COVID-19: Vaccine/antidote and testing procedures Megathread [Mod Warning - Post #1]

Inquitus · 16-10-2020 03:50PM

Deleted User wrote: »

It's from July but this suggested 100m will be ready for the US under Operation Warp speed by year end.

https://www.fiercepharma.com/manufacturing/pfizer-biontech-snare-1-95b-deal-u-s-government-for-100m-plus-doses-covid-19-vaccine#:~:text=The%20partners%20have%20stated%20their,by%20the%20end%20of%202021.&text=Last%20week%2C%20Pfizer%20and%20BioNTech,3%20trials%20later%20this%20month.

From the article:

"The supply pact puts hard numbers to Pfizer and BioNTech's agreement with HHS and the U.S. Department of Defense to supply up to 300 million doses of their vaccine stateside by the end of 2021. The partners have stated their goal of producing 100 million vaccine doses by the end of 2020 and 1.3 billion doses total by the end of 2021."

Is it a one shot vaccine or does it require any additional boosters? 1.3bn would cover all the US and EU for instance.

seamie78 · 16-10-2020 03:55PM

from what I can make out from pfizers press release, the effectiveness can not be predicted when the results come but the safety of it is essentially after two months(I know further monitoring after that). as a result the earliest they can go for approval is novemeber. I assume that means for trial that started earlier if they where to get positive results in terms of effacy the could be ready even earlier. I would imagine the recent reassurance would speed up the results

JacksonHeightsOwn · 16-10-2020 04:51PM

Inquitus wrote: »

Is it a one shot vaccine or does it require any additional boosters? 1.3bn would cover all the US and EU for instance.

Not that I'm an expert, but im fairly sure Johnson & Johnson was the only one shot vaccine in testing at the minute. The rest require a booster shot.

I have two arms, I'm willing to take the vaccine in the left and the booster in the right ðŸ˜

stephenjmcd · 16-10-2020 05:03PM

Gael23 wrote: »

Looks like US will get priority.

I would contain the excitement for a bit longer

No, EU has similar deal also in place.

16-10-2020 05:56PM

Gael23 wrote: »

Looks like US will get priority.

I would contain the excitement for a bit longer

They initially did prioritise manufacturing in the US, but it is also in production in Europe with dedicated facilities being set up.

Important to remember Astra Zeneca is also in production in Europe. Latest I saw is total global capacity of 3 billion doses by end of 2021 (sounds a little ambitious). We are going to need a few options.

theguzman · 16-10-2020 06:38PM

Gael23 wrote: »

Looks like US will get priority.

I would contain the excitement for a bit longer

100m doses would cover alot of the worlds Septuagenarians and Octogenarians plus the younger at risk groups with underlying medical conditions. Vaccinate the most likely to die first and then it becomes less of a health emergency, if Ireland received 1m doses it would easily kill off the pandemic here as it would stop the infection rates and lower transmission also. If science can cure and invent a vaccine it just shows what other medical breakthroughs could be made and makes you wonder also what is being suppressed also by big pharma. Big oil for example suppressed the electric car by over 15 years.

ACitizenErased · 16-10-2020 06:53PM

I've been reading a bit of commentary on the Pfizer statement.
1) They made no mention of the Canada or EMA rolling approval process.
2) This means that the statement was likely aimed at US voters to say there won't be a vaccine until after the election. They might be trying to reassure people in the US that the election has no effect on the trials and approval process for their vaccine.
3) It's widely believed that it will be approved in the EU/Canada by early to mid-November.
4) Their trials have expanded to kids as young as 12. This is a REALLY good sign for safety/efficacy, based on what I've read. They've also began including people with HIV.

I honestly believe we'll see Pfizer's effort approved by the middle of November.

Hmmzis · 16-10-2020 09:40PM

Some pre-clinical data from Sanofi:

https://www.biorxiv.org/content/10.1101/2020.10.14.337535v1.full

Looks like they arrived at basically the same conclusion as J&J and a good few others - 2 proline substitutions and removing the furin site in the S seems to work best for nAB production.

