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COVID-19: Vaccine/antidote and testing procedures Megathread [Mod Warning - Post #1]

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  • #6092
    CountNjord
    Closed Accounts Posts: 108 ✭✭CountNjord


    Thierry12 wrote: »
    How does it work for you every year if the vaccine doesn't include the influenza that's circulating?

    Last year H3N2 wasn't in the flu vaccine and was spreading like wild fire

    If you got the vaccine for the last 10 years, you were unprotected for 5 years with its 50% efficacy

    Placebo affect?

    Maybe I am more healthy than most people, or you could be right with the placebo effect.

    I live alone so that gives me my own place where I don't have the potential of having viruses floating around and lying on surfaces.

    My son's 20 and up until he was 17 I only seen him every second weekend and if he was sick he'd stay at home.

    Working in parklands I'm in open spaces and have my own tool shed etc so that break's it down more.

    So I'm probably lucky.


  • #6093
    stephenjmcd
    Registered Users, Registered Users 2 Posts: 15,443 ✭✭✭✭stephenjmcd


    As reported last night Pfizer & BioNTech have reached all safety and efficiency milestones

    Final efficacy analysis have shown 95% were protected from the virus within 28 days of the first dose - up from last weeks interim analysis.

    It also proved 94% effective among adults over the age of 65.

    The Pfizer-BioNTech data shows 170 trial participants contracted Covid-19 overall. Eight participants who got the vaccine fell ill, while 162 cases were seen among those who got the placebo. The shot helped to prevent severe disease, according to the analysis, with nine of 10 severe cases in the trial occurring in the placebo group.

    For safety data, no serious side affects.
    2% of the 43,000 involved reporting a headache and 3.7% reporting fatigue.



    Submission for EUA to FDA within days


  • #6094
    polesheep
    Closed Accounts Posts: 2,950 ✭✭✭polesheep


    stephenjmcd wrote: »
    As reported last night Pfizer & BioNTech have reached all safety and efficiency milestones

    Final efficacy analysis have shown 95% were protected from the virus within 28 days of the first dose - up from last weeks interim analysis.

    It also proved 94% effective among adults over the age of 65.

    The Pfizer-BioNTech data shows 170 trial participants contracted Covid-19 overall. Eight participants who got the vaccine fell ill, while 162 cases were seen among those who got the placebo. The shot helped to prevent severe disease, according to the analysis, with nine of 10 severe cases in the trial occurring in the placebo group.

    For safety data, no serious side affects.
    2% of the 43,000 involved reporting a headache and 3.7% reporting fatigue.



    Submission for EUA to FDA within days

    That's fantastic news.


  • #6095
    hmmm
    Registered Users, Registered Users 2 Posts: 11,203 ✭✭✭✭hmmm


    stephenjmcd wrote: »
    As reported last night Pfizer & BioNTech have reached all safety and efficiency milestones

    Final efficacy analysis have shown 95% were protected from the virus within 28 days of the first dose - up from last weeks interim analysis.

    It also proved 94% effective among adults over the age of 65.

    For safety data, no serious side affects.
    2% of the 43,000 involved reporting a headache and 3.7% reporting fatigue.
    That's about as good news as we could have hoped for isn't it? There was a risk that the vaccines could be effective for younger people but still leave older people unprotected.


  • #6096
    stephenjmcd
    Registered Users, Registered Users 2 Posts: 15,443 ✭✭✭✭stephenjmcd


    hmmm wrote: »
    That's about as good news as we could have hoped for isn't it? There was a risk that the vaccines could be effective for younger people but still leave older people unprotected.

    Yup effective for all age groups it looks like. Better than anyone expected a few months ago. Really excellent results


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  • #6097
    Russman
    Registered Users, Registered Users 2 Posts: 5,977 ✭✭✭Russman


    stephenjmcd wrote: »
    As reported last night Pfizer & BioNTech have reached all safety and efficiency milestones

    Final efficacy analysis have shown 95% were protected from the virus within 28 days of the first dose - up from last weeks interim analysis.

    It also proved 94% effective among adults over the age of 65.

    The Pfizer-BioNTech data shows 170 trial participants contracted Covid-19 overall. Eight participants who got the vaccine fell ill, while 162 cases were seen among those who got the placebo. The shot helped to prevent severe disease, according to the analysis, with nine of 10 severe cases in the trial occurring in the placebo group.

    For safety data, no serious side affects.
    2% of the 43,000 involved reporting a headache and 3.7% reporting fatigue.



    Submission for EUA to FDA within days

    Fantastic news !
    Got a link to any of that info ? Not doubting you, just genuinely interested.


  • #6098
    stephenjmcd
    Registered Users, Registered Users 2 Posts: 15,443 ✭✭✭✭stephenjmcd


    Russman wrote: »
    Fantastic news !
    Got a link to any of that info ? Not doubting you, just genuinely interested.

