COVID-19: Vaccine/antidote and testing procedures Megathread [Mod Warning - Post #1]

ShineOn7

NegativeCreep wrote: »

https://m.independent.ie/world-news/coronavirus/nasal-spray-could-give-96pc-protection-from-coronavirus-39567304.html

Might’ve already been posted but this would be great!

To give people context

Nasal spray could give 96pc protection from coronavirus

We need more of this. Treatments will squash this long before the carrot on a stick vaccine

Stark

Sounds like it's only been tested in rodents/ferrets? Vaccines are already in phase 3 human trials.

Edit: Says here it'll be 4 months before it progresses to human clinical trials https://www.prnewswire.co.uk/news-releases/preventative-nasal-spray-shown-to-reduce-viral-replication-by-up-to-96-in-covid-19-challenge-study-879335575.html . Should have a few vaccines approved for at least emergency use by then.

Beasty

Threads merged

Beasty

Pauliedragon wrote: »

I have what seems to be a cold. My GP says I've no need for a covid test as my symtoms aren't enough but my boss says he wants to see a negative test to let me back. How do you go about a private test? How much do they cost? I'm in Cork by the way.

I would be asking my employer to sort it out.

hmmm

https://www.statnews.com/2020/09/28/operation-warp-speed-vast-military-involvement/

Fascinating article. I know some might be put off by the thoughts of the military being involved, but there is probably no other organisation in the US which has the logistics capability of the military in terms of scaling up production and distribution.

"Operation Warp Speed’s central goal is to develop, produce, and distribute 300 million doses of a coronavirus vaccine by January — and the military is intimately involved, according to Paul Mango, HHS’ deputy chief of staff for policy. It has already helped prop up more than two dozen vaccine manufacturing facilities — flying in equipment and raw materials from all over the world. "

"SiO2 Materials Science, an Auburn, Ala.-based company that is making vials for the effort, used its status as an Operation Warp Speed grantee to force a vendor to cut production time from 75 days to just seven."

mr zulu

What do posters think of this treatment
https://bgr.com/2020/09/26/coronavirus-cure-icam-protocol-florida/

MerlinSouthDub

mr zulu wrote: »

What do posters think of this treatment
https://bgr.com/2020/09/26/coronavirus-cure-icam-protocol-florida/

There have been countless stories about supposedly effective treatments. I only believe treatments that have been proven to work via a randomised placebo controlled trial.

Call me Al

User1998 wrote: »

Tell your GP your symptoms have worsened and have become more covid-like and you’ll get tested

You're to isolate for 14 days if you're tested due to being symptomatic. I can't see an employer being ok with that if it's a cold. Maybe a private test is the only option..

Call me Al

Call me Al wrote: »

You're to isolate for 14 days if you're tested due to being symptomatic. I can't see an employer being ok with that if it's a cold. Maybe a private test is the only option..

No - you isolate until you get a negative result and have had no symptoms for 48 hours

Hmmzis

NegativeCreep wrote: »

https://m.independent.ie/world-news/coronavirus/nasal-spray-could-give-96pc-protection-from-coronavirus-39567304.html

Might’ve already been posted but this would be great!

Here is the pre-print for it:

https://www.biorxiv.org/content/10.1101/2020.09.25.309914v1.full.pdf

The sample sizes are bit small and the point values are quite a bit all over the shop, but there is an effect and it's not small. A higher n would be needed to get to the bottom of the dose response curve, it looks like too much of the compound might not be all that great as the 2x100ug group seems to do the worst of the treatment groups (maybe just down to that one single ferret that seems to have done no better than the controls overall, day 7 looks like a relapse for that animal).

is_that_so

This may have been posted on the main thread but potentially exciting news for real mass testing!