Overall to me their data looks fine, pretty much in line with any other mRNA candidate we've seen. No CD8+ T cell data, so either they didn't look for or it or there was none, kind of like for Moderna (in their case there were CD8+ T cells in humans).

daheff · 16-10-2020 10:27PM

[quote="XsApollo;114948453"it needs to be stored in the minus 90’s Fahrenheit.
So that answers that.
Much harder to roll out through GP’s and pharmacy’s at that temp.[/quote]

Does it need to stay at this temp right up to injection or can it get to room temperature first? Gonna be tough to take if it's cold!

Hmmzis · 16-10-2020 10:41PM

daheff wrote: »

Does it need to stay at this temp right up to injection or can it get to room temperature first? Gonna be tough to take if it's cold!

Can't open the slide posted by hmmm on the previous page, but from memory it was storable at refrigeration temps for a few days and it has to be thawed before administration.

The sole purpose of those very low temps is to freeze the lipid emulsion solid to preserve the dose accuracy. There are multiple doses per vial. When left at the liquid state the emulsion starts to stratify and you get the wrong doses from the vial. Refrigeration and freezer temps slow the stratification down.

Tenzor07 · 16-10-2020 10:44PM

Hmmzis wrote: »

The sole purpose of those very low temps is to freeze the lipid emulsion solid to preserve the dose accuracy. There are multiple doses per vial. When left at the liquid state the emulsion starts to stratify and you get the wrong doses from the vial. Refrigeration and freezer temps slow the stratification down.

So from what you're saying, the vaccine has to be transported in a strictly controlled refrigerated container, are these vaccines going to be manufactured in Ireland then?

hmmm · 16-10-2020 10:44PM

Hmmzis wrote: »

Can't open the slide posted by hmmm on the previous page, but from memory it was storable at refrigeration temps for a few days and it has to be thawed before administration.

Yes. Slide says it can be stored at refrigerator 2 to 8C for up to 24 hours, room temp for 2 hours after thawing.

mandrake04 · 16-10-2020 11:21PM

Tenzor07 wrote: »

are these vaccines going to be manufactured in Ireland then?

Ha Ha ..eh no. India, Germany, Australia and USA etc

ACitizenErased · 16-10-2020 11:27PM

There will be vaccines produced in Ireland. I know for a fact that Thermofisher Scientific, Pfizer and J&J are all in preparatory phases for production in Ringaskiddy in Cork.

Tenzor07 · 16-10-2020 11:33PM

ACitizenErased wrote: »

There will be vaccines produced in Ireland. I know for a fact that Thermofisher Scientific, Pfizer and J&J are all in preparatory phases for production in Ringaskiddy in Cork.

All for the domestic Irish market then? Have the Irish government set aside the millions(billions?) of Euro in the budget to get the first couple of million doses?

ACitizenErased · 16-10-2020 11:57PM

Tenzor07 wrote: »

All for the domestic Irish market then? Have the Irish government set aside the millions(billions?) of Euro in the budget to get the first couple of million doses?

We don't need to. Europe already done it for us.

ACitizenErased · 17-10-2020 12:34AM

Moderna 500 off the full enrollment.
https://twitter.com/moderna_tx/status/1317227309678665729?s=20

JacksonHeightsOwn · 17-10-2020 07:42AM

Tenzor07 wrote: »

All for the domestic Irish market then? Have the Irish government set aside the millions(billions?) of Euro in the budget to get the first couple of million doses?

You'd like to think we'd be proactive on this. But I fear we're just hoping to piggy back off the EU.

I couldn't understand why we never had our own vaccine trials. Not of vaccines we actually produced and developed, because heaven forbid professor luke O'Neill left the news talk studio's to actually do some work and not big up his book with Pat Kenny.

MerlinSouthDub · 17-10-2020 10:02AM

I see the government are looking at introducing antigen testing.

Interesting quote from Varadkar re NPHET making a decision on it:

“I will, however, encourage them to make that decision as quickly as possible. Decisions were made slowly on face coverings. They should not be made slowly on this.”