    Yeah no worries.

    Being reported across multiple platforms but the first one that popped up for me was Bloomberg so may as well link that

    https://www.bloomberg.com/amp/news/articles/2020-11-18/pfizer-biontech-plan-filing-as-vaccine-proves-95-effective?__twitter_impression=true


  • #6099
    Cork2021
    Registered Users, Registered Users 2 Posts: 2,420 ✭✭✭Cork2021


    So Is 1 dose enough???? That would be huge!!


  • #6100
    Gael23
    Registered Users, Registered Users 2 Posts: 12,149 ✭✭✭✭Gael23


    CIARAN_BOYLE wrote: »
    Excellent news. That could be a way for the vaccines to separate themselves out for governments.

    What do you mean by this?


  • #6101
    stephenjmcd
    Registered Users, Registered Users 2 Posts: 15,443 ✭✭✭✭stephenjmcd


    Cork2021 wrote: »
    So Is 1 dose enough???? That would be huge!!

    I'd still say 2 shot regime, its been tested as that and proves a robust immune response so likely to stay that way.


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  • #6102
    Russman
    Registered Users, Registered Users 2 Posts: 5,977 ✭✭✭Russman


    stephenjmcd wrote: »
    Yeah no worries.

    Being reported across multiple platforms but the first one that popped up for me was Bloomberg so may as well link that

    https://www.bloomberg.com/amp/news/articles/2020-11-18/pfizer-biontech-plan-filing-as-vaccine-proves-95-effective?__twitter_impression=true

    Fair play, thanks !


  • #6103
    afatbollix
    Registered Users, Registered Users 2 Posts: 4,127 ✭✭✭afatbollix


    hmmm wrote: »
    Oxford/Astra Zeneca are swabbing to see whether the vaccine also reduces transmission as part of their trial.

    https://twitter.com/BBCRadio4/status/1328657018111004672

    I wonder if this means that the % won't be as high as the other ones as they have been swabbing more.

    If it was up to Trump he would of stopped swabbing to get better results :pac:

    Thankfully science sees a benefit of it that we will know if even with a vaccine the virus can still be transmitted or how many of the people actually got it.

    It's going to be fascinating if 50% of them got covid during the tests but nearly no one shows symptoms.


  • #6104
    CIARAN_BOYLE
    Registered Users, Registered Users 2 Posts: 14,599 ✭✭✭✭CIARAN_BOYLE


    Gael23 wrote: »
    What do you mean by this?

    None of the vaccines need to show that they effect transmission to get approval.

    A lot of vaccines (sinovac pfizer moderna) are coming out with preliminary figures are 90% regarding the prevention of symptoms.

    If a vaccine tries to prove it can effect the transmissions of the disease other vaccines will do similar trials to show the same thing.

    I feared we would get vaccines approved with no evidence on if they effect the spread of the virus.

    If vaccines can prove they effect the spread of the virus it would be great so governments and people can choose the one that makes people less likely to spread covid.

    Id rather take a vaccine that means I protect my parents from catching it off me as well as protecting me from symptoms.


  • #6105
    stephenjmcd
    Registered Users, Registered Users 2 Posts: 15,443 ✭✭✭✭stephenjmcd


    Full Pfizer & BioNTech statement

    https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-conclude-phase-3-study-covid-19-vaccine/

    "Pfizer is confident in its vast experience, expertise and existing cold-chain infrastructure to distribute the vaccine around the world.""

    "The companies have developed specially designed, temperature-controlled thermal shippers utilizing dry ice to maintain temperature conditions of -70°C±10°C. They can be used be as temporary storage units for 15 days by refilling with dry ice"


  • #6106
    Cork2021
    Registered Users, Registered Users 2 Posts: 2,420 ✭✭✭Cork2021


    stephenjmcd wrote: »
    Full Pfizer & BioNTech statement

    https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-conclude-phase-3-study-covid-19-vaccine/

    "Pfizer is confident in its vast experience, expertise and existing cold-chain infrastructure to distribute the vaccine around the world.""

    "The companies have developed specially designed, temperature-controlled thermal shippers utilizing dry ice to maintain temperature conditions of -70°C±10°C. They can be used be as temporary storage units for 15 days by refilling with dry ice"

    Excellent news!!!


  • #6107
    Cork2021
    Registered Users, Registered Users 2 Posts: 2,420 ✭✭✭Cork2021


    If approved which is likely by the EMA, how many will the EU get this side of Xmas?


  • #6108
    Gael23
    Registered Users, Registered Users 2 Posts: 12,149 ✭✭✭✭Gael23


    Cork2021 wrote: »
    Excellent news!!!

