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Johnson & Johnson (Janssen) Vaccine

Comments

  • Registered Users Posts: 2,065 ✭✭✭funnydoggy


    Not in an at-risk group and got the J&J shot a few months ago when it was made available for younger adults. I'd much rather see a vaccine go to somebody who desperately needs it, than as a booster for me. I'll wait for govt/NIAC advice but I am not in any rush right now as the vaccine is still a very effective one.



  • Registered Users, Registered Users 2 Posts: 3,272 ✭✭✭Azatadine


    I'd be perfectly comfortable taking a second shot of it. In reality, it should have been a 2 shot vaccine to begin with.



  • Registered Users, Registered Users 2 Posts: 32,136 ✭✭✭✭is_that_so


    Well, the first one worked well enough anyway and the single dose was a huge speed boost for any programme. Be a surprise to see it be offered as a second/booster dose and mRNA would be more likely IMO. Not sure we will necessarily get to that stage anyway.



  • Registered Users Posts: 118 ✭✭Skipduke


    Anywhere doing the J&j in Ireland now ? Have someone with a severe fear of needles



  • Registered Users, Registered Users 2 Posts: 10,462 ✭✭✭✭WoollyRedHat




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  • Registered Users, Registered Users 2 Posts: 16,885 ✭✭✭✭astrofool


    I think it's more the reduction in injections (1 instead of 2), J&J seems finished but a few people found them at pharmacies.

    I wouldn't recommend it, but getting 1 dose of Pfizer/Moderna will be better than 0 doses (and you can always work on getting a second dose later down the line, larger gaps can help). If it's from a COVID cert perspective, just figure out how to get 2 injections into them (and that's saying it like it's simple when for people with a fear of something, it definitely isn't).



  • Registered Users, Registered Users 2 Posts: 975 ✭✭✭Parachutes


    Why should have it been a two shot? Where are you basing this from? Or do you just really enjoy taking shots.



  • Posts: 0 [Deleted User]


    A recent preprint has it's efficacy against symptomatic infection dropping to 3%.

    If they had run the trial over a longer period and submitted that kind of data for approval, it would not be in use as a single dose vaccine. Their own data is better, but realistically, anyone over 50 that got it, should be getting another dose.



  • Registered Users, Registered Users 2 Posts: 3,272 ✭✭✭Azatadine


    Yep, and I'm scraping over 50.....and would gladly take a second dose of Janssen or a dose of Pfizer or Moderna.

    It does feel like the Janssen recipients in Ireland are somewhat forgotten about as I don't hear much about boosters for them (and they arguably need them more than AZ).



  • Registered Users, Registered Users 2 Posts: 4,082 ✭✭✭afatbollix


    I'm on the two shot trial for the Janssen vaccine.

    Great to hear of such great results! I'll be monitored for 2 years and have anti body tests each month.

    Works great! Turns out I spent a weekend with a family and a couple of kids had Covid recently and all tests came back negative and no symptoms!



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  • Registered Users, Registered Users 2 Posts: 16,885 ✭✭✭✭astrofool


    Is the 2 shot trial the single dose twice or is the formulation different? Can you get a vaccine certificate for it?



  • Registered Users, Registered Users 2 Posts: 7,610 ✭✭✭eigrod


    I got the Janssen at end of May. I tested positive on 12th October having had symptoms of a heavy cold and cough, no temperature. My 3 close contacts-, wife & 2 sons, didn’t contract it. I guess the vaccine did its job.



  • Registered Users, Registered Users 2 Posts: 614 ✭✭✭random_banter


    Glad to see a thread on this. My mother is mid 60’s so recommended for a booster when the time comes, but got a Jannsen first time around.

    She’s allergic to a preservative in the Pfizer vaccine. In the UK, they avoided giving Pfizer to people with this allergy but here they have no policy regarding that allergy. So she had to push to get a J&J from the HSE when her time came.

    She’s very conscious of covid and still nervous about it, so I’d love to see her get a booster - but she can’t take the Pfizer. And there’s nothing out there about J&J recipients. The GP knows nothing about it either and can’t help. Limbo indeed!



  • Posts: 0 [Deleted User]


    Is the same preservative in Moderna? Not sure if we still have any of that, but might be an option.

    It's probably a bit short sighted for us to become too reliant on Pfizer, especially as Moderna's 6 month efficacy is holding strongest of those available.



  • Registered Users, Registered Users 2 Posts: 16,885 ✭✭✭✭astrofool


    I think Moderna is still available, the contract certainly has lots of deliveries left and their Swiss plant isn't that long online, I wonder if the time will come when some of the adenovector vaccines might be available privately. Other than that it's waiting for Novavax (and hoping they don't use the same preservative).

