Electronic cigarettes... amazing.

Toxicity

Anti-smoking advocates highlight the long-term health effects, like cancer and emphysema, that result from a lifetime of smoking or chewing tobacco -- but these maladies are the result of chemicals in cigarettes other than nicotine. Unfortunately, the fact that nicotine alone is an extremely toxic poison often goes unmentioned. Not many people realize that nicotine is also sold commercially in the form of a pesticide! And every year, many children go to the emergency room after eating cigarettes or cigarette butts. Sixty milligrams of nicotine (about the amount in three or four cigarettes if all of the nicotine were absorbed) will kill an adult, but consuming only one cigarette's worth of nicotine is enough to make a toddler severely ill.

What happens to people after ingesting nicotine? Nicotine poisoning causes vomiting and nausea, headaches, difficulty breathing, stomach pains and seizures. Each of these symptoms can be traced back to excessive stimulation of cholinergic neurons. People poisoned by organophosphate insecticides experience the exact same symptoms. With organophosphates, acetylcholine builds up at synapses and overstimulates the neurons. Because nicotine is so similar to acetylcholine, and binds to cholinergic receptors, nicotine in excess produces the same overstimulation and toxicity. The more nicotine binding to the nicotinic cholinergic receptors, the more acetylcholine is subsequently released and free to activate other subsets of cholinergic receptors.

Freemasonry wrote: »

I think you're an idiot for smoking in the first place, but that's just me and I'm all for depopulating the world of idiots and letting the smarter breed.

CJC999 wrote: »

This fella I know was telling me about his brothers girlfriends mothers nephew who went off the smokes and started smoking e-fags and is now addicted to them and on 5 of them a day. His mother is afraid he's going to want a bigger hit and move on to e-cigars and e-pipes and who knows where it'll end. She tried to wean him off them with John Player Black but he was having none if it. This a sad case so beware people, they're not just for the short term, they're for a lot longer.

Allah_ wrote: »

To the user "Freemasonry":




Judging by your recent threads it looks like you're trying to repeat your Leaving Cert..... LOLOLOL!!!!!!:D Smarter breed eh? Hmmmm... Oh by the way, Leaving Cert tip: 2+2=4. Don't forget your crayons. And a change of nappy.

Allah_ wrote: »

Ok I'll ask again *ahem* Dear Esel, can you tell me how many people die in Ireland per year due to nicotine poisoning, thank you.

Side Effects

Nicotine not only increases blood pressure and heart rate in humans, but it also mimics the venous endothelial dysfunction caused by smoking.[57] Nicotine can stimulate abnormal proliferation of vascular endothelial cells, similar to that seen in atherosclerosis.[58] Nicotine induces potentially atherogenic genes in human coronary artery endothelial cells.[59] Nicotine could cause microvascular injury through its action on nicotinic acetylcholine receptors (nAChRs),[60] however other mechanisms are also likely at play.
A study on rats showed that nicotine exposure abolishes the beneficial and protective effects of estrogen on the hippocampus,[61] an estrogen-sensitive region of the brain involved in memory formation and retention.

Toxicology

See also: Nicotine poisoning
NFPA 704

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The LD[SIZE=-1]50[/SIZE] of nicotine is 50 mg/kg for rats and 3 mg/kg for mice. 30–60 mg (0.5–1.0 mg/kg) can be a lethal dosage for adult humans.[6][69] Nicotine therefore has a high toxicity in comparison to many other alkaloids such as cocaine, which has an LD50 of 95.1 mg/kg when administered to mice. It is unlikely that a person would overdose on nicotine through smoking alone, although overdose can occur through combined use of nicotine patches or nicotine gum and cigarettes at the same time.[7] Spilling a high concentration of nicotine onto the skin can cause intoxication or even death, since nicotine readily passes into the bloodstream following dermal contact.[70]
Historically, nicotine has not been regarded as a carcinogen and the IARC has not evaluated nicotine in its standalone form and assigned it to an official carcinogen group. While no epidemiological evidence supports that nicotine alone acts as a carcinogen in the formation of human cancer, research over the last decade has identified nicotine's carcinogenic potential in animal models and cell culture.[71][72] Nicotine has been noted to directly cause cancer through a number of different mechanisms such as the activation of MAP Kinases.[73] Indirectly, nicotine increases cholinergic signalling (and adrenergic signalling in the case of colon cancer[74]), thereby impeding apoptosis (programmed cell death), promoting tumor growth, and activating growth factors and cellular mitogenic factors such as 5-LOX, and EGF. Nicotine also promotes cancer growth by stimulating angiogenesis and neovascularization.[75][76] In one study, nicotine administered to mice with tumors caused increases in tumor size (twofold increase), metastasis (nine-fold increase), and tumor recurrence (threefold increase).[77]
Though the teratogenic properties of nicotine may or may not yet have been adequately researched, women who use nicotine gum and patches during the early stages of pregnancy face an increased risk of having babies with birth defects, according to a study of around 77,000 pregnant women in Denmark. The study found that women who use nicotine-replacement therapy in the first 12 weeks of pregnancy have a 60% greater risk of having babies with birth defects, compared to women who are non-smokers.I][URL="http://en.wikipedia.org/wiki/Wikipedia:Citation_needed"]citation needed[/URL][/I
Effective April 1, 1990, the Office of Environmental Health Hazard Assessment (OEHHA) of the California Environmental Protection Agency added nicotine to the list of chemicals known to the state to cause developmental toxicity, for the purposes of Proposition 65.[78]

dj jarvis wrote: »

yea , milk is lethal is large amounts also - my point was, in SAFE doses you can use and take nicotine with NO adverse health affects EVERY DAY ,
dont be such a wiseinhiemer about it - you know what was meant

my cardiologist stated that even if the vape is bad for me, it has to be better than smoking cigarettes that include 4000 harmful chemicals

dont care what smart arsed post you put up , they are HEALTHIER than smokes , cost less and pollute the air for other less - win win win

Alan_Curry wrote: »

Nicotine is harmless, it's the 3000 other poisonous chemicals in tobacco that is the problem.

dj jarvis wrote: »

but nicotine is not harmful at all - granted you may be addicted but it wont kill you...

Esel wrote: »

Wow. Too much nicotine can certainly kill you. Also, if you already have high blood pressure, nicotine in any form is definitely contra-indicated.

dj jarvis wrote: »

its harmless delivered in the doses by the devices we were all talking about

Allah_ wrote: »

Yep, I was smoking it in the nightclubs and pubs last night. A few of the barmen saw me, didn't say anything. Got some inquisitive drunken langers asking about the gadget, they were generally impressed by it.

Smoked it in Super Valu today too.

It's only my second day with it... I'll try it on the bus tomorrow!

If people ask about it I'd say it's best to just call it a "nicotine inhaler". Calling it an electronic cigarette might make thick people think it's an actual cigarette.

kilograms wrote: »

No Ryanair do not sell smokes, they sell fake smokes.

I quit smoking 2 years ago, but if you are using something that substitutes actual smoking, the concept of smoking is very much alive in your head so there is a high chance that you will go back on the smokes.

You need to banish smoking from your mind to be successful