COVID-19: Vaccine and testing procedures Megathread Part 3 - Read OP

is_that_so

IRISHSPORTSGUY wrote: »

https://www.reuters.com/article/reutersComService_2_MOLT/idUSKCN2AT1J0

Fair play to AZ looks like they're going to fulfill their commitments. The government's vaccine forecast took in to account shortfalls from AZ so were in for a bumper Q2 if they follow through on this and the EU gets 180m in Q2 rather than 90m.

Maybe the spotlight should be turned on Moderna now? Pitiful supplies from them thus far.

Think from Q2-Q3 they'll be up to speed. I'd cut them some slack as they are a almost a one man band in comparison with the rest.

lbj666

timsey tiger wrote: »

https://edition.cnn.com/2021/03/01/health/us-coronavirus-monday/index.html

US begining to roll out J&J (Jansen) vaccine, yet we have to wait until April. I thought that the EU leaders were under pressure because of our slow roll out. Not enough to do anything it seems. Depressing.

US have first dibs on anything funded under project Warp speed, same with Moderna. I know someone queried it today but Moderna have been cut some amount of slack compared to Astra Zeneca because they made clear their promises supply would be very slow to begin.

Charles Babbage

This study suggests that there is little benefit in the second Pfizer vaccine, that it reaches 90%+ after the first shot.
If this data holds up then it would seem that there is little need for the second shot immediately, we could inject everyone once and then have a booster tweaked for new variants to ensure longevity of the protection.

https://www.medrxiv.org/content/10.1101/2021.02.23.21252315v1

ACitizenErased

Belgium is re-inventing their vaccine programme - approving AZ for all age groups and spacing out the time between first and second doses.

timsey tiger

lbj666 wrote: »

US have first dibs on anything funded under project Warp speed, same with Moderna. I know someone queried it today but Moderna have been cut some amount of slack compared to Astra Zeneca because they made clear their promises supply would be very slow to begin.

SA have it already.

is_that_so

ACitizenErased wrote: »

Belgium is re-inventing their vaccine programme - approving AZ for all age groups and spacing out the time between first and second doses.

They do have a stack of it to use up!

is_that_so

timsey tiger wrote: »

SA have it already.

Their deal is a bit like Israel and Pfizer , a form of real-time trial.

Wolf359f

ACitizenErased wrote: »

Belgium is re-inventing their vaccine programme - approving AZ for all age groups and spacing out the time between first and second doses.

Are they increasing the space between doses on AZ or Pfizer? Or both?

ACitizenErased

Wolf359f wrote: »

Are they increasing the space between doses on AZ or Pfizer? Or both?

I think both

RebelButtMunch

Are we seeing any statistical evidence that the vaccination program is making a difference to hospitalizations or deaths?
I'm looking for good news

Edit: In Ireland

JacksonHeightsOwn

ACitizenErased wrote: »

I think both

You just know our patsies will be good little boys and do what they're told.

As opposed to being proactive and looking to get the job done whole using their own initiative

Hmmzis

Charles Babbage wrote: »

This study suggests that there is little benefit in the second Pfizer vaccine, that it reaches 90%+ after the first shot.
If this data holds up then it would seem that there is little need for the second shot immediately, we could inject everyone once and then have a booster tweaked for new variants to ensure longevity of the protection.

https://www.medrxiv.org/content/10.1101/2021.02.23.21252315v1

I'd be careful reading too much into this study. It uses mathematical modelling on top of phase 3 trial data. The gap between the efficacy onset (11 days) and the 2nd shot (21 days) is very short and extrapolations on the general trends of infections would be quite ambitious.

I'd very much like this one to be true though, we have a huge vaccine supply problem and this would effectively double the amount of people we can vaccinate with it.

The data coming out of the UK with their 12 week gap between doses would be more fitting for this sort of analysis as it would give a much larger window between onset of efficacy and 2nd dose, giving much better signal to noise in the model. You could even then run a straight up comparison between the phase 3 trial incidence curves and the real world incidence curves and see what the differences are.

Also, this would be frickin' brilliant if confirmed:

The efficacy post first vaccination substantially preceded the development of detectable serum neutralizing antibody.

leahyl

RebelButtMunch wrote: »

Are we seeing any statistical evidence that the vaccination program is making a difference to hospitalizations or deaths?
I'm looking for good news

Edit: In Ireland

From a few days ago

http://www.irishtimes.com/news/health/vaccine-effect-behind-80-drop-in-nursing-home-cases-says-hse-official-1.4494861

ArmaniJeanss

timsey tiger wrote: »

Hopefully they have. If they were already flat out working at the weekend, then it wouldn't seem to suggest that they would have much capacity to react when supplies increase.

