COVID-19: Vaccine/antidote and testing procedures Megathread [Mod Warning - Post #1]

Kermit.de.frog · 10-10-2020 07:12PM

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charlie14 · 10-10-2020 07:14PM

Diarmuid wrote: »

What a bizarre post. No mention in my post about masks for or against. Classic whatbaoutery, when you are unable to deal with the substance of the post

No whataboutery. Just factual information on one of the countries you mentioned as far as I remember.
You may not have noticed the title of this thread, Vaccine/antidote and testing procedures.

If there is whataboutery here then is it the "what about face masks" that have nothing whatsoever to do with the title of this thread.

Royal Irish · 10-10-2020 07:19PM

Dionaibh wrote: »

But you've just described the problem: the normalisation of masks. Masks rob people of their humanity. No smiles, no expressions, just masks everywhere.

Rubbish. I lived in Bangkok and regularly wore a mask due to the traffic pollution and the only time I felt robbed of my humanity was when I visited a gogo bar.

charlie14 · 10-10-2020 07:22PM

Beasty wrote: »

Take your mask discussion to the masks thread - it's not for here

If you don`t mind I`ll hang on here.

Not really into psychobabble or conspiracy theories.

Dionaibh · 10-10-2020 07:24PM

Cordell wrote: »

Because no one really trust them. No one trust them that they didn't fudge the numbers so far, so they would have to start from phase 1, and they're already doing that with their own vaccines.
The russians are not ahead with their vaccine, not even them actually claim that, but they launched some rumors that imply they are. They aren't.

I think you're right, but I would not hesitate to take the Russian vaccine if I had to take one to be able to travel. It's based on an Ebola vaccine, and on a vaccine they worked on for MERS for around 6 years. It uses proven technology, and I think it has a good chance of being effective.

Cordell · 10-10-2020 07:33PM

You only have their word and Putin's seal of approval for it. You can't trust neither.
The western vaccines in phase 3 are at least safe, at least with a high degree of probability, and that's based on actual evidence.
None of them is proven to be effective, so at least go with what's safe.

Dionaibh · 10-10-2020 07:47PM

Cordell wrote: »

You only have their word and Putin's seal of approval for it. You can't trust neither.
The western vaccines in phase 3 are at least safe, at least with a high degree of probability, and that's based on actual evidence.
None of them is proven to be effective, so at least go with what's safe.

A Q&A style article by Kirill Dmitriev, CEO of the Russian Direct Investment Fund: https://www.rt.com/russia/500087-worlds-first-covid-19-vaccine-questions/

I hope people won't dismiss it because it's on rt. It's very informative and he compares the Russian vaccine with other vaccines in development.

An interview with Denis Logunov, a microbiologist who worked on the vaccine: https://meduza.io/en/feature/2020/07/23/russia-s-way-out

Also very informative.

Cordell · 10-10-2020 07:55PM

I hope people won't dismiss it because it's on rt

No, but I would dismiss any claim coming from the russians. Q&A interviews are not a substitute for actual tests, let's see those, not empty claims.

Dionaibh · 10-10-2020 07:59PM

Cordell wrote: »

No, but I would dismiss any claim coming from the russians. Q&A interviews are not a substitute for actual tests, let's see those, not empty claims.

You're right, but they published the results of the Phase 1 clinical trials in the Lancet and they looked good. I thought it was interesting to learn how and why they were able to move quickly developing the vaccine. The media would have people believe that they had a vaccine after a couple of months when in reality they tweaked existing vaccines that they worked on for years.

Cordell · 10-10-2020 08:02PM

I really don't get the point so I'm stopping at this: there are many vaccines that passed both phase 1 and 2 and there are a few in phase 3. Yet you are still putting all your hopes into a vaccine that arguably passed phase 1. Your choice I suppose.

Dionaibh · 10-10-2020 08:04PM

Cordell wrote: »

I really don't get the point so I'm stopping at this: there are many vaccines that passed both phase 1 and 2 and there are a few in phase 3. Yet you are still putting all your hopes into a vaccine that arguably passed phase 1. Your choice I suppose.

Sorry, I didn't mean to labour the point.

cgc5483 · 10-10-2020 08:09PM

Hmmzis wrote: »

AstraZeneca kicking off their monoclonal antibody phase 3 trials as well:

https://www.astrazeneca.com/media-centre/press-releases/2020/covid-19-long-acting-antibody-laab-combination-azd7442-rapidly-advances-into-phase-iii-clinical-trials.html

Similar to Regeneron they're using two mABs in their cocktail and in addition they're engineered for stability (6 to 12 months per dose) and are lacking the Fc receptor (can't serve as tags, but they're neutralizing anyway, so nothing lost there). Price for the US government looks to be around 5k per dose, 100k doses in 2020.

The Fc receptor is found on cells not antibodies. These antibodies have site directed mutations in their Fc region which prevents/diminishes them interacting with the Fc receptor resulting in less clearance and longer half-life.

Hmmzis · 10-10-2020 09:53PM

cgc5483 wrote: »

The Fc receptor is found on cells not antibodies. These antibodies have site directed mutations in their Fc region which prevents/diminishes them interacting with the Fc receptor resulting in less clearance and longer half-life.

Thank you very much for the correction and further explanation, duly noted.

Rrrrrr2 · 10-10-2020 11:06PM

Dionaibh wrote: »

I fear it's because it's from Russia, and the media are programmed to oppose all things Russia.