More criticism of NPHET...

is_that_so · 17-10-2020 10:03AM

MerlinSouthDub wrote: »

I see the government are looking at introducing antigen testing.

Interesting quote from Varadkar re NPHET making a decision on it:

“I will, however, encourage them to make that decision as quickly as possible. Decisions were made slowly on face coverings. They should not be made slowly on this.”

More criticism of NPHET...

Wouldn't NPHET pass that on to NVRL or HIQA to do anyway?

MerlinSouthDub · 17-10-2020 10:06AM

is_that_so wrote: »

Wouldn't NPHET pass that on to NVRL or HIQA to do anyway?

Yes, but the decision to use antigen testing seems to rest with NPHET.

Gael23 · 17-10-2020 10:08AM

MerlinSouthDub wrote: »

I see the government are looking at introducing antigen testing.

Interesting quote from Varadkar re NPHET making a decision on it:

“I will, however, encourage them to make that decision as quickly as possible. Decisions were made slowly on face coverings. They should not be made slowly on this.”

More criticism of NPHET...

That was because they were afraid that everyone would stockpile masks and there wouldn’t be enough for the health service

is_that_so · 17-10-2020 10:09AM

MerlinSouthDub wrote: »

Yes, but the decision to use antigen testing seems to rest with NPHET.

DeGascun I would have thought.

MerlinSouthDub · 17-10-2020 10:10AM

Gael23 wrote: »

That was because they were afraid that everyone would stockpile masks and there wouldn’t be enough for the health service

Yes, that was the rationale but we moved slower on recommending face coverings compared to lots of other countries. I think Varadkar's criticism is valid.

CIARAN_BOYLE · 17-10-2020 10:10AM

MerlinSouthDub wrote: »

I see the government are looking at introducing antigen testing.

Interesting quote from Varadkar re NPHET making a decision on it:

“I will, however, encourage them to make that decision as quickly as possible. Decisions were made slowly on face coverings. They should not be made slowly on this.”

More criticism of NPHET...

Mask wearing decision making was delayed because a significant portion of the population wear masks in a manner that will only increase the transmissions of the virus.

What I don't u derstand is how they haven't made a video explaining masks and how to wear them and put it on advertisements on all channels.

Golfman64 · 17-10-2020 10:11AM

MerlinSouthDub wrote: »

I see the government are looking at introducing antigen testing.

Interesting quote from Varadkar re NPHET making a decision on it:

“I will, however, encourage them to make that decision as quickly as possible. Decisions were made slowly on face coverings. They should not be made slowly on this.”

More criticism of NPHET...

Leo is right though. Many countries have already introduced these tests (Germany, Greece, Portugal to name a few). As well as supplementing standard testing, these tests are key for enabling travel inter-country safe again.

is_that_so · 17-10-2020 10:12AM

CIARAN_BOYLE wrote: »

Mask wearing decision making was delayed because a significant portion of the population wear masks in a manner that will only increase the transmissions of the virus.

What I don't understand is how they haven't made a video explaining masks and how to wear them and put it on advertisements on all channels.

YouTube is full of enough well-meaning "medics" to take care of that.

CIARAN_BOYLE · 17-10-2020 10:12AM

is_that_so wrote: »

YouTube is full of enough well-meaning "medics" to take care of that.

Yeah but the idiots won't watch that.

MerlinSouthDub · 17-10-2020 10:13AM

Golfman64 wrote: »

Leo is right though. Many countries have already introduced these tests (Germany, Greece, Portugal to name a few). As well as supplementing standard testing, these tests are key for enabling travel inter-country safe again.

Oh yes, I agree with Varadkar but I found it interesting that we are seeing more open criticism of NPHET.

is_that_so · 17-10-2020 10:18AM

CIARAN_BOYLE wrote: »

Yeah but the idiots won't watch that.

We should have no idea nor care what others are doing, just do what's required of us. Leave them to it.

COVID-19: Vaccine/antidote and testing procedures Megathread [Mod Warning - Post #1]

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