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What exactly is happening with AstraZeneca?

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Comments

  • Registered Users, Registered Users 2 Posts: 15,553 ✭✭✭✭stephenjmcd


    Your point is a strawman which distracts from a dangerous side effect in the section of population at smallest risk of Covid. False equivalence, these vaccines are not Paracetamol.

    Again you miss that point completely on the assessment of risk so I won't bother going around in circles here, it's like banging my head off a brick wall, when you've an issue with comprehension. One for the ignore list. Good luck


  • Moderators, Science, Health & Environment Moderators, Sports Moderators Posts: 24,146 Mod ✭✭✭✭robinph


    Wolf359f wrote: »
    Countries like Australia and NZ, basically any zero covid country will have the same issues, especially with take-up and of course when they try to reopen their borders.
    It has to be sold as take the vaccine to reopen the borders and you can travel, as apposed to here where it's get vaccinated to protect yourself and others.

    They have a much bigger task to convince populations to be vaccinated. Will be able to get those wanting to travel to take it, and possibly those who get the flu jab each year once they do them as a combination jab. Reaching any kind of decent level of immunity among the population as a whole will be next to impossible though.

    They will be able to relax incoming restrictions a bit based on other countries having been vaccinated, but will be a tough ask. Can't see them getting much support for having to lockdown again whilst the rest of the world opens up despite them having done great so far.


  • Registered Users, Registered Users 2 Posts: 289 ✭✭sekond


    Wolf359f wrote: »
    Countries like Australia and NZ, basically any zero covid country will have the same issues, especially with take-up and of course when they try to reopen their borders.
    It has to be sold as take the vaccine to reopen the borders and you can travel, as apposed to here where it's get vaccinated to protect yourself and others.

    Relatives in NZ are extremely anti taking a vaccine. "Why would we need to, we haven't got covid here". And the travel argument doesn't win them over, particularly as there has been some talk of a travel agreement with Australia - and for most of them, that's as far as they would go. We had a bit of a row with my MIL as we tried to make her understand that without re-opening borders (and therefore a vaccinated population) she wouldn't be able to see her grandchildren any time soon.


  • Registered Users, Registered Users 2 Posts: 21,722 ✭✭✭✭Strazdas


    sekond wrote: »
    Relatives in NZ are extremely anti taking a vaccine. "Why would we need to, we haven't got covid here". And the travel argument doesn't win them over, particularly as there has been some talk of a travel agreement with Australia - and for most of them, that's as far as they would go. We had a bit of a row with my MIL as we tried to make her understand that without re-opening borders (and therefore a vaccinated population) she wouldn't be able to see her grandchildren any time soon.

    NZ have rightly won praise for eliminating Covid but many observers have questioned how on earth they are going to extract themselves out of the pandemic. The country is completely shut down from the rest of the world with no travel or tourism allowed and no sign of this changing any time soon.


  • Registered Users, Registered Users 2 Posts: 215 ✭✭Lazy Bhoy


    fly_agaric wrote: »
    Ah now you're a bit of a mad lad/contrarian wanting Sputnik vaccine so badly yet fearing to take AstraZeneca.
    It does not seem rational, but I suppose (assuming you are serious) some people like to go for the mystery prize.

    Russia is an autocratic state which is not transparent. In Russia/China you can expect that equivalents of our regulators, the health service etc. (and scientists too) will be captured and beholden to the political system. That reduces my trust in what they say about their vaccines.

    Their vaccine is in use in poorer non Western countries with...I'd expect not so good health services compared to the Western European countries that have managed to pick up on a very infrequently occuring potential problem with AZ vaccine in a small cohort of people.

    Sputnik has not been through an approval process yet in the likes of EU/US/UK/Japan etc. either.

    If it passes through that successfully (same as the other ones that have already been approved) I would not have any problem taking it but would prefer it was manufactured locally (in the EU) if that happens.


    I never said that I wanted the Sputnik vaccine "so badly" I said that I would take it if it was available over the AZ vaccine because of its growing quality and supply issues. I also said that I would take the Pfizer or Moderna over the AZ vaccine too for the same reason. If you are OK with taking the AZ vaccine then go for it. You can even have mine (if its offered to me).


