COVID-19: Vaccine and testing procedures Megathread Part 3 - Read OP

lucernarian · 24-02-2021 11:21PM

Anyone wondering about the J&J vaccine in terms of efficacy? I think they determine severe covid as where hospitalisation was required - 85% efficacy is rather lower than what the mRNA vaccines (or AZ and Sputnik) have been shown to achieve so far.

ACitizenErased · 24-02-2021 11:23PM

lucernarian wrote: »

Anyone wondering about the J&J vaccine in terms of efficacy? I think they determine severe covid as where hospitalisation was required - 85% efficacy is rather lower than what the mRNA vaccines (or AZ and Sputnik) have been shown to achieve so far.

"The Janssen COVID-19 vaccine candidate demonstrated complete protection against COVID-related hospitalization and death, 28 days post-vaccination. There was a clear effect of the vaccine on COVID-19 cases requiring medical intervention (hospitalization, ICU admission, mechanical ventilation, extracorporeal membrane oxygenation (ECMO), with no reported cases among participants who had received the Janssen COVID-19 vaccine, 28 days post-vaccination."
https://www.jnj.com/johnson-johnson-announces-single-shot-janssen-covid-19-vaccine-candidate-met-primary-endpoints-in-interim-analysis-of-its-phase-3-ensemble-trial

Water John · 24-02-2021 11:23PM

If no one ends up in hospital, it's a pretty effective vaccine.

Stheno · 24-02-2021 11:24PM

ACitizenErased wrote: »

"The Janssen COVID-19 vaccine candidate demonstrated complete protection against COVID-related hospitalization and death, 28 days post-vaccination. There was a clear effect of the vaccine on COVID-19 cases requiring medical intervention (hospitalization, ICU admission, mechanical ventilation, extracorporeal membrane oxygenation (ECMO), with no reported cases among participants who had received the Janssen COVID-19 vaccine, 28 days post-vaccination."
https://www.jnj.com/johnson-johnson-announces-single-shot-janssen-covid-19-vaccine-candidate-met-primary-endpoints-in-interim-analysis-of-its-phase-3-ensemble-trial

Didn't notice that thats great news!

NIMAN · 24-02-2021 11:28PM

lucernarian wrote: »

Anyone wondering about the J&J vaccine in terms of efficacy? I think they determine severe covid as where hospitalisation was required - 85% efficacy is rather lower than what the mRNA vaccines (or AZ and Sputnik) have been shown to achieve so far.

Did I not hear rte say it has 68% efficacy?

ACitizenErased · 24-02-2021 11:29PM

NIMAN wrote: »

Did I not hear rte say it has 68% efficacy?

Thats at preventing mild disease. You might get a sniffle. That's higher than the average flu vaccine.

hmmm · 24-02-2021 11:31PM

Moderna have a vaccine tweaked to better cope with the South African variant ready for testing. These new mRNA vaccines are incredible.

https://twitter.com/WSJ/status/1364686233679626242

lucernarian · 24-02-2021 11:35PM

ACitizenErased wrote: »

"The Janssen COVID-19 vaccine candidate demonstrated complete protection against COVID-related hospitalization and death, 28 days post-vaccination. There was a clear effect of the vaccine on COVID-19 cases requiring medical intervention (hospitalization, ICU admission, mechanical ventilation, extracorporeal membrane oxygenation (ECMO), with no reported cases among participants who had received the Janssen COVID-19 vaccine, 28 days post-vaccination."
https://www.jnj.com/johnson-johnson-announces-single-shot-janssen-covid-19-vaccine-candidate-met-primary-endpoints-in-interim-analysis-of-its-phase-3-ensemble-trial

Thanks! I was clearly misinformed on that definition of severe covid. This is excellent news.

Edit: puzzling definition of severe covid cases:

"In the study, the definition of severe COVID-19 disease included laboratory-confirmed SARS-CoV-2 and one or more of the following: signs consistent with severe systemic illness, admission to an intensive care unit, respiratory failure, shock, organ failure or death, among other factors" - I would contend that any of those aspects of the disease necessarily involve hospitalisation.

Can anyone shed light on why they said it prevents 85% of severe infections, but 100% effective at preventing hospitalisation?

Stheno · 24-02-2021 11:44PM

hmmm wrote: »

Moderna have a vaccine tweaked to better cope with the South African variant ready for testing. These new mRNA vaccines are incredible.

https://twitter.com/WSJ/status/1364686233679626242

Wow

The good news has been in abundance this week

Stheno · 24-02-2021 11:45PM

lucernarian wrote: »

Thanks! I was clearly misinformed on that definition of severe covid. This is excellent news.

Edit: puzzling definition of severe covid cases:

"In the study, the definition of severe COVID-19 disease included laboratory-confirmed SARS-CoV-2 and one or more of the following: signs consistent with severe systemic illness, admission to an intensive care unit, respiratory failure, shock, organ failure or death, among other factors" - I would contend that any of those aspects of the disease necessarily involve hospitalisation.

Can anyone shed light on why they said it prevents 85% of severe infections, but 100% effective at preventing hospitalisation?