    The fact that the HSE isn't listing it as an issue may indicate that the amount of the preservative is too small to be of issue for those allergic, but you really need a well trained doctor/consultant to make that determination (i.e. don't rely on the internet and that's understanding that it's hard to find some qualified to make that determination).



  • Registered Users, Registered Users 2 Posts: 32,136 ✭✭✭✭is_that_so


    HSE may be a better place to check on that. There is nothing about J&J because almost all of them are in the under 60s and there are no plans to offer boosters to anyone in younger age groups yet.



  • Registered Users Posts: 357 ✭✭Barney224


    I think I have symptoms as well and I got J&J in July. I'm giong to go for a test tomorrow.

    BTW, were you told to self-isolate for 10 days?



  • Registered Users, Registered Users 2 Posts: 7,610 ✭✭✭eigrod


    Yes. But back dated to the date i first experienced symptoms, which was about 5 days before i got the contact tracing call as i waited a few days to get tested.



  • Registered Users, Registered Users 2 Posts: 4,082 ✭✭✭afatbollix


    It was a single dose twice, 3 months apart.

    I was able to get a vaccine cert, We had to kick up a fuss to get them at the beginning but it's essentially a letter saying we had an approved vaccine and I haven't had issues in the 4 countries I have visited. Most people just look to see if you have had a jab and that's all they care about. I had more questions getting into Ireland in May as I had just been unblinded and the vaccine passports were still an idea and I didn't have a vaccine card that they gave out as I wasn't told at the time what I had.



  • Registered Users, Registered Users 2 Posts: 884 ✭✭✭keno-daytrader


    Considering how long NIAC take to make decisions I wouldnt hold out any hope they they will consider a second jab for J and J single dose people any time soon. I hope Im wrong.


    The US is now recommending a second jab for anyone in the US who only got the single dose J and J.

    ☀️ 7.8kWp ⚡3.6kWp south, ⚡4.20kWp west



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  • Registered Users, Registered Users 2 Posts: 32,136 ✭✭✭✭is_that_so


    We are more likely to see an mRNA option offered instead and it depends how useful they think it is moving into the under 60s for boosters.



  • Registered Users, Registered Users 2 Posts: 14,190 ✭✭✭✭Goldengirl


    Polyethylene glycol ( PEG ) is the ingredient in Pfizer that can cause issues and is the same in Moderna . The two adenovector vaccines that were used here , J and J , and AZ don't have this but really your mother will most likely have to get a referral from your doctor to an immunologist/ allergy specialist and have them decide what to do.

    There must be some supplies left somewhere in the country of J and J or Moderna ,for just this reason.



  • Registered Users, Registered Users 2 Posts: 884 ✭✭✭keno-daytrader


    People aged 50-60 were given J & J in May, so they will be over 6 months any day now with only one jab, why do NIAC continue to delay and delay when it comes to peoples risk of covid? These people only have one JAB!


    J & J and the FDA in America are now saying that J and J should be at least a 2 dose vaccine.

    Wake up NIAC and please do your job.

    ☀️ 7.8kWp ⚡3.6kWp south, ⚡4.20kWp west



  • Registered Users, Registered Users 2 Posts: 32,136 ✭✭✭✭is_that_so


    NIAC wait for the EMA and as the EU is not going to buy any more J&J it'll be mRNA boosters if any at all. It would be well after Christmas even if they decided to recommend it.



  • Registered Users, Registered Users 2 Posts: 884 ✭✭✭keno-daytrader


    I understand it will be an MRNA booster for anyone now in Ireland, NIAC have already authorized heterologous vaccine mixing.

    You will have within 2 weeks a large cohort of people (50-60 year olds) who will be over 6 months with only 1 jab, that is my point.

    ☀️ 7.8kWp ⚡3.6kWp south, ⚡4.20kWp west



  • Registered Users, Registered Users 2 Posts: 8,913 ✭✭✭Danno


    I got J&J in late-August, it should see me over the winter. Do not want a mRNA vaccine, or not keen on another jab either.



  • Registered Users Posts: 1,604 ✭✭✭Amadan Dubh


    +1


    It's enough to get us through this 4th wave and after that, we will be in the spring when there is a lot lower transmission. As such, this is the final push with covid as far as I can see so by the time it actually comes to even recommend boosters for us, covid will be in the back mirror.



