COVID-19: Vaccine and testing procedures Megathread Part 2 [Mod Warning - Post #1]

gally74

The us bought 200m vs the 80m for europe of moderna,

Howver yet again we are getting pittance vs the us,

This is s scandal by the EMA and the EC.

https://www.bloomberg.com/graphics/covid-vaccine-tracker-global-distribution/contracts-purchasing-agreements.html

gally74

https://twitter.com/redouad/status/1359199835056967680?s=21

eoinbn

gally74 wrote: »

The us bought 200m vs the 80m for europe of moderna,

Howver yet again we are getting pittance vs the us,

This is s scandal by the EMA and the EC.

https://www.bloomberg.com/graphics/covid-vaccine-tracker-global-distribution/contracts-purchasing-agreements.html

It has zero to do with the EMA.
Moderna are a US company that were funded by the US and are serving the US first. I believe nearly all the doses they have created have gone to the US market and have supplied more than Pfizer. The UK aren't due to get any from them until March.

Happydays2020

Stheno wrote: »

Depends on age AZ is twelve weeks for the u 65

4 weeks for Pfizrtand Moderna

The 12 weeks between doses for AZ means that even if we had supply of it and it was recommended for over 65, the better strategy is probably Pfizer in terms of getting as many vaccinated in the shortest period of time. Hopefully we will not have the syringe issues like elsewhere.

If AZ supplies come in, who will get it?

stephenjmcd

Happydays2020 wrote: »

The 12 weeks between doses for AZ means that even if we had supply of it and it was recommended for over 65, the better strategy is probably Pfizer in terms of getting as many vaccinated in the shortest period of time. Hopefully we will not have the syringe issues like elsewhere.

If AZ supplies come in, who will get it?

They're already coming in and going to healthcare workers at the moment

Happydays2020

stephenjmcd wrote: »

They're already coming in and going to healthcare workers at the moment

But who after them. It is a trickle now but supply will increase.

iamwhoiam

Happydays2020 wrote: »

But who after them. It is a trickle now but supply will increase.

As far as I understand the next group which is 65-70 will get AZ . That group could run parallel to the 70-85 who are getting Pfizer. So in theory a 69 year old could be vaccinated before a 70 year old
But it is what it is unless they take the WHO recommendations on board now

Golfman64

stephenjmcd wrote: »

Highly caveated study that didn't adhere to the dosing schedule to start with.

Remember the Danish mink scare-mongering. We were all doomed, until we weren't, once cool heads and some proper research prevailed.

I am starting to think that once the schools go back, the quality of posting on here will improve again.

stephenjmcd

Golfman64 wrote: »

Remember the Danish mink scare-mongering. We were all doomed, until we weren't, once cool heads and some proper research prevailed.

I am starting to think that once the schools go back, the quality of posting on here will improve again.

Indeed cool heads and proper research.

Some people will jump on anything and try to present it as fact. As for the SA study, it doesn't seem to matter to some people that basic principles such as dosing schedule weren't adhered to. I mean if something as basic as that is done wrong then what's the point in jumping to conclusions.

I partially blame the level of journalism to be fair, its constantly who can be first to break a story, never mind fact checking just get it out there as soon as possible.

SheepsClothing

Golfman64 wrote: »

Remember the Danish mink scare-mongering. We were all doomed, until we weren't, once cool heads and some proper research prevailed.

I am starting to think that once the schools go back, the quality of posting on here will improve again.

Remember the Wuhan coronavirus outbreak? We were all doomed, until we weren't, once cool heads and some proper research prevailed.

Polar101

stephenjmcd wrote: »

Indeed cool heads and proper research.

Yeah. While the reports of the variants sound worrying, it's nothing unexpected. 10 months ago I didn't think we'd be vaccinating people before the end of the year, but that happened. I'm not a virologist, so I won't be able to do anything about the variants, so why would I worry about them? The actual experts will be able to do whatever updates are required to the vaccines.

Sanjuro

Not sure if this was posted yet-

https://www.ft.com/content/f654d813-5c4c-4d86-827f-c6a73eea9a30

caveat emptor

Yeah I was only messing with South Africa. I called them up and said it won't work so they stop the AZ roll out. :eek:

WTF are people on. A country trying to get out of this realises the vaccine is not effective at all against the variant in a clinical trial and the logical conclusion is random internet poster who I don't like is making it up.

Grow up will ye.

stephenjmcd

Sanjuro wrote: »

Not sure if this was posted yet-

https://www.ft.com/content/f654d813-5c4c-4d86-827f-c6a73eea9a30

I think they had been potentially lined up to manufacture Sputnik, good to see the capacity being used.

Any indication of how long it'll take to come on stream ?

VG31

stephenjmcd wrote: »

I think they had been potentially lined up to manufacture Sputnik, good to see the capacity being used.

Any indication of how long it'll take to come on stream ?

Late next year according to the Guardian. Not much use really.

https://www.theguardian.com/business/2021/feb/10/astrazeneca-to-build-new-covid-19-vaccine-facility-in-germany

Golfman64

SheepsClothing wrote: »

Remember the Wuhan coronavirus outbreak? We were all doomed, until we weren't, once cool heads and some proper research prevailed.

For the majority it is a mild virus and unfortunately for some, it's lethal. This is far better than was initially expected. Secondly, within a year, we have in this country, 3 effective vaccines already proven to prevent and/or reduce infection and the severity of the disease for all known strains. I would certainly agree that we are not all doomed.

Gael23

Has anybody heard of over 85s being contacted regarding g getting the vaccine next week?

