Vaccine Megathread No 2 - Read OP before posting

Eod100 · 01-07-2021 02:24PM

Good to see about 30-34s. Seemed a bit of anecdotal evidence of people that age if not younger getting vaccines through GP already so guess as age cohorts go down there's more chance of that

PTH2009 · 01-07-2021 02:30PM

So for us 30-34 will we get a choice ?

I imagine big demand for the J&J for obvious reasons

TheDoctor · 01-07-2021 02:30PM

Eod100 wrote: »

Good to see about 30-34s. Seemed a bit of anecdotal evidence of people that age if not younger getting vaccines through GP already so guess as age cohorts go down there's more chance of that

I would be in that cohort and I know of loads that have already got jabbed through their GP, underlying conditions or not.

xboxdad · 01-07-2021 02:31PM

KrustyUCC wrote: »

That's 140,000 fully vaccinated people

A significant figure that needs to be used asap

Few weeks tops

Ppl usually say J&J is very similar to 1 dose of AZ which we don't consider full protection.
I'm confused about this, can you shed some light on this please?

Eod100 · 01-07-2021 02:33PM

TheDoctor wrote: »

I would be in that cohort and I know of loads that have already got jabbed through their GP, underlying conditions or not.

Only personally know a few but through friends of friends seems to be happening a bit. Seems to depend on GP having spares so varies a lot

cgcsb · 01-07-2021 02:33PM

I managed to secure a vaccine appointment from boots in just over 2 weeks time, they may cancel because I'm officially too young for it at the moment. Should I still register when it opens up for 30-34s and then cancel one of them (whichever is first).

Why does the government create all this uncertainty for people?

lucernarian · 01-07-2021 02:37PM

xboxdad wrote: »

OK, I agree this is too complex of a topic to try and discuss in detail.
What I mean when I say they "experiment" is evolution. E.g. trial and error. Mutations happen on a regular basis, but most of them are less successful than the existing strain(s), e.g. you only ever hear about the mutations that were more/similarly successful as the existing strain(s). The larger the "sandbox" (=unvaccinated population) the virus has to do this trial&error the faster we'll see successful mutations/strains appear in our stats.
This is what I attempted to avoid typing in by just saying "experimenting"

What has that got to do with the issues surrounding NPHET's latest modelling and the vaccine rollout? It's a very simplistic analogy I gotta say, and the "sandbox" you refer to is a rapidly-shrinking thing. Also I think it's disingenuous to talk about elimination of cases/strains as the vaccines' successful endpoint is the avoidance of hospitalisation and death.

Reducing transmission and symptomatic cases is an additional bonus if you will. some informed commentators also believe on available evidence, the Mac n Chise tweeter, that e.g. the mRNA vaccine induced immunity is so effective that the virus would no longer be able to readily bind with huACE2 receptors if it were to escape vaccine-induced immunity (in effect that would make the "variant fear" basically moot).

lucernarian · 01-07-2021 02:39PM

Lucas Hood wrote: »

Agree wih Alan Kellys sentiment but as a 32 year old i would like to be included in that. 30-34 year olds haven't been offered a jab yet.

Agreed also, plus there are those in the 40+ age group who haven't availed of vaccines for whatever reason. It should be available to all, not yet another age group.

is_that_so · 01-07-2021 02:55PM

Lucas Hood wrote: »

Agree wih Alan Kellys sentiment but as a 32 year old i would like to be included in that. 30-34 year olds haven't been offered a jab yet.

Not his call, that is down to NIAC. He likes grandstanding and really has shown a very poor grasp of what's going on at times during this!

Apogee · 01-07-2021 03:02PM

8,000 J&J administered via pharmacies.

Total J&J administered ~70K.

01-07-2021 03:06PM

PTH2009 wrote: »

So for us 30-34 will we get a choice ?

I imagine big demand for the J&J for obvious reasons

You'll be able choose to get J&J or AZ (probably in a pharmacy) or wait for an mRNA vaccine through the MVCs.

Goldengirl · 01-07-2021 03:16PM

According to Colm Henry on HSE briefing, " the vaccine wall is holding in UK and Scotland preventing deaths from Delta" unlike Russia where deaths are going up, as vaccinations there are at a much lower level.

Strazdas · 01-07-2021 03:16PM

Apogee wrote: »

Revised plan including AZ/JJ option for under 50s now with Minister

We should have an announcement fairly quickly then. They know full well the urgency of the situation.

celt262 · 01-07-2021 03:18PM

xboxdad wrote: »

Ppl usually say J&J is very similar to 1 dose of AZ which we don't consider full protection.
I'm confused about this, can you shed some light on this please?

