Vaccine Megathread No 2 - Read OP before posting

duffman13 · 11-06-2021 12:28PM

podgeandrodge wrote: »

It is somewhat disappointing to hear that of 42 deaths from confirmed Delta variant that 12 of them were over 2 weeks since second dose. If that can happen to vaccinated people, what's the way out of this?

A headline figure, its disappointing but not unexpected at all to be honest. People receive a flu vaccine every year yet vaccinated people die every year too. It will be interesting to see the breakdown of the data in terms of time post vaccine, age and also which vaccine was usedd.

Geuze · 11-06-2021 12:35PM

Interesting research on dose-stretching published:

A Half Dose of Moderna is More Effective Than a Full Dose of AstraZeneca

https://marginalrevolution.com/marginalrevolution/2021/06/a-half-dose-of-moderna-is-more-effective-than-a-full-dose-of-astrazeneca.html

"Today we are releasing a new paper on dose-stretching co-authored by Witold Wiecek, Amrita Ahuja, Michael Kremer, Alexandre Simoes Gomes, Christopher M. Snyder, Brandon Joel Tan and myself.

The paper makes three big points. First, Khoury et al (2021) just published a paper in Nature which shows that “Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection.” What that means is that there is a strong relationship between immunogenicity data that we can easily measure with a blood test and the efficacy rate that it takes hundreds of millions of dollars and many months of time to measure in a clinical trial. Thus, future vaccines may not have to go through lengthy clinical trials (which may even be made impossible as infections rates decline) but can instead rely on these correlates of immunity.

Here is where fractional dosing comes in. We supplement the key figure from Khoury et al.’s paper to show that fractional doses of the Moderna and Pfizer vaccines have neutralizing antibody levels on par with those of many approved vaccines. Indeed, a one-half or one-quarter dose of the Moderna or Pfizer vaccine looks to be more effective than the standard dose of some of the other vaccines like the AstraZeneca, J&J or Sinopharm vaccines. The point is not that these other vaccines aren’t good–they are great! The point is that by using fractional dosing we could rapidly and safely expand the number of effective doses of the Moderna and Pfizer vaccines."

Link to working paper:

https://bfi.uchicago.edu/wp-content/uploads/2021/06/BFI_WP_2021-68.pdf

Could Vaccine Dose Stretching Reduce COVID-19 Deaths?

Geuze · 11-06-2021 12:35PM

Vaccine-Efficacy-Figure_Social-and-Web-Share-Graphic_v04.jpg

11-06-2021 12:42PM

Geuze wrote: »

Having received the text for the Moderna 1st dose yesterday, this chart pleases me

votecounts · 11-06-2021 12:53PM

https://twitter.com/sinnfeinireland/status/1403310430651621376

I wouldn't have thought this was the smartest move considering the high cases in Limerick, surely the health of people trumps a feckin horse race meeting

11-06-2021 12:56PM

votecounts wrote: »

https://twitter.com/sinnfeinireland/status/1403310430651621376

I wouldn't have thought this was the smartest move considering the high cases in Limerick, surely the health of people trumps a feckin horse race meeting

Who owns the racecourse?

xboxdad · 11-06-2021 01:02PM

podgeandrodge wrote: »

It is somewhat disappointing to hear that of 42 deaths from confirmed Delta variant that 12 of them were over 2 weeks since second dose. If that can happen to vaccinated people, what's the way out of this?

Those vaccinated ppl only died because there are tons of unvaccinated people who they could meet.

Once it'll be really hard to run into unvaccinated ppl, vaccinated ppl's risks will drop dramatically. (not looking forward to being forced to sit next to a couple of flat earther unvaccinated colleagues once back to office)

"no one is safe until everyone is safe"

RavenBea17b · 11-06-2021 01:09PM

Deleted User wrote: »

Who owns the racecourse?