Sconsey

Golfman64 wrote: »

For the majority it is a mild virus and unfortunately for some, it's lethal. This is far better than was initially expected. Secondly, within a year, we have in this country, 3 effective vaccines already proven to prevent and/or reduce infection and the severity of the disease for all known strains. I would certainly agree that we are not all doomed.

What was the initial fatallity rate expected to be?

ACitizenErased

caveat emptor wrote: »

Yeah I was only messing with South Africa. I called them up and said it won't work so they stop the AZ roll out. :eek:

WTF are people on. A country trying to get out of this realises the vaccine is not effective at all against the variant in a clinical trial and the logical conclusion is random internet poster who I don't like is making it up.

Grow up will ye.

You continuously refer to a study which wouldn't pass junior cert science, well done.

Bubbaclaus

Gael23 wrote: »

Has anybody heard of over 85s being contacted regarding g getting the vaccine next week?

Only the 84 largest GP practices are getting doses for next week, and only finding out in the last day or so when to expect delivery. They need to ensure the process is working first before sending out tens of thousands of doses.

Micky 32

ACitizenErased wrote: »

You continuously refer to a study which wouldn't pass junior cert science, well done.

The hilarious bit is that said poster was claiming 10% efficacy of the vaccine vs the SA variant as fact. But when it was pointed out that it still prevents serious illlness and death he jumped on the keyboard with this little beauty “ There’s no clinical evidence of this yet” :pac: talk about contradicting oneself!

I think the vaccines are a thorn in the side for some.

Tchaikovsky

caveat emptor wrote: »

Yeah I was only messing with South Africa. I called them up and said it won't work so they stop the AZ roll out. :eek:

WTF are people on. A country trying to get out of this realises the vaccine is not effective at all against the variant in a clinical trial and the logical conclusion is random internet poster who I don't like is making it up.

Grow up will ye.

It's not as effective against mild to moderate cases of that particular strain. The objective is to eliminate the possibility of hospitalisation and death, which it does do.

Melanchthon

Suppose it's better late than never. Remember being told here they had a deal signed in early January :-/

https://mobile.reuters.com/article/amp/idUSKBN2AB10H

Novaxax is very effective against the UK variant and it's UK trial included a significant amount of older people (27% of over 65's) so shouldn't be any worries on this front.

South African results seem a bit worrying, of the vaccinated group but it's still at least partially effective. Has anybody found the more in depth data from the study? 15 people from the trial group caught Covid but it doesn't mention hospitalisation etc. 60% or higher effectiveness isn't bad anyway for a new strain.

https://www.nature.com/articles/d41586-021-00268-9

D.Q

ACitizenErased wrote: »

You continuously refer to a study which wouldn't pass junior cert science, well done.

I can't believe this back and forth is still going on haha one of the great rivalries of our time.

ACitizenErased

Melanchthon wrote: »

Suppose it's better late than never. Remember being told here they had a deal signed in early January :-/

https://mobile.reuters.com/article/amp/idUSKBN2AB10H

Novaxax is very effective against the UK variant and it's UK trial included a significant amount of older people (27% of over 65's) so shouldn't be any worries on this front.

South African results seem a bit worrying, of the vaccinated group but it's still at least partially effective. Has anybody found the more in depth data from the study? 15 people from the trial group caught Covid but it doesn't mention hospitalisation etc. 60% or higher effectiveness isn't bad anyway for a new strain.

https://www.nature.com/articles/d41586-021-00268-9

The Novavax SA trial is another that is basically meaningless, tiny sample size and massive confidence intervals.

irishlad.

Numbers updated for Monday 8th:

https://twitter.com/COVID19DataIE/status/1359810666488619015


https://docs.google.com/spreadsheets/d/1cUZy6AMCwuA2zhtRuKK7cqMVgmhdDsGsZrFWJTkw9DY/edit#gid=0

Melanchthon

ACitizenErased wrote: »

The Novavax SA trial is another that is basically meaningless, tiny sample size and massive confidence intervals.

Yeah unfortunately it was too small, 4.400 participants. I would say though before it's sh-t on too much, at least it was a real world trial in a situation where the, SA strain 501Y.V2 ,was dominant. It shows a significant reduction in the real world, it's not a serum study like the recent Pfizer one where the real world impact isn't known.

As far as I understand it, and it's a big ray of hope none of the information about the various vaccine effectiveness and the SA variant has really considered T cell response. E.g people will get mild to moderate symptoms but T cells might prevent severe infection.

ACitizenErased

Melanchthon wrote: »

Yeah unfortunately it was too small, 4.400 participants. I would say though before it's sh-t on too much, at least it was a real world trial in a situation where the, SA strain 501Y.V2 ,was dominant. It shows a significant reduction in the real world, it's not a serum study like the recent Pfizer one where the real world impact isn't known.

As far as I understand it, and it's a big ray of hope none of the information about the various vaccine effectiveness and the SA variant has really considered T cell response. E.g people will get mild to moderate symptoms but T cells might prevent severe infection.

TBH i'll take any vaccine that results in me not drowning in my own lung fluid in an ICU bed. A cough is manageable.

Micky 32

irishlad. wrote: »

Numbers updated for Monday 8th:

https://twitter.com/COVID19DataIE/status/1359810666488619015


https://docs.google.com/spreadsheets/d/1cUZy6AMCwuA2zhtRuKK7cqMVgmhdDsGsZrFWJTkw9DY/edit#gid=0

Matches the Covid App figures. Seems they are keeping the app up to date too.

irishlad.

The daily figures have been a bit slow but its here now and I'm glad to see it.

Hopefully there will be big jumps in the next few weeks