COVID-19: Vaccine and testing procedures Megathread Part 3 - Read OP

is_that_so · 05-03-2021 11:24AM

Van.Bosch wrote: »

Yeah, I would have thought MVCs would be so much more efficient but maybe for elderly people, going to their GP is preferable due to familiarity and proximity.

As an overall group there would be a wider range of considerations than for the rest of the general population plus this is the first venture by the programme outside very specific locations. With other groups running concurrently there are a lot of moving parts to it all.

Chawosfski · 05-03-2021 11:25AM

Russman wrote: »

I know what my own GP did was when the shipment of vaccines arrived they shut the practice to normal patients and just did vaccinations all day. 2 GPs and a nurse.

Ya I suppose, taking GPs surgeries out of commision though

Donnelly even talking about dentists lol

These people are over-qualified and needed elsewhere

Complicates rollout imo

hmmm · 05-03-2021 11:31AM

Oxford vaccine data in the Lancet
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00528-6/fulltext

"Modelling analyses showed an increase in vaccine efficacy after two standard doses from 55·1% (95% CI 33·0 to 69·9) with an interval of less than 6 weeks to 81·3% (60·3 to 91·2) with an interval of at least 12 weeks. A single standard dose had an efficacy against symptomatic COVID-19 in the first 90 days of 76·0% (59·3 to 85·9)"

I'm not qualified to make judgement, but reading this data it looks obvious that we should be using a 12 weeks gap minimum (and possibly longer).

"Notably, in exploratory analyses, vaccine efficacy after a single standard dose was 76·0% (59·3–85·9) from day 22 to day 90, and antibody levels were maintained during this period with minimal waning. "

stephenjmcd · 05-03-2021 11:32AM

hmmm wrote: »

Oxford vaccine data in the Lancet
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00528-6/fulltext

"Modelling analyses showed an increase in vaccine efficacy after two standard doses from 55·1% (95% CI 33·0 to 69·9) with an interval of less than 6 weeks to 81·3% (60·3 to 91·2) with an interval of at least 12 weeks. A single standard dose had an efficacy against symptomatic COVID-19 in the first 90 days of 76·0% (59·3 to 85·9)"

I'm not qualified to make judgement, but reading this data it looks obvious that we should be moving to a 12 weeks gap (and possibly longer).

"Notably, in exploratory analyses, vaccine efficacy after a single standard dose was 76·0% (59·3–85·9) from day 22 to day 90, and antibody levels were maintained during this period with minimal waning. "

We're already at a 12 week gap between Oxford doses

hmmm · 05-03-2021 11:34AM

stephenjmcd wrote: »

We're already at a 12 week gap between Oxford doses

4-12 weeks I believe, but happy to be corrected.

iamwhoiam · 05-03-2021 11:37AM

stephenjmcd wrote: »

We're already at a 12 week gap between Oxford doses

I heard from BC in Canada that the second dose will have a four month gap there .The army have started to vaccinate the indigenous people living in far flung remote areas .

stefanovich · 05-03-2021 11:43AM

iamwhoiam wrote: »

I heard from BC in Canada that the second dose will have a four month gap there .The army have started to vaccinate the indigenous people living in far flung remote areas .

I would have thought their isolated location would make them very low risk.

iamwhoiam · 05-03-2021 11:45AM

stefanovich wrote: »

I would have thought their isolated location would make them very low risk.

Apparently not , they come to town to shop etc and live in very big family groups plus many of them have uncontrolled Type 2 diabetes . It was spreading among them and the death rate was high I believe

timsey tiger · 05-03-2021 11:47AM

iamwhoiam wrote: »

Apparently not , they come to town to shop etc and live in very big family groups plus many of them have uncontrolled Type 2 diabetes . It was spreading among them and the death rate was high I believe

I'd imagine everything has to be done indoors up there at this time of yer as well. Ventilate - you die of frost bite, don't ventilate - you might get covid.