    It always amuses me how people can point the finger at Russia or China being less transparent while the US jails whistleblowers for decades for reporting war crimes. Western governments also have no problems doing business with the likes of the Saudis when it suits them despite them being one of the most brutal regimes on the planet.



    Also, where were our health service and regulators recently when 18 women died of cervical cancer despite been given a clean bill of health? Our health service is far from perfect and we are certainly not in any position to to go looking down our nose and pointing the finger at others.


    The German government has recently announced that it is due to start negotiations with Russia to be supplied with the Sputnik vaccine if it is approved by the EMA (Germany also has no problems buying gas from this supposedly evil state despite protests from the US) France and Italy have also declared their interest in Sputnik. So again, if it is made available here then I would have no problem taking it. (or any other vaccine without the issues surrounding AZ)



    The AZ vaccine has gone from

    1. Its working grand and has passed all of its trials
    2. We can now take orders from countries who wish to be supplied with the AZ jab

    3. Some people in Norway had problems but that had nothing to do with the AZ vaccine
    4. OK those people in Norway may have had problems related to the AZ jab (suspended in some countries)
    5. Hey just plough along with the AZ vaccine, it's not like anybody has died. Its just some clotting.
    6. Ok, some people have died

    7. Ah but sure the benefits outweigh the risks so keep going.
    8. Actually wait, we cant even really supply the countries who have ordered it from us.


    Now why would I bother with a vaccine like the AZ one when there are alternatives out there with far less issues.


    If you are happy enough to use AZ despite its growing amount of issues then fair enough. That's your choice and good luck with it.


    I am not happy to use AZ. That is my choice.


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  • Moderators, Science, Health & Environment Moderators, Sports Moderators Posts: 24,146 Mod ✭✭✭✭robinph


    Lazy Bhoy wrote: »
    I never said that I wanted the Sputnik vaccine "so badly" I said that I would take it if it was available over the AZ vaccine because of its growing quality and supply issues. I also said that I would take the Pfizer or Moderna over the AZ vaccine too for the same reason. If you are OK with taking the AZ vaccine then go for it. You can even have mine (if its offered to me).


    It always amuses me how people can point the finger at Russia or China being less transparent while the US jails whistleblowers for decades for reporting war crimes. Western governments also have no problems doing business with the likes of the Saudis when it suits them despite them being one of the most brutal regimes on the planet.



    Also, where were our health service and regulators recently when 18 women died of cervical cancer despite been given a clean bill of health? Our health service is far from perfect and we are certainly not in any position to to go looking down our nose and pointing the finger at others.


    The German government has recently announced that it is due to start negotiations with Russia to be supplied with the Sputnik vaccine if it is approved by the EMA (Germany also has no problems buying gas from this supposedly evil state despite protests from the US) France and Italy have also declared their interest in Sputnik. So again, if it is made available here then I would have no problem taking it. (or any other vaccine without the issues surrounding AZ)



    The AZ vaccine has gone from

    1. Its working grand and has passed all of its trials
    2. We can now take orders from countries who wish to be supplied with the AZ jab

    3. Some people in Norway had problems but that had nothing to do with the AZ vaccine
    4. OK those people in Norway may have had problems related to the AZ jab (suspended in some countries)
    5. Hey just plough along with the AZ vaccine, it's not like anybody has died. Its just some clotting.
    6. Ok, some people have died

    7. Ah but sure the benefits outweigh the risks so keep going.
    8. Actually wait, we cant even really supply the countries who have ordered it from us.


    Now why would I bother with a vaccine like the AZ one when there are alternatives out there with far less issues.


    If you are happy enough to use AZ despite its growing amount of issues then fair enough. That's your choice and good luck with it.


    I am not happy to use AZ. That is my choice.

    The only issue that should concern the individual is the clotting one, and then it's really only something for you to query with your GP and let them figure out the personal risks to you.

    All the issues regarding supply and orders or contracts and exports to wherever are irrelevant to the individual. That is for the companies and government's to argue over, and the rest of us can look on curiously. But contacts and supplies should have less than zero impact on if an individual takes the vaccine or not, that is just down to is it authorised and if between you and your GP it's considered a good choice to take vaccine A, vaccine B or maybe none.


