭ACitizenErased


    Belgium is re-inventing their vaccine programme - approving AZ for all age groups and spacing out the time between first and second doses.


  • Registered Users, Registered Users 2 Posts: 1,599 ✭✭✭timsey tiger


    lbj666 wrote: »
    US have first dibs on anything funded under project Warp speed, same with Moderna. I know someone queried it today but Moderna have been cut some amount of slack compared to Astra Zeneca because they made clear their promises supply would be very slow to begin.

    SA have it already.


  • Advertisement
  • Registered Users, Registered Users 2 Posts: 32,132 ✭✭✭✭is_that_so


    Belgium is re-inventing their vaccine programme - approving AZ for all age groups and spacing out the time between first and second doses.
    They do have a stack of it to use up!


  • Registered Users, Registered Users 2 Posts: 32,132 ✭✭✭✭is_that_so


    SA have it already.
    Their deal is a bit like Israel and Pfizer , a form of real-time trial.


  • Registered Users, Registered Users 2 Posts: 6,570 ✭✭✭Wolf359f


    Belgium is re-inventing their vaccine programme - approving AZ for all age groups and spacing out the time between first and second doses.

    Are they increasing the space between doses on AZ or Pfizer? Or both?


  • Registered Users, Registered Users 2 Posts: 11,789 ✭✭✭✭ACitizenErased


    Wolf359f wrote: »
    Are they increasing the space between doses on AZ or Pfizer? Or both?
    I think both


  • Registered Users, Registered Users 2 Posts: 2,409 ✭✭✭RebelButtMunch


    Are we seeing any statistical evidence that the vaccination program is making a difference to hospitalizations or deaths?
    I'm looking for good news :)

    Edit: In Ireland


  • Advertisement
  • Registered Users, Registered Users 2 Posts: 1,913 ✭✭✭JacksonHeightsOwn


    I think both

    You just know our patsies will be good little boys and do what they're told.

    As opposed to being proactive and looking to get the job done whole using their own initiative


  • Registered Users, Registered Users 2 Posts: 2,004 ✭✭✭Hmmzis


    This study suggests that there is little benefit in the second Pfizer vaccine, that it reaches 90%+ after the first shot.
    If this data holds up then it would seem that there is little need for the second shot immediately, we could inject everyone once and then have a booster tweaked for new variants to ensure longevity of the protection.

    https://www.medrxiv.org/content/10.1101/2021.02.23.21252315v1

    I'd be careful reading too much into this study. It uses mathematical modelling on top of phase 3 trial data. The gap between the efficacy onset (11 days) and the 2nd shot (21 days) is very short and extrapolations on the general trends of infections would be quite ambitious.

    I'd very much like this one to be true though, we have a huge vaccine supply problem and this would effectively double the amount of people we can vaccinate with it.

    The data coming out of the UK with their 12 week gap between doses would be more fitting for this sort of analysis as it would give a much larger window between onset of efficacy and 2nd dose, giving much better signal to noise in the model. You could even then run a straight up comparison between the phase 3 trial incidence curves and the real world incidence curves and see what the differences are.

    Also, this would be frickin' brilliant if confirmed:
    The efficacy post first vaccination substantially preceded the development of detectable serum neutralizing antibody.


  • Registered Users, Registered Users 2 Posts: 14,439 ✭✭✭✭leahyl


    Are we seeing any statistical evidence that the vaccination program is making a difference to hospitalizations or deaths?
    I'm looking for good news :)

    Edit: In Ireland

    From a few days ago

    http://www.irishtimes.com/news/health/vaccine-effect-behind-80-drop-in-nursing-home-cases-says-hse-official-1.4494861


  • Registered Users, Registered Users 2 Posts: 13,894 ✭✭✭✭ArmaniJeanss


    Hopefully they have. If they were already flat out working at the weekend, then it wouldn't seem to suggest that they would have much capacity to react when supplies increase.

    I'd have a theory that the roll-out might be quicker as you go down through the age-groups.
    For my mother (85+, in a home, with dementia) it was a bit of a saga requiring staff present during and after providing reassurance.
    For you and me, when the time comes, it should hopefully be a quick and easy 15 minutes on a conveyor belt.


  • Registered Users, Registered Users 2 Posts: 113 ✭✭Deenie78


    My Dad (82 years) living in North Dublin got the date for his first jab - 11th March - that's just next week!! Has given my parents (and the whole family) such a boost! My Mam's 75 so will be a little later, but we're on the way at least :-)


  • Registered Users, Registered Users 2 Posts: 6,453 ✭✭✭brickster69


    is_that_so wrote: »
    They do have a stack of it to use up!

    Or maybe they just accepted they were sold porkies by Macron and the German press.

    "if you get on the wrong train, get off at the nearest station, the longer it takes you to get off, the more expensive the return trip will be."