Chawosfski · 05-03-2021 11:48AM

timsey tiger wrote: »

I'd imagine everything has to be done indoors up there at this time of yer as well. Ventilate - you die of frost bite, don't ventilate - you might get covid.

I'd take the covid lol

Although the way things are gone they'd prob advise us to take the frostbite first

timsey tiger · 05-03-2021 11:53AM

Chawosfski wrote: »

I'd take the covid lol

Although the way things are gone they'd prob advise us to take the frostbite first

Well hopefully the vaccine roll out will sort it out. Sucky stressful situation either way, esp. with the large family groupings most people will be living with somebody vunerable.

stefanovich · 05-03-2021 11:55AM

timsey tiger wrote: »

I'd imagine everything has to be done indoors up there at this time of yer as well. Ventilate - you die of frost bite, don't ventilate - you might get covid.

Wear a jumper.

Wolf359f · 05-03-2021 11:59AM

hmmm wrote: »

4-12 weeks I believe, but happy to be corrected.

4 weeks for over 70's (assuming they can't get an mRna vaccine appointment within 3 weeks)
The rest of the population, 12 week interval.

Russman · 05-03-2021 12:39PM

Wolf359f wrote: »

4 weeks for over 70's (assuming they can't get an mRna vaccine appointment within 3 weeks)
The rest of the population, 12 week interval.

Is it not 6 weeks for 65-69 and then 12 weeks for under 65 ? Thought I saw that a few weeks ago, but open to correction.

Charles Babbage · 05-03-2021 12:48PM

Chawosfski wrote: »

Ya I suppose, taking GPs surgeries out of commision though

Donnelly even talking about dentists lol

These people are over-qualified and needed elsewhere

Complicates rollout imo

Many GPs are also using Saturdays, putting in the extra effort.

As time goes on and vaccine supply increases then we need all hands on board.

For instance, there was a 70 year old retired doctor on the radio who the HSE refused to hire because of his vulnerability to Covid. But if he had both vaccine doses then he could have been hired to give people second vaccinations as these would be unlikely to have Covid.

Wolf359f · 05-03-2021 12:51PM

Russman wrote: »

Is it not 6 weeks for 65-69 and then 12 weeks for under 65 ? Thought I saw that a few weeks ago, but open to correction.

Nevermind, they updated the guidelines the end of February, 12 week interval for all ages.

Cork2021 · 05-03-2021 01:10PM

Wise words!

https://twitter.com/sailorrooscout/status/1367809456415866883?s=21

05-03-2021 01:36PM

https://www.nytimes.com/2021/03/04/world/europe/austria-south-africa-variant.html

Something to keep an eye on. Austria are planning to vaccinate every single adult in the Schwaz District in Tyrol in order to try and contain the outbreak of the South African variant. The EU have allocated them an extra 100,000 Pfizer doses in order to collect data. Vaccination is expected to start next week and it will take about a month to gather results.

Amirani · 05-03-2021 01:42PM

Hardyn wrote: »

https://www.nytimes.com/2021/03/04/world/europe/austria-south-africa-variant.html

Something to keep an eye on. Austria are planning to vaccinate every single adult in the Schwaz District in Tyrol in order to try and contain the outbreak of the South African variant. The EU have allocated them an extra 100,000 Pfizer doses in order to collect data. Vaccination is expected to start next week and it will take about a month to gather results.

This has some similarities to how the Smallpox vaccine was rolled out. Target those most likely to get infected in order to break chains of transmission. Sort of a form of ring vaccination on a district scale: https://en.wikipedia.org/wiki/Ring_vaccination

Sanjuro · 05-03-2021 01:59PM

Cork2021 wrote: »

Wise words!

https://twitter.com/sailorrooscout/status/1367809456415866883?s=21

Unavailable. What did it say?

IRISHSPORTSGUY · 05-03-2021 02:01PM

Will J&J definitely be able to hit the ground running come April? Has there been any news from their CEO to the EU about potential shortages to the EU supply chain?

