COVID-19: Vaccine/antidote and testing procedures Megathread [Mod Warning - Post #1]

timsey tiger

hmmm wrote: »

J&J are going to test up to 60,000 people with their vaccine. 60,000!

https://www.cnbc.com/2020/08/20/coronavirus-johnson-johnson-to-start-vaccine-trial-in-september-with-60000-people.html

Maybe, double, the sample size half the time, discounting a couple of weeks at start. They are really throwing money at it which is good.

Hmmzis

Gael23 wrote: »

What volume of vaccines are in this deal.
I hope they are actually for us and not all for donations

If I'm reading it right, then it's 225 million doses from CureVac.

Hmmzis

Gael23 wrote: »

How many will the EU actually use rather than give away t developing countries?

My personal hope is that the doses would be allocated at least somewhat proportionally among the various countries who need them. I know, it might be a naive hope.

Hmmzis

eleventh wrote: »

An earlier post
My immune system was in bits as a child and I got all the vaccines and all the boosters. I got every disease going - as did all the kids around me who all got their vaccinations as well.
I was off school a week or more at a time with measles, whooping cough and all the diseases that pharma propagandists like yourself would have us believe are prevented by injecting vaccines.

Really sorry to hear that, it's exactly people like you, who can't get the direct protection from vaccines, who stand to benefit the most from universal vaccination programs.

What you are describing sounds to me an awful lot like an immune compromised state. With those conditions vaccines work rather poorly and might only provide an attenuating effect for the diseases they are intended for.

It might not be the worst of ideas to check with you GP if you MMR antibody levels are still in the protective range. The newer MMR shots might do better for you than what you had as a child, especially if your immune system has become better over the years. Catching the measles (the king of immune dysregulation) again with covid around (another immune suppressor) might not be exactly great.

timsey tiger

Hmmzis wrote: »

My personal hope is that the doses would be allocated at least somewhat proportionally among the various countries who need them. I know, it might be a naive hope.

I can't see why manufacture should be the limiting factor. Hopefully there will be more than enough to go round and organising the distribution will be the bottleneck.

Actually, I can, but it shouldn't.

timmy_mallet

LessOutragePlz wrote: »

I think a discussion about mandatory vaccines is a legitimate one given that it is being considered in some countries at the moment and shutting down the discussion of that isn't a good idea IMO but, of course people will scream "anti vaxxer" the second someone suggests that they are against mandatory vaccinations. They will all be tarred with the same brush.

I mean its farcical, the blind faith these types have in mega multinationals chasing a profit to protect their health, lining themselves up to accept an emergency use medical intervention, its absurd.

Someone on the this thread, devoid of irony, quoted a Dr who was pointing out hed be happy to only take 1 of the 3 most likely candidates as it looked safer. And yet here they are, ready to be marching to the GP to take whatever they are offered, unquestioningly, and wanting everyone else to wear a bloody tag!!! If they dont do the same. Mad!

Sconsey

timmy_mallet wrote: »

I mean its farcical, the blind faith these types have in mega multinationals chasing a profit to protect their health, lining themselves up to accept an emergency use medical intervention, its absurd.

Someone on the this thread, devoid of irony, quoted a Dr who was pointing out hed be happy to only take 1 of the 3 most likely candidates as it looked safer. And yet here they are, ready to be marching to the GP to take whatever they are offered, unquestioningly, and wanting everyone else to wear a bloody tag!!! If they dont do the same. Mad!

You probably don't realize 'mega multinationals' are involved in all aspects of healthcare do you? hopefully you don't need a stent, or a replacement heart valve. I can guarantee you will be lining up to to accept emergency medical intervention.

eleventh

Hmmzis wrote: »

Really sorry to hear that, it's exactly people like you, who can't get the direct protection from vaccines, who stand to benefit the most from universal vaccination programs.

What you are describing sounds to me an awful lot like an immune compromised state. With those conditions vaccines work rather poorly and might only provide an attenuating effect for the diseases they are intended for.

It might not be the worst of ideas to check with you GP if you MMR antibody levels are still in the protective range. The newer MMR shots might do better for you than what you had as a child, especially if your immune system has become better over the years. Catching the measles (the king of immune dysregulation) again with covid around (another immune suppressor) might not be exactly great.

All the kids around me were vaccinated as well, as I mentioned. That's universal enough in a time when people didn't travel much compared to now.

The other children got the diseases as well. So it wasn't just me, though I remember my own experience more clearly obviously and how long it took to recover etc.

My health in adulthood has been excellent though. The last time I had a vaccine was age 16. Approx 6 months later I had a mystery viral infection. I had to take 4 weeks off school.
Correlation doesn't equal causation of course, but I can't ignore personal experience that health in adulthood has been great with no vaccines compared to childhood with all the recommended vaccines of the time.

