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Covid vaccines - thread banned users in First Post

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Comments

  • Registered Users, Registered Users 2 Posts: 18,190 ✭✭✭✭Dohnjoe


    For the umpteenth time, you aren't qualified to look at those figures, you have no idea whether that number is high or low or anything.

    If e.g. 40k people are reported to have died within 30 days of taking the annual flu jab, it could mean zero have died as a result of flu jab. As a lay-person you aren't in any position to "analyse" those particular figures. The related experts are.

    If you think you know as much as the experts, or that you have spotted something they "missed" - you are on the forum for people who have those beliefs.



  • Registered Users, Subscribers, Registered Users 2 Posts: 6,162 ✭✭✭hometruths


    It has already been explained to you multiple times why the numbers reported for Covid vaccines are not comparable with other vaccines. There are different reporting protocols.

    And I've acknowledged this. The unique circumstances of the Covid vaccines undoubtedly caused an increase in reporting to VAERS, not just for deaths but everything else, like somebody getting cramps in their legs. My point is that looking at the reports of deaths alone, the figures are way off the charts compared to anything in history. That is not a misrepresentation.

    On the VAERS homepage there is a link to more information on Post-licensure vaccine safety monitoring using VAERS, a very comprehensive document authored in 2015 addressing all the strengths and weaknesses of the VAERS system, including that of "stimulated reporting" - i.e increased public awareness of a vaccination campaign will lead to increased reporting from all quarters, including the general public.

    However it also points out:

    Vaccine manufacturers, which accounted for >99% of foreign source reporting, are required by law to submit foreign source adverse event reports that are both serious and unexpected [21], but not other types of foreign source reports.

    Death, unsurprisingly is considered serious and unexpected. It is possible to search VAERS for all the foreign reports from all vaccines from 1990 - 2022.

    As far as foreign reports are concerned the reporting protocol was no different. Vaccine manufacturers were obliged by law to submit reports of deaths as part of the post licensing monitoring requirements, irrespective of whether the drug was EUA or not.

    Covid vaccines account for 79.29% of all foreign source reports of deaths from any vaccine since 1990. That seems remarkably high.



  • Registered Users, Registered Users 2 Posts: 25,323 ✭✭✭✭King Mob


    But it's not remarkably high to experts, including the guy actually running VAERS for covid.

    You cannot explain this issue and keep ignoring it because it exposes the issue with your claims.


    Also, the page you linked to said some other things you seem to have missed:

    Perhaps the two most common misconceptions about VAERS are that temporally associated reports represent true adverse reactions caused by vaccination, and that VAERS reports equate to rates of adverse events or indicate risk of adverse events associated with vaccination. The VAERS website has specific guidance on interpreting case report information, which includes the statement: “When evaluating data from VAERS, it is important to note that for any reported event, no cause-and-effect relationship has been established … VAERS collects data on any adverse event following vaccination, be it coincidental or truly caused by a vaccine” [38]. Despite this cautionary guidance, VAERS reports have been misinterpreted and erroneously communicated as definitive evidence of causally associated adverse events. For example, during the U.S. multi-state measles outbreak of 2015 [39], unsubstantiated claims of over 100 deaths caused by MMR vaccine in the United States during the previous decade began circulating on the Internet [40,41]. The claim was based on VAERS reports in the public data. The authors of the Internet article further stated that no measles related deaths had been reported in the United States during the same time period, implying that MMR vaccine was doing more harm than good. In fact, many of the death reports after MMR vaccination involved children with serious preexisting medical conditions or were likely unrelated to vaccination (e.g., accidents). The complete VAERS reports and accompanying health records, autopsy reports and death certificates were reviewed in depth by CDC and FDA physicians and no concerning patterns emerged that would suggest a causal relationship with MMR vaccination and death [42].

    And, ever more relevant:

    The relatively rapid increase in numbers of reports to VAERS following the introduction and initial uptake of a new vaccine, an expected occurrence [43], has been misinterpreted as actual increases in incidence of adverse events and vaccine related risk. This has been the case with VAERS reports following quadrivalent human papillomavirus (HPV4) vaccination [44], which as expected, increased as uptake of HPV4 vaccine increased following licensure in 2006. However, post-licensure epidemiologic studies have consistently demonstrated the safety of HPV4 vaccine [45-51], confirming the limitations of passive surveillance systems like VAERS.



  • Registered Users, Registered Users 2 Posts: 32,154 ✭✭✭✭odyssey06


    You haven't shown that the number of US produced vaccines used outside the US for covid was comparable with non covid vaccines.

