COVID-19: Vaccine/antidote and testing procedures Megathread [Mod Warning - Post #1]

sideswipe

tobefrank321 wrote: »

Hopefully Oxford and AstraZenica publish details of the adverse reaction so that other vaccine makers can learn from it, and commercial considerations don't play a part.

Their vaccine was considered one of the front runners and probably the best option.

Large numbers of vaccine candidates often make it to phase 3 but the success rate at this stage drops dramatically.

AFAIK there is no details of an adverse reaction, trials paused to investigate a possible one. I'm no expert but I'd image this happens in trial all the time, the difference here is the huge interest and publicity.

Gael23

ACitizenErased wrote: »

The Serum Institute of India is continuing it’s Oxford trials. They say that the issue is not vaccine related.
Taken from Reddit:

That’s different although o would not consider Reddit to be the most reputable source.

ACitizenErased

ACitizenErased wrote: »

R/COVID19 is the science subreddit for COVID, you have to have a degree to post on there basically. Some really good discussion.

A degree in what?

Sconsey

tobefrank321 wrote: »

Hopefully Oxford and AstraZenica publish details of the adverse reaction so that other vaccine makers can learn from it, and commercial considerations don't play a part.

Their vaccine was considered one of the front runners and probably the best option.

Large numbers of vaccine candidates often make it to phase 3 but the success rate at this stage drops dramatically.

6 out of 10 on the trolling there....you do a fairly good job of linking any continuation of the Oxford trail to being financially driven. Unfortunately it was a bit ham-fisted and is fairly transparent. You should be guiding the reader to your moronic conclusions as opposed to sticking it in their faces.

Next time try being a bit more subtle, you might catch a few more fish that way. Complementing your moronic statement with some unrealted but accurate facts after is a nice touch, add a sens of accuracy for the really blind that can't see through your sh1te.

Tokyo

Sconsey wrote: »

6 out of 10 on the trolling there....

Mod: @Sconsey - you're not a mod of this forum - if you have an issue with a post, report it. Take 48 hours away from the thread to reconsider this, and your posting style.

Hmmzis

Press release from Pfizer and BioNTech:

https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-potentially-supply-eu-200-million-doses

All going well, they'd start deliveries by end of year, the deal, if closed, would be for 200 + 100 million doses.

tobefrank321

The fact Astrazenica share price dropped dramatically on the back of the news indicates there does appear to be a commercial consideration.

Not my opinion, the financial market's opinion. A company cannot afford to see its share price drop even if their motives are benign and non profit.

Gael23

Hmmzis wrote: »

Press release from Pfizer and BioNTech:

https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-potentially-supply-eu-200-million-doses

All going well, they'd start deliveries by end of year, the deal, if closed, would be for 200 + 100 million doses.

Looks like its the front runner now. Does it work in a similar way to the Oxford. one?
In the. event Oxford/AZ work through this difficulty we could well have enough vaccines to stop this within a year

Sweet.Science

Hmmzis wrote: »

Press release from Pfizer and BioNTech:

https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-potentially-supply-eu-200-million-doses

All going well, they'd start deliveries by end of year, the deal, if closed, would be for 200 + 100 million doses.

You would think this would be front page news tomorrow but no . More scaremongering i would guess.

Hmmzis

Gael23 wrote: »

Looks like its the front runner now. Does it work in a similar way to the Oxford. one?
In the. event Oxford/AZ work through this difficulty we could well have enough vaccines to stop this within a year

Different delivery mechanisms, similar antigen presentation. They both would code for the S protein of the virus. ChAdOx1 uses a viral vector for cellular delivery, Pfizer/BioNTech use mRNA directly packed in lipid nano-particles.

IF there indeed turns out to be a problem with the ChAdOx1 vaccine, the question then will be what part of it causes it. Is it the viral vector, the antigen? There have been some cases of TM reported for SARS-cov-2 infections apparently (see Derek Lowe's latest blog post).

If the event is unrelated to the vaccine, then trials will resume as normal.

If the event is caused by the vector, then simian Ad viruses might not be usable for all populations.

If the event is caused by the antigen itself, then it's a bigger problem and could potentially affect multiple vaccine candidates.

The oversight committee will now do their jobs and figure that out.

In any case, the event appears to be rare and might be limited to certain populations, the UK arm of the trial was recruiting more of the risk populations than the other arms.

stephenjmcd

Hmmzis wrote: »

Press release from Pfizer and BioNTech:

https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-potentially-supply-eu-200-million-doses

All going well, they'd start deliveries by end of year, the deal, if closed, would be for 200 + 100 million doses.

Excellent news, Pfizer seem very confident going by the public comments last few days.

Posted it into the main thread as well. Not sure how many look at this thread

iguana

Sweet.Science wrote: »

You would think this would be front page news tomorrow but no . More scaremongering i would guess.

We (Europe) have 5 vaccine deals like this already.

