COVID-19: Vaccine/antidote and testing procedures Megathread [Mod Warning - Post #1]

snotboogie

CIARAN_BOYLE wrote: »

I would hope that once a vaccine is available in small numbers (to protect our most vulnerable people) we will only need small scale behavioural changes (social distancing, cough etiquette and regular hand sanitisation) but we may need to do something til at least mid 2023.

Social distancing is not a small scale behaviour change! It's hardly on par with cough etiquette or hand sanitisation.

Gael23

Can only be good news from Oxford

Ce he sin

ACitizenErased wrote: »

Interesting that Oxford could jump ahead again. Was expecting Pfizer to lead the way.

Also interesting that trials for the Oxford vaccine are still paused in America. Fortunately I'm not cynical or I'd think that political pressure was being imposed to increase the chances of an American vaccine becoming available by the deadline of the 3rd of November.

hmmm

https://www.youtube.com/watch?v=oLBif1Phn0U

Hand in Your Pants

I would like to inoculate her

ShineOn7

Hand in Your Pants wrote: »

I would like to inoculate her

Username checks out

So where are we at this week on the timeline lads?

And I mean the timeline of distributing a successful vaccine to the EU, not just one that eventually is a winner

I still think treatments will get there first. I know I keep saying it, but there just seems to be a "carrot on a stick" feel to this

Case in point:

This thread is a Megathread of a few threads started back in March/April of this

I started the one with a poll that appears in this Megathread, the one talking about the "rushed September vaccine and will you be taking it"

Fast forward 6 months and this is nowhere to be seen for the EU, even for frontline Healthcare workers

Azatadine

How fast are Russia and China rolling out their vaccines? Interesting to see when they have rolled out "x" amount whether an impact on the spread of the disease is observed. Real time evaluation of efficacy I suppose.

funnydoggy

COVID research updates: A front-runner vaccine shows promise in older people - https://www.nature.com/articles/d41586-020-00502-w

Older people injected with one of the most prominent candidate vaccines for COVID-19 developed high levels of antibodies against the new coronavirus.

The_Brood

Amazing RTE poll results. So I guess 1/3rd of voters are backwater swamp-brain Trumptards. Good to know.

JimmyVik

The_Brood wrote: »

Amazing RTE poll results. So I guess 1/3rd of voters are backwater swamp-brain Trumptards. Good to know.

I wouldnt take any notice of that poll.
Myself and everyone I work with all answer polls with the opposite of what we would actually answer.
This started when an outside company came in to poll us all on what we thought of different aspects of the company.
We just kept the tradition and all decided to do it will all polls
Even ones who call to the door.
Pretty sure we arent the only people doing this too.

plodder

funnydoggy wrote: »

COVID research updates: A front-runner vaccine shows promise in older people - https://www.nature.com/articles/d41586-020-00502-w

Was just going to ask this exact question, whether any of them are showing to be effective and safe among the elderly. Good news, especially in light of the survey showing 32% of the population unwilling to take a vaccine. If it's available to and effective for the elderly and front-line workers etc. then I think it will be hard to justify the major restrictions any longer, regardless of such surveys

CIARAN_BOYLE

The_Brood wrote: »

Amazing RTE poll results. So I guess 1/3rd of voters are backwater swamp-brain Trumptards. Good to know.

I believe most people saying they wouldn't be vaccinated are commenting in fear of a rushed vaccine.

A lot of vaccine candidates are cutting corners in trials.

Personally I'll sit down with some friends of mine who work in pharmaceutical research before getting a vaccine.

funnydoggy

CIARAN_BOYLE wrote: »

I believe most people saying they wouldn't be vaccinated are commenting in fear of a rushed vaccine.

A lot of vaccine candidates are cutting corners in trials.

Personally I'll sit down with some friends of mine who work in pharmaceutical research before getting a vaccine.

Are they? Which candidates?

CIARAN_BOYLE

funnydoggy wrote: »

Are they? Which candidates?

To be more accurate there is fear of vaccine candidates cutting corners in final stage trials.

The Russian and Chinese vaccines cut corners to rush into final stage trials.

There are rumours that the usa are going to issue an eua to rush the Pfizer and AstraZeneca vaccines into use on late October despite not finishing trials.

I'm not saying it will happen. Im actually most worried about final stage being cut short when the time comes.

Ill review in detail with someone who knows details when the time comes. I can't say i would take a vaccine until I know that it was approved after going through relatively full trials and not rushed.

Le Bruise

CIARAN_BOYLE wrote: »

To be more accurate there is fear of vaccine candidates cutting corners in final stage trials.

The Russian and Chinese vaccines cut corners to rush into final stage trials.

There are rumours that the usa are going to issue an eua to rush the Pfizer and AstraZeneca vaccines into use on late October despite not finishing trials.

I'm not saying it will happen. Im actually most worried about final stage being cut short when the time comes.

Ill review in detail with someone who knows details when the time comes. I can't say i would take a vaccine until I know that it was approved after going through relatively full trials and not rushed.

First you said that 'A lot of vaccine candidates are cutting corners in trails', as if it was gospel truth. Now you're saying 'there is a fear' and 'rumours' of such things. The fears and rumours are only spread by people making statements as fact such as you did in the first instance, with no hard evidence for it.

Fair play for saying you'll discuss with those in the know before taking it though, as there seem to be a cohort that have made the decision to not take it without any research at all.

