COVID-19: Vaccine/antidote and testing procedures Megathread [Mod Warning - Post #1]

As reported last night Pfizer & BioNTech have reached all safety and efficiency milestones

Final efficacy analysis have shown 95% were protected from the virus within 28 days of the first dose - up from last weeks interim analysis.

It also proved 94% effective among adults over the age of 65.

The Pfizer-BioNTech data shows 170 trial participants contracted Covid-19 overall. Eight participants who got the vaccine fell ill, while 162 cases were seen among those who got the placebo. The shot helped to prevent severe disease, according to the analysis, with nine of 10 severe cases in the trial occurring in the placebo group.

For safety data, no serious side affects.
2% of the 43,000 involved reporting a headache and 3.7% reporting fatigue.

Submission for EUA to FDA within days

polesheep

stephenjmcd wrote: »

As reported last night Pfizer & BioNTech have reached all safety and efficiency milestones

Final efficacy analysis have shown 95% were protected from the virus within 28 days of the first dose - up from last weeks interim analysis.

It also proved 94% effective among adults over the age of 65.

The Pfizer-BioNTech data shows 170 trial participants contracted Covid-19 overall. Eight participants who got the vaccine fell ill, while 162 cases were seen among those who got the placebo. The shot helped to prevent severe disease, according to the analysis, with nine of 10 severe cases in the trial occurring in the placebo group.

For safety data, no serious side affects.
2% of the 43,000 involved reporting a headache and 3.7% reporting fatigue.

Submission for EUA to FDA within days

That's fantastic news.

hmmm

stephenjmcd wrote: »

As reported last night Pfizer & BioNTech have reached all safety and efficiency milestones

Final efficacy analysis have shown 95% were protected from the virus within 28 days of the first dose - up from last weeks interim analysis.

It also proved 94% effective among adults over the age of 65.

For safety data, no serious side affects.
2% of the 43,000 involved reporting a headache and 3.7% reporting fatigue.

That's about as good news as we could have hoped for isn't it? There was a risk that the vaccines could be effective for younger people but still leave older people unprotected.

hmmm wrote: »

That's about as good news as we could have hoped for isn't it? There was a risk that the vaccines could be effective for younger people but still leave older people unprotected.

Yup effective for all age groups it looks like. Better than anyone expected a few months ago. Really excellent results

Russman

stephenjmcd wrote: »

As reported last night Pfizer & BioNTech have reached all safety and efficiency milestones

Final efficacy analysis have shown 95% were protected from the virus within 28 days of the first dose - up from last weeks interim analysis.

It also proved 94% effective among adults over the age of 65.

The Pfizer-BioNTech data shows 170 trial participants contracted Covid-19 overall. Eight participants who got the vaccine fell ill, while 162 cases were seen among those who got the placebo. The shot helped to prevent severe disease, according to the analysis, with nine of 10 severe cases in the trial occurring in the placebo group.

For safety data, no serious side affects.
2% of the 43,000 involved reporting a headache and 3.7% reporting fatigue.

Submission for EUA to FDA within days

Fantastic news !
Got a link to any of that info ? Not doubting you, just genuinely interested.

Russman wrote: »

Fantastic news !
Got a link to any of that info ? Not doubting you, just genuinely interested.

Yeah no worries.

Being reported across multiple platforms but the first one that popped up for me was Bloomberg so may as well link that

https://www.bloomberg.com/amp/news/articles/2020-11-18/pfizer-biontech-plan-filing-as-vaccine-proves-95-effective?__twitter_impression=true

So Is 1 dose enough???? That would be huge!!

Gael23

CIARAN_BOYLE wrote: »

Excellent news. That could be a way for the vaccines to separate themselves out for governments.

What do you mean by this?

Cork2021 wrote: »

So Is 1 dose enough???? That would be huge!!

I'd still say 2 shot regime, its been tested as that and proves a robust immune response so likely to stay that way.

Russman

stephenjmcd wrote: »

Yeah no worries.

Being reported across multiple platforms but the first one that popped up for me was Bloomberg so may as well link that

https://www.bloomberg.com/amp/news/articles/2020-11-18/pfizer-biontech-plan-filing-as-vaccine-proves-95-effective?__twitter_impression=true

Fair play, thanks !

afatbollix

hmmm wrote: »

Oxford/Astra Zeneca are swabbing to see whether the vaccine also reduces transmission as part of their trial.

https://twitter.com/BBCRadio4/status/1328657018111004672

I wonder if this means that the % won't be as high as the other ones as they have been swabbing more.

If it was up to Trump he would of stopped swabbing to get better results :pac:

Thankfully science sees a benefit of it that we will know if even with a vaccine the virus can still be transmitted or how many of the people actually got it.

It's going to be fascinating if 50% of them got covid during the tests but nearly no one shows symptoms.