  • Registered Users, Registered Users 2 Posts: 8,913 ✭✭✭Danno


    Looking at the way things are going now, I'm delighted I left it so late in the programme to get vaccinated, however if I was unvaccinated still and looking at how things are currently going, I wouldn't even bother with getting vaccinated. It looks like we were sold a pup in general with regards to how things would look like post 90% vaccination rates.



  • Registered Users, Registered Users 2 Posts: 32,136 ✭✭✭✭is_that_so


    Yeah, but they are far less likely to have the same risk levels as far older or more at risk people. The aim is to get them to those who need them.



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  • Registered Users, Registered Users 2 Posts: 884 ✭✭✭keno-daytrader


    Mícheál Lehane  @MichealLehane

    1h

    The more than 600,000 people aged between 50 and 59 are likely to be eligible soon to receive a vaccine booster under NIAC advice going to Government later, this amid warnings from NPHET that covid cases in hospitals will continue to rise in the coming weeks.

    ☀️ 7.8kWp ⚡3.6kWp south, ⚡4.20kWp west



  • Registered Users, Registered Users 2 Posts: 884 ✭✭✭keno-daytrader


    RTE reporting this morning that if you got Janssen 1 shot vaccine and you are in an eliagble group for boosters (over 50 and vulnerable cohorts) you should get the booster (Pfizer or Moderna) 3 months after your 1st jab.

    Still not clear if one would get a text from HSE, or seek one from GP/vac centre, or pharmacist.

    On an interesting note Phillip Nolan on NPET is in this 50-60 group who got Janssen 1 shot vaccine and is now passing the 6 month mark. Although he didnt say if he has been boosted yet.

    Post edited by keno-daytrader on

    ☀️ 7.8kWp ⚡3.6kWp south, ⚡4.20kWp west



  • Registered Users, Registered Users 2 Posts: 3,272 ✭✭✭Azatadine


    I got mine in May.



  • Registered Users, Registered Users 2 Posts: 614 ✭✭✭random_banter


    The mother got hers from the HSE in June. And got a text last week with an appointment for Pfizer. She declined (as mentioned earlier in this thread, she's allergic to a preservative in the pfizer). She's going to try to get a second dose of J&J privately, speaking to her GP about this first. If I hear anything of use, I'll share it here.



  • Posts: 0 [Deleted User]



    they really need to get their story straight on this.

    https://www2.hse.ie/screening-and-vaccinations/covid-19-vaccine/get-the-vaccine/covid-19-vaccine-booster-dose/#who-does-not-need-a-booster

    Who does not need a booster

    If you are under 60, and you are not a healthcare worker, you do not need a booster dose at this time. This includes people under 60 who got the single-dose Janssen vaccine




  • Moderators, Science, Health & Environment Moderators, Society & Culture Moderators Posts: 60,170 Mod ✭✭✭✭Wibbs


    As I noted in another thread here on boosters and specifically the J&J:

    One of their announcements here.Today’s newly announced studies reinforce the ability of the Johnson & Johnson COVID-19 vaccine to help protect the health of people globally,” said Paul Stoffels, M.D., Vice Chairman of the Executive Committee and Chief Scientific Officer at Johnson & Johnson. “We believe that our vaccine offers durable protection against COVID-19 and elicits neutralizing activity against the Delta variant. This adds to the robust body of clinical data supporting our single-shot vaccine’s ability to protect against multiple variants of concern.” “Current data for the eight months studied so far show that the single-shot Johnson & Johnson COVID-19 vaccine generates a strong neutralizing antibody response that does not wane; rather, we observe an improvement over time. In addition, we observe a persistent and particularly robust, durable cellular immune response,”

    Then a couple of weeks after Pfizer was going on about the need for boosters(and it seems Pfizer vaccine does wane pretty quickly) J&J came along and said oh yeah boosters sound good. Which is it lads?

    And now we're being told that you getter get another different vaccine three months after your J&J? GTFO. I'm smelling bullshít tbh. Not from the government advisors as such, they seem to run around like headless chickens in panic mode throughout this crisis, but more from the vaccine companies looking to keep flogging their wares. Either J&J's various studies were BS, or they weren't. Somebody's telling porkies.

    Rejoice in the awareness of feeling stupid, for that’s how you end up learning new things. If you’re not aware you’re stupid, you probably are.



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  • Registered Users, Registered Users 2 Posts: 32,136 ✭✭✭✭is_that_so


    You have to balance off the data, which probably does as it says and what was effectively the Phase IV trials Israel ran by lining everyone up again that showed boosters were good too. Delta too has continued to throw spanners in the works. J&J have only recently got approval for the second dose regimen from the FDA and the argument there is that it is really a two dose vaccine.