  • Registered Users, Registered Users 2 Posts: 19,130 ✭✭✭✭murphaph


    The clandestine exports of UK sourced AZ (was it made in the UK or just routed through the UK after manufacture in the EU?) to Australia are not a "good thing" for the UK's image at all at all. They allowed these exports at a time they were telling us their contract trumped ours (did the Australian contract trump theirs or what?) and that they couldn't spare a single drop and indeed that they wanted more AZ from the EU plants (and India).

    The UK and EU needed these doses much more than Australia at the time too.

    The UK government and AZ have been working hand in glove to further the UK's interests in all this. You can be absolutely sure that Johnson discussed this directly with Morrison and that a quid pro quo is expected (favourable FTA perhaps?)

    The UK Ambassador to Ireland not a week ago was telling us that the UK was far from having any spare vaccine.

    Untrustworthy to their cores.


  • Moderators, Science, Health & Environment Moderators, Sports Moderators Posts: 24,146 Mod ✭✭✭✭robinph


    The export to Australia amounted to less than a day's worth of what the UK was sticking in people's arms during March. It didn't make any difference to the UK.


  • Closed Accounts Posts: 727 ✭✭✭NeuralNetwork


    Meanwhile Pfizer and BioNTech have been supplying Australia from Puurs without any issues, because they're meeting their contractual requirements in Europe without problems.

    This whole thing is down to AstraZeneca's supply chain and is being politicised by the UK media.


  • Registered Users, Registered Users 2 Posts: 19,130 ✭✭✭✭murphaph


    Could have vaccinated the whole Luxembourg with those shipments, the first dose anyway. UK chose to send it to their "hope to be new best pals". We know why: they want a good FTA out of the Australians.

    This was all done in secret and if it turns out these doses were actually made in the EU and shipped via the UK to get around EU export restrictions there will be a price to pay for that.

    It's bad enough that they were saying they didn't have enough of their own and were demanding more from the EU plants, now it seems they were siphoning stuff off to send to a country with very low Covid rates.

    It all rather stinks.


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  • Closed Accounts Posts: 727 ✭✭✭NeuralNetwork


    If anything it smacks of desperation from the UK to get trade deals, which looks to me more like they're struggling to get preferential deals in the way they'd imagined.

    It also looks like Australia's is taking exactly the same position as European countries on the EMA report:

    https://www.abc.net.au/news/2021-04-08/scott-morrison-announces-pfizer-preferred-for-younger-people/100057184


  • Registered Users, Registered Users 2 Posts: 4,593 ✭✭✭LLMMLL


    murphaph wrote: »
    I've seen this thrown around but I'm also concerned about AZ in younger people. I'm happy to take any and all the usual vaccines. My kids are all vaccinated.

    Those vaccines have decades of evidence behind them and the diseases they prevent are typically very dangerous, even to children.

    These Covid 19 vaccines are all brand new with the bare minimum of testing done to satisfy the regulators. I understand why. The situation is dire for most people and vaccination is the only way out. But for young people the risk of death from Covid 19 can be lower than from the AZ vaccine.

    Nobody should ask that age group to take one for the team because there are alternative vaccines available. AZ should be given to the older people where the risk benefit is best and other vaccines should be given to younger people.

    If even the UK has now adopted this approach then there's clearly something to it.

    In my early 40s and being slightly overweight, I would take the AZ shot if offered and be very vigilant for the severe symptoms.

    I wouldn't give it to my kids though. There simply are no ICU's full of pre-teens. The disease isn't dangerous enough to my kids that I feel the need to risk the AZ vaccine rather than wait for another type.

    If the above thinking applies to AZ then it applies to all vaccines. They’re all new.

    People make the faulty assumption that because AZ MIGHT have one issue, which is blood clotting within 2 weeks in a TINY number of people then it is the bad vaccine. That if there’s a different problem within a year it will be with the AZ vaccine. That’s not how it works.


