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COVID-19: Vaccine and testing procedures Megathread Part 3 - Read OP

Beasty

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Thread 2

No anti-vax stuff in this thread - it's to discuss the various vaccines available and how they are getting rolled out, as well as testing procedures

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Chris_5339762

coconnellz wrote: »

I understand vaccination can be a way forward and Im definitely pro vaccines but the cure has to be better than covid itself.

It is.

A handful of people in the hospital I work had a 2 day fever immediately after the vaccine, one or two of them took to the bed for a day.

Every single one of them said they would take that happily over getting COVID.

hmmm

JPA wrote: »

Isn't that already the plan? Well 82% of adults. But if we could get that number up then it's all good.

I think our current interval between first and second dose is 28 days (happy to be corrected if wrong).

Moving that out to 3 months would substantially increase the number of people who would get a first dose of the vaccine. It would also get us through the worst of the supply crunch.

ACitizenErased

https://twitter.com/andrewiconnell/status/1366471690276995073?s=20

Stheno

coconnellz wrote: »

I'm not here to scare People but we have to talk about this perspective about how wonderful this vaccine is and how safe it is, but what is not discussed enough is the serious side effects to the vaccine for many people, these are not just sore arms but high temperatures shakes feeling absolutely wipe out even 11 days struggling to stand!, and being put on steroids. This is not a one of case and my girlfriend fainted after it and some of her colleges were quite sick after it aswell, I understand vaccination can be a way forward and Im definitely pro vaccines but the cure has to be better than covid itself.

You do know high temperatures and exhaustion are symptoms of covid and you can catch it after the first dose until protection kicks in?

Did any of those people get a Covid test or report the reactions?

JPA

hmmm wrote: »

If the EMA approves an extended gap between first and second doses, it would transform the speed of vaccine rollout and potentially how quickly we could reopen. It has to be looking very attractive.

First dose for everyone by June?

Isn't that already the plan? Well 82% of adults. But if we could get that number up then it's all good.

coconnellz

I'm not here to scare People but we have to talk about this perspective about how wonderful this vaccine is and how safe it is, but what is not discussed enough is the serious side effects to the vaccine for many people, these are not just sore arms but high temperatures shakes feeling absolutely wipe out even 11 days struggling to stand!, and being put on steroids. This is not a one of case and my girlfriend fainted after it and some of her colleges were quite sick after it aswell, I understand vaccination can be a way forward and Im definitely pro vaccines but the cure has to be better than covid itself.

Indestructable

So France has recommended the AstraZeneca jab for the over 65s. I really think we should follow suit, if it will speed up our rollout. Real world data from the UK is really encouraging.

ninebeanrows

Yeah,

I'd say they'll do double dose for 70+, HCW and vulnerable groups.

But they should reconsider other cohorts and just 1 jab with a booster in the autumn.

[Deleted User]

hmmm wrote: »

If the EMA approves an extended gap between first and second doses, it would transform the speed of vaccine rollout and potentially how quickly we could reopen. It has to be looking very attractive.

First dose for everyone by June?

Has it even been proposed? I've not even seen articles suggesting its being discussed, which is crazy.

hmmm

If the EMA approves an extended gap between first and second doses, it would transform the speed of vaccine rollout and potentially how quickly we could reopen. It has to be looking very attractive.

First dose for everyone by June?

mick087

Pablo Escobar wrote: »

Everybody was not saying that. I personally remember stating that it was too much of a risk, but at the same time it would probably work. Fair play, it worked, but I still think it was too big a gamble.

The benefit for the world now is that the UK has seeemingly run a very successful trial which could benefit everyone.

Or maybe there experts was spot on and our experts are getting it wrong.

mick087

brickster69 wrote: »

Do you remember when everyone were saying it was a crazy idea and would lead to thousands of deaths.

People will still say this because the Oxford vaccine is very political.
An outstanding excellent vaccine that some euro leaders had issues with.

Any idiot with half a brain could see the Oxford vaccine was and is a excellent cheap non profit vaccine.

Charles Babbage

lbj666 wrote: »

I keep gettingconfused by this metric,

So that I have this right, of those that unfortunately still getting infected despite being vacined, they are still 5 times less of a chance ending up in hospital, than they would if they were infected pre vacination.

The reporting of this is a bit unclear.
I do not think it means that if you get Covid that you have 5 times less chance of going to hospital, but only one fifth go to hospital, some because they never got Covid at all, some because they got a mild infection only.

But I am happy to be corrected on this.

Pablo Escobar

brickster69 wrote: »

Do you remember when everyone were saying it was a crazy idea and would lead to thousands of deaths.

Everybody was not saying that. I personally remember stating that it was too much of a risk, but at the same time it would probably work. Fair play, it worked, but I still think it was too big a gamble.

The benefit for the world now is that the UK has seeemingly run a very successful trial which could benefit everyone.