  • Moderators, Science, Health & Environment Moderators, Society & Culture Moderators Posts: 60,170 Mod ✭✭✭✭Wibbs


    I'm still not even close to convinced. J&J's own studies as referenced above showed after eight months a strong efficacy that actually improved over time and one of their largest scale studies was with half a million healthcare workers in South Africa where Delta was the main strain involved. So clearly it was efficacious against that, though also showed it had higher efficacy in US trials than African(others have shown similar). AZ showed a significantly reduced action against Delta, Pfizer was about the same. J&J got into discussing boosters and "oh well it should have been a twofor" only after Pfizer came out with it and showed their particular vaccine lost efficacy over six months. Up to that point they were gung ho about how longer term studies showed good their vaccine was and only after one and done(their shareholders would have prefered a two jab). Funny that. Again imho somebody's telling porkies.

    Rejoice in the awareness of feeling stupid, for that’s how you end up learning new things. If you’re not aware you’re stupid, you probably are.



  • Registered Users, Registered Users 2 Posts: 614 ✭✭✭random_banter


    I thought it might be worth checking in on this thread to see if anyone with an interest in the Janssen vaccines has seen any more information about their efficacy, waning or otherwise?

    I'm still struggling with a mother who is happy to take a J&J Booster but is only being offered mRNA by the HSE. She has an allergy to something in Pfizer so is very hesitant and can't seem to get the attention of a GP to discuss. She's had bad cases of anaphylaxis before from this additive.

    The recent coverage has me alarmed about the potential level of protection she has - for example a link in one of the other vaccine threads which indicates research is showing that J&J has zero (?!) ability to neutralise Omicron. But I think that's my simplistic take away, and surely that can't be true? Here's the link: https://twitter.com/DrEricDing/status/1471035675382358018?s=20

    Also the updated WHO guidance on Janssen Vaccine is linked here. It indicates that they are happy with some effectiveness on one dose, as symptomatic disease protection wanes but protection against hospitalisation remains strong? They are recommending that spare doses are sent to those who need them but that countries can administer a second dose in due course. They do note that older recipients can have waning protection faster. (again that's my rudimentary, unqualified interpretation). https://www.who.int/publications/i/item/WHO-2019-nCoV-vaccines-SAGE-recommendation-Ad26.COV2.S-2021.1

    Anyway, if anyone has any other interesting info to share, it would be appreciated.



  • Registered Users, Registered Users 2 Posts: 32,128 ✭✭✭✭odyssey06


    The MVCs are using Moderna, not Pfizer... do you know if the additive is in Moderna?

    If you do get to speak to GP \ pharmacist they can advise on that perhaps.

    "To follow knowledge like a sinking star..." (Tennyson's Ulysses)



  • Registered Users, Registered Users 2 Posts: 8,913 ✭✭✭Danno


    Novavax is being approved today, so perhaps that might be an option?



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  • Registered Users, Registered Users 2 Posts: 614 ✭✭✭random_banter


    I (think) the additive of concern is PEG and it's implied that it's in Moderna too. I believe it's in some forms of Penicillin and this is where the allergy (anaphylaxis) was first discovered due to the reaction.

    The HSE website advice seems to say that if you've got an allergy to PEG than you shouldn't get either of the mRNA vaccines. (https://www2.hse.ie/screening-and-vaccinations/covid-19-vaccine/pfizer-biontech/safety/). The advice varies country to country, too. Some say go for it, some say don't. For example, this is from the CDC website:

    If You Are Allergic to Polyethylene Glycol (PEG) or Polysorbate

    PEG and polysorbate are closely related to each other. PEG is an ingredient in the mRNA vaccines, and polysorbate is an ingredient in the J&J/Janssen vaccine.

    If you are allergic to PEG, you should not get an mRNA COVID-19 vaccine. Ask your doctor if you can get the J&J/Janssen vaccine.

    If you are allergic to polysorbate, you should not get the J&J/Janssen COVID-19 vaccine. Ask your doctor if you can get an mRNA COVID-19 vaccine.

    It's a real shame that there's no choice over kind of vaccine anymore in Ireland for people like this, since there seems to be this narrative that the J&J isn't any use now if you've only had one shot and no booster.



  • Registered Users, Registered Users 2 Posts: 614 ✭✭✭random_banter


    Thanks, I was reading about this earlier, and it sounds promising but there doesn't seem to be any indication of when it'll be available in Ireland (as fas as I've seen...).



  • Registered Users, Registered Users 2 Posts: 3,272 ✭✭✭Azatadine


    That narrative is certainly out there alright. The impression is that one dose of J&J is useless.



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