  • Registered Users, Registered Users 2 Posts: 11,789 ✭✭✭✭ACitizenErased




  • Registered Users, Registered Users 2 Posts: 2,065 ✭✭✭funnydoggy




    F*cking yes. The news in the last 2 weeks in particular have been amazing. Mother of jesus science is astonishing.


  • Registered Users, Registered Users 2 Posts: 6,193 ✭✭✭trellheim


    correct me if I'm wrong but weren't we supposed to get approx 620,000 deliveries in Jan/Feb ; actual numbers as of today are showing to 26th Feb 426000 with prob 30,000 in the last couple of days bringing that to 456,000 for the feb , as we have been running close to 95% of deliveries being administered

    wheres the missing 170,000 or did they just arrive in the country on the last day of february

    or are they not giving AZ out at the moment or something ?


  • Registered Users, Registered Users 2 Posts: 6,453 ✭✭✭brickster69


    funnydoggy wrote: »
    F*cking yes. The news in the last 2 weeks in particular have been amazing. Mother of jesus science is astonishing.

    Do you remember when everyone were saying it was a crazy idea and would lead to thousands of deaths.

    "if you get on the wrong train, get off at the nearest station, the longer it takes you to get off, the more expensive the return trip will be."



  • Advertisement
  • Registered Users, Registered Users 2 Posts: 2,027 ✭✭✭lbj666



    I keep gettingconfused by this metric,

    So that I have this right, of those that unfortunately still getting infected despite being vacined, they are still 5 times less of a chance ending up in hospital, than they would if they were infected pre vacination.


  • Registered Users, Registered Users 2 Posts: 1,669 ✭✭✭Klonker


    This study suggests that there is little benefit in the second Pfizer vaccine, that it reaches 90%+ after the first shot.
    If this data holds up then it would seem that there is little need for the second shot immediately, we could inject everyone once and then have a booster tweaked for new variants to ensure longevity of the protection.

    https://www.medrxiv.org/content/10.1101/2021.02.23.21252315v1

    Looks like the UK took a gamble and its paid off better than they could of hoped for.


  • Registered Users, Registered Users 2 Posts: 676 ✭✭✭Pablo Escobar


    Do you remember when everyone were saying it was a crazy idea and would lead to thousands of deaths.

    Everybody was not saying that. I personally remember stating that it was too much of a risk, but at the same time it would probably work. Fair play, it worked, but I still think it was too big a gamble.

    The benefit for the world now is that the UK has seeemingly run a very successful trial which could benefit everyone.


  • Registered Users, Registered Users 2 Posts: 6,617 ✭✭✭Charles Babbage


    lbj666 wrote: »
    I keep gettingconfused by this metric,

    So that I have this right, of those that unfortunately still getting infected despite being vacined, they are still 5 times less of a chance ending up in hospital, than they would if they were infected pre vacination.


    The reporting of this is a bit unclear.
    I do not think it means that if you get Covid that you have 5 times less chance of going to hospital, but only one fifth go to hospital, some because they never got Covid at all, some because they got a mild infection only.



    But I am happy to be corrected on this.


  • Registered Users, Registered Users 2 Posts: 1,122 ✭✭✭mick087


    Do you remember when everyone were saying it was a crazy idea and would lead to thousands of deaths.

    People will still say this because the Oxford vaccine is very political.
    An outstanding excellent vaccine that some euro leaders had issues with.

    Any idiot with half a brain could see the Oxford vaccine was and is a excellent cheap non profit vaccine.


  • Registered Users, Registered Users 2 Posts: 1,122 ✭✭✭mick087


    Everybody was not saying that. I personally remember stating that it was too much of a risk, but at the same time it would probably work. Fair play, it worked, but I still think it was too big a gamble.

    The benefit for the world now is that the UK has seeemingly run a very successful trial which could benefit everyone.

    Or maybe there experts was spot on and our experts are getting it wrong.


  • Registered Users, Registered Users 2 Posts: 11,202 ✭✭✭✭hmmm


    If the EMA approves an extended gap between first and second doses, it would transform the speed of vaccine rollout and potentially how quickly we could reopen. It has to be looking very attractive.

    First dose for everyone by June?


  • Posts: 12,836 ✭✭✭✭ [Deleted User]


    hmmm wrote: »
    If the EMA approves an extended gap between first and second doses, it would transform the speed of vaccine rollout and potentially how quickly we could reopen. It has to be looking very attractive.

    First dose for everyone by June?

    Has it even been proposed? I've not even seen articles suggesting its being discussed, which is crazy.


  • Registered Users, Registered Users 2 Posts: 12,780 ✭✭✭✭ninebeanrows


    Yeah,

    I'd say they'll do double dose for 70+, HCW and vulnerable groups.

    But they should reconsider other cohorts and just 1 jab with a booster in the autumn.


  • Advertisement
  • Registered Users, Registered Users 2 Posts: 1,381 ✭✭✭Indestructable


    So France has recommended the AstraZeneca jab for the over 65s. I really think we should follow suit, if it will speed up our rollout. Real world data from the UK is really encouraging.


This discussion has been closed.
Advertisement