Vaccine Megathread - See OP for threadbans

brickster69

Novavax contracts delayed.

http://www.pharmafile.com/news/573952/novavax-delays-100-million-vaccines-eu

Strazdas

Micky 32 wrote: »

The only reason it’s being paused is for caution and the fact their other options won’t hinder their roll out. If the world depended on AZ and J&J you can bet the pauses would be very short lived.

I'm struck by how low their J & J doses are - 7m doses given but they're heading up towards 200m vaccinations in total.

Scuid Mhór

Corholio wrote: »

The one thing I've noticed since the start of the situation where vaccines are now part of everyone's daily conversation almost is the easy substitution in language from regular conversation topics. All this 'the vaccines are now useless', from early, limited news bites, is similar to 'he's feckin useless' after their teams striker misses a chance. Over the top, reactionary, impatient and non logical assessments just to have an exaggerated opinion on something. I mean, I'm not surprised as that's how a lot of modern life is, it's just interesting to see in something more important.

Thanks for that David Foster Wallace.

dominatinMC

And no surprise to see the media here jumping all over the J&J story. Will they be as eager and quick to report when it's being used again I wonder

Hurrache

dominatinMC wrote: »

And no surprise to see the media here jumping all over the J&J story. Will they be as eager and quick to report when it's being used again I wonder

Media in reporting news story shocker.

Where on earth would you get it.

astrofool

funnydoggy wrote: »

Fúck me what's going on?? Mods can the thread be locked for the day or something?

Just report the posts, the mods will do their thing.

Corholio

Scuid Mhór wrote: »

Thanks for that David Foster Wallace.

Ironically Infinite Jest is how I'd treat such snark.

dominatinMC

mandrake04 wrote: »

Australia is not using Moderna, they using Pfizer as the preferred and Novavax and AZ is actually still available to under 50s just have to consult your doctor and sign a waiver.

They wont approve J&J as it will probably go same as AZ, which is more bad news than a bad vaccine.

They are now considering making Pfizer onshore but the biggest problem is sourcing the Lipids, I listened to a discussion on the Radio that the Pfizer will probably need a booster so it would be thinking long term.

Pfizer has its own bad news lingering in the background just AZ stole the limelight.

https://onlinelibrary.wiley.com/doi/10.1002/ajh.26132

Is this a genuine issue with Pfizer? Haven't seen any reports

stephenjmcd

Intersting comments from Prof Nolan

https://twitter.com/gavreilly/status/1381941893295132673?s=19

dominatinMC

Hurrache wrote: »

Media in reporting news story shocker.

Where on earth would you get it.

Of course they are going to report but it's the veracity of the reporting I have an issue with. As I said, will they be as eager to report if the vaccines are given the all clear? Doubt it, and that won't be a "shocker"

Fair play to those of you giving reasonable arguments and having the patience to do so, you’re all better people than I am.

Those who believe that AZ is poison and that J&J is finished before it’s even started will never change their views sadly.

This was a really interesting thread, gone to the dogs the last few days though.

Turtwig

dominatinMC wrote: »

Is this a genuine issue with Pfizer? Haven't seen any reports

Not believed to be an issue for either PB or MD. It's always possible there are issues relating to these that are undetected. It's always possible there are no such issues. What's known at this time is that there are no issues relating clotting associated with either of these vaccines.

hmmm

brickster69 wrote: »

Novavax contracts delayed.

http://www.pharmafile.com/news/573952/novavax-delays-100-million-vaccines-eu

Novavax as far as I'm aware have no history of producing vaccines, yet were promising huge volumes of their Covid vaccine. I realise they have partnered with some major manufacturers, but it was always an odd story I thought.

I'd be delighted to be proved wrong, but I wouldn't be surprised if they didn't meet their targets.

mandrake04

mandrake04 wrote: »

Australia is not using Moderna, they using Pfizer as the preferred and Novavax and AZ is actually still available to under 50s just have to consult your doctor and sign a waiver.

They wont approve J&J as it will probably go same as AZ, which is more bad news than a bad vaccine.

They are now considering making Pfizer onshore but the biggest problem is sourcing the Lipids, I listened to a discussion on the Radio that the Pfizer will probably need a booster so it would be thinking long term.

Pfizer has its own bad news lingering in the background just AZ stole the limelight.

https://onlinelibrary.wiley.com/doi/10.1002/ajh.26132

I think the rates in AZ are significantly higher than expected with vaccines and medications in general.

Lots of drugs can trigger Thrombocytopenia. The rates in Pfizer dont seem to be of any concern

Furze99

iamwhoiam wrote: »

I read yesterday that there are 400k between age 60-69

400K who are no fools and will make up their own minds. A high proportion of which vote..

funnydoggy

stephenjmcd wrote: »

Intersting comments from Prof Nolan

https://twitter.com/gavreilly/status/1381941893295132673?s=19

That vaccine transmission being part of modeling now is absolutely fantastic.