CIARAN_BOYLE

CIARAN_BOYLE wrote: »

To be more accurate there is fear of vaccine candidates cutting corners in final stage trials.

The Russian and Chinese vaccines cut corners to rush into final stage trials.

There are rumours that the usa are going to issue an eua to rush the Pfizer and AstraZeneca vaccines into use on late October despite not finishing trials.

I'm not saying it will happen. Im actually most worried about final stage being cut short when the time comes.

Ill review in detail with someone who knows details when the time comes. I can't say i would take a vaccine until I know that it was approved after going through relatively full trials and not rushed.

We won't be taking the Russian or Chinese vaccines so what they do won't bother us. Pfizer and AstraZeneca alongside the other major companies have already agreed that they will NOT release a vaccine before trials are complete. Trump can issue all the EUAs he likes. It won't make a difference.

https://www.bbc.com/news/world-54046157

seamie78

with the oxford trials being forward for accelerated review, I was wondering is this because they already have seen positive results in phase 3 or would it be on the basis of previous trial. I suppose why just the oxford one ?

hmmm

Nice graphic from Barclays with their predictions. I think it's a bit optimistic myself, but they have lots of analysts who know more than I do. Note that "supplies available" are initial doses, you could probably add +6 months for widespread availability and full regulator approval.

The_Brood

CIARAN_BOYLE wrote: »

To be more accurate there is fear of vaccine candidates cutting corners in final stage trials.

The Russian and Chinese vaccines cut corners to rush into final stage trials.

There are rumours that the usa are going to issue an eua to rush the Pfizer and AstraZeneca vaccines into use on late October despite not finishing trials.

I'm not saying it will happen. Im actually most worried about final stage being cut short when the time comes.

Ill review in detail with someone who knows details when the time comes. I can't say i would take a vaccine until I know that it was approved after going through relatively full trials and not rushed.

And who do you think is "cutting corners" - it's the medical experts themselves who deem it safe enough and urgent enough to do so. Who is saying they are wrong to do so? The WHO? Why would you trust them and their endless conflicted political bureaucracy? It took them half a year of conflicting messages before they corrected themselves and reversed their previous position telling the world that masks are unsafe. You're gonna wait on them to tell you a vaccine is ok?

I'm not sure how this happened that anti-vaxxer opinions suddenly became the accepted mainstream of western governments. 2 minutes ago it was the opposite.

Le Bruise

hmmm wrote: »

Nice graphic from Barclays with their predictions. I think it's a bit optimistic myself, but they have lots of analysts who know more than I do. Note that "supplies available" are initial doses, you could probably add +6 months for widespread availability and full regulator approval.

So just one month to go until approval and initial doses of 3 different vaccines. Very optimistic, even by my standards....but I'll take it!:)

Gael23

Push wave 1 out to Q1 2021 and I don’t think it’s that far fetched

funnydoggy

Gael23 wrote: »

Push wave 1 out to Q1 2021 and I don’t think it’s that far fetched

What's lovely is that we're talking about it and it's so close

ACitizenErased

funnydoggy wrote: »

What's lovely is that we're talking about it and it's so close

It's actually quite exciting

funnydoggy

ACitizenErased wrote: »

It's actually quite exciting

Pints for all!

Edit: But being serious, it's the return to normality on the horizon that excites me most. Socialisation (in or out of a pub), going to see shows / films, less having to be super aware of your movements, businesses recovering, etc. etc

Gael23

funnydoggy wrote: »

What's lovely is that we're talking about it and it's so close

I would add a caveat that I imagine supply will be quite limited to begin with and there will be far from enough vaccines for everyone that wants one

funnydoggy

Gael23 wrote: »

I would add a caveat that I imagine supply will be quite limited to begin with and there will be far from enough vaccines for everyone that wants one

You're just saying that so you don't have to invite us to your birthday party for pints hahahaha

But yeah, of course. Once it gets rolled out even to a small few though it'll be an exciting road to recovery!

Hmmzis

Mark1916 wrote: »

https://www.bloomberg.com/news/articles/2020-09-30/oxford-astra-covid-vaccine-review-said-to-start-in-europe

Looks like the EU are starting the ball rolling!

Here is the official statement from EMA:

https://www.ema.europa.eu/en/news/ema-starts-first-rolling-review-covid-19-vaccine-eu

To me it sounds much like the reviews that FDA is doing for promising treatments and vaccines. Going through the data the moment it's available. That's good stuff, doesn't compromise the review integrity but compresses the timeline by a good chunk.

seamie78

Is it a sign that promising results are expected shortly, its interesting that this only seems to be applied to one particular candidate

Call me Al

I think it gives hope, and right now its needed.

But once there is an end in sight people's focus will change, impatience frustration that we are having to wait, and then of course the hysterics of those anti-vaxxers advocating for natural immunity.
I can see the headlines already.

JTMan

The FT reports on the latest on the Moderna vaccine here (paywall).

- November 25 at the earliest for the submission to the regulators for emergency use (healthcare workers etc)
- FDA previously said turnaround for emergency authorisation is about 1 month. So Moderna might get emergency authorisation by Christmas day.
- Full approval to distribute the drug to all sections of the population not expected until next spring.
- Pfizer seem to be moving the quickest and still hope to have “an answer” on their vaccine by the end of October.