I'd have a theory that the roll-out might be quicker as you go down through the age-groups.
For my mother (85+, in a home, with dementia) it was a bit of a saga requiring staff present during and after providing reassurance.
For you and me, when the time comes, it should hopefully be a quick and easy 15 minutes on a conveyor belt.

Deenie78

My Dad (82 years) living in North Dublin got the date for his first jab - 11th March - that's just next week!! Has given my parents (and the whole family) such a boost! My Mam's 75 so will be a little later, but we're on the way at least :-)

brickster69

is_that_so wrote: »

They do have a stack of it to use up!

Or maybe they just accepted they were sold porkies by Macron and the German press.

ACitizenErased

https://twitter.com/SkyNewsBreak/status/1366446967103062016?s=20

funnydoggy

ACitizenErased wrote: »

https://twitter.com/SkyNewsBreak/status/1366446967103062016?s=20

F*cking yes. The news in the last 2 weeks in particular have been amazing. Mother of jesus science is astonishing.

trellheim

correct me if I'm wrong but weren't we supposed to get approx 620,000 deliveries in Jan/Feb ; actual numbers as of today are showing to 26th Feb 426000 with prob 30,000 in the last couple of days bringing that to 456,000 for the feb , as we have been running close to 95% of deliveries being administered

wheres the missing 170,000 or did they just arrive in the country on the last day of february

or are they not giving AZ out at the moment or something ?

brickster69

funnydoggy wrote: »

F*cking yes. The news in the last 2 weeks in particular have been amazing. Mother of jesus science is astonishing.

Do you remember when everyone were saying it was a crazy idea and would lead to thousands of deaths.

lbj666

ACitizenErased wrote: »

https://twitter.com/SkyNewsBreak/status/1366446967103062016?s=20

I keep gettingconfused by this metric,

So that I have this right, of those that unfortunately still getting infected despite being vacined, they are still 5 times less of a chance ending up in hospital, than they would if they were infected pre vacination.

Klonker

Charles Babbage wrote: »

This study suggests that there is little benefit in the second Pfizer vaccine, that it reaches 90%+ after the first shot.
If this data holds up then it would seem that there is little need for the second shot immediately, we could inject everyone once and then have a booster tweaked for new variants to ensure longevity of the protection.

https://www.medrxiv.org/content/10.1101/2021.02.23.21252315v1

Looks like the UK took a gamble and its paid off better than they could of hoped for.

Pablo Escobar

brickster69 wrote: »

Do you remember when everyone were saying it was a crazy idea and would lead to thousands of deaths.

Everybody was not saying that. I personally remember stating that it was too much of a risk, but at the same time it would probably work. Fair play, it worked, but I still think it was too big a gamble.

The benefit for the world now is that the UK has seeemingly run a very successful trial which could benefit everyone.

Charles Babbage

lbj666 wrote: »

I keep gettingconfused by this metric,

So that I have this right, of those that unfortunately still getting infected despite being vacined, they are still 5 times less of a chance ending up in hospital, than they would if they were infected pre vacination.

The reporting of this is a bit unclear.
I do not think it means that if you get Covid that you have 5 times less chance of going to hospital, but only one fifth go to hospital, some because they never got Covid at all, some because they got a mild infection only.



But I am happy to be corrected on this.

mick087

brickster69 wrote: »

Do you remember when everyone were saying it was a crazy idea and would lead to thousands of deaths.

People will still say this because the Oxford vaccine is very political.
An outstanding excellent vaccine that some euro leaders had issues with.

Any idiot with half a brain could see the Oxford vaccine was and is a excellent cheap non profit vaccine.

mick087

Pablo Escobar wrote: »

Everybody was not saying that. I personally remember stating that it was too much of a risk, but at the same time it would probably work. Fair play, it worked, but I still think it was too big a gamble.

The benefit for the world now is that the UK has seeemingly run a very successful trial which could benefit everyone.

Or maybe there experts was spot on and our experts are getting it wrong.

hmmm

If the EMA approves an extended gap between first and second doses, it would transform the speed of vaccine rollout and potentially how quickly we could reopen. It has to be looking very attractive.

First dose for everyone by June?

hmmm

hmmm wrote: »

If the EMA approves an extended gap between first and second doses, it would transform the speed of vaccine rollout and potentially how quickly we could reopen. It has to be looking very attractive.

First dose for everyone by June?

Has it even been proposed? I've not even seen articles suggesting its being discussed, which is crazy.

ninebeanrows

Yeah,

I'd say they'll do double dose for 70+, HCW and vulnerable groups.

But they should reconsider other cohorts and just 1 jab with a booster in the autumn.

Indestructable

So France has recommended the AstraZeneca jab for the over 65s. I really think we should follow suit, if it will speed up our rollout. Real world data from the UK is really encouraging.