Sever infection may not need hospitalisation?

landofthetree · 24-02-2021 11:55PM

https://twitter.com/ariehkovler/status/1364707433768173570

Stark · 24-02-2021 11:56PM

Yevon wrote: »

Is there problems with Moderna production or did the EU just order that vaccine in more modest amounts? In June, 6 months after approval in the EU, Ireland are only getting 127,600 doses.

EU ordered 310 million Moderna doses for this year. Most won't arrive till Q3/Q4 though.

hmmm · 24-02-2021 11:56PM

Yevon wrote: »

Is there problems with Moderna production or did the EU just order that vaccine in more modest amounts? In June, 6 months after approval in the EU, Ireland are only getting 127,600 doses.

Moderna focused on the US, and have said that the rest-of-the-world supply chain is about one quarter behind their US production.

dublin_paul · 24-02-2021 11:56PM

landofthetree wrote: »

https://twitter.com/ariehkovler/status/1364707433768173570

Awesome news!:cool:

lbj666 · 25-02-2021 12:03AM

dublin_paul wrote: »

Awesome news!:cool:

When he quotes;

92% against infection (88-95%)
94% against symptomatic Covid (87-98%)
92% against severe disease (75-100%)

Surely the severe disease is a subset of the %tage of infections.
So it's 8% of those infected had a severe case, not 8% of those vacinated?

dublin_paul · 25-02-2021 12:06AM

lbj666 wrote: »

When he quotes;

92% against infection (88-95%)
94% against symptomatic Covid (87-98%)
92% against severe disease (75-100%)

Surely the severe disease is a subset of the %tage of infections.
So it's 8% of those infected had a severe case, not 8% of those vacinated?

I presume its 92% less people having severe disease when compared to unvaccinated people, 92% less people being infested when compared to unvaccinated people, and 94% less symptomatic covid people when compared to unvaccinated people...

Micky 32 · 25-02-2021 12:08AM

https://twitter.com/vinguptamd/status/1363924018215096322?s=21

ACitizenErased · 25-02-2021 12:19AM

Moderna is testing 3 approaches for boosters:

1) The new variant specific booster
2) A multivalent booster combining the 'old' version and the 'new version' of the vaccine in a single dose
3) A third dose of the 'old' vaccine

Mark1916 · 25-02-2021 12:28AM

https://twitter.com/reuters/status/1364718050700894208?s=21

lbj666 · 25-02-2021 12:30AM

dublin_paul wrote: »

I presume its 92% less people having severe disease when compared to unvaccinated people, 92% less people being infested when compared to unvaccinated people, and 94% less symptomatic covid people when compared to unvaccinated people...

Ah not thinking right , so In our case over 70s hospitalisation rate is 15-20%, but vaccined knocks it down to 1.2-1.6%. Great outcome but not a neglible %tage either.

lbj666 · 25-02-2021 12:56AM

https://twitter.com/DarrenEuronews/status/1364611262961844231?s=20

Wow, if anyone wants to see what an abysmal rollout due to poor communication and messaging looks like, they shouldnt be looking for it on this island.

Stheno · 25-02-2021 12:58AM

lbj666 wrote: »

https://twitter.com/DarrenEuronews/status/1364611262961844231?s=20

Wow, if anyone wants to see what an abysmal rollout due to poor communication and messaging looks like, they shouldnt be looking for it on this island.

Perhaps we can buy these from Germany?

hynesie08 · 25-02-2021 12:58AM

lbj666 wrote: »

https://twitter.com/DarrenEuronews/status/1364611262961844231?s=20

Wow, if anyone wants to see what an abysmal rollout due to poor communication and messaging looks like, they shouldnt be looking for it on this island.

Can we swap them? 10 AZ for 4 pfizer?

Frank Bullitt · 25-02-2021 01:07AM

https://twitter.com/laoneill111/status/1364726483974053889

Good news again.

Stark · 25-02-2021 01:16AM

Wonder when we could expect to receive Novavax doses assuming EMA approval?

lbj666 · 25-02-2021 01:17AM

Stheno wrote: »

Perhaps we can buy these from Germany?

Nah they'll hold out in the hope the US trial results will finally convince them.

astrofool · 25-02-2021 01:25AM

hynesie08 wrote: »

Can we swap them? 10 AZ for 4 pfizer?

No, there is plenty of supply coming and we'd be stupid to swap mRNA vaccines for AZ.

lbj666 · 25-02-2021 01:31AM

https://twitter.com/sailorrooscout/status/1364375627953020937?s=20

Will we just turn this thread to a feed of whoever this is.

marno21 · 25-02-2021 01:34AM

Stark wrote: »

Wonder when we could expect to receive Novavax doses assuming EMA approval?

The EU haven’t done a deal with Novavax yet but they are currently concluding one for 100m doses + 100m options.

The Novavax vaccine is supposed to be easy to mass manufacture so if we include that shortly we’ll be entering snuff at a wake territory when it comes to vaccines.

KrustyUCC · 25-02-2021 01:35AM

lbj666 wrote: »

https://twitter.com/sailorrooscout/status/1364375627953020937?s=20

Will we just turn this thread to a feed of whoever this is.

Funny Bouchar-Hayes, Claire Byrne and George Lee all mentioned the California Variant yesterday

COVID-19: Vaccine and testing procedures Megathread Part 3 - Read OP

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