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COVID-19: Vaccine/antidote and testing procedures Megathread [Mod Warning - Post #1]

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  • #3422
    jackboy
    Registered Users, Registered Users 2 Posts: 5,030 ✭✭✭jackboy


    Gael23 wrote: »
    The traditional flu vaccine has to be taken every year so I don’t see the issue.

    Covid is more infectious and more deadly than the flu. A Covid vaccine would need to perform much better than the annual flu job or it won’t get us out of trouble. Hopefully it will, maybe Covid evolves slower than flu which will gives vaccine scientists a better chance.


  • #3423
    Russman
    Registered Users, Registered Users 2 Posts: 5,978 ✭✭✭Russman


    If, as has been suggested somewhere, the first generation vaccines give limited protection, and the second generation (somewhere down the line) might be “better”, would you be able to take a second version or would it be negated by the first one ?


  • #3424
    timsey tiger
    Registered Users, Registered Users 2 Posts: 1,768 ✭✭✭timsey tiger


    Russman wrote: »
    If, as has been suggested somewhere, the first generation vaccines give limited protection, and the second generation (somewhere down the line) might be “better”, would you be able to take a second version or would it be negated by the first one ?

    Wouldn't think it should be a problem, you can take a new flu shot every year.


  • #3425
    dominatinMC
    Registered Users, Registered Users 2 Posts: 3,130 ✭✭✭dominatinMC


    A lot of good news on the vaccine front. Despite the odd anti-mask/anti-vax sentiment, this thread is a breath of fresh air compared to all the doom and gloom on the other threads!


  • #3426
    Le Bruise
    Registered Users, Registered Users 2 Posts: 1,353 ✭✭✭Le Bruise


    dominatinMC wrote: »
    A lot of good news on the vaccine front. Despite the odd anti-mask/anti-vax sentiment, this thread is a breath of fresh air compared to all the doom and gloom on the other threads!

    Amen brother!


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  • #3427
    landofthetree
    Registered Users, Registered Users 2 Posts: 2,463 ✭✭✭landofthetree


    Micky 32 wrote: »
    Yep. The vaccine doesn’t need to eradicate Covid 19 or is it a silver bullet . All this vaccine needs to do is reduce the severity of the virus. It should bring it down to levels that will be no peskier than the normal flu. Life then should get back to some normality.

    Youre way too optimistic. I told you around 6 weeks ago full lockdown was coming back. You and others mocked me.
    Enjoy your lockdown, when i’m passing your house i’ll wave at you through the window behind the curtains.
    https://www.boards.ie/vbulletin/showthread.php?t=2058106893&page=422

    Im telling you now vaccines wont stop restrictions.


  • #3428
    Deeper Blue
    Registered Users, Registered Users 2 Posts: 8,406 ✭✭✭Deeper Blue


    landofthetree wrote: »
    vaccines wont stop restrictions.

    Source?


  • #3429
    Hmmzis
    Registered Users, Registered Users 2 Posts: 2,004 ✭✭✭Hmmzis


    jackboy wrote: »
    Covid is more infectious and more deadly than the flu. A Covid vaccine would need to perform much better than the annual flu job or it won’t get us out of trouble. Hopefully it will, maybe Covid evolves slower than flu which will gives vaccine scientists a better chance.

    Nothing to do with infectiousness. Influenza has quite rapid antigenic drift (it mutates fast), so the vaccines and our immune systems have to adjust to that all the time.
    Measles uses infectiousenss as an immune system outrunning mechanism.

    Coronaviruses and lots of other viruses use different tactics, the most prominent among the common cold hCoVs seems to be 'canyoning'. This is a feature where the binding motifs in the virus receptor domain are shielded by being recessed in what looks like grooves (hence the term 'canyoning'). This needs higher affinity and larger quantities of neutralizing antibodies. The odd bit about SARS-cov-2 is that the whole RBD is very flat, there is no sign of any 'canyoning' so far. This should make it quite prone to neutralization by even modest amounts of nABs.