JTMan

Interesting WSJ article trying to answer 2 key questions on immunity length, protection on new variants and boosters:

1. How long will protection last?
- As previously reported, Pfizer and Moderna vaccines last at least 6 months.
- University of Arizona said the Pfizer and Moderna vaccines "likely provide at least some degree of protection for a long time because there are so many layers of immunity".
- It’s possible some level of protection could last for years or even decades, some scientists say.
- A 2020 Nature study found that patients who got SARS—a similar coronavirus to the one that causes Covid-19—still had T cell immunity 17 years later.
- A 2008 Nature study found that survivors of the 1918 influenza pandemic were able to produce antibodies from memory B cells when exposed to the same influenza strain nine decades later.


2. Will we need boosters?
- It’s possible for a variant to reduce a vaccine’s protection but not entirely eliminate it.
- The mRNA vaccines elicit antibody levels that are generally higher than a natural infection. Even if a variant prevents some antibodies from binding to the virus, the vaccines create so many antibodies that they should still offer some protection, says Dr. Hensley. But we don’t know how much, and for how long.
- Boosters will likely be needed for at least a few years “out of an abundance of caution, knowing that immunity does wane in some individuals more than others”.

Sounds like immunity is likely to last for many years but due to a (1) likely abundance of caution, (2) exceptional cases where immunity wanes and (3) slightly weakened protection from variants ... that we will need boosters but maybe only for the next few years. Hopefully the Irish government is starting to plan for boosters.

RavenBea17b

brendanwalsh wrote: »

Every man and woman deserves a MRNA vaccine.

Send the bag of dung AZ vaccines to the deepest darkest pits of Africa as part of COVAX, and give Pfizer whatever they want for the good stuff.

Are you for real???
:eek:

Pussyhands

Pussyhands wrote: »

Well well well, the US now calling for a halt on the JNJ vaccine due to blood clots...

Guess those "nutjobs" saying they had concerns about a vaccine rushed through without the full effects being known were onto something after all.

Looking forward to the "it's still less risky than getting the virus!" comments.

The exact opposite of your point is the case. Phase III safety trials were completed in full. No trial can possibly detect all risks, especially those are an extremely low occurrence rate. The only way these can be detected is during mass rollout. The ongoing monitoring that has detected the additional risks is the system working as intended. This process will likely refine the risk to specific subsets in the medium term.

So, in summary, the nutjobs are still nutjobs

WoollyRedHat

The decisions made yesterday about AZ and today in relation to J & J are all subject to review, there are far too many Chicken Littles in this thread declaring the sky is falling, some deliberately so.

I would be very surprised if restrictions.on AZ to age groups over 60 is still in place in a months time, they are buying time to scrutinize data.

Turtwig

funnydoggy wrote: »

That vaccine transmission being part of modeling now is absolutely fantastic.

Has been since late Feb.

RavenBea17b

brickster69 wrote: »

Novavax contracts delayed.

http://www.pharmafile.com/news/573952/novavax-delays-100-million-vaccines-eu

That delay in contract was being discussed back in mid March.

funnydoggy

Turtwig wrote: »

Has been since late Feb.

Ah, I didn't know. Still though it's good to see!

Sanjuro

brendanwalsh wrote: »

Send the bag of dung AZ vaccines to the deepest darkest pits of Africa as part of COVAX, and give Pfizer whatever they want for the good stuff.

RavenBea17b

dominatinMC wrote: »

And no surprise to see the media here jumping all over the J&J story. Will they be as eager and quick to report when it's being used again I wonder

Media was all over AZ when EMA and individual countries when regulation differing applied for age groups.

eoinbn

Deleted User wrote: »

Fair play to those of you giving reasonable arguments and having the patience to do so, you’re all better people than I am.

Those who believe that AZ is poison and that J&J is finished before it’s even started will never change their views sadly.

This was a really interesting thread, gone to the dogs the last few days though.

I much preferred reading all the good news as well but there has been no denying that the last week has been terrible.
A few weeks ago there was 5 known cases of clotting in the UK linked to AZ. All of a sudden it turned into 80.
The 6 out of 7m will likely increase as well.
I am just giving my opinion on the facts that we have at hand. The UK has already suggested that it will not use AZ on under 30s. Ireland has been far more cautious and I can see that continuing when it comes to J&J.

RavenBea17b

dominatinMC wrote: »

Is this a genuine issue with Pfizer? Haven't seen any reports

Sure I saw some comments about this on UK Yellow Cards.
Can someone add a link to Irish equivalent to UK yellow cards system. I know that there is an overall EU equivalent, but don't think it breaks it down by country gender age group etc.

ixoy

I'd be curious now if the people who are looking to the UK and going, "Why are we so far behind - joke shop Ireland" are also going, "I don't want AZ! Terrible vaccine!" I wouldn't be surprised if there's an overlap in those groups.

Hurrache

dominatinMC wrote: »

Of course they are going to report but it's the veracity of the reporting I have an issue with. As I said, will they be as eager to report if the vaccines are given the all clear? Doubt it, and that won't be a "shocker"

Of course they will.

keno-daytrader

*J&J: TO PROACTIVELY DELAY ROLLOUT OF VACCINE IN EUROPE