Ce he sin

eleventh wrote: »

All the kids around me were vaccinated as well, as I mentioned. That's universal enough in a time when people didn't travel much compared to now.

The other children got the diseases as well. So it wasn't just me, though I remember my own experience more clearly obviously and how long it took to recover etc.

My health in adulthood has been excellent though. The last time I had a vaccine was age 16. Approx 6 months later I had a mystery viral infection. I had to take 4 weeks off school.
Correlation doesn't equal causation of course, but I can't ignore personal experience that health in adulthood has been great with no vaccines compared to childhood with all the recommended vaccines of the time.

I'm intrigued by the claim which I've emboldened. You're suggesting I think that children got the diseases they were vaccinated against? From 1948 to 1984 Ireland averaged about 5,000 notified cases of measles per year. Since 2001 we've had at most a few hundred cases per year. The vaccine was introduced in 1985 and since there have only been two years (1993 and 2000) when cases reached the low thousands. If we accept that the vaccine doesn't stop you getting measles I wonder what else has caused the dramatic reductions? Also, we haven't had a case of polio since 1984. Can you think of any reason why this is the case?

Stark

Oh this is where getting into "discussions" with anti-vaxxers gets fun.

Did you know that every country had a sanitation rollout that just happened to coincide with the vaccine rollout for the particular virus that went away within that country? And there's a separate sanitation rollout per-virus, also coinciding with when the vaccine for that virus was rolled out? The things you learn. If you ask really nicely, they'll even draw you graphs.

MadYaker

timmy_mallet wrote: »

I mean its farcical, the blind faith these types have in mega multinationals chasing a profit to protect their health, lining themselves up to accept an emergency use medical intervention, its absurd.

Someone on the this thread, devoid of irony, quoted a Dr who was pointing out hed be happy to only take 1 of the 3 most likely candidates as it looked safer. And yet here they are, ready to be marching to the GP to take whatever they are offered, unquestioningly, and wanting everyone else to wear a bloody tag!!! If they dont do the same. Mad!

So you've never been vaccinated for anything then?

They all go through the same procedure before public use.

Do you think masks are useless also?

Sconsey

Sconsey wrote: »

You probably don't realize 'mega multinationals' are involved in all aspects of healthcare do you? hopefully you don't need a stent, or a replacement heart valve. I can guarantee you will be lining up to to accept emergency medical intervention.

Of course not they are posting in the covid thread that it's nothing, but for everyone to embrace death.

timmy_mallet

MadYaker wrote: »

So you've never been vaccinated for anything then?

They all go through the same procedure before public use.

Do you think masks are useless also?

I know what procedures they go through, and how that process works too, I've been a part of it on multiple occasions

timmy_mallet

Sconsey wrote: »

You probably don't realize 'mega multinationals' are involved in all aspects of healthcare do you? hopefully you don't need a stent, or a replacement heart valve. I can guarantee you will be lining up to to accept emergency medical intervention.

I suppose you've highlighted your ignorance here, theres a differnece between emergency medicine and emergency use exemptions for vaccines. Of course I realise how they work, thanks. Probably significantly more than you do.

irishgeo

What's the anti vaccer thinking on polio? Proof vaccines work.

timmy_mallet

irishgeo wrote: »

What's the anti vaccer thinking on polio? Proof vaccines work.

Do anti vaxxers claim vaccines dont work?

Van.Bosch

When are the phase 3 trials for the oxford vaccine due to end?

Santy2015

Van.Bosch wrote: »

When are the phase 3 trials for the oxford vaccine due to end?

I second that question

timsey tiger

irishgeo wrote: »

What's the anti vaccer thinking on polio? Proof vaccines work.

Prob. the exact same as covid 19. That they are not in the at risk age range and anyway most people have no symptoms at all. And the best one people who don't take vaccines are way healthier.

https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.generon.ie/read/newsletter-26/covid-19-saliva-test-in-1-hour-2293.html&ved=2ahUKEwic_o2wyq7rAhWGT8AKHUIoCvIQFjAJegQIBRAB&usg=AOvVaw2dQ0YAhTs3wcjEi_MVu4-Y&cshid=1598091850670

Why doesn't the government pay private companies like these to send out these new saliva test kits to every household in the country once a month?

Doesn't require a visit to a lab, kits are posted out and sent back to labs.

They were able to send out those stupid postcards why not covid tests?

If the household doesn't do the test there is a financial penalty or even pay people to do tests or a reduction in TV licence?

We will pick up all those people with no symptoms who can then quarantine.