  • #3430
    Le Bruise
    Registered Users, Registered Users 2 Posts: 1,353 ✭✭✭Le Bruise


    landofthetree wrote: »
    Youre way too optimistic. I told you around 6 weeks ago full lockdown was coming back.

    What do lockdowns right now have to do with vaccines early next year?


  • #3431
    FrogmanBegins
    Banned (with Prison Access) Posts: 57 ✭✭FrogmanBegins


    El Sueño wrote: »
    Source?

    As much as I hate to say it he's probably right. The crowd here will be glacial in lifting restrictions even if a vaccine somehow rolls out in the next 3 months.


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  • #3432
    landofthetree
    Registered Users, Registered Users 2 Posts: 2,463 ✭✭✭landofthetree


    El Sueño wrote: »
    Source?

    https://www.dailysabah.com/world/europe/oxford-expert-vaccines-not-going-to-end-coronavirus-pandemic


  • #3433
    Le Bruise
    Registered Users, Registered Users 2 Posts: 1,353 ✭✭✭Le Bruise


    landofthetree wrote: »
    https://www.dailysabah.com/world/europe/oxford-expert-vaccines-not-going-to-end-coronavirus-pandemic

    A report from August?


  • #3434
    Deeper Blue
    Registered Users, Registered Users 2 Posts: 8,406 ✭✭✭Deeper Blue


    landofthetree wrote: »
    https://www.dailysabah.com/world/europe/oxford-expert-vaccines-not-going-to-end-coronavirus-pandemic


    The pandemic won't be over for a while but that doesn't mean restrictions won't be lifted, or at least the majority of them


  • #3435
    landofthetree
    Registered Users, Registered Users 2 Posts: 2,463 ✭✭✭landofthetree


    El Sueño wrote: »
    The pandemic won't be over for a while but that doesn't mean restrictions won't be lifted, at least the majority of them
    But she was hopeful that by 2022 there would be no need for people to wear face masks, and was more confident that we could be bringing in 2022 with family gatherings and parties.

    https://www.bbc.com/news/uk-scotland-54573288

    I think it will be 2022 at the earliest before we can get out of levels and got back to normal.


  • #3436
    Le Bruise
    Registered Users, Registered Users 2 Posts: 1,353 ✭✭✭Le Bruise


    FrogmanBegins wrote: »
    As much as I hate to say it he's probably right. The crowd here will be glacial in lifting restrictions even if a vaccine somehow rolls out in the next 3 months.

    Even if a vaccine ’Somehow rolls out’....are you following this thread at all?? Signs are really good for a vaccine and expert after expert are falling in line to say so. Every economy in the world will be dying to open up once there is some manner of roll out...they can’t afford an alternative!


  • #3437
    ACitizenErased
    Registered Users, Registered Users 2 Posts: 11,751 ✭✭✭✭ACitizenErased


    I'd put money that some people in Ireland will be vaccinated before year's end.


  • #3438
    Thierry12
    Closed Accounts Posts: 979 ✭✭✭Thierry12


    FrogmanBegins wrote: »
    As much as I hate to say it he's probably right. The crowd here will be glacial in lifting restrictions even if a vaccine somehow rolls out in the next 3 months.

    Its a good question

    Expected minimum results from vaccines are no sterilising immunity and 50% efficacy

    Do we presume the other 50% wont get sick from the disease or do we expect some to still die

    Say 45% don't get very sick and 5% do and might require hospitalisation

    Would we cope with no restrictions and letting it free at that stage hospital wise?


  • #3439
    [Deleted User]
    Posts: 0 ✭ [Deleted User]


    We just need to get some of the guys who are rolling out Covid-19 through the 5g network to switch sides. Then the eventual vaccine can be rolled out the same way.


