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The Omicron variant

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Comments

  • Registered Users, Registered Users 2 Posts: 8,401 ✭✭✭corkie


    @dominatinMC

    Just reporting on them is all. Don't have any fixation on them.

    Based on limited information provided not overly concerned for myself, just for Elderly relatives in my family if I get infected.

    Some people considering traveling might be interested to know where cases are.

    These are only confirmed GS Cases, it has already stated it is spreading in community. And cases are only a small percentage of possible numbers.

    Like tracking the early spread of it, at some stage cases count will be higher and widespread that reporting on them will cease.


    ⓘ "At some point something inside me just clicked and I realized that I didn't have to deal with anyone's bullshit ever again."
    » “mundus sine caesaribus” «



  • Registered Users, Registered Users 2 Posts: 3,348 ✭✭✭Rebelbrowser


    Agreed, had already read it and formed just that view. I think PCR tests still recognise this "stealth" variant as Covid, they just don't pick up necessarily that it is Omicron. You need to read carefully and to the very end to pick up on that though, the headline stuff is misleading (if I'm reading it correctly). I'm a Guardian subscriber/donater and would expect better from them of all newspapers.



  • Registered Users, Registered Users 2 Posts: 7,632 ✭✭✭timmyntc


    A virus so deadly you have to be tested to even know you have it!



  • Registered Users, Registered Users 2 Posts: 7,632 ✭✭✭timmyntc


    Shoddy reporting from the guardian.

    It means you cannot use PCR assays only to identify the variant - it will still test positive for covid. Our own Cillian de Gascun said as much last week, PCR is not reliable for detecting specific variant. The samples need to be separately sequenced to determine the genetic lineage.



  • Posts: 0 [Deleted User]


    That's a terrible article. What's happened is Omicron has been divided into two separate lineages. One of these carries a mutation in the S gene in one of the targets for the PCR. This can be used as a proxy to track it. The other lineage does not carry this mutation so cannot be tracked in this way. That's all.



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  • Registered Users, Registered Users 2 Posts: 2,150 ✭✭✭TonyMaloney


    It's been, to varying degrees, the same for every country since the beginning of the pandemic.



  • Registered Users, Registered Users 2 Posts: 8,401 ✭✭✭corkie


    Coronavirus (COVID-19)› The Omicron variant

    First Omicron variant cases confirmed in Northern Ireland

    Three Omicron cases have been confirmed in total, the department said.

    Two are from same household in the greater Belfast area and a third unconnected case in the South Eastern Trust area.

    The Department of Health said all three positive cases have a link to travel from Great Britain to Northern Ireland.


    Omicron thread and I'm sharing relevant news. Nobody is forcing you to read this thread.

    ⓘ "At some point something inside me just clicked and I realized that I didn't have to deal with anyone's bullshit ever again."
    » “mundus sine caesaribus” «



  • Registered Users, Registered Users 2 Posts: 596 ✭✭✭deholleboom


    After reading all the comments, if you disgard all the obvious nonsense and keep a healthy distance from the extremes i think it is fair to say that every development since the onset of Omicron over the last 28 days leans more and more towards the positive the longer time goes by. It is quite clear this variant is very different and if we just concentrate on the data from South Africa we can compare the various waves with one another, keeping the population age profile of just that country as a non variable. The relationship between cases and hospitalizations, the symptoms, the effect of the symptoms and the duration, the stay in hospitals (duration), the age groupsand deaths.

    In most of the well known variants (Alpha to Delta) we quickly saw the rise in cases followed by hospitalizations(7-10 days) and deaths (calculated 28 days after infection). Respiratory problems, cytokine storms etc. The last one, Delta did enormous damage and the images went around the world, starting from India and spread globally.

    People with co-morbidities and impaired immune systems, the usual first in line victims, should be heavily impacted by Omicron by now but they are not. It is mostly younger people. That could be because of vaccines, despite the below average uptake, lower exposure due to older people being more careful. Anyway, we still do not see them going into hospitals in large numbers due to Omicron. This after a rapid spread over a month time, in the epicentre. We should see a big rise right now but we dont. Given time it IS likely hospital numbers will go up if the infection rate keeps growing.

    That looks like good news.

    Now, on the other hand i can understand the various counter arguments:

    Too early to tell, different countries different responses. Hospital numbers are still high from Delta so caution is needed to diminish extra incoming patients. We dont really know how infectious it is, long term severity etc etc.

    Every week it gets more positive.

    It is my personal view that government and health bodies will maintain the caution line at least until the first monday in january to get us through Christmas despite the likely growing positive news over time.

    It will be ignored and sold as 'keeping us safe'. It is understandable.

    So, anyone complaining about PCR tests , effectiveness of restrictions, health measures etc, just see it as a form of virtue signalling. It is quite often not grounded in science, or i should say the right kind of the scientific method. It is not important.

    What IS important is to show that somebody IS doing something.

    If we can just see the reality playing out we can all have solid low expectations of governments and institutions. It is closer to the truth..

    And eventually we will get out of this..



  • Registered Users, Registered Users 2 Posts: 167 ✭✭Mango321




  • Posts: 0 [Deleted User]


    First bit of neutralization data for Omicron. 41-fold reduction in neutralization for 2x dose of Pfizer (N.B. does not mean 41-fold drop in protection).

    Good news is hybrid immunity still successfully neutralized. 3rd dose of vaccine likely to do the same.