Account Number

Does the EU have a deal with Pfizer for their vaccine? Or what others besides Oxford/AZ and J+J?

iguana

Account Number wrote: »

Does the EU have a deal with Pfizer for their vaccine? Or what others besides Oxford/AZ and J+J?

Moderna, Curevac and Sanofi-GSK in addition to the above.

con___manx1

I work in pharma. there is no way in hell I will take a rushed vaccine. These pharma companys are just out for money. That's there priority not you or me. They are all racing each other now for the big pay day.

Gael23

iguana wrote: »

Moderna, Curevac and Sanofi-GSK in addition to the above.

Not all going to be ready as quick as Oxford was though

FutureTeashock

con___manx1 wrote: »

I work in pharma. there is no way in hell I will take a rushed vaccine. These pharma companys are just out for money. That's there priority not you or me. They are all racing each other now for the big pay day.

Finally, someone on my side!:o

The wheels are falling off the rushed vaccine in any case.

With the tracker app also in the toilet, the Covid agenda is taking a hammering.

Jolly good.

IHaveTheFlag

con___manx1 wrote: »

I work in pharma. there is no way in hell I will take a rushed vaccine. These pharma companys are just out for money. That's there priority not you or me. They are all racing each other now for the big pay day.

Astra zeneca are so out for money that they're manufacturing not for profit and charging$3 per shot. But you're the professional.

tobefrank321

Lets hope they share the data with other vaccine makers. I'm sure they will.

I'm know I'll be accused of being a big pharma sceptic, anti vaxxer, Trump supporting Jim Corr wannabe. One poster already inferred similar.
I'm none of these. I want a vaccine delivered to the market asap and I don't care who does it. In that regard I want all the vaccine makers to share as much details as possible.

Hmmzis

Update form AstraZeneca:

https://www.statnews.com/2020/09/09/astrazeneca-covid19-vaccine-trial-hold-patient-report/

First event during the summer was triggered by a participant with multiple sclerosis being hospitalized (unrelated to the vaccine).
The current event is still under investigation, but does not appear to be serious, the lady in question is expected to be discharged today.

So far looks like they're being as open as it's feasible, good to see. Very glad the lady is doing fine. I know there are risks in clinical trials, their very purpose is to suss those risks out, but would still hate to see a volunteer, doing the right thing, suffer potentially permanent consequences.

IHaveTheFlag

Wonder if rte the guardian etc will be as quick to publish articles on that as they were to break the bad news this morning

Thierry12

IHaveTheFlag wrote: »

Astra zeneca are so out for money that they're manufacturing not for profit and charging$3 per shot. But you're the professional.

They are world famous now, all over the news from April,

They'll make profit on the other products they sell

astrofool

The numbers involved in the trials would mean that if these events didn't happen, something would be suspect, the fact that it has occurred, and is being investigated properly, shows that the trials are proceeding safely. As lots of people are paying attention, markets will swing every which way on every bit of news due to lack of education on those reading the information.

Speaking of which, what is this "Covid Agenda"?

IHaveTheFlag

FutureTeashock wrote: »

Finally, someone on my side!:o

The wheels are falling off the rushed vaccine in any case.

With the tracker app also in the toilet, the Covid agenda is taking a hammering.

Jolly good.

I'll probably regret asking but what's the covid agenda?

IHaveTheFlag

Thierry12 wrote: »

They are world famous now, all over the news from April,

They'll make profit on the other products they sell

So what's the alternative to having chemical companies manufacturing the vaccine? Is there a vaccine cottage industry I've never heard of? Maybe we can brew a vaccine in the bathtub or something?

Thierry12

IHaveTheFlag wrote: »

So what's the alternative to having chemical companies manufacturing the vaccine? Is there a vaccine cottage industry I've never heard of? Maybe we can brew a vaccine in the bathtub or something?

Why are you talking about manufacturing?

You said they won't make money, I said they will

IHaveTheFlag

Thierry12 wrote: »

Why are you talking about manufacturing?

You said they won't make money, I said they will

I said off manufacturing and the vaccine. I said nothing about anything else they manufacture.

hmmm

tobefrank321 wrote: »

The fact Astrazenica share price dropped dramatically on the back of the news indicates there does appear to be a commercial consideration.

Not my opinion, the financial market's opinion. A company cannot afford to see its share price drop even if their motives are benign and non profit.

Momentum trading, automated trades based on press releases. It's just noise.

Astra Zeneca's share price has barely budged, and has recovered most of the fall.

The Modernas and Inovios of this world are more dependent financially on their vaccines succeeding and I'd be more wary of any news from them as a consequence. For AstraZeneca the profit will be negligible, but it's good for their company to be seen doing what they are doing.

Delighted with the EU/Pfizer news.

FutureTeashock

IHaveTheFlag wrote: »

I'll probably regret asking but what's the covid agenda?

Basically this technocratic hell.

I will fight it with everything I've got!

https://www.youtube.com/watch?v=U88ZKJhztiM&t=2s

Gael23

Reassuring update from AstraZeneca