Tests for Covid-19 that show on-the-spot results in 15 to 30 minutes are about to be rolled out across the world, potentially saving many thousands of lives and slowing the pandemic in both poor and rich countries.

https://www.theguardian.com/world/2020/sep/28/covid-19-tests-that-give-results-in-minutes-to-be-rolled-out-across-world

ACitizenErased

FDA aren't too keen on the UK's challenge trial approach, surprisingly
https://www.politico.com/news/2020/09/28/fda-vaccine-guidance-may-not-be-released-422648

funnydoggy

is_that_so wrote: »

This may have been posted on the main thread but potentially exciting news for real mass testing!



https://www.theguardian.com/world/2020/sep/28/covid-19-tests-that-give-results-in-minutes-to-be-rolled-out-across-world

Would be great.


Imagine showing up for your workshift 30 minutes before you start for a test. Fantastic!

Diarmuid

Good bit on the BBC Science Hour Podcast this week about vaccines. https://www.bbc.co.uk/programmes/w3cszkx6

Interestingly I never knew that some vaccines stop the disease progressing in a person but that same person can still transmit the disease, while others stop the progression and the transmission

funnydoggy

https://www.nature.com/articles/s41586-020-2798-3.epdf?sharing_token=uEUn7jqOpl9pPZd5hQH-ydRgN0jAjWel9jnR3ZoTv0PNa0tpUm38tEAOEu3ocLlP6tjVQGYR4DvBAUmCP3KKUBOfiH60azV6GvChsQTBRqzQ6nm4sz3nKdXUsZRVCOB34QAtDoLaJnFGDViTWMvQG0A4EEbyyCuc_-4P3_t7ayQ%3D

It is highly likely that the AstraZeneca, Moderna and Pfizer vaccine candidates, which are along the furthest in the US and Europe, all show sufficient efficacy and will be licensed if sufficiently safe. However, it may also be that these vaccines will later on be replaced by vaccines that show similar efficacy but have reactogenicity profiles that are more tolerable. In addition, it is hard to predict how availability and production capacity will shape the global landscape of SARS-CoV-2 vaccines. While likely not being licensed in the US and Europe, it is very likely that AdV5-based and inactivated vaccines produced in China, as well as different vaccine candidates produced in India and elsewhere will play a major role to satisfy the global demand for SARS-CoV-2 vaccines. Despite all the challenges discussed here, we are in the process of developing vaccines as countermeasure against COVID-19 at record speed and it is certainly possible that vaccines with safety and efficacy proven in Phase III trials might already enter the market in 2020.

Diarmuid

Diarmuid wrote: »

Good bit on the BBC Science Hour Podcast this week about vaccines. https://www.bbc.co.uk/programmes/w3cszkx6

Interestingly I never knew that some vaccines stop the disease progressing in a person but that same person can still transmit the disease, while others stop the progression and the transmission

Some vaccines can actually make you infectious for a short period, you should avoid contact with people with poor immune function after them.

PopePalpatine

Deleted User wrote: »

Some vaccines can actually make you infectious for a short period, you should avoid contact with people with poor immune function after them.

If that's the case for the Covid-19 vaccine, I wonder how many will have their post-vaccination seshes scuppered.

PopePalpatine

PopePalpatine wrote: »

If that's the case for the Covid-19 vaccine, I wonder how many will have their post-vaccination seshes scuppered.

Think it's only live vaccines that can do this and it's very rare. None of the covid candidates I know of are going that route.

ACitizenErased

Deleted User wrote: »

Think it's only live vaccines that can do this and it's very rare. None of the covid candidates I know of are going that route.

The Chinese one is inactivated as far as I know.

Pauliedragon

I have to go for a test and spoke to a few people who have been and they said they got no results and that the only people contacted are the positive tests. Surely this can't be true. I need proof of a negative test for work. Anybody heard of this?

Hmmzis

ACitizenErased wrote: »

The Chinese one is inactivated as far as I know.

Inactivated vaccines do not contain live virus, the ones with a live virus in them are called "live attenuated". One of the polio vaccines is like that and it can happen that the attenuated virus is shed enough to get to another person, it's not the norm though.

What happens with other vaccines that do not provide sterilizing protection is that the wild type infection can still cause some shedding to happen (like with the inactivated polio vaccine).