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  • Registered Users, Registered Users 2 Posts: 1,744 ✭✭✭kingtiger


    Can someone explain that chart to me, just pretend you are talking to an 8 year old ;)



  • Registered Users, Registered Users 2 Posts: 167 ✭✭Mango321


    (Not a virologist, so would recommend following e.g. the study author and other virologists explaining significance)





  • Registered Users, Registered Users 2 Posts: 713 ✭✭✭cheezums




  • Posts: 0 [Deleted User]


    It's a measure of antibodies ability to neutralize the virus (i.e. render ot incapable of binding to cells). The chart measures how much the samples are diluted. The numbers at the top are an average. The line across the bottom signifies loss of neutralization.

    On the left the samples are tested against the ancestral variant. As you can see they're all well above the line (bear in mind it's a log scale). This indicates strong protection against infection.

    On the right they are tested against Omicron. Most of the samples are below the line meaning they failed to neutralize. Notably though those with hybrid immunity ( vaxx + infection) were still above the line. This indicates it still provides protection. A 3rd dose will very likely do similar.

    Very important to point out this this exclusively tests protection by antibodies. They are only one aspect of the immune system. This also only measures protection against infection. Protection against severe disease is likely conserved.



  • Registered Users, Registered Users 2 Posts: 11,759 ✭✭✭✭ACitizenErased


    Big statement from Fauci today.

    WASHINGTON, Dec 7 (Reuters) - Preliminary evidence indicates that the Omicron variant of the coronavirus likely has a higher degree of transmissibility but is less severe, top U.S. infectious disease expert Anthony Fauci said on Tuesday.

    Although more data is needed, early cases of Omicron seem to require fewer hospitalizations and patients are less likely to need oxygen, Fauci told reporters at a White House briefing.

    More data is expected next week, Fauci said, but it will take a few weeks to reach any definitive conclusions.

    https://www.reuters.com/world/us/fauci-says-early-evidence-points-omicron-being-more-transmissible-less-severe-2021-12-07/?taid=61afe0714c9fd40001a02082&utm_campaign=trueAnthem:+Trending+Content&utm_medium=trueAnthem&utm_source=twitter



  • Posts: 0 [Deleted User]


    Worst case scenario was complete loss of neutralization. Instead we see hybrid immunity still provides protection. 3rd doses will likely do the same.

    Does mean though we're gonna have to go hard on ensuring uptake of boosters.

    Fun times.



  • Registered Users, Registered Users 2 Posts: 713 ✭✭✭cheezums


    well i hope you're right about the third shot. otherwise we are kind of fcuked.



  • Registered Users, Registered Users 2 Posts: 4,225 ✭✭✭amandstu


    A very great man but his credibility may take a big hit if he is badly wrong on this (even if we are supposed to emphasize the "preliminary" )


    Let him be right on this and let us hopefully move on.



  • Registered Users, Registered Users 2 Posts: 11,759 ✭✭✭✭ACitizenErased


    They say infection is essentially an additional dose so theoretically the third jab would have the same effect. We've 1 million here boosted so that's a good start.



  • Registered Users, Registered Users 2 Posts: 17,444 ✭✭✭✭astrofool


    He'll be vilified if he's wrong and vilified if he's right because he wasn't right soon enough.



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  • Registered Users, Registered Users 2 Posts: 31,289 ✭✭✭✭Lumen




  • Registered Users, Registered Users 2 Posts: 2,027 ✭✭✭lbj666


    Early estimates of the r0 in the UK is over 3. Its a flawed estimate because they are still targeting suspected cases for sequencing at the minute. But that would mean doubling every 3 days. If you ran that starting from 1 here, thats the whole population exposed/infected in 2 months, hospitalisation rate would have to plummet to the 1:1000s to put up with that ie. very mild and very effective boosters. Its around the 1% ish at the minute.

    I am happy to bin the above as doomsday prophesizing but it just shows how much the data needs to keep emerging on the good side of things. Granted if the actual reproduction is broadens to doubling every 5-6 days and the severity is say half that of delta (post boosters) we could be in with a shot.



  • Registered Users, Registered Users 2 Posts: 31,289 ✭✭✭✭Lumen


    @lbj666 wrote

    Early estimates of the r0 in the UK is over 3

    Source? That sounds way off. Are you sure you're not quoting a tweet with a typo?



  • Registered Users, Registered Users 2 Posts: 11,759 ✭✭✭✭ACitizenErased


    Weird how 50% of the vaccinated sample are only 12 days post dose 2. No info on intervals listed.

    Is this a possible explanation for such a big difference between vaccination vs vaccination + infection ?



  • Registered Users, Registered Users 2 Posts: 167 ✭✭Mango321


    It's Rt, not R0.


    Rt = in a specific time and place.

    R0 = in a completely uninfected/unvaxxed population with no public health measures.



  • Registered Users, Registered Users 2 Posts: 167 ✭✭Mango321


    Several sources agree that Rt for Omicron in the UK is currently around 3 (i.e. 1 person infects an average of 3).

    (If Rt is 1, cases plateau.)





  • Registered Users, Registered Users 2 Posts: 6,425 ✭✭✭Wolf359f


    The vaccinated only was 12 days post dose, vaccinated and infected was twice that.

    Guess if you look at antibody levels from people after their second dose, you could see if there's a significant difference between day 12 and day 24 etc...

    Be nice to see if other countries do a similar test, just to confirm it etc... Still early days.



  • Registered Users, Registered Users 2 Posts: 2,027 ✭✭✭lbj666


    You'll see the source post , same source say that's double every 3 days.



  • Registered Users, Registered Users 2 Posts: 4,225 ✭✭✭amandstu


    I heard them say double every 2 days (BBC I think)



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  • Registered Users, Registered Users 2 Posts: 2,027 ✭✭✭lbj666




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