Turtwig · 05-03-2021 02:06PM

Sanjuro wrote: »

Unavailable. What did it say?

[paraphrased]

Never let perfect be the enemy of good. The best vaccine to use is the one available.

Irish Stones · 05-03-2021 02:06PM

Hardyn wrote: »

https://www.nytimes.com/2021/03/04/world/europe/austria-south-africa-variant.html

Something to keep an eye on. Austria are planning to vaccinate every single adult in the Schwaz District in Tyrol in order to try and contain the outbreak of the South African variant. The EU have allocated them an extra 100,000 Pfizer doses in order to collect data. Vaccination is expected to start next week and it will take about a month to gather results.

It may sounds like the Austrians have found a way to work around the doses allocations and get an extra supply

DaSilva · 05-03-2021 02:45PM

hmmm wrote: »

Oxford vaccine data in the Lancet
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00528-6/fulltext

"Modelling analyses showed an increase in vaccine efficacy after two standard doses from 55·1% (95% CI 33·0 to 69·9) with an interval of less than 6 weeks to 81·3% (60·3 to 91·2) with an interval of at least 12 weeks. A single standard dose had an efficacy against symptomatic COVID-19 in the first 90 days of 76·0% (59·3 to 85·9)"

I'm not qualified to make judgement, but reading this data it looks obvious that we should be using a 12 weeks gap minimum (and possibly longer).

"Notably, in exploratory analyses, vaccine efficacy after a single standard dose was 76·0% (59·3–85·9) from day 22 to day 90, and antibody levels were maintained during this period with minimal waning. "

Yeah, the message I have gotten from real experts on this whole interval debate is that vaccine intervals are normally in the months/years range and not weeks, and that the likely decision for such small intervals (3/4 weeks) in the pfizer/moderna vaccines was that it was the shortest possible interval while still offering a good benefit, highly likely though a longer interval would be better. That doesn't stop it becoming a raging debate nowadays though

eoinbn · 05-03-2021 02:56PM

IRISHSPORTSGUY wrote: »

Will J&J definitely be able to hit the ground running come April? Has there been any news from their CEO to the EU about potential shortages to the EU supply chain?

The only news that I have seen is that they had issues with fill and finish in the US. The EU doses are also fill and finished there so it will likely have a negative impact on the initial EU allocation. However we have no idea how many doses to expect in April. We might find out after approval next week.

stephenjmcd · 05-03-2021 03:02PM

eoinbn wrote: »

The only news that I have seen is that they had issues with fill and finish in the US. The EU doses are also fill and finished there so it will likely have a negative impact on the initial EU allocation. However we have no idea how many doses to expect in April. We might find out after approval next week.

Some fill & finish is taking place in the US but not all.

J&J currently finishing off deals for more fill and finish capacity in Europe, most recently Sanofi have come on board for extra European capacity

Mark1916 · 05-03-2021 03:32PM

https://twitter.com/forexlive/status/1367844556000100357?s=21

hmmm · 05-03-2021 03:50PM

DaSilva wrote: »

Yeah, the message I have gotten from real experts on this whole interval debate is that vaccine intervals are normally in the months/years range and not weeks, and that the likely decision for such small intervals (3/4 weeks) in the pfizer/moderna vaccines was that it was the shortest possible interval while still offering a good benefit, highly likely though a longer interval would be better. That doesn't stop it becoming a raging debate nowadays though

That makes sense, there was a need to get data from the Phase 3 trials as quickly as possibly and they already knew from earlier trials that the vaccines were more than likely going to work.

DylanJM · 05-03-2021 04:57PM

Mark1916 wrote: »

https://twitter.com/forexlive/status/1367844556000100357?s=21

Devastating news for RTE.

05-03-2021 05:10PM

DylanJM wrote: »

Devastating news for RTE.

I doubt they'll notice vaccine news from a twitter account about foreign exchange.

Does anyone have a link to the data they are referring to?

COVID-19: Vaccine and testing procedures Megathread Part 3 - Read OP

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