Gael23

Hmmzis wrote: »

Inactivated vaccines do not contain live virus, the ones with a live virus in them are called "live attenuated". One of the polio vaccines is like that and it can happen that the attenuated virus is shed enough to get to another person, it's not the norm though.

What happens with other vaccines that do not provide sterilizing protection is that the wild type infection can still cause some shedding to happen (like with the inactivated polio vaccine).

I have an autoimmune disease so I cannot take a live vaccine

Charles Babbage

is_that_so wrote: »

This may have been posted on the main thread but potentially exciting news for real mass testing!



https://www.theguardian.com/world/2020/sep/28/covid-19-tests-that-give-results-in-minutes-to-be-rolled-out-across-world

Mass testing could bring this malady under control without a vaccine.



Meanwhile though, the Bill Gates foundation is ramping up vaccine production capability in advance. Fair play. I'll bet he pays more tax than Trump too.

https://twitter.com/i/events/1310894158094061568

is_that_so

A company claim research story linked to on the Sweden thread. Apparently good results in animals but a long way off human trials yet.


https://www.indiatoday.in/science/story/nasal-spray-can-reduce-covid-19-growth-study-australian-biotech-company-ena-respiratory-1726280-2020-09-28

com1

Pauliedragon wrote: »

I have to go for a test and spoke to a few people who have been and they said they got no results and that the only people contacted are the positive tests. Surely this can't be true. I need proof of a negative test for work. Anybody heard of this?

They ring you if you’re positive and text you if they dont find the virus (I wont say negative)

Pauliedragon

com1 wrote: »

They ring you if you’re positive and text you if they dont find the virus (I wont say negative)

Cheers. I should explained myself better. What I meant was I'll need a hard copy for my boss before he lets me back (he's a dinosaur) he barely knows what a text is. HSE don't seem to have any system where you can print results.

Van.Bosch

Pauliedragon wrote: »

Cheers. I should explained myself better. What I meant was I'll need a hard copy for my boss before he lets me back (he's a dinosaur) he barely knows what a text is. HSE don't seem to have any system where you can print results.

Why does he need to see it, if it’s “no Covid detected” you just need to restrict movements for 14 days if you were a close contact or you’re good to go if you were symptomatic and have been 48 hours without symptoms.

Happydays2020

hmmm wrote: »

I've read that most people are at their most infectious 2 days before symptoms, and 3-5 days afterwards. Would you know where in that scale one of those quick tests would detect the presence of the virus?

And the same for any scenario beyond full lock down. It is a risk based approach which is further mitigated by enhanced hygiene standards and mask wearing.

dominatinMC

A bit dismayed by the news this evening and the reporting of Paul Reid's assessment that "Covid will be with us for a very long time - irrespective of a vaccine". He is insisting that behavioural changes across society will be needed for a long time (didn't quantify this) even with a vaccine. To which it begs the question, why the hell do we need a vaccine if things can't go back to normal? I know the vaccine isn't a "silver bullet" but my understanding was that it would suppress the virus to such an extent that things could, indeed, go back to normal. We get it, the virus will always be with us, but if it's not rampaging through society, I fail to see why we can't go back to normal.

Santy2015

dominatinMC wrote: »

A bit dismayed by the news this evening and the reporting of Paul Reid's assessment that "Covid will be with us for a very long time - irrespective of a vaccine". He is insisting that behavioural changes across society will be needed for a long time (didn't quantify this) even with a vaccine. To which it begs the question, why the hell do we need a vaccine if things can't go back to normal? I know the vaccine isn't a "silver bullet" but my understanding was that it would suppress the virus to such an extent that things could, indeed, go back to normal. We get it, the virus will always be with us, but if it's not rampaging through society, I fail to see why we can't go back to normal.

Their media training comes in there. Dampening expectations. They know all going well we’ll have 2/4 vaccines approved within the next 6 months and hopefully before that for emergency use.
Yeah certainly won’t be the silver bullet, it will become endemic like influenza but hopefully will burn itself out.