Ineedaname

Van.Bosch wrote: »

When are the phase 3 trials for the oxford vaccine due to end?

There's no set date. But hopefully we'll have something by September/October with approval by November. All going well obviously.

They just started trials in the US and India this week the fact that they're expanding is a good sign.

MerlinSouthDub

Deleted User wrote: »

https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.generon.ie/read/newsletter-26/covid-19-saliva-test-in-1-hour-2293.html&ved=2ahUKEwic_o2wyq7rAhWGT8AKHUIoCvIQFjAJegQIBRAB&usg=AOvVaw2dQ0YAhTs3wcjEi_MVu4-Y&cshid=1598091850670

Why doesn't the government pay private companies like these to send out these new saliva test kits to every household in the country once a month?

Doesn't require a visit to a lab, kits are posted out and sent back to labs.

They were able to send out those stupid postcards why not covid tests?

If the household doesn't do the test there is a financial penalty or even pay people to do tests or a reduction in TV licence?

We will pick up all those people with no symptoms who can then quarantine.

Em, have you any information on whether the test is reliable or not?

timsey tiger

timmy_mallet wrote: »

Do anti vaxxers claim vaccines dont work?

An anti vaxxer who knows they work must be a misanthrope.

Dressoutlet

Me and my husband and our baby were tested yesterday all at the same time by the same person. Earlier on today I received a text saying I was negative, I have no symptoms and GP sent referral as a precaution. Husband and baby both coughing, temps, colds and Husband has chest pain. We received no contact for them two at all. I'm unsure why I was declared negative hours ago and not a text nor a call in reference to them. Does it take longer for a positive person to be contacted?

Hmmzis

This was made available as a pre-print about a month ago, now it's also been peer reviewed and published in Cell:

https://www.cell.com/action/showPdf?pii=S0092-8674%2820%2931068-0

Chimp adenovirus vectored vaccine delivered intra-nasaly. Shows very good results in the mouse model, full protection from a single dose. Hooefully they can get to NHP and then human trials soon enough.

Personally, the more I'm reading and learning about this, the more I think that the intra-nasal route might end up being the better way to administer vaccines against respiratory pathogens.

Gael23

Hmmzis wrote: »

This was made available as a pre-print about a month ago, now it's also been peer reviewed and published in Cell:

https://www.cell.com/action/showPdf?pii=S0092-8674%2820%2931068-0

Chimp adenovirus vectored vaccine delivered intra-nasaly. Shows very good results in the mouse model, full protection from a single dose. Hooefully they can get to NHP and then human trials soon enough.

Personally, the more I'm reading and learning about this, the more I think that the intra-nasal route might end up being the better way to administer vaccines against respiratory pathogens.

Wasn’t there a nasal vaccine mentioned previously?

Beasty

Threads merged

ACitizenErased

Hmmzis wrote: »

This was made available as a pre-print about a month ago, now it's also been peer reviewed and published in Cell:

https://www.cell.com/action/showPdf?pii=S0092-8674%2820%2931068-0

Chimp adenovirus vectored vaccine delivered intra-nasaly. Shows very good results in the mouse model, full protection from a single dose. Hooefully they can get to NHP and then human trials soon enough.

Personally, the more I'm reading and learning about this, the more I think that the intra-nasal route might end up being the better way to administer vaccines against respiratory pathogens.

Seems to be the way to go. Likely way easier to administer too. If the majority of the virus is contained in the nasal passage and airway then it seems to be a no brainer.

4068ac1elhodqr

ACitizenErased wrote: »

Seems to be the way to go. Likely way easier to administer too. If the majority of the virus is contained in the nasal passage and airway then it seems to be a no brainer.

The way to go with the easist administration, is a developing (but proven) technology, that uses a simple plaster.

Whola: QuantumDotTattoo

https://www.sciencealert.com/an-invisible-quantum-dot-tattoo-is-being-suggested-to-id-vaccinated-kids
https://news.rice.edu/2019/12/18/quantum-dot-tattoos-hold-vaccination-record/

This may also act as a unique digital identifer per person, the embodiment will store within it (unique QRCode like scanable data pattern): all previous vaccine records, or medical histories.

This has plenty of plus factors, but also 'ethical' minus points.
The main benefit is the non-requirement of refrigeration, and ease of application.
It will also double up as a digital immunisation certification product (this was the primary brief).

Very, very few people are even aware of this next gen technoloogy.
Originally developed by DARPA way back, since then funded by Gates using the smart bioengineering folks over at MIT.

dominatinMC

Gael23 wrote: »

Wasn’t there a nasal vaccine mentioned previously?

I seem to recall it being mentioned that the Oxford vaccine could be administered that way.