YEAH, EXACTLY, bloody awful to close tomorrow. Sending people to Dublin an other locations because of a horserace.

km79 · 11-06-2021 01:11PM

My vaccine portal has now updated to reflect I have gotten vaccine 1
I got it from the GP though so wasn’t sure what would happen with the online portal
Looks like all the information is collated together which is good as I may end up going to MVC for second shot

11-06-2021 01:17PM

12 deaths so far of Fully vaccinated people from the delta variant in England according to BBC news
Thats actually a lot
They don't say what ages,underlying conditions or which vaccine
I'd be prepared almost to bet its AstraZeneca

ClosedAccountFuzzy · 11-06-2021 01:19PM

[Deleted User] wrote: »

Who owns the racecourse?

I assume it's owned, used by and visited by people involved in a sport that gets lots of state funding...

11-06-2021 01:19PM

RavenBea17b wrote: »

YEAH, EXACTLY, bloody awful to close tomorrow. Sending people to Dublin an other locations because of a horserace.

It was a genuine question. Who owns the racecourse? Because if it’s not the state, the agreement to use would certainly have included a provision for use for pre planned activities or required compensation in the event of cancellation.

And are people being sent elsewhere or or appointments not just being planned for tomorrow? There is tonnes of capacity so no one is missing out by more than a couple of days

ClosedAccountFuzzy · 11-06-2021 01:21PM

Whatever about the contract, it's a PR and political disaster!

Micky 32 · 11-06-2021 01:24PM

More excellent news:

https://www.rte.ie/news/coronavirus/2021/0611/1227522-coronavirus-ireland/

“” Eight adult hospitals have no Covid-19 inpatients today including St James's hospital in Dublin and hospitals in Sligo, Galway and Waterford.””

11-06-2021 01:25PM

FuzzyThinking wrote: »

Whatever about the contract, it's a PR and political disaster!

Because certain parties love making mountains out of molehills while ignoring the real issues because that would actually involve applying some logical reasoning?

JimmyVik · 11-06-2021 01:29PM

Stone Deaf 4evr wrote: »

Got Pfizer at 11:45 am yesterday,
by 2pm I felt noticeably tired - particularly around the eyes - as if I had been reading for hours.
Slept ok-ish last night but arm was / is quite sore - cant lift it above shoulder level.
Very tired today still, probably take an early day from work and get some rest in.

Delighted to have the 1st dose done though.

Exactly the same myself.
I get a sore arm any time someone sticks a needle in it so nothing new there, but the tiredness wasnt expected. Fine after a sleep though.

iamwhoiam · 11-06-2021 01:31PM

Micky 32 wrote: »

More excellent news:

https://www.rte.ie/news/coronavirus/2021/0611/1227522-coronavirus-ireland/

“” Eight adult hospitals have no Covid-19 inpatients today including St James's hospital in Dublin and hospitals in Sligo, Galway and Waterford.””

I watched St James on a TV documentary filmed during high Covid cases
The staff were absolutely exhausted and stressed . I am so pleased for them that they can hopefully take a break and get time off and recharge their batteries now

eoinbn · 11-06-2021 01:41PM

Delivery update on ecdc. Two weeks but I think it is missing this week.

Pfizer... 2352k +466k
AZ...........779k +153k
Moderna 348k +65k
J&J..........133k +72k

Pat_bottom · 11-06-2021 01:43PM

xboxdad wrote: »

Those vaccinated ppl only died because there are tons of unvaccinated people who they could meet.

Once it'll be really hard to run into unvaccinated ppl, vaccinated ppl's risks will drop dramatically. (not looking forward to being forced to sit next to a couple of flat earther unvaccinated colleagues once back to office)

"no one is safe until everyone is safe"

This is a really good post on my opinion and it answers all the people you meet that claim "oh I'm not getting that because even tho you still have it we still ain't safe" I don't know how people can't get their heads around this.

Micky 32 · 11-06-2021 01:48PM

Pat_bottom wrote: »

This is a really good post on my opinion and it answers all the people you meet that claim "oh I'm not getting that because even tho you still have it we still ain't safe" I don't know how people can't get their heads around this.