    You haven't shown that the reports were done on the same basis as per the increased awareness disclaimer. For example, is there a spike in reports for 'new vaccines', if so all things being equal a new vaccine rolled out in large numbers will generate more reports.

    You haven't shown that the age distribution of the vaccines were the same. Are you comparing covid vaccines in high use in older demographics with vaccines in high use in children?

    You have shown none of these things.

    "To follow knowledge like a sinking star..." (Tennyson's Ulysses)



  • Registered Users, Registered Users 2 Posts: 25,323 ✭✭✭✭King Mob


    And we've still not seen a single expert or organisation that shares his opinion.


    Again he's trapped himself in a corner. The typical conspiracy response would be to accuse all experts, including the fellow who runs VAERS are all part of a coverup. But he can't claim that as he understands that's ridiculous.

    He also can't claim that he's simply discovered something all of these experts missed. Which again he can't claim cause it's ridiculous.


    There are no other options. Hence he plugs his ears and keeps pretending not to see it.



  • Registered Users, Subscribers, Registered Users 2 Posts: 6,162 ✭✭✭hometruths


    You haven't shown that the number of US produced vaccines used outside the US for covid was comparable with non covid vaccines.

    As I understand it this makes no difference. VAERS logs reports of deaths of all vaccines available in the US, irrespective of country of manufacture. A domestic report is a death on US soil, a foreign report is a death outside the US. If the vaccine is available in the US the manufacturer is obliged to report it.

    You haven't shown that the reports were done on the same basis as per the increased awareness disclaimer. For example, is there a spike in reports for 'new vaccines', if so all things being equal a new vaccine rolled out in large numbers will generate more reports.

    A death is a death irrespective of whether the vaccine is new or not. And the manufacturers are obliged to report deaths irrespective of whether the vaccine is new or not.

    You haven't shown that the age distribution of the vaccines were the same. Are you comparing covid vaccines in high use in older demographics with vaccines in high use in children?

    The figures are for all vaccines administered in the last 30 years. Undoubtedly there will be differences in age profiles between the different individual vaccines.



  • Registered Users, Registered Users 2 Posts: 32,154 ✭✭✭✭odyssey06


    Nope.

    This is your claim "VAERS logs reports of deaths of all vaccines available in the US, irrespective of country of manufacture."

    You haven't shown the quantities are the same. Available in the US means FDA approved. Not just any other vaccine in use anywhere else in the world. How many such vaccines are there? What is their quantity? It if your claim, if you are raising it as concern to others it is up to you to support it.

    You haven't shown that the reports are logged as diligently for new vaccines as vaccines in long use. It is specifically listed as a VAERS disclaimer in the page you linked to:

    VAERS is subject to reporting bias, including underreporting of adverse events – especially common, mild ones [33,34] – and stimulated reporting, which is elevated reporting that might occur in response to intense media attention and increased public awareness

    And you accept that the age profile of the vaccines distributed may be significantly different. Therefore you are not comparing like with like, unless you somehow expect there to be the same number of incidental deaths in 80 years olds as 8 or 28 year olds.

    "To follow knowledge like a sinking star..." (Tennyson's Ulysses)



  • Registered Users, Subscribers, Registered Users 2 Posts: 6,162 ✭✭✭hometruths


    elevated reporting that might occur in response to intense media attention and increased public awareness

    Intense media attention and increased public awareness leads unsurprisingly to elevated domestic reporting, particularly from the general public.

    It makes no difference to the reports that the manufacturers are required to submit by the law, irrespective of the headlines. Hence why I quoted the figures for foreign reports. These are the reports that over 99% are submitted by manufacturers as part of their obligations to comply with licensing requirements.

    And you accept that the age profile of the vaccines distributed may be significantly different. Therefore you are not comparing like with like, unless you somehow expect there to be the same number of incidental deaths in 80 years olds as 8 or 28 year olds.

    No, of course not. That would be ridiculous. Just as I wouldn't expect the same number of Covid deaths in 8 year olds or 28 year olds as 80 year olds.



  • Registered Users, Registered Users 2 Posts: 32,154 ✭✭✭✭odyssey06


    So two of the three claims you made to support your argument have been rebutted.

    You cannot demonstrate that the quanitites were comparable.

    You cannot demonstrate that the age profile of distribution and risk of death were comparable.

    And on the third claim, VAERS specifically lists it as a disclaimer in relation to public awareness.

