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Vaccine Megathread No 2 - Read OP before posting

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  • Registered Users, Registered Users 2 Posts: 7,206 ✭✭✭Lucas Hood




  • Registered Users, Registered Users 2 Posts: 2,004 ✭✭✭Hmmzis


    A small update about the booster tweet from yesterday, here is the actual presentation:

    Slides 25 to 32 are where it's at, though the other programs they have running are also super interesting.

    In slide 30 you can see the source of the 42 fold increase in titers claim. It's from a 6+ months waned titer to a boosted titer (2 weeks post booster). Overall the booster brings the VOC related titers within the original titer against the WT variant. While the numbers against Beta do look a bit lower, real world data would suggest that it's well above (like an order magnitude) the levels that provide a greater than 90% efficacy against it (96% in the Qatar study).

    The one important thing not mentioned in the slides is the relative difference between the WT titer and the VOC titers after the boost. Those are significantly less pronounced after boost.

    After dose 2:

    WT to Beta - 14 fold difference

    WT to Gamma - 6.4 fold difference

    After booster (3rd dose)

    WT to Beta - 5.3 fold difference

    WT to Gamma - 3.6 fold difference (Delta looks similar to Gamma there, but no direct comparison available)

    That's significant as it tells us that antibody maturation has happened over those 6 months post dose 2 and the recall response after the booster is much more potent than straight after the 2nd dose. The thing is, the same maturation process should now happen after the 3rd dose as well. Since two weeks isn't a long enough time for that to happen, the response is most likely to improve even more over time. The exact same effect that has been seen in convalescent individuals and in the Janssen eight month checkup data for their vaccine.

    PS. This is just antibodies shown here, there is much more happening. Otherwise we wouldn't be seeing anywhere near the protection we're seeing out in the wild given the 6+ month titers against VOCs.

    PS2. They're also throwing some shade on their Beta booster, saying there is no distinct advantage to using it, the WT booster works well enough.



  • Registered Users, Registered Users 2 Posts: 17,487 ✭✭✭✭astrofool


    One for the anti-vax lunatics who target pregnant women to be proud of:

    Pregnant women a ‘disproportionate’ number of Covid ICU admissions (breakingnews.ie)



  • Registered Users, Registered Users 2 Posts: 54 ✭✭tippingpoint


    Waiting on a second appointment for Moderna. 28 days since my first. Anyone else waiting on dose 2 Moderna for the Sligo or Leitrim vaccine center?



  • Registered Users, Registered Users 2 Posts: 338 ✭✭XVII




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  • Registered Users, Registered Users 2 Posts: 1,691 ✭✭✭timsey tiger


    Study until they, understand predicate calculus and Bayes theorem.



  • Registered Users, Registered Users 2 Posts: 2,861 ✭✭✭Irishcrx


    Is it possible to request an earlier date from the HSE for your second dose? And how would you go about that?

    I'm due a second dose this day two weeks (But haven't received a text yet) however I am under a bit of pressure in work to travel in early September and I don't want to do that until I've recevied 2nd dose and waited a least two weeks for it to take effect...thanks



  • Registered Users, Registered Users 2 Posts: 1,011 ✭✭✭JPup


    How long is it since you got your first dose? I think 17 days is the minimum gap now. Most people recently have been getting the second pfizer vaccine about 3 weeks after the first.



  • Registered Users, Registered Users 2 Posts: 2,861 ✭✭✭Irishcrx




  • Registered Users, Registered Users 2 Posts: 322 ✭✭muddypuppy


    You might have some luck ringing the HSE or just showing up to a vaccination centre, or try to look for a GP that can vaccinate you - but no guarantees that you will be able to.

    And as other have said, usually the interval is 21-28 days, but the minimum is 17 days. If you get your second dose earlier than 17 days it doesn't count.



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  • Registered Users, Registered Users 2 Posts: 2,861 ✭✭✭Irishcrx


    Thanks - I think I'll wait until the 21 days and then see if I don't have a date if I can get one - I really don't want to upset the effect of the vaccine , ideally I'd wait the 28 days anyway....



  • Registered Users, Registered Users 2 Posts: 73,032 ✭✭✭✭L1011


    21 is and always was the manufacturers recommendation for Pfizer. 28 was the HSE stretching limited stocks.



  • Registered Users, Registered Users 2 Posts: 12,340 ✭✭✭✭castletownman


    Update.

    My DCC arrived in the post this morning, so just under two days after I got the second jab. Thrilled for myself.

    Does anyone know whether I can take a photo of the document and that it'll scan properly on the machine (laminating it has caused issues), as its quite a size to be carrying around the whole time.



  • Registered Users, Registered Users 2 Posts: 205 ✭✭Skygord


    Just scan it into Covid Tracker App, and then you carry it around digitally.



  • Registered Users, Registered Users 2 Posts: 12,340 ✭✭✭✭castletownman


    Got rid of that blasted app when it was completely draining my battery and never re-downloaded it.



