COVID-19: Vaccine/antidote and testing procedures Megathread [Mod Warning - Post #1]

hmmm

hmmm wrote: »

Pfizer has run into problems with quality in its supply chain.
https://www.cnbc.com/2020/12/02/stock-market-futures-open-to-close-news.html

"Pfizer now expects to ship half of the doses it had previously planned this year after finding raw materials in early production that didn’t meet its standard, Dow Jones reported."

It's good to see that quality control is being maintained, even if it costs supply in the short-term.

This is great news. Standards are maintained throughout, and further evidence that as much as some think these companies are willing to release any old ****e, the systems in place are robust enough to ensure quality is maintained

ShineOn7

hmmm wrote: »

"Pfizer now expects to ship half of the doses it had previously planned this year after finding raw materials in early production that didn’t meet its standard, Dow Jones reported."

That's just for their 2020 distribution though right?

hmmm

ShineOn7 wrote: »

That's just for their 2020 distribution though right?

Yes, the article says later on they are still planning 1.3 billion doses next year.

I wonder if this was the reason why we saw stock being flown to the US from Belgium.

Hmmzis

If you are wondering if two vaccines can be taken interchangeably then the latest blog post from Derek Lowe is worth a read:

https://blogs.sciencemag.org/pipeline/archives/2020/12/02/taking-two-different-vaccines

Interesting that it was done with polio vaccines with great results. The attenuated oral drops used first and then boosted later with the inactivated type giving a much better response than boosting with the same type.

There has been research done on viral vectors with protein vaccine boosters with similar efects observed, curiously enough after the viral vector prime the protein booster also increases the cellular response.

funnydoggy

Pasteur. wrote: »

There's too much optimism and good news overall with the vaccines

There's gonna be a shedload of problems next year

The vaccine itself , efficacy, supply ,distribution etc

OP :pac:

charlie14

Pasteur. wrote: »

There's too much optimism and good news overall with the vaccines

There's gonna be a shedload of problems next year

The vaccine itself , efficacy, supply ,distribution etc

Your really not a glass half full type of individual are you.

hotmail.com

Interesting that Fauci in America said Britain rushed the vaccine approval and he then says the FDA is the best in the world.

Americans worse than the Brits for hyping their own country.

Pasteur.

charlie14 wrote: »

Your really not a glass half full type of individual are you.

Was posing the question

Not a statement

Water John

hotmail.com wrote: »

Interesting that Fauci in America said Britain rushed the vaccine approval and he then says the FDA is the best in the world.

Americans worse than the Brits for hyping their own country.

The key difference is Fauci is a science specialist making the claim, whilst in the UK it's politicians of the calibre of Williamson.

Sky King

hotmail.com wrote: »

Interesting that Fauci in America said Britain rushed the vaccine approval and he then says the FDA is the best in the world.

No he said its the gold standard, which it is.

hotmail.com

Sky King wrote: »

No he said its the gold standard, which it is.

It sort of sounds like something Trump would say.

hotmail.com

Water John wrote: »

The key difference is Fauci is a science specialist making the claim, whilst in the UK it's politicians of the calibre of Williamson.

A pretty amazing claim, to imply the FDA is the best in the world and better than what Britain has.

It's a Trump comment.

wes

brisan wrote: »

By their own admission the HSEs IT systems are not fit for purpose and are currently being upgraded
To ask them to repurpose the PPS numbers would be stretching them a bit far

I have no clue about how old the HSE systems are, but if they can't be modified for something like this, then we are in trouble.

Pasteur.

wes wrote: »

I have no clue about how old the HSE systems are, but if they can't be modified for something like this, then we are in trouble.

We'll do what we've done up to now

Wait to see what everyone else is doing and try to copy it the best we can

Public sector tech is prehistoric here, that's a big problem

Gael23

Is it a big job to upgrade assuming cost is not an issue?

lbj666

Pasteur. wrote: »

We'll do what we've done up to now

Wait to see what everyone else is doing and try to copy it the best we can

Public sector tech is prehistoric here, that's a big problem

I know people love to think Ireland are alone with such issues.

https://www.independent.co.uk/life-style/gadgets-and-tech/news/nhs-cyber-attack-hospitals-hack-big-mistake-latest-news-a7733361.html

Remember when the UK and the pentagon had to ask microsoft maintain support for windows xp.

astrofool

Gael23 wrote: »

Is it a big job to upgrade assuming cost is not an issue?

Cost is never the issue with the HSE, the issue is always with people who work for and take advantage of the HSE, undoing the herculean efforts of many of the frontline workers.

speckle

yoouhooo anyone know why it has to be exactly -70 degrees and not say -50 etc did I miss on on a day when it was discussed on the thread?

nocoverart

I haven’t got laid in quite a while, so if restrictions are loosened and it’s known that i received the vaccine could I pull a hot chick easier than before this madness?