It could be a good post if we knew the full story of the 12 that died. Even so come July/August things will be a lot different as the months pass by. There will be a huge amount more vaccinated say by August.

ClosedAccountFuzzy · 11-06-2021 01:49PM

[Deleted User] wrote: »

Because certain parties love making mountains out of molehills while ignoring the real issues because that would actually involve applying some logical reasoning?

Closing a mass vaccination centre in a city where there's a spike in numbers and with concerning variants on the horizon, in the middle of a pandemic, all to facilitate a horse race.

Yup that's totally reasonable (rolls eyes). Nothing to see here! Anyone who says otherwise is just a trouble maker...

Wibbs · 11-06-2021 01:54PM

Marine Layer wrote: »

12 deaths so far of Fully vaccinated people from the delta variant in England according to BBC news
Thats actually a lot
They don't say what ages,underlying conditions or which vaccine

And that's the big problem. If they're all over 80, or severly compromised with comorbidities then it's of course a personal tragedy for them and loved ones, but otherwise means little enough.

11-06-2021 01:55PM

FuzzyThinking wrote: »

Closing a mass vaccination centre in a city where there's a spike in numbers and with concerning variants on the horizon, in the middle of a pandemic, all to facilitate a horse race.

Yup that's totally reasonable (rolls eyes). Nothing to see here! Anyone who says otherwise is just a trouble maker...

It’s not being closed, it just wasn’t planned on being used tomorrow. In the real world this vaccination centre only opened this week to replace the one at the radisson which in fact will still be operating tomorrow maintaining the 7 day vaccine programme for the people of Limerick. Doesn’t stop the needless frothing unfortunately

RavenBea17b · 11-06-2021 01:59PM

Marine Layer wrote: »

12 deaths so far of Fully vaccinated people from the delta variant in England according to BBC news
Thats actually a lot
They don't say what ages,underlying conditions or which vaccine
I'd be prepared almost to bet its AstraZeneca

No it doesn't say what conditions they had, nor does it state the vaccine.
Pfizer and AZ are c33% efficacy against Delta at one dose, Pfizer c83+, AZ expected to be 80-90% range (slow burn etc).

One thing I did read recently, because of Delta, fully vaccinated and protected, may not be 2-3 weeks as before, but 4-5 weeks, is being reviewed. But wasn't sure of the source validity. It will be interesting to see results. One thing for certain, the vaccines are working, take the second jab.

JimmyVik · 11-06-2021 02:09PM

RavenBea17b wrote: »

No it doesn't say what conditions they had, nor does it state the vaccine.
Pfizer and AZ are c33% efficacy against Delta at one dose, Pfizer c83+, AZ expected to be 80-90% range (slow burn etc).

One thing I did read recently, because of Delta, fully vaccinated and protected, may not be 2-3 weeks as before, but 4-5 weeks, is being reviewed. But wasn't sure of the source validity. It will be interesting to see results. One thing for certain, the vaccines are working, take the second jab.

The efficacy of J&J on this variant seems to have been disregarded.
I cant find a word about it.

L1011 · 11-06-2021 02:10PM

JimmyVik wrote: »

The efficacy of J&J on this variant seems to have been disregarded.
I cant find a word about it.

So little of it has arrived its barely relevant.

Azatadine · 11-06-2021 02:13PM

L1011 wrote: »

So little of it has arrived its barely relevant.

It is to me.....I got it.....

JimmyVik · 11-06-2021 02:14PM

L1011 wrote: »

So little of it has arrived its barely relevant.

I think its relevant to the people who received it though.
And surely J&J should be checking out how their vaccine performs against the variant, even in other countries where its use is more widespread.
I just think the silence is loud.

IRISHSPORTSGUY · 11-06-2021 02:21PM

https://twitter.com/kaitlancollins/status/1403338849565110277

11-06-2021 02:22PM

JimmyVik wrote: »

The efficacy of J&J on this variant seems to have been disregarded.
I cant find a word about it.

J & J isn't really in use anywhere the variant is prevalent. Which is a concern.

Vaccine Megathread No 2 - Read OP before posting

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