That’s what I thought (they’ve a great scientific reputation throughout history) plus the USA and European pharma industry would not be in control

Rrrrrr2 · 10-10-2020 11:11PM

Cordell wrote: »

You only have their word and Putin's seal of approval for it. You can't trust neither.
The western vaccines in phase 3 are at least safe, at least with a high degree of probability, and that's based on actual evidence.
None of them is proven to be effective, so at least go with what's safe.

What does that even mean- “Putins seal of approval”? Sounds anti Russian to me (I can’t stand putin btw)- surely you take the vaccine on its scientific merits. You test it under the prescribed reg conditions in clinical trials.
You say it’s not proven to be effective- is there data available to prove that?

Rrrrrr2 · 10-10-2020 11:14PM

Cordell wrote: »

No, but I would dismiss any claim coming from the russians. Q&A interviews are not a substitute for actual tests, let's see those, not empty claims.

But we should be do in h those tests under license here in Europe and test he Russian vaccine. If it fails, then we know it’s not effective. But I don’t think we should be dismissing and borderline sniggering at it “ah sure it’s only the Russians I wouldn’t trust them” narrative

hmmm · 10-10-2020 11:20PM

Rrrrrr2 wrote: »

Question- why dont authorities here test the Russian vaccine or a western bio pharma company licence it from the Russians and go through the regulatory tests it would need for European registration?

Because Sergei there are lots of perfectly good other vaccines in trials. If the Russians themselves want to spend a few hundred million testing their vaccine to Western standards then good for them. The Russians haven't helped themselves by hyping it up based on what was Phase 1/2 studies.

Dionaibh · 10-10-2020 11:20PM

Rrrrrr2 wrote: »

That’s what I thought (they’ve a great scientific reputation throughout history) plus the USA and European pharma industry would not be in control

They have. The media are so dishonest. They claimed Russia had a vaccine after a couple of months. In reality they were able to produce one quickly because they had done years of research and development on vaccines for Ebola and MERS.

Dionaibh · 10-10-2020 11:23PM

hmmm wrote: »

Because there are lots of perfectly good other vaccines in trials. If the Russians themselves want to spend a few hundred million testing their vaccine to Western standards then good for them. The Russians haven't helped themselves by hyping it up based on what was Phase 1/2 studies.

I believe the reason they are very confident about the vaccine is because they did years of research on vaccines they worked on for Ebola and MERS. That meant they were able to move quickly. They just had to tweak those vaccines. They are also using proven technology whereas other vaccines are using experimental technology.

hmmm · 10-10-2020 11:25PM

Dionaibh wrote: »

I believe the reason they are very confident about the vaccine is because they did years of research on vaccines they worked on for Ebola and MERS. That meant they were able to move quickly. They just had to tweak those vaccines. They are also using proven technology whereas other vaccines are using experimental technology.

Same with Oxford, and they are testing it on 30,000+ people anyway because that's how we do things. Good for the Russians, and they have plenty of expertise in this area, but it's up to them if they want to have their vaccine tested and approved to Western standards.

Dionaibh · 10-10-2020 11:29PM

hmmm wrote: »

Same with Oxford, and they are testing it on 30,000+ people anyway because that's how we do things. Good for the Russians, and they have plenty of expertise in this area, but it's up to them if they want to have their vaccine tested and approved to Western standards.

But, if I'm not mistaken, the Russians are testing it on 40,000 people in various countries as we speak.

hmmm · 10-10-2020 11:32PM

Dionaibh wrote: »

But, if I'm not mistaken, the Russians are testing it on 40,000 people in various countries as we speak.

Great stuff, here's hoping you'll take it.

Dionaibh · 10-10-2020 11:45PM

hmmm wrote: »

Great stuff, here's hoping you'll take it.

If I had to take one I'd probably take that one

charlie14 · 10-10-2020 11:58PM

Dionaibh wrote: »

If I had to take one I'd probably take that one

Rather than one that has gone through the CDC vaccine testing and approval process ?

rottie 11 · 11-10-2020 12:33AM

I was tested yesterday morning at 10am , I was told I’d get a text or phone call probably today but received nothing. Is it possible to get the text on a Sunday does anyone know ? I kind of want to know ASAP if I’m negative or not, it’s doing my brain in thinking about it

charlietheminxx · 11-10-2020 12:37AM

rottie 11 wrote: »

I was tested yesterday morning at 10am , I was told I’d get a text or phone call probably today but received nothing. Is it possible to get the text on a Sunday does anyone know ? I kind of want to know ASAP if I’m negative or not, it’s doing my brain in thinking about it

Standard for results at the moment is 24-48 hours, though I believe there’s a backlog in some areas. Texts come 7 days a week, you’ll likely hear tomorrow.

rottie 11 · 11-10-2020 12:37AM

charlietheminxx wrote: »

Standard for results at the moment is 24-48 hours, though I believe there’s a backlog in some areas. Texts come 7 days a week, you’ll likely hear tomorrow.

Perfect wasn’t sure if they’d be texts on a Sunday. Thanks a mil

Away With The Fairies · 11-10-2020 03:14AM

For those following the vaccines, is it true that a vaccine isn't going to give immunity?

Thierry12 · 11-10-2020 07:47AM

Away With The Fairies wrote: »

For those following the vaccines, is it true that a vaccine isn't going to give immunity?

Yes its true

No sterilising immunity

Nasal vaccines might give it in the future

Away With The Fairies · 11-10-2020 08:20AM

Thierry12 wrote: »

Yes its true

No sterilising immunity

Nasal vaccines might give it in the future

What the fcuk? So basically, we're all getting this virus?

COVID-19: Vaccine/antidote and testing procedures Megathread [Mod Warning - Post #1]

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