  • Registered Users, Registered Users 2 Posts: 3,041 ✭✭✭Call me Al


    Strazdas wrote: »
    NZ have rightly won praise for eliminating Covid but many observers have questioned how on earth they are going to extract themselves out of the pandemic. The country is completely shut down from the rest of the world with no travel or tourism allowed and no sign of this changing any time soon.

    I was thinking about this.
    Zero Covid is great if it can work.
    But what happens when you need to open up your country and your population don't feel the need to vaccinate?
    How can you open up an unvaccinated country while Covid-19 exists?


  • Posts: 5,853 ✭✭✭ [Deleted User]


    Call me Al wrote: »
    I was thinking about this.
    Zero Covid is great if it can work.
    But what happens when you need to open up your country and your population don't feel the need to vaccinate?
    How can you open up an unvaccinated country while Covid-19 exists?

    I would suggest that Slovakia and Czechia are perfect examples of how it can go wrong.


  • Registered Users, Registered Users 2 Posts: 5,516 ✭✭✭fly_agaric


    Lazy Bhoy wrote: »
    I never said that I wanted the Sputnik vaccine "so badly" I said that I would take it if it was available over the AZ vaccine because of its growing quality and supply issues.

    That is not a rational position. Sputnik is not approved in the EU yet.
    It's not in great supply as far as I understand, so if it ever is approved would be interesting to see how that goes too.
    As posted above, supply and these rows with manufacturers should be irrelevant to any individual's decision to take a vaccine when offered.
    You have no basis whatsoever to compare the relative "quality" of Sputnik/AZ and come to conclusion you'd prefer Sputnik!
    Lazy Bhoy wrote: »
    It always amuses me how people can point the finger at Russia or China being less transparent while the US jails whistleblowers for decades for reporting war crimes. Western governments also have no problems doing business with the likes of the Saudis when it suits them despite them being one of the most brutal regimes on the planet.

    This is completely irrelevant to the discussion in this thread. It amuses you - that's fine. I know this sort of whataboutism about the US/West is great fun, but maybe somewhere else is better for discussions of US foreign policy and the grubby global arms business + sale of weapons and instruments of repression to nasty people (which Russia/China are up to their necks in as well).
    Lazy Bhoy wrote: »
    Also, where were our health service and regulators recently when 18 women died of cervical cancer despite been given a clean bill of health? Our health service is far from perfect and we are certainly not in any position to to go looking down our nose and pointing the finger at others.

    Again this is more whataboutism. It is the EMA first, and I suppose more widely the actions of US/UK etc. that the regulators and health service here will look to. To authorise the Sputnik, obtain supplies [from Russia?] + ensure they are good quality and safe (assuming it will not be made here/in the EU) and then get it into your arm for you, they will need to go do a fairly courageous solo run.
    Given that health authorities here have not very competent at times (as you point out by referring to a past scandal) taking on a load of high risk tasks like that would worry me somewhat to say the least.
    Lazy Bhoy wrote: »
    Now why would I bother with a vaccine like the AZ one when there are alternatives out there with far less issues.

    If you are happy enough to use AZ despite its growing amount of issues then fair enough. That's your choice and good luck with it.

    I am not happy to use AZ. That is my choice.

    Yes that is your choice. However Sputnik is not one of those "alternatives with far less issues".
    AZ potentially has an issue which you've exaggerated to make a point.
    AZs issue is very rare and seems it is quite hard even for countries with excellent health services + tracking of these problems to pin down exactly what is going on given the small numbers. It would never be seen in any trial. Sputnik is an unknown quantity as yet and therefore it is a gamble to prefer it over AZ.


  • Registered Users, Registered Users 2 Posts: 201 ✭✭trixi001


    Astra Zeneca vaccine is not Paracetamol :rolleyes:

    To quote yourself "What an utter load of nonsense"

    Other vaccines (specifically Pfizer and Moderna) against Covid have on other hand proven to be completely safe, which goes back to my point, forget about this load of ****e and concetrate on procuring more of the good stuff into peoples arms

    The other vaccines have not be proven to be safe either..

    The Pfizer vaccine guidance was updated following people going into Anaphylatic shock after it, just like the AZ guidance has been updated following issues with blood clots..