Thanks

Nocoverart

MrMusician18

hotmail.com wrote: »

A pretty amazing claim, to imply the FDA is the best in the world and better than what Britain has.

It's a Trump comment.

The FDA is widely regarded as the best medicines regulator, where it goes, others usually follow. The FAA has a similar global reputation but that tbf has taken a hammering over the 737 max fiasco.

The FDA is 10x larger than MHRA.

joseywhales

odyssey06 wrote: »

Billions spent on 2020 on presumptive vaccine development... parallel phases of development...
We didnt have to develop the vaccine but we should have build a presumptive IT system to keep track of multiple vaccine variants and doses. Ffs.

I mean one page of one spreadsheet meets the requirements

mandrake04

MrMusician18 wrote: »

The FDA is widely regarded as the best medicines regulator, where it goes, others usually follow. The FAA has a similar global reputation but that tbf has taken a hammering over the 737 max fiasco.

The FDA is 10x larger than MHRA.

True but not always the case.

I’ve been working in Medical Devices for over 23 years, FDA is notoriously difficult to get approval. I work in Australia and Asia, a lot of products are field tested in APAC and sometimes Europe before they seek FDA approval. I’m always ahead of my American counterparts in experience.

speckle

speckle wrote: »

yoouhooo anyone know why it has to be exactly -70 degrees and not say -50 etc did I miss on on a day when it was discussed on the thread?

Cold slows down the rate of chemical reaction, the colder the slower. RNA is very susceptible to degradation due to chemical reactions, therefore the colder the better. Now it may turn out that the efforts they have made to stabilise the RNA will mean it will be relatively stble at fridge temperatures also. So for example at 12 months in a Fridge it may be just as effective as straight out of the freezer. But to know that they have to prove it - eg. leave it 12 months in a Freezer and then test the effectivity again. It is easier go with Ultra cold and know its still effective, than wait to do the studies for storage at higher temperatures. These studies are likely ongoing as when more stable vaccines come to the market, BioNTech will be at a significant disadvantage

brisan

wes wrote: »

I have no clue about how old the HSE systems are, but if they can't be modified for something like this, then we are in trouble.

They have been working on the modifications recently but still not finished
it was mentioned again on the tonight show last night

mandrake04

mandrake04 wrote: »

True but not always the case.

I’ve been working in Medical Devices for over 23 years, FDA is notoriously difficult to get approval. I work in Australia and Asia, a lot of products are field tested in APAC and sometimes Europe before they seek FDA approval. I’m always ahead of my American counterparts in experience.

I have found Australia seem to be the slowest. But its true to say a lot of Med Device companies go foe CE approval well in advance of submitting to the FDA.

Interestingly having experienced regulatory body audits by FDA, Korea, Japan, Brazil, China, Australia and a number of notified bodies, by far and away the toughest auditors are those from HPRA

Irish Stones

ShineOn7 wrote: »

The Irish Times is a great resource if you want to keep it Irish

I was said the opposite...

Irish Stones

hmmm wrote: »

Pfizer has run into problems with quality in its supply chain.
https://www.cnbc.com/2020/12/02/stock-market-futures-open-to-close-news.html

"Pfizer now expects to ship half of the doses it had previously planned this year after finding raw materials in early production that didn’t meet its standard, Dow Jones reported."

It's good to see that quality control is being maintained, even if it costs supply in the short-term.

Would this slow down the process of vaccination in the continent?

Irish Stones

hotmail.com wrote: »

Interesting that Fauci in America said Britain rushed the vaccine approval and he then says the FDA is the best in the world.

Why does Fauci say that?
If the EMA or FDA are going to approve the Pfizer vaccine anyway, where's the problem to have it approved a couple of week earlier?

Irish Stones

Deleted User wrote: »

Cold slows down the rate of chemical reaction, the colder the slower. RNA is very susceptible to degradation due to chemical reactions, therefore the colder the better.

I have read somewhere that this deep cold chain might be a problem in countries where technologies and power supply is a problem, like in certain villages or remote towns in Africa. The distances between towns are huge and the temperatures are higher than here, so it might be a real problem to maintain the cold chain for them.

Ashbourne hoop

Irish Stones wrote: »

Why does Fauci say that?
If the EMA or FDA are going to approve the Pfizer vaccine anyway, where's the problem to have it approved a couple of week earlier?

Because there's still data coming in and being reviewed as far as I know. The UK have taken a "well we've seen most of the data and it's fine, the rest should be too" approach. It will, most likely, be fine, but the EMA and FDA have taken a slightly more cautious approach, rightly so imo.