    So now all we need is dry ice. How easy is that to get?


  • #6109
    CIARAN_BOYLE
    Registered Users, Registered Users 2 Posts: 14,599 ✭✭✭✭CIARAN_BOYLE


    Cork2021 wrote: »
    If approved which is likely by the EMA, how many will the EU get this side of Xmas?

    I think our allocation is likely to be 280k by the end of january.

    Piddling amounts by christmas I'd say


  • #6110
    funnydoggy
    Registered Users, Registered Users 2 Posts: 2,065 ✭✭✭funnydoggy


    *waits for negative spin from media/government*


  • #6111
    funnydoggy
    Registered Users, Registered Users 2 Posts: 2,065 ✭✭✭funnydoggy


    More on testing

    Coronavirus (COVID-19) Update: FDA Authorizes First COVID-19 Test for Self-Testing at Home | FDA - https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-first-covid-19-test-self-testing-home


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  • #6112
    lbj666
    Registered Users, Registered Users 2 Posts: 2,027 ✭✭✭lbj666


    hmmm wrote: »
    Oxford/Astra Zeneca are swabbing to see whether the vaccine also reduces transmission as part of their trial.

    https://twitter.com/BBCRadio4/status/1328657018111004672

    How do they do that? given the sample size of those in contact with the virus is likely to be small since the Pfizer number of those vaccinated that got infected was 9?

    Or do they swap a large sample size from both group and compare viral load in each?


    More great news from Pfizer by the way


  • #6113
    CIARAN_BOYLE
    Registered Users, Registered Users 2 Posts: 14,599 ✭✭✭✭CIARAN_BOYLE


    lbj666 wrote: »
    How do they do that? given the sample size of those in contact with the virus is likely to be small since the Pfizer number of those vaccinated that got infected was 9?

    Or do they swap a large sample size from both group and compare viral load in each?


    More great news from Pfizer by the way

    In these trials infected are only infected with symptoms. More than 9 have been infected most likely.

    Large scale pcr amount the trial tests most likely.


  • #6114
    el Fenomeno
    Registered Users, Registered Users 2 Posts: 3,563 ✭✭✭el Fenomeno


    Is Pfizer's 95% announcement a response to that other firm who announced 94% earlier in the week? :pac:


  • #6115
    Gael23
    Registered Users, Registered Users 2 Posts: 12,149 ✭✭✭✭Gael23


    CIARAN_BOYLE wrote: »
    I think our allocation is likely to be 280k by the end of january.

    Piddling amounts by christmas I'd say

    280k won’t make much difference


  • #6116
    stephenjmcd
    Registered Users, Registered Users 2 Posts: 15,443 ✭✭✭✭stephenjmcd


    Gael23 wrote: »
    280k won’t make much difference

    Better than 0 isn't it ?? Did you expect massive numbers so soon after approval?

    Plus it'll be a start early in the year.


  • #6117
    polesheep
    Closed Accounts Posts: 2,950 ✭✭✭polesheep


    CIARAN_BOYLE wrote: »
    None of the vaccines need to show that they effect transmission to get approval.

    A lot of vaccines (sinovac pfizer moderna) are coming out with preliminary figures are 90% regarding the prevention of symptoms.

    If a vaccine tries to prove it can effect the transmissions of the disease other vaccines will do similar trials to show the same thing.

    I feared we would get vaccines approved with no evidence on if they effect the spread of the virus.

    If vaccines can prove they effect the spread of the virus it would be great so governments and people can choose the one that makes people less likely to spread covid.

    Id rather take a vaccine that means I protect my parents from catching it off me as well as protecting me from symptoms.

    But if your parents have been vaccinated where's the issue? These vaccines are a huge step out of this mess even if they don't do everything we would like them to do.


  • #6118
    funnydoggy
    Registered Users, Registered Users 2 Posts: 2,065 ✭✭✭funnydoggy


    Gael23 wrote: »
    280k won’t make much difference

    Give it a bit of time. We're on the home stretch :D


  • #6119
    xabi
    Registered Users, Registered Users 2 Posts: 3,030 ✭✭✭xabi


    Gael23 wrote: »
    So now all we need is dry ice. How easy is that to get?

    Don't you be worrying about it, leave it to the experts.


  • #6120
    Russman
    Registered Users, Registered Users 2 Posts: 5,977 ✭✭✭Russman


    Gael23 wrote: »
    280k won’t make much difference

    Ahh it will. I would have thought 140k people being vaccinated maybe by mid Feb would be a really good start if it’s going to HCWs and care home residents ?


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  • #6121
    Cork2021
    Registered Users, Registered Users 2 Posts: 2,420 ✭✭✭Cork2021


    Will the EMA fast track this??
    FDA waiting 3 weeks to review it?


This discussion has been closed.
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