    And there have been other queries on pfizer as well:
    https://nypost.com/2021/01/15/23-die-in-norway-after-receiving-pfizer-covid-19-vaccine/


  • Registered Users, Registered Users 2 Posts: 21,722 ✭✭✭✭Strazdas


    Call me Al wrote: »
    I was thinking about this.
    Zero Covid is great if it can work.
    But what happens when you need to open up your country and your population don't feel the need to vaccinate?
    How can you open up an unvaccinated country while Covid-19 exists?

    It's almost as if they are planning to wait until Covid-19 mostly 'dies down' in the world, but that could be years away.....maybe as much as four or five years. Have they given up on the idea of tourism to their country for the foreseeable?


  • Closed Accounts Posts: 727 ✭✭✭NeuralNetwork


    Call me Al wrote: »
    I was thinking about this.
    Zero Covid is great if it can work.
    But what happens when you need to open up your country and your population don't feel the need to vaccinate?
    How can you open up an unvaccinated country while Covid-19 exists?

    I don't think there is a perfect answer to this.

    Some countries, like NZ in particular, were able to self-isolate on a national level, but I think you could have issues undoing that as time goes on.

    If the vaccines provide 'sterilising immunity' i.e. prevent transmission, it may just be a case of banning unvaccinated people from entering the country.

    However, in the long term, having a largely unvaccinated population in a situation where a disease has become globally endemic would be pretty risky, particularly something this transmissible, as you would just need a handful of cases to get in and you'd have major problems.


  • Posts: 1,178 ✭✭✭ [Deleted User]


    If anything it smacks of desperation from the UK to get trade deals, which looks to me more like they're struggling to get preferential deals in the way they'd imagined.

    It also looks like Australia's is taking exactly the same position as European countries on the EMA report:

    https://www.abc.net.au/news/2021-04-08/scott-morrison-announces-pfizer-preferred-for-younger-people/100057184

    Indeed. That's now almost all of Western Europe, Canada and Australia placing age restrictions on it.

    How likely are we to follow suit?

    Interesting article here about EU health ministers' reaction to the EMA briefing.

    https://www.irishtimes.com/news/health/eu-ministers-frustrated-by-lack-of-ema-guidance-on-astrazeneca-vaccine-1.4532072


  • Moderators, Science, Health & Environment Moderators, Sports Moderators Posts: 24,146 Mod ✭✭✭✭robinph


    trixi001 wrote: »
    The other vaccines have not be proven to be safe either..

    The Pfizer vaccine guidance was updated following people going into Anaphylatic shock after it, just like the AZ guidance has been updated following issues with blood clots..

    And there have been other queries on pfizer as well:
    https://nypost.com/2021/01/15/23-die-in-norway-after-receiving-pfizer-covid-19-vaccine/

    In fairness to the Pfizer vaccine, that update to the guidance was mostly changing the font to bold and putting it in a red box with some arrows pointing to it saying "Read this, it's very important". It had instructions about not giving to people with severe allergies from the start, but a couple of nurses carrying epi pens for some reason thought that didn't apply to them.

    So now we all have to sit around for 15 minutes after the jab.


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  • Registered Users, Registered Users 2, Paid Member Posts: 21,277 ✭✭✭✭Stark


    Anaphylatic shock is a risk after any vaccine and it's fairly easily treatable. In Norway they gave it to people who were already on death's door and they died. Bit different to giving it a young healthy person and that person dying.


  • Registered Users, Registered Users 2 Posts: 10,934 ✭✭✭✭fin12


    appledrop wrote: »
    The fact is the rate of blood clots is going to rise if they don't stop now giving this to young people.

    In most countries the only young people that are getting vaccinated are health care workers.

    Even in Ireland a lot of these got Pfizer because there was a delay at the start getting AZ.

    No one not even UK are on the youngest group yet.

    Ya that’s true , I asked the nurse yday what vaccine she got and it was Pfizer.