    How does the manufacturer know if someone has died or had a severe reaction in order to submit this mandatory report? So the public awareness disclaimer applies here also.

    Your claim is baseless and is not supported by evidence.

    "To follow knowledge like a sinking star..." (Tennyson's Ulysses)



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  • Registered Users, Registered Users 2 Posts: 16,885 ✭✭✭✭astrofool


    Unsurprising that when proven factually wrong on all else, it's back to VAERS again, only to be proven factually wrong again (mixed in with a bit of emergency approval, even when CMA was used in Europe and they're fully approved by the FDA now).

    Some conspiracy though, make all data and information public, have multiple different groups analyse and publish papers using that public data.

    When asked why the experts find no issue, offer no explanation.

    Also, let's just mix in all vaccine data when it suits, but specify only 1 vaccine at other times randomly.



  • Registered Users, Subscribers, Registered Users 2 Posts: 6,162 ✭✭✭hometruths


    So two of the three claims you made to support your argument have been rebutted.

    No, that's incorrect. My argument is that the death reports for covid vaccines are extraordinarily large compared to all other vaccines. This has not been rebutted. It is a fact. Obviously we can debate why that might be so, but the volume of death reports remains a fact.

    You cannot demonstrate that the quantities were comparable.

    There is no doubt that all vaccines administered since 1990 dwarf the amount covid vaccines administered thus far. Flu vaccines alone in that period amount to about 5 times that of covid vaccines. That's the point - the quantities of other vaccines are not comparable, they are far greater yet show a far lower number of reports of deaths.

    You cannot demonstrate that the age profile of distribution and risk of death were comparable.

    No I cannot demonstrate that the age profile of distribution was comparable. But again using flu vaccines, presumably they tend towards the elderly? The reports of deaths in flu vaccines are miniscule compared to covid vaccines.

    And course I cannot demonstrate a risk of death either for flu vaccines or covid vaccines using VAERS data. That's not what it is collected for. But not being able to demonstrate a comparable risk of death does not change the fact that the number of reports of deaths is huge by comparison.

    How does the manufacturer know if someone has died or had a severe reaction in order to submit this mandatory report? So the public awareness disclaimer applies here also.

    OK that's a fair point assuming you mean the vaccine manufacturers are more likely to hear about deaths after increased public awareness. But I suspect that's more likely to apply to deaths occurring longer post vaccination. Deaths occurring within days of vaccination are likely to be largely unaffected by this.



  • Registered Users, Subscribers, Registered Users 2 Posts: 6,162 ✭✭✭hometruths


    Unsurprising that when proven factually wrong on all else

    You seem to have forgotten I have not been proven factually wrong on the point that the regulators said the estimates of efficacy against severity were unreliable due to limited data.

    Unless you're referring to something else?

    When asked why the experts find no issue, offer no explanation.

    The only person who asked me that question was KIngMob, who I ignore for the good of the thread.

    But to respond to you on that point, that's exactly what I find puzzling, which is what I said in one of my first points on the VAERS data.

    At the very least, in the interests of public confidence in vaccines, why are the experts not detailing and explaining the fact that the numbers of death reports in VAERS are colossal - over 86% of the total - compared to other vaccines and offering detailed explanations of why this is so? The general response seems to be focusing on you can't use VAERS to prove causality so there is nothing to see here.

    86% of all death reports since 1990 does seem to be an awful lot to be in line with expectations. If this is true then it would suggest VAERS has hitherto been woefully inadequate as an early warning signal, because the extent of the underreporting has been colossal.

    The only explanation I can offer is when doctors and experts are rightly worried about being reprimanded or discredited as anti-vaxxers, they are inclined to say nothing at all.



  • Registered Users, Registered Users 2 Posts: 32,154 ✭✭✭✭odyssey06


    No. You said it was a red flag. You can continue to hold that opinion but don't pretend it is on the basis of evidence. And I have shown the basis for the claim is baseless and without evidence.

    See how you changed the goal posts again every time.

    "There is no doubt that all vaccines administered since 1990 dwarf the amount covid vaccines administered thus far."

    But we're not talking about that. You keep changing the goalposts when caught out posting misinformation even though your comparison with flu vaccines has already been debunked.

    We're talking about the vaccines available in the US reported under the same basis.

    Were flu vaccines reported under the same basis? No.

    Were flu vaccines available in the US distributed worldwide to the same extent as Covid? You have not shown this.

    What quantities of vaccines available to children were included in the reporting figures? You don't have this data.