  • #3440
    blowitupref
    Registered Users, Registered Users 2 Posts: 2,134 ✭✭✭blowitupref


    ACitizenErased wrote: »
    I'd put money that some people in Ireland will be vaccinated before year's end.
    The some people as in Simon, Michael, Leo and Stephen?


  • #3441
    stephenjmcd
    Registered Users, Registered Users 2 Posts: 15,445 ✭✭✭✭stephenjmcd


    landofthetree wrote: »
    https://www.bbc.com/news/uk-scotland-54573288

    I think it will be 2022 at the earliest before we can get out of levels and got back to normal.

    It doesn't go back to normal overnight. Healthy young people won't get a vaccine until late 2021, thats what she's getting at. Of course she's right saying next Christmas/ new year should be normal. They should be all going well.

    You don't need everyone vaccinated for restictions to be eased up on. When front line and vulnerable are vaccinated then that's a huge part of transmission broken. Q2 is when I would suspecting pending enough have received a vaccine for restrictions to be eased significantly.

    Also your linking to the UK discussing their supplies of vaccine. While they have contracts with companies, the EU supply is far greater. They made the choice not to join the EU vaccine alliance which has secured a massive stockpile, 100m doses promised in first batch.

    Also if you think this will be "over", it won't be, covid will eventually become another virus that you get a vaccine for and we'll be back about our normal lives


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  • #3442
    FrogmanBegins
    Banned (with Prison Access) Posts: 57 ✭✭FrogmanBegins


    stephenjmcd wrote: »
    It doesn't go back to normal overnight. Healthy young people won't get a vaccine until late 2021, thats what she's getting at. Of course she's right saying next Christmas/ new year should be normal. They should be all going well.

    You don't need everyone vaccinated for restictions to be eased up on. When front line and vulnerable are vaccinated then that's a huge part of transmission broken. Q2 is when I would suspecting pending enough have received a vaccine for restrictions to be eased significantly.

    Also your linking to the UK discussing their supplies of vaccine. While they have contracts with companies, the EU supply is far greater. They made the choice not to join the EU vaccine alliance which has secured a massive stockpile, 100m doses promised in first batch.

    Also if you think this will be "over", it won't be, covid will eventually become another virus that you get a vaccine for and we'll be back about our normal lives

    **** it once I'm vaccinated I'm doing whatever I want. **** the restrictions I'm getting absolutely pissed


  • #3443
    stephenjmcd
    Registered Users, Registered Users 2 Posts: 15,445 ✭✭✭✭stephenjmcd


    ACitizenErased wrote: »
    I'd put money that some people in Ireland will be vaccinated before year's end.

    I wouldn't be surprised if there was but I think new year might be a more realistic chance.

    I'm thinking of it from a purely logistical mindset, we're looking at mid November for phase 3 data and add on time for EMA approval which shouldn't take long, takes us to early December.

    Seeing as its the HSE who couldn't have worse organisational skills I'd say they push it to early January. All eyes will be on them, they'll need to get it right.

    I'd suspect they probably copy the British approach of drive through centers.


  • #3444
    Le Bruise
    Registered Users, Registered Users 2 Posts: 1,353 ✭✭✭Le Bruise


    FrogmanBegins wrote: »
    **** it once I'm vaccinated I'm doing whatever I want. **** the restrictions I'm getting absolutely pissed

    That’s the spirit


  • #3445
    hmmm
    Registered Users, Registered Users 2 Posts: 11,203 ✭✭✭✭hmmm


    Good interview with Osterholm on US TV. I think we need commentators in this country laying down the law & saying similar.

    https://www.nbcnews.com/meet-the-press/video/full-osterholm-next-six-to-twelve-weeks-are-going-to-be-the-darkest-of-the-entire-pandemic-94087237514


  • #3446
    FrogmanBegins
    Banned (with Prison Access) Posts: 57 ✭✭FrogmanBegins


    Le Bruise wrote: »
    That’s the spirit

    I'll probably have someone on lecturing me about how we need to lockdown in case the virus evolves to beat the vaccine and cause everyone's nipples to fall off.