I would like to see some information on this also have seen charts and information on AZ and Pfizer against delta but nothing on j&j.

Farrelk · 01-07-2021 03:21PM

Got my (23) first Pfizer a few minutes ago. My GP was taking names for cancellations and being someone WFH I was in a position to drop my work and be there in 10 minutes. Feeling very grateful to my GP for running such a brilliant set up

xboxdad · 01-07-2021 03:32PM

lucernarian wrote: »

What has that got to do with the issues surrounding NPHET's latest modelling and the vaccine rollout? It's a very simplistic analogy I gotta say, and the "sandbox" you refer to is a rapidly-shrinking thing. Also I think it's disingenuous to talk about elimination of cases/strains as the vaccines' successful endpoint is the avoidance of hospitalisation and death.

Reducing transmission and symptomatic cases is an additional bonus if you will. some informed commentators also believe on available evidence, the Mac n Chise tweeter, that e.g. the mRNA vaccine induced immunity is so effective that the virus would no longer be able to readily bind with huACE2 receptors if it were to escape vaccine-induced immunity (in effect that would make the "variant fear" basically moot).

"the "sandbox" you refer to is a rapidly-shrinking"

10.9% of the world's population fully vaccinated, 18 months in.
That's not rapid given that new successful mutations come every couple of months.

"Also I think it's disingenuous to talk about elimination of cases/strains as the vaccines' successful endpoint is the avoidance of hospitalisation and death."

The good results we achieve in Ireland must be matched globally for our own good results to stick. 89.1% unvaccinated ppl globally means this is nowhere near over. If you think this is disingenuous to say, it's OK with me. I hope you're right for everybody's sake.

josip · 01-07-2021 04:02PM

xboxdad wrote: »

"the "sandbox" you refer to is a rapidly-shrinking"

10.9% of the world's population fully vaccinated, 18 months in.
That's not rapid given that new successful mutations come every couple of months.

"Also I think it's disingenuous to talk about elimination of cases/strains as the vaccines' successful endpoint is the avoidance of hospitalisation and death."

The good results we achieve in Ireland must be matched globally for our own good results to stick. 89.1% unvaccinated ppl globally means this is nowhere near over. If you think this is disingenuous to say, it's OK with me. I hope you're right for everybody's sake.

This is disingenuous.
Vaccine rollout is not linear which makes your association of "18 months", with the percentages, invalid.

crossman47 · 01-07-2021 04:08PM

Eod100 wrote: »

Good to see about 30-34s. Seemed a bit of anecdotal evidence of people that age if not younger getting vaccines through GP already so guess as age cohorts go down there's more chance of that

How come GPs are still vaccinating? I didn't think they had any role in the age group based roll out.

is_that_so · 01-07-2021 04:13PM

Strazdas wrote: »

We should have an announcement fairly quickly then. They know full well the urgency of the situation.

It was always going to be at least a week anyway, to get everything set up properly.

Skygord · 01-07-2021 04:13PM

duffman13 wrote: »

No 15 minutes observation time? Usually compulsory after vaccination in the event of a reaction

GP said just hang around nearby, so I was out of their building and car park away from others coming in, and stood by my car 100m away for 10 minutes.

Skygord · 01-07-2021 04:21PM

Skygord wrote: »

https://twitter.com/CureVacRNA/status/1410566574461931520?s=20

I 'think' I recall seeing that they've already made 100M doses in advance of approval, all for EU.

Assuming EMA give approval quickly, and they are suitable for younger people which the data suggests, could that mean 1M doses coming here soon, like July????

Guardian blog....

13:36
CureVac is to pursue European approval for its coronavirus vaccine candidate, despite disappointing overall efficacy results.

It announced preliminary data on 16 June from a 40,000-person trial, which showed that its two-dose vaccine was just 47% effective at preventing disease. But it argues that final analysis of its late-stage trial shows 53% protection against mild disease, 77% protection against severe disease and full protection against hospitalisation and death, the Financial Times reported.

The company said that the higher efficacy against severe disease meant it still had a pathway for approval from the European Medicines Agency.

“In this final analysis, CVnCoV demonstrates a strong public health value in fully protecting study participants in the age group of 18 to 60 against hospitalisation and death and 77% against moderate and severe disease – an efficacy profile, which we believe will be an important contribution to help manage the Covid-19 pandemic and the dynamic variant spread,” Franz-Werner Haas, chief executive, said.

The FT said that CureVac has argued that performance of its mRNA vaccine, which it is producing with the pharmaceutical giant Bayer, was lower because it dealt with 15 different virus variants.

eoinbn · 01-07-2021 04:23PM

Skygord wrote: »

I 'think' I recall seeing that they've already made 100M doses in advance of approval, all for EU.