    If you use the VAERS data as a red flag safety concern, you do not do so on the basis of evidence and it is contrary to the professional expert opinion of those whose job it is to monitor VAERS data and understand the numbers. You do so simply using the raw numbers.

    The VAERS data specifically warns against AND I have demonstrated multiple reasons (reporting protocol, public awareness, quantity, age profile of recipients) why the raw numbers cannot be used to used to make conclusions about the safety of a vaccine.

    You have failed to demonstrate that the numbers are comparable.

    So you do accept there is no VAERS evidence or expert opinion which supports your opinion that conclusions about safety can be drawn from the numbers?

    "To follow knowledge like a sinking star..." (Tennyson's Ulysses)



  • Registered Users, Registered Users 2 Posts: 16,885 ✭✭✭✭astrofool


    You haven't been able to factually prove it because you're misunderstanding what one sentence means, even though others and myself have explained it to you multiple times using very simplistic terms (again, if you promise to concede the point when evidence is provided, then evidence will be readily provided) :)

    that's exactly what I find puzzling

    So, are you with the experts on the approval data (including proven severity efficacy if you would actually read it properly...) but not for the VAERS data?



  • Registered Users, Registered Users 2 Posts: 16,885 ✭✭✭✭astrofool


    See how you changed the goal posts again every time.

    This is why it's not worth engaging without a promise of backdown, as soon as the point is refuted, the poster spins off elsewhere, they've got themselves stuck in VAERS data again as they've been proven wrong everywhere.

    But it also shows for all the "Just asking questions" and "puzzlement" and "I don't know" answers, that they have an anti-vax agenda and no amount of factual evidence will change that.



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  • Registered Users, Subscribers, Registered Users 2 Posts: 6,162 ✭✭✭hometruths


    because you're misunderstanding what one sentence means

    I'll remind you once again that you simply telling me I am misunderstanding something is not that same as factually proving me wrong.

    It's just waffle. And expressly against the forum charter to boot.



  • Registered Users, Subscribers, Registered Users 2 Posts: 6,162 ✭✭✭hometruths


    The VAERS data specifically warns against AND I have demonstrated multiple reasons (reporting protocol, public awareness, quantity, age profile of recipients) why the raw numbers cannot be used to used to make conclusions about the safety of a vaccine.

    I am making conclusions about red flags. I am not saying these numbers prove anything about the safety of the vaccines

    Post edited by hometruths on


  • Registered Users, Registered Users 2 Posts: 16,885 ✭✭✭✭astrofool


    You are misunderstanding what secondary endpoint means, Fighting Tao already explained it to you, you are choosing to ignore it because you know it proves you factually wrong.

    It is not against the forum charter to point out where you are factually wrong, pretending not to understand (or actually not understanding) explanations doesn't change this.

    You can certainly say that it is your opinion that severity wasn't proven, but again, others could point out that you are factually wrong based on the trial data, you can still keep your opinion in that case but won't be able to represent it as fact.

    And again, you haven't presented any evidence of your theory, hence it is on you, the theorist, to show some evidence rather than on others to refute it (that presented without evidence can be dismissed without evidence). Misunderstanding a sentence is not evidence.



  • Registered Users, Subscribers, Registered Users 2 Posts: 6,162 ✭✭✭hometruths


    And again, you haven't presented any evidence of your theory, hence it is on you, the theorist, to show some evidence rather than on others to refute it (that presented without evidence can be dismissed without evidence)

    My theory is that at the time approval was granted the regulators - specifically the EMA - could not reliably evaluate estimates of efficacy against severe disease because sufficient data to do so was unavailable at that time.

    The evidence I have shown repeatedly in support of this theory is quoting verbatim from the regulators approval reports (emphasis mine):

    Pfizer

    Based on the available limited data, no reliable conclusion on the efficacy of the vaccine against severe COVID-19 can be drawn from 7 days after the second dose (secondary endpoint).

    Moderna

    From the experience with other vaccines it is expected that prevention of severe COVID-19 will be achieved by preventing COVID-19 overall.


    The case-driven readout and high VE translates into limited case numbers at present and resulting limited precision for estimating VE in several substrata including elderly, people with comorbidities and efficacy against severe COVID-19.

    AstraZeneca

    Although encouraging trends were observed, reliable efficacy estimates against severe COVID-19 and hospitalisation caused by COVID-19 could not be established due to the lack of a sufficient number of cases within the clinical studies. From the experience with other vaccines it is expected that prevention of severe COVID-19 will be achieved by preventing COVID-19 overall.