  • #3447
    marno21
    Moderators, Science, Health & Environment Moderators Posts: 14,650 Mod ✭✭✭✭marno21


    I sincerely hope there is some sort of a plan within Government to heed advance notice from the EU regarding when vaccines become available and throw every logistical asset at vaccinating as many people as possible as soon as possible.

    This is the most critical operation for the country in my lifetime and likely sometime before that. The list of elements of life in this country that are dependent on a quick and effective rollout of a vaccine is endless. People want normal back and it should be the number one priority.


  • #3448
    FrogmanBegins
    Banned (with Prison Access) Posts: 57 ✭✭FrogmanBegins


    marno21 wrote: »
    I sincerely hope there is some sort of a plan within Government to heed advance notice from the EU regarding when vaccines become available and throw every logistical asset at vaccinating as many people as possible as soon as possible.

    This is the most critical operation for the country in my lifetime and likely sometime before that. The list of elements of life in this country that are dependent on a quick and effective rollout of a vaccine is endless. People want normal back and it should be the number one priority.

    The HSE have ****ed everything up so far why would this be different? They probably still don't believe there'll be a vaccine that soon. Glynn and Holohan rarely mention it.


  • #3449
    stephenjmcd
    Registered Users, Registered Users 2 Posts: 15,445 ✭✭✭✭stephenjmcd


    marno21 wrote: »
    I sincerely hope there is some sort of a plan within Government to heed advance notice from the EU regarding when vaccines become available and throw every logistical asset at vaccinating as many people as possible as soon as possible.

    This is the most critical operation for the country in my lifetime and likely sometime before that. The list of elements of life in this country that are dependent on a quick and effective rollout of a vaccine is endless. People want normal back and it should be the number one priority.

    They should already be planning, the EU have told countries to prepare their for rollout so between dept of health and the HSE there just has to be a team dedicated to this.

    All eyes on them, hopefully its a realistic plan.

    If they haven't started planning they'd want to get moving and quickly


  • #3450
    FintanMcluskey
    Registered Users, Registered Users 2 Posts: 8,624 ✭✭✭FintanMcluskey


    stephenjmcd wrote: »
    It doesn't go back to normal overnight. Healthy young people won't get a vaccine until late 2021, thats what she's getting at. Of course she's right saying next Christmas/ new year should be normal. They should be all going well.

    You don't need everyone vaccinated for restictions to be eased up on. When front line and vulnerable are vaccinated then that's a huge part of transmission broken. Q2 is when I would suspecting pending enough have received a vaccine for restrictions to be eased significantly.

    Also your linking to the UK discussing their supplies of vaccine. While they have contracts with companies, the EU supply is far greater. They made the choice not to join the EU vaccine alliance which has secured a massive stockpile, 100m doses promised in first batch.

    Also if you think this will be "over", it won't be, covid will eventually become another virus that you get a vaccine for and we'll be back about our normal lives

    What’s your opinion of when normal will be?

    Sports stadiums, foreign travel etc?


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  • #3451
    marno21
    Moderators, Science, Health & Environment Moderators Posts: 14,650 Mod ✭✭✭✭marno21


    FrogmanBegins wrote: »
    The HSE have ****ed everything up so far why would this be different? They probably still don't believe there'll be a vaccine that soon. Glynn and Holohan rarely mention it.

    This should be above the HSE. It’s more important. It’s a national health, economic and social requirement. It doesn’t need to be HSE led. The army and Gardai should be involved to help with logistics - if Gardai can be deployed asking people not to leave their county they certainly should be helping the logistics of a mass vaccination programme.

    There is nothing more important than this in the next few months. There is little that doesn’t depend on it. Critical is an understatement.


This discussion has been closed.
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