Klonker

Charles Babbage wrote: »

This study suggests that there is little benefit in the second Pfizer vaccine, that it reaches 90%+ after the first shot.
If this data holds up then it would seem that there is little need for the second shot immediately, we could inject everyone once and then have a booster tweaked for new variants to ensure longevity of the protection.

https://www.medrxiv.org/content/10.1101/2021.02.23.21252315v1

Looks like the UK took a gamble and its paid off better than they could of hoped for.

lbj666

ACitizenErased wrote: »

https://twitter.com/SkyNewsBreak/status/1366446967103062016?s=20

I keep gettingconfused by this metric,

So that I have this right, of those that unfortunately still getting infected despite being vacined, they are still 5 times less of a chance ending up in hospital, than they would if they were infected pre vacination.

brickster69

funnydoggy wrote: »

F*cking yes. The news in the last 2 weeks in particular have been amazing. Mother of jesus science is astonishing.

Do you remember when everyone were saying it was a crazy idea and would lead to thousands of deaths.

trellheim

correct me if I'm wrong but weren't we supposed to get approx 620,000 deliveries in Jan/Feb ; actual numbers as of today are showing to 26th Feb 426000 with prob 30,000 in the last couple of days bringing that to 456,000 for the feb , as we have been running close to 95% of deliveries being administered

wheres the missing 170,000 or did they just arrive in the country on the last day of february

or are they not giving AZ out at the moment or something ?

funnydoggy

ACitizenErased wrote: »

https://twitter.com/SkyNewsBreak/status/1366446967103062016?s=20

F*cking yes. The news in the last 2 weeks in particular have been amazing. Mother of jesus science is astonishing.

ACitizenErased

https://twitter.com/SkyNewsBreak/status/1366446967103062016?s=20

brickster69

is_that_so wrote: »

They do have a stack of it to use up!

Or maybe they just accepted they were sold porkies by Macron and the German press.

Deenie78

My Dad (82 years) living in North Dublin got the date for his first jab - 11th March - that's just next week!! Has given my parents (and the whole family) such a boost! My Mam's 75 so will be a little later, but we're on the way at least :-)

ArmaniJeanss

timsey tiger wrote: »

Hopefully they have. If they were already flat out working at the weekend, then it wouldn't seem to suggest that they would have much capacity to react when supplies increase.

I'd have a theory that the roll-out might be quicker as you go down through the age-groups.
For my mother (85+, in a home, with dementia) it was a bit of a saga requiring staff present during and after providing reassurance.
For you and me, when the time comes, it should hopefully be a quick and easy 15 minutes on a conveyor belt.

leahyl

RebelButtMunch wrote: »

Are we seeing any statistical evidence that the vaccination program is making a difference to hospitalizations or deaths?
I'm looking for good news

Edit: In Ireland

From a few days ago

http://www.irishtimes.com/news/health/vaccine-effect-behind-80-drop-in-nursing-home-cases-says-hse-official-1.4494861

Hmmzis

Charles Babbage wrote: »

This study suggests that there is little benefit in the second Pfizer vaccine, that it reaches 90%+ after the first shot.
If this data holds up then it would seem that there is little need for the second shot immediately, we could inject everyone once and then have a booster tweaked for new variants to ensure longevity of the protection.

https://www.medrxiv.org/content/10.1101/2021.02.23.21252315v1

I'd be careful reading too much into this study. It uses mathematical modelling on top of phase 3 trial data. The gap between the efficacy onset (11 days) and the 2nd shot (21 days) is very short and extrapolations on the general trends of infections would be quite ambitious.

I'd very much like this one to be true though, we have a huge vaccine supply problem and this would effectively double the amount of people we can vaccinate with it.

The data coming out of the UK with their 12 week gap between doses would be more fitting for this sort of analysis as it would give a much larger window between onset of efficacy and 2nd dose, giving much better signal to noise in the model. You could even then run a straight up comparison between the phase 3 trial incidence curves and the real world incidence curves and see what the differences are.

Also, this would be frickin' brilliant if confirmed:

The efficacy post first vaccination substantially preceded the development of detectable serum neutralizing antibody.

JacksonHeightsOwn

ACitizenErased wrote: »

I think both

You just know our patsies will be good little boys and do what they're told.

As opposed to being proactive and looking to get the job done whole using their own initiative

RebelButtMunch

Are we seeing any statistical evidence that the vaccination program is making a difference to hospitalizations or deaths?
I'm looking for good news

Edit: In Ireland

ACitizenErased

Wolf359f wrote: »

Are they increasing the space between doses on AZ or Pfizer? Or both?

I think both

Wolf359f

ACitizenErased wrote: »

Belgium is re-inventing their vaccine programme - approving AZ for all age groups and spacing out the time between first and second doses.

Are they increasing the space between doses on AZ or Pfizer? Or both?

is_that_so

timsey tiger wrote: »

SA have it already.

Their deal is a bit like Israel and Pfizer , a form of real-time trial.