    In addition to the regulators reports I quoted Tal Zaks, chief medical officer at Moderna, in an article in the BMJ, October 2020, pre-approval (emphasis added):

    But Tal Zaks, chief medical officer at Moderna, told The BMJ that the company’s trial lacks adequate statistical power to assess those outcomes. “The trial is precluded from judging [hospital admissions], based on what is a reasonable size and duration to serve the public good here,” he said.

    Hospital admissions and deaths from covid-19 are simply too uncommon in the population being studied for an effective vaccine to demonstrate statistically significant differences in a trial of 30 000 people. The same is true of its ability to save lives or prevent transmission: the trials are not designed to find out.

    You have repeatedly told me that my theory is wrong, and that I have misunderstood all of the evidence above, but you have not in fact offered anything further than this other than some waffle about if I promise to admit that if I have understood this in advance you will provide the evidence of your theory that I am wrong.

    For the avoidance of doubt, I am stating as fact that no reliable estimates of efficacy against severity could be established in the trials and the evidence of that fact is above.

    Simply repeating time and again that this is "factually wrong, pretending not to understand (or actually not understanding)" is against the forum charter being repeatedly criticising the tone of the writing without attacking the substance of the argument and attacking the characteristics or authority of the writer without addressing the substance of the argument.

    If, in your opinion, you think I am wrong, fine but in the absence of any evidence to the contrary, as you put it, that presented without evidence can be dismissed without evidence.

    @Big Bag of Chips made the valid point that "circular arguments like "No it's not" "Yes it is" are boring to read and add nothing to the discussion". This destroys the thread and the discussion, but if I just ignore the fact you have provided absolutely nothing that disputes what the regulators said and move on, you later wheel this out as a counterargument to totally unrelated posts, as you did this morning:

    Unsurprising that when proven factually wrong on all else, it's back to VAERS again, only to be proven factually wrong again

    And we're back to criticising the tone of the writing without attacking the substance of the argument and attacking the characteristics or authority of the writer without addressing the substance of the argument.

    It's insane.



  • Registered Users, Registered Users 2 Posts: 1,442 ✭✭✭bad2thebone


    But my question is, what's a reliable source of the truth ?

    Because I always go back to agriculture systemic translocation weed killers.

    They lied about that poison left right and center, and whomever did the research has as much brains as a plant, actually a plant is probably more intelligent.

    Supposedly that chemical fades away within a minimal time frame, and it disappears. A beaver with a mallet up his arse now knows that the systemic translocation weed killers weren't as safe as we were being told.

    I've seen plants mutate into awful looking things where that weed killer has been sprayed. Anything that grows there after is an absolute mutant.

    You have posted that they're safe, ok it's obviously you're quite confident about that. That's ok.

    But is there a tiny part of you that thinks hmmmmm I wonder am I right.

    I'm not trying to catch you out, I'm just wondering do you trust the research wholeheartedly ?



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  • Registered Users, Registered Users 2 Posts: 16,885 ✭✭✭✭astrofool


    All I'm saying is that if severity efficacy was proven in trial, that you will admit you were wrong on proven effect against severity and promise not to spin elsewhere.

    The reason being that every other time you were proven wrong (before this mini obsession) you spun off elsewhere.

    Given your track record, I don't believe that is unreasonable. Odyssey06 is also experiencing this behaviour from you on the VAERS data.

    If you are truly seeking information and not pretending or actually "puzzled" by data and evidence, this would be acceptable for you.

    If it is not acceptable for you, it means you are solely posting with an anti-vax agenda regardless of facts, which is fine, but very few will engage with you if that is your MO.

    (and the quotes you included are not evidence, they're opinions).



  • Registered Users, Registered Users 2 Posts: 16,885 ✭✭✭✭astrofool


    If you're going to make a case that the evidence is flawed, then that's fine, you also have to say why the evidence was flawed (or incomplete in a lot of cases) or why it's being covered up.

    In this case, the poster is using the data in some cases to mean one thing and then ignoring that same data for some other point, or ignoring information about how and why the data is collected. It's the reason why someone like Markus would refute all scientific data, you can't build a cogent theory by being selective or ignoring the process.

    (I would also note your weedkiller evidence is entirely anecdotal, we have farmers in the family who use it who don't see issues, while also have produced and sold our own organic weedkillers and understand how they work and their limitations, my summers used to be spent filling and packaging the organic stuff, but again, this is an anecdote and can be dismissed by anyone).