  • Registered Users, Registered Users 2 Posts: 1,089 ✭✭✭Ashbourne hoop


    robinph wrote: »
    In fairness to the Pfizer vaccine, that update to the guidance was mostly changing the font to bold and putting it in a red box with some arrows pointing to it saying "Read this, it's very important". It had instructions about not giving to people with severe allergies from the start, but a couple of nurses carrying epi pens for some reason thought that didn't apply to them.

    So now we all have to sit around for 15 minutes after the jab.

    One of who had a previous allergic reaction to.........a vaccine


  • Registered Users, Registered Users 2 Posts: 5,490 ✭✭✭stefanovich


    Stark wrote: »
    Anaphylatic shock is a risk after any vaccine and it's fairly easily treatable. In Norway they gave it to people who were already on death's door and they died. Bit different to giving it a young healthy person and that person dying.

    These aren't your standard vaccines. They are the first to utilise mRNA tech. Instead of deactivated or live virus they use mRNA to program your cells to create antibodies.

    The unknowns here are greater for sure - and these approvals are temporary because of the pandemic.


  • Closed Accounts Posts: 727 ✭✭✭NeuralNetwork


    The EMA seems to restrict itself to very technical information production and then defer a lot to national regulators for the practical steps they might want to take on the basis of that.

    I don't think that's done much for public confidence as you've had 27+ countries all trying to follow each other's lead on this.


  • Registered Users, Registered Users 2 Posts: 5,490 ✭✭✭stefanovich


    The EMA seems to restrict itself to very technical information production and then defer a lot to national regulators for the practical steps they might want to take on the basis of that.

    I don't think that's done much for public confidence as you've had 27+ countries all trying to follow each other's lead on this.

    None of them want to be held accountable. See Slovakia - go out on your own, take a risk and you will be crucified.


  • Moderators, Science, Health & Environment Moderators, Sports Moderators Posts: 24,146 Mod ✭✭✭✭robinph


    appledrop wrote: »
    No one not even UK are on the youngest group yet.

    UK health secretary stated on breakfast telly this morning that 20% of the UK population aged between 20-29 had been vaccinated already. Was something like 3-4 million he said within that age group who had been vaccinated.


  • Closed Accounts Posts: 727 ✭✭✭NeuralNetwork


    None of them want to be held accountable. See Slovakia - go out on your own, take a risk and you will be crucified.

    You can hardly expect the EMA to standover medicines they've no oversight of. If you approve something at a national level, you are very much on your own or depending entirely on the supplier.

    Sputnik V hasn't been through the EMA's approvals process yet. There's an Italian company moving towards doing that, but it's not there yet.

    So, I'm really not sure what else you'd expect the EMA to do ?

    The EU is still a 27-country bloc, it's not a federal state and the EMA is pooled regulatory agency.


  • Registered Users, Registered Users 2 Posts: 5,516 ✭✭✭fly_agaric


    Strazdas wrote: »
    NZ have rightly won praise for eliminating Covid but many observers have questioned how on earth they are going to extract themselves out of the pandemic. The country is completely shut down from the rest of the world with no travel or tourism allowed and no sign of this changing any time soon.

    I think they can live with it for quite some time.
    If there's a real need for someone to travel there they can still do it I think.

    Setting aside the deaths and disease from Covid-19 they've avoided...it was far preferable to sacrifice the sector completely than try and maintain it and spread the damage to ruin large parts of your society/economy (position we are in).

    It is also still not yet certain that vaccines alone will get us fully out of this in Europe and back to life as it was pre-pandemic. Travel/foreign tourism sectors here are decimated anyway despite fact we did not close borders in the way Asian countries did.

    Ironically it's also a sector that really has to be trimmed down rather than continually grown each year given the environmental problems facing the planet.


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  • Registered Users, Registered Users 2, Paid Member Posts: 17,747 ✭✭✭✭astrofool


    These aren't your standard vaccines. They are the first to utilise mRNA tech. Instead of deactivated or live virus they use mRNA to program your cells to create antibodies.

    The unknowns here are greater for sure - and these approvals are temporary because of the pandemic.

    The approvals aren't temporary, the mRNA vaccines no more "program" your cells than any other vaccine type.

    Very simple to understand graphic is here to counter the misinformation above:
    https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different-vaccines/mrna.html


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