Assuming EMA give approval quickly, and they are suitable for younger people which the data suggests, could that mean 1M doses coming here soon, like July????

Someone did report that here. It is total BS. Curevac weren't going to have significant volumes until Q4. The 'stockpile' was about 5m-10m.

is_that_so · 01-07-2021 04:24PM

Skygord wrote: »

I 'think' I recall seeing that they've already made 100M doses in advance of approval, all for EU.

Assuming EMA give approval quickly, and they are suitable for younger people which the data suggests, could that mean 1M doses coming here soon, like July????

Guardian blog....

Efficacy might make people fussy but TBH it'll still do the trick.

Wolf359f · 01-07-2021 04:25PM

is_that_so wrote: »

Efficacy might make people fussy but TBH it'll still do the trick.

It still exceeds the WHO threshold of 50% in that age group. It's not like if they had any sort of stockpile, that they would dump it.

Charles Babbage · 01-07-2021 04:29PM

Weekly report from Pubic Health England
https://www.gov.uk/government/publications/covid-19-vaccine-surveillance-report

Good news generally.
AZ is 94% effective at reducing deaths in over 65s.

Interestingly, one dose of Moderna is slightly better than Pfizer in under 40s, so good for those who got Moderna recently, but makes it more regrettable that the Irish government missed out on additional Moderna.

On Curevac, it might be useful for people who already had Covid or as a booster shot for someone who already received another vaccine and a good use of any capacity.

Skygord · 01-07-2021 04:32PM

eoinbn wrote: »

Someone did report that here.

I think it was me.

This says there's 'some' finished stick, but not 100M

https://nuernberger-blatt.de/2021/04/tuebinger-oberbuergermeister-palmer-fordert-notfallzulassung-fuer-curevac-impfstoff-99407/

Wolf359f · 01-07-2021 04:38PM

Charles Babbage wrote: »

Weekly report from Pubic Health England
https://www.gov.uk/government/publications/covid-19-vaccine-surveillance-report

Good news generally.
AZ is 94% effective at reducing deaths in over 65s.

Interestingly, one dose of Moderna is slightly better than Pfizer in under 40s, so good for those who got Moderna recently, but makes it more regrettable that the Irish government missed out on additional Moderna.

On Curevac, it might be useful for people who already had Covid or as a booster shot for someone who already received another vaccine and a good use of any capacity.

The CI on moderna are quite hight though.
I think moderna also had a slightly higher efficacy on vanilla covid.

Goldengirl · 01-07-2021 04:45PM

Wolf359f wrote: »

The CI on moderna are quite hight though.
I think moderna also had a slightly higher efficacy on vanilla covid.

While reactions aren't life threatening and are somewhat rare, some very nasty skin reactions with Moderna.
So much so that " Moderna arm" is part of the ER vocabulary now.

ACitizenErased · 01-07-2021 04:45PM

That PHE report is tremendous.
My favourite point from it:
"PHE estimates to 13 June 2021 based on the direct effect of vaccination and vaccine coverage rates, are that around 44,500 hospitalisations have been prevented in those aged 65 years and over in England (approximately 6,000 admissions in those aged 65 to 74, 17,200 in those aged 75 to 84, and 21,300 in those aged 85 and over) as a result of the vaccination programme (Figure 5). There is increasing evidence that vaccines prevent infection and transmission. The indirect effects of the vaccination programme will not be incorporated in this analysis, therefore the figure of 44,500 hospitalisations averted is likely to be an underestimate."

duffman13 · 01-07-2021 04:53PM

Charles Babbage wrote: »

Weekly report from Pubic Health England
https://www.gov.uk/government/publications/covid-19-vaccine-surveillance-report

Good news generally.
AZ is 94% effective at reducing deaths in over 65s.

Interestingly, one dose of Moderna is slightly better than Pfizer in under 40s, so good for those who got Moderna recently, but makes it more regrettable that the Irish government missed out on additional Moderna.

On Curevac, it might be useful for people who already had Covid or as a booster shot for someone who already received another vaccine and a good use of any capacity.

Some good stuff in there
Almost 15% of population with antibodies from infection

Vaccine effectiveness weaker at preventing symptomatic disease in Delta than Alpha (79%v89%)

Vaccine more effective in preventing hospitalisations with Delta over Alpha (96%v93%)

The UK dont have as good vaccine uptake in the older age demographics as we do (Only a small 2-3% diff generally)

Significant drop off in hospitalisations in over 65s

27,200 fewer deaths due to vaccines

Vaccine Megathread No 2 - Read OP before posting

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