  • Registered Users, Subscribers, Registered Users 2 Posts: 6,162 ✭✭✭hometruths


    (and the quotes you included are not evidence, they're opinions).

    Evidence of the regulators opinion that they could not reliably evaluate estimates of efficacy against severe disease because sufficient data to do so was unavailable at that time.

    And evidence of the Moderna chief medical officer's opinion that the trials were not large enough to reliably evaluate estimates of efficacy against severe disease.

    I find their opinion credible. If you don't, fine, entirely up to you. But that's very different to saying I have been factually proven wrong.



  • Registered Users, Registered Users 2 Posts: 16,885 ✭✭✭✭astrofool


    And if efficacy was proven, are you willing to accept that you are factually proven wrong?



  • Registered Users, Subscribers, Registered Users 2 Posts: 6,162 ✭✭✭hometruths


    It wasn't proven. According to the regulators. That's the theory and I have posted the evidence to back it up. You've posted nothing to contradict that.

    All if this "if" stuff is just waffle. Stating the opposing case with little or no supporting evidence.



  • Registered Users, Registered Users 2 Posts: 25,323 ✭✭✭✭King Mob


    So you're ignoring the point I ask. Typical.

    Your explanation is that all experts are not raising concerns because they are reprimanded or discredited. This sounds like a conspiracy to me. And it's a very silly implausible explanation for why there's no experts who agree with you.

    How does this account for experts like for example the fellow in charge of VAERS who directly contradict you opinion? Why would he do this if he was just afraid of being reprimanded?


    But of course that isn't the only explanation. There's another one you don't want to consider.

    That your opinion is simply wrong.



  • Registered Users, Registered Users 2 Posts: 1,442 ✭✭✭bad2thebone


    I would also note your weedkiller evidence is entirely anecdotal, we have farmers in the family who use it who don't see issues, while also have produced and sold our own organic weedkillers and understand how they work and their limitations, my summers used to be spent filling and packaging the organic stuff, but again, this is an anecdote and can be dismissed by anyone).

    Well that's your opinion and we both differ with our anecdotal assumptions.

    I've a degree in horticulture and have been keeping up to date with various chemicals and their uses,dangers and benefits, since 1995 so I think I could possibly be ahead of you by a long way.

    Anyhow I'm going off track, so what you're observing about someone like Marcus is he's getting numbers and scenarios mixed up If you both had a graph or something to work off maybe that would be easier and ye could point out where you are both not meeting where its right.



  • Registered Users, Registered Users 2 Posts: 16,885 ✭✭✭✭astrofool


    Bloody hell, it just needs a simple yes/no if efficacy is proven, you restating an opinion with no evidence doesn't change that.

    What will happen when you are presented with evidence is that you will spin off and claim something else, this is to stop you doing that (again, for the umpteenth time) as you are committing to respecting the evidence and conceding the point (you can of course claim the evidence was falsified if you wish).



  • Registered Users, Registered Users 2 Posts: 16,885 ✭✭✭✭astrofool


    I've a degree in horticulture and have been keeping up to date with various chemicals and their uses,dangers and benefits, since 1995 so I think I could possibly be ahead of you by a long way.

    You'd be wrong on that, anecdotally of course :)



  • Registered Users, Subscribers, Registered Users 2 Posts: 6,162 ✭✭✭hometruths


    What will happen when you are presented with evidence is that you will spin off and claim something else,

    I've been like a broken record on this point through our disagreement.

    Your claims that I have spun off to claim something else in the face of the irrefutable evidence you have presented is just another falsehood you persist with.



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  • Registered Users, Registered Users 2 Posts: 16,885 ✭✭✭✭astrofool


    So you will concede the point if evidence of positive efficacy is presented?

    (you are of course ignoring the post I made documenting the different areas you spun off into when proven wrong in other areas, and as if to prove this, you will comment on this sentence rather than saying you will concede in front of evidence)



  • Registered Users, Subscribers, Registered Users 2 Posts: 6,162 ✭✭✭hometruths


    What will happen when you are presented with evidence is that you will spin off and claim something else,

    I have not spun off and claimed anything else. My point has consistently been that in the approval reports the regulators stated there was insufficient data to reliably estimate efficacy against severe covid and I have quoted them verbatim stating exactly that.

    Irrespective of your belief and evidence of positive efficacy against severity, is this true or not? Did the regulators say this or not? What we are arguing about is that simple.