Gael23 wrote: »

What do you mean by this?

None of the vaccines need to show that they effect transmission to get approval.

A lot of vaccines (sinovac pfizer moderna) are coming out with preliminary figures are 90% regarding the prevention of symptoms.

If a vaccine tries to prove it can effect the transmissions of the disease other vaccines will do similar trials to show the same thing.

I feared we would get vaccines approved with no evidence on if they effect the spread of the virus.

If vaccines can prove they effect the spread of the virus it would be great so governments and people can choose the one that makes people less likely to spread covid.

Id rather take a vaccine that means I protect my parents from catching it off me as well as protecting me from symptoms.

Full Pfizer & BioNTech statement

https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-conclude-phase-3-study-covid-19-vaccine/

"Pfizer is confident in its vast experience, expertise and existing cold-chain infrastructure to distribute the vaccine around the world.""

"The companies have developed specially designed, temperature-controlled thermal shippers utilizing dry ice to maintain temperature conditions of -70°C±10°C. They can be used be as temporary storage units for 15 days by refilling with dry ice"

stephenjmcd wrote: »

Full Pfizer & BioNTech statement

https://www.pfizer.com/news/press-release/press-release-detail/pfizer-and-biontech-conclude-phase-3-study-covid-19-vaccine/

"Pfizer is confident in its vast experience, expertise and existing cold-chain infrastructure to distribute the vaccine around the world.""

"The companies have developed specially designed, temperature-controlled thermal shippers utilizing dry ice to maintain temperature conditions of -70°C±10°C. They can be used be as temporary storage units for 15 days by refilling with dry ice"

Excellent news!!!

If approved which is likely by the EMA, how many will the EU get this side of Xmas?

Gael23

Cork2021 wrote: »

Excellent news!!!

So now all we need is dry ice. How easy is that to get?

Cork2021 wrote: »

If approved which is likely by the EMA, how many will the EU get this side of Xmas?

I think our allocation is likely to be 280k by the end of january.

Piddling amounts by christmas I'd say

funnydoggy

*waits for negative spin from media/government*

funnydoggy

More on testing

Coronavirus (COVID-19) Update: FDA Authorizes First COVID-19 Test for Self-Testing at Home | FDA - https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-first-covid-19-test-self-testing-home

lbj666

hmmm wrote: »

Oxford/Astra Zeneca are swabbing to see whether the vaccine also reduces transmission as part of their trial.

https://twitter.com/BBCRadio4/status/1328657018111004672

How do they do that? given the sample size of those in contact with the virus is likely to be small since the Pfizer number of those vaccinated that got infected was 9?

Or do they swap a large sample size from both group and compare viral load in each?

More great news from Pfizer by the way

lbj666 wrote: »

How do they do that? given the sample size of those in contact with the virus is likely to be small since the Pfizer number of those vaccinated that got infected was 9?

Or do they swap a large sample size from both group and compare viral load in each?

More great news from Pfizer by the way

In these trials infected are only infected with symptoms. More than 9 have been infected most likely.

Large scale pcr amount the trial tests most likely.

el Fenomeno

Is Pfizer's 95% announcement a response to that other firm who announced 94% earlier in the week? :pac:

Gael23

CIARAN_BOYLE wrote: »

I think our allocation is likely to be 280k by the end of january.

Piddling amounts by christmas I'd say

280k won’t make much difference

Gael23 wrote: »

280k won’t make much difference

Better than 0 isn't it ?? Did you expect massive numbers so soon after approval?

Plus it'll be a start early in the year.

polesheep

CIARAN_BOYLE wrote: »

None of the vaccines need to show that they effect transmission to get approval.

A lot of vaccines (sinovac pfizer moderna) are coming out with preliminary figures are 90% regarding the prevention of symptoms.

If a vaccine tries to prove it can effect the transmissions of the disease other vaccines will do similar trials to show the same thing.

I feared we would get vaccines approved with no evidence on if they effect the spread of the virus.

If vaccines can prove they effect the spread of the virus it would be great so governments and people can choose the one that makes people less likely to spread covid.

Id rather take a vaccine that means I protect my parents from catching it off me as well as protecting me from symptoms.

But if your parents have been vaccinated where's the issue? These vaccines are a huge step out of this mess even if they don't do everything we would like them to do.

funnydoggy

Gael23 wrote: »

280k won’t make much difference

Give it a bit of time. We're on the home stretch

xabi

Gael23 wrote: »

So now all we need is dry ice. How easy is that to get?

Don't you be worrying about it, leave it to the experts.

Russman

Gael23 wrote: »

280k won’t make much difference

Ahh it will. I would have thought 140k people being vaccinated maybe by mid Feb would be a really good start if it’s going to HCWs and care home residents ?

Will the EMA fast track this??
FDA waiting 3 weeks to review it?