  • Registered Users, Registered Users 2 Posts: 16,222 ✭✭✭✭Goldengirl


    You can down load app again, scan the cert and use the cert without having the app on

    It's a handy way to keep it.

    Other than that people have used some other app that they have downloaded.



  • Registered Users, Registered Users 2 Posts: 3,604 ✭✭✭Azatadine




  • Registered Users, Registered Users 2 Posts: 2,065 ✭✭✭funnydoggy


    What's everyone's take on the South African study that's showed the J&J vaccine being 71% effective against hospitalisation from delta?


    In my opinion, I'm perfectly fine with it. I have gotten J&J myself and I'm young with no underlying illnesses.


    My immune system will be handy enough so that 70%~ is more than enough protection for me.

    Edit: just to clarify, I see 70% as being excellent protection still. Great too for those afraid of needles or skeptical about mRNA (however misguided).

    Post edited by funnydoggy on


  • Registered Users, Registered Users 2 Posts: 3,604 ✭✭✭Azatadine




  • Registered Users, Registered Users 2 Posts: 2 maniaxx88


    Has anyone been successful in getting the second jab at a walk-in centre?

    My wife and I got vaccinated during a Germany trip in June and we are still waiting to get the second dose in Ireland... My wife called HSE again yesterday and they said we should just wait, they need to check with German authorities (which is bs). It's now day 40 since our first jab 😒



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  • Registered Users, Registered Users 2 Posts: 5,553 ✭✭✭murphyebass


    I’m due in for my second dose tomorrow morning in Swords.

    What’s the chance of getting it today instead if I rock up randomly?



  • Registered Users, Registered Users 2 Posts: 4 dry


    Hi,

    I am searching for a Janssen vaccine for my son who will be in Ireland for only 3 weeks - not long for the 2 shot jabs.

    I have tried some pharmacies but they were not taking appointments and were rather vague about dates for receiving their doses.


    Thanks


    Pat



  • Registered Users, Registered Users 2 Posts: 1,678 ✭✭✭Multipass


    My daughter just had her appointment cancelled, the pharmacy said that there will be no more Jansen deliveries. They’re being sent Pfizer at a later date instead.



  • Registered Users, Registered Users 2 Posts: 2,274 ✭✭✭Economics101


    Ireland now has a higher % of the population vaccinated than the UK, and for about a month the Irish % has been fairly close to the UK. Ireland has had much more stringent rules on indoor gatherings and mask wearing then the UK (especially England). Yet the Irish daily case rates are rising and those in the UK have been falling.

    Why is this? Different testing rates leading to different apparent case rates? A bigger gap between formal rules and actual compliance with those rules? (no snide Healy-Rae or Zappone-Varadkar remarks please!). I know cases don’t matter as much as they used to, but hospitalisations do matter - even if only because they spook NPHET.

    The longer we wait for a turning point in the data the more acute these questions become

    Finally, the HSE must have information on the number of tests on a daily tests, as well as reported cases, so why is there almost no information on positivity rates? Either the HSE are flying blind because of the hack (last May, for heaven’s sake), or else they are not giving us full information. In that case, why not? Or maybe there is more information, but the journalists are useless at reporting it?



  • Registered Users, Registered Users 2 Posts: 805 ✭✭✭Relax brah


    Our vaccine rollout has been truly spectacular. Hats off to all involved.

    We are nearly there folks



  • Registered Users, Registered Users 2 Posts: 805 ✭✭✭Relax brah


    You can clearly see the positivity rates on the covid app.

    Last 7 days:

    Tests completed 129,535

    Positive rate 2.4%



  • Registered Users, Registered Users 2 Posts: 1,570 ✭✭✭Tyrone212


    Delta took over in England first . Over 20k people landed from India in a couple of weeks when they had already added Pakistan and Bangladesh to the red list. Boris was supposed to go to India for a trade deal so the train of thought is he delayed adding India to the red list for 3 weeks after he had added Pakistan and Bangladesh who were in much worse place at that time.

    So delta rattled through there while Ireland pretty much had no cases. It slowly filtered over here before becoming dominant. So we're weeks and weeks behind them in regards to delta.



  • Registered Users, Registered Users 2 Posts: 11,767 ✭✭✭✭ACitizenErased


    Testing data hasn't been updated since May, that's old data



  • Registered Users, Registered Users 2 Posts: 2,274 ✭✭✭Economics101


    This is wrong. If you look at the Covid tracing app it states clearly that the testing data you refer to is from May, just prior to the hack. The app has left us totally in the dark about testing/positivity rates for about 3 months.



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  • Registered Users, Registered Users 2 Posts: 2,274 ✭✭✭Economics101


    Delta has been totally dominant (80 to 90%) in Ireland for over a month, so in that respect we have caught up with the UK. Now why the differences in case trends that I first asked about?



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