  • Registered Users, Registered Users 2 Posts: 16,885 ✭✭✭✭astrofool


    So you're abandoning your claim that positive efficacy for severity wasn't shown during the trials?

    And it's "here's what some people said about efficacy against severity" before the trial results were available?

    You see the difference between the two?

    Remembering that proven efficacy against severity during the trials also refutes your point that they got "lucky" with the vaccines post trial and approval.

    And bear in mind, this is not my belief, this is evidence that was already posted that you missed and I will have to go back and explain to you and then you will have to agree that efficacy against severe disease was proven during trials.

    Are you OK with that happening and wiling to accept that your "lucky" claim is refuted? (when the evidence is explained of course). Again, only a simple yes/no is needed.



  • Registered Users, Subscribers, Registered Users 2 Posts: 6,162 ✭✭✭hometruths


    Here's what some people said?!! Not just some people. What are you on about. I am talking about the regulators tasked with reviewing the trial data and deciding whether or not to grant the emergency approval!

    My claim was always about what the regulators said about the trials. That's what's important. Sure vaccine manufacturers may well have said X, Y and Z look at our new miracle drug, but in the context of why they were approved that doesn't count for sh*t.

    You appear to be abandoning your claim that you agreed with the regulators' opinion that the data on severity was extremely comprehensive and proven in massive trials. Now you are just dismissing their statements as simple opinions rather than evidence. Talk about spinning off in a new direction.



  • Registered Users, Registered Users 2 Posts: 16,885 ✭✭✭✭astrofool


    As said, I am quite clear, data against severity was extremely comprehensively proven in the trials, I am not squirming away and hiding what I am saying. Again, if you are prepated to acknowledge the data, it will be pointed out to you.

    However, are you now saying that your "lucky" comment was based purely on those comments that were made before the trial results were available? (I mean, there is a different reason they were said that wasn't anything to do with luck and based off trial endpoints, but that's a different conversation).

    This is a first, you are now spinning away from your argument about the trials not being conclusive before the evidence was presented. You must be getting dizzy.

    This is precisely why the parameters need to be agreed before the explanation occurs, you are further cornering yourself.

    Do you accept that the trial results show that efficacy against severity was proven? Another yes/no for you to try and ignore I guess.



  • Registered Users, Subscribers, Registered Users 2 Posts: 6,162 ✭✭✭hometruths


    You must be getting dizzy.

    At least we can agree on that. I doubt I'm the only one, on the off chance anybody else is trying to follow this.

    Do you accept that the trial results show that efficacy against severity was proven? Another yes/no for you to try and ignore I guess.

    No. I have seen no evidence of that.



  • Registered Users, Registered Users 2 Posts: 16,885 ✭✭✭✭astrofool


    No. I have seen no evidence of that.

    If irrefutable evidence of it is presented, will you accept it? (and drop the lucky claim based on trial results, you can maintain it for pre-trial result comments if you wish).



  • Registered Users, Subscribers, Registered Users 2 Posts: 6,162 ✭✭✭hometruths


    And will this irrefutable evidence also explain why the EMA said that the data on severity was limited, insufficient etc and that the estimates of efficacy against severity were unreliable?

    The kucky comment was made in the context of how things turned out real world - ie unlucky with the trial proven efficacy against infection, but lucky with the unproven efficacy against severity that turned out well.



  • Registered Users, Registered Users 2 Posts: 16,885 ✭✭✭✭astrofool


    It will explain what was said in the approval document for the Pfizer vaccine (which Fighting Tao also explained incidentally).

    but lucky with the unproven efficacy

    This bit wasn't lucky, as you may soon see.



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  • Registered Users, Subscribers, Registered Users 2 Posts: 6,162 ✭✭✭hometruths


    But it will not explain why the EMA said of Moderna - "limited case numbers at present and resulting limited precision" comments and of AstraZeneca reliable estimates "could not be established due to the lack of a sufficient number of cases"?

    Were they wrong?



  • Registered Users, Registered Users 2 Posts: 25,323 ✭✭✭✭King Mob


    He won't answer this because it would lock him down to a position he can't backtrack out of.



  • Registered Users, Subscribers, Registered Users 2 Posts: 6,162 ✭✭✭hometruths


    For the benefit of KingMob:

    Do you accept that the trial results show that efficacy against severity was proven? Another yes/no for you to try and ignore I guess.

    No. I have seen no evidence of that.

    If irrefutable evidence of it is presented, will you accept it?

    Yes.

    Let's see the irrefutable evidence.



  • Registered Users, Registered Users 2 Posts: 16,885 ✭✭✭✭astrofool


    Remember, this is across multiple usernames and spinning and squirming around to different arguments (back to VAERS again, really?) and multiple posters, including myself being extremely patient and explaining and presenting data, only to be met with puzzlement and "I don't know" JAQ'ing off answers.

    So, let's tackle the comments first.

    The trials primary goals were to establish safety and efficacy of 50% against symptomatic COVID. Once those endpoints were reached, the trials would finish, data collated and presented for approval and approval granted.

    So they were correct, they weren't running the trials specifically for severe cases. Why? Because they know by reducing symptomatic cases by X% that severe cases would also be reduced significantly, that's how vaccines work, have always worked and will continue to work. Had this not been the case, it would have been a whole brand new area of science to study. This is why all the comments were made, they weren't specifically after severity data, no one was arguing otherwise.

    However, that's not irrefutable, there is wiggle room for anti-vaxxers in there "yes, science is wrong, magic happens".

    However, the vaccines performed above expectations, 95% symptomatic reduction was much higher than even the optimistic projections and because this was so high, it meant that data on severity could be gathered and proven at the same time and was.

    The next bit is important, check your sources, do your own work rather than letting twitter and facebook do it as you may have avoided this (I mean, not understanding how to narrow a CI after so many posts, mocking others who present their findings, not being able to calculate a simple CFR?).

    I posted the hselibrary data on severity.

    Go back and check it, find where that data comes from, if you can't find it (and do say where you looked) say so, and we can go to the next step.

    The next step will be proven efficacy but a little bit of wiggle room that an anti-vaxxer will try and sit into.

    The step after that will be proven efficacy with no wiggle room.

    After that it will be spinning out again. It should be acceptance that the vaccines worked as expected and that they're safe.

    But it won't be.

    It might even be a new username.



  • Registered Users, Subscribers, Registered Users 2 Posts: 6,162 ✭✭✭hometruths


    Just so I am clear, is this is your irrefutable evidence that data on severity was proven in the trials:

    95% efficacy in preventing symptomatic infection:

    meant that data on severity could be gathered and proven at the same time and it was.

    Are you by any chance going to share this data that was gathered and proven?



  • Registered Users, Registered Users 2 Posts: 16,885 ✭✭✭✭astrofool


    This is your next step, as explained, it was posted previously, once I'm satisfied you've been unable to find it with your own effort (or actually found it) then the next set of data can be accessed (and less of the mocking tone, do you really think I'd be referencing the 95% efficacy against symptomatic infection? You saw another poster pay up on a losing bet, you should have learned something by now) :)

    I posted the hselibrary data on severity.

    Go back and check it, find where that data comes from, if you can't find it (and do say where you looked) say so, and we can go to the next step.



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  • Registered Users, Subscribers, Registered Users 2 Posts: 6,162 ✭✭✭hometruths


    I can’t find any HSelibrary data on severity that is irrefutable evidence the data on severity was proven in clinical trials.

    i have googled extensively in an extremely comprehensive search.

    can I now proceed to the next step?



  • Registered Users, Registered Users 2 Posts: 25,323 ✭✭✭✭King Mob


    Yay finally. Not so hard is it?

    Now could you actually address the points I made to you for my benefit?


    Why do no experts agree with you?

    Why do experts including the guy in charge of VAERS disagree with you?

    Vague handwaving about "being afraid of being reprimanded" is not an answer to this.



  • Registered Users, Registered Users 2 Posts: 16,885 ✭✭✭✭astrofool


    Kindly show some of your attempted Google searches, this only works when you find the answer and work it out (I've no doubt you won't understand how it is irrefutable, but maybe you'll surprise everyone), as we have shown numerous times across the thread.

    It is the top hit and to give you a hint, it was posted on this thread just slightly over a month ago.

    Now your penchant is going to be to try and lash out, but we're on an enlightenment journey here :)



  • Registered Users, Subscribers, Registered Users 2 Posts: 6,162 ✭✭✭hometruths


    In the interests of establishing what is right rather than who is right, I'll humour you on our enlightenment journey.

    I found the hse data on severity you posted earlier in the thread:

    The information you reference appears to me to have come from the clinical trials as submitted to the regulators eg Pfizer: "Nine of the 10 severe cases that occurred during the study were in the placebo group."



  • Registered Users, Registered Users 2 Posts: 16,885 ✭✭✭✭astrofool


    Perfect, and what is the source of that data? You can find it on NEJM and post the efficacy on severity from there.



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