What exactly is happening with AstraZeneca?

Wolf359f · 01-05-2021 11:31PM

Melanchthon wrote: »

https://globalgapa.org/index.php/2020/03/27/gapc-2020-in-dublin-ireland/

https://gript.ie/harris-gapc-covid-19/

Gript can put people off so included the video that's most relevant to this where he is questioned about why he is attending the event

https://youtu.be/dmZydRIKhxM?t=709

Rest of your post is pretty reasonable point.

Anyway my relevant to the thread question. I presume there is on going population study of impact of the Indian variant on Astra Zeneca effectiveness but it hasn't been reported yet?

Since these questions tend to bring out the people that hate astra zeneca due to other political reasons and will say "good thing we are using Pfizer unlike those granny killing Tories" I will quote the Israelis. Note the underlined part

"The impression is that the Pfizer vaccine has efficacy against it, albeit a reduced efficacy," the ministry's director-general, Hezi Levy, told Kan public radio

Conference on Alcohol, no wonder the CMO wanted it going ahead, was certain rumblings he sees alcohol as a serious issue.

Anyways, as India are widespread using AZ, they will be able to gather data on infections in unvaccinated people vs vaccinated with AZ and they will be able to report it. Reduced Efficiency ≠ ineffective vaccine.
All approved vaccines here have a crazy high efficiency rate, higher than people expected, it's not just mRNA that were high.
AZ, Pfizer and Moderna real world data shows high efficiency, I'd expect J&J should follow the same trend.

Melanchthon · 02-05-2021 08:52AM

correct horse battery staple wrote: »

https://theintercept.com/2021/05/01/covid-brazil-deaths-bolsonaro-investigation/

BRAZIL SEEKS TO HOLD BOLSONARO ACCOUNTABLE FOR MORE THAN 400,000 COVID-19 DEATHS

AVOID ACCOUNTABILITY, attract attention through outrage, win reelection. This has been the holy trinity of Brazilian President Jair Bolsonaro’s decadeslong career in politics.

——-

Replace Bolsonaro with Boris and 400000 with 130000 …

Shouldn't this thread be about Astra Zeneca / Oxford not an excuse for posters to complain about the Tories and "da Brits"

And what the hell does that have to do with Astra Zeneca

Ten of Swords · 02-05-2021 01:06PM

correct horse battery staple do not post in this thread again

Everyone else, back on topic please

Melanchthon · 07-05-2021 04:50PM

https://www.bbc.co.uk/news/health-57021738

So it's over 40's now in the UK. Not that unexpected news really particularly as dropping case numbers in the UK mean the risk reward calculation has changed.

brickster69 · 07-05-2021 04:56PM

Melanchthon wrote: »

https://www.bbc.co.uk/news/health-57021738

So it's over 40's now in the UK. Not that unexpected news really particularly as dropping case numbers in the UK mean the risk reward calculation has changed.

Novavax approval imminent also. 20 million doses are made and ready to be deployed

odyssey06 · 07-05-2021 05:00PM

brickster69 wrote: »

Novavax approval imminent also. 20 million doses are made and ready to be deployed

Isn't that a similar type of vaccine to AZ and therefore likely to have the a clot risk issue?

is_that_so · 07-05-2021 05:08PM

odyssey06 wrote: »

Isn't that a similar type of vaccine to AZ and therefore likely to have the a clot risk issue?

It's a protein based vaccine.

https://ir.novavax.com/news-releases/news-release-details/novavax-covid-19-vaccine-demonstrates-893-efficacy-uk-phase-3

Melanchthon · 07-05-2021 05:12PM

odyssey06 wrote: »

Isn't that a similar type of vaccine to AZ and therefore likely to have the a clot risk issue?

The Novavax jab is a new kind of vaccine - instead of injecting the genetic material for the spike protein, this is the protein itself.

It combines an engineered protein from the virus that causes COVID-19 with a plant-based ingredient to help generate a stronger immune response. If the body encounters coronavirus in the future, the body is primed to fend it off.

news.sky.com/story/covid-19-how-do-the-pfizer-oxford-moderna-novavax-and-johnson-johnson-coronavirus-vaccines-compare-12202329

brickster69 · 07-05-2021 06:41PM

Patent waiver not looking good

https://www.reuters.com/world/europe/eu-split-vaccine-waiver-idea-unlikely-take-clear-stance-2021-05-07/

Xpro · 07-05-2021 06:46PM

Wolf359f wrote: »

All approved vaccines here have a crazy high efficiency rate, higher than people expected, it's not just mRNA that were high.
AZ, Pfizer and Moderna real world data shows high efficiency, I'd expect J&J should follow the same trend.

High efficiency rate? And how is that? By not testing any longer?

Same as Irish nursing homes, as soon as they got everyone vaccinated they stopped testing people for covid.

And then when they had an alleged covid case ( a positive nurse) they tested everyone and 8 out 10 was positive for Covid. So they decided to re test and bingo, now everyone was negative. And then Leo comes and says those things happen and false positives are common. Only when is convenient for them to say that lol.

Wolf359f · 07-05-2021 06:55PM

Xpro wrote: »

High efficiency rate? And how is that? By not testing any longer?

Same as Irish nursing homes, as soon as they got everyone vaccinated they stopped testing people for covid.

And then when they had an alleged covid case ( a positive nurse) they tested everyone and 8 out 10 was positive for Covid. So they decided to re test and bingo, now everyone was negative. And then Leo comes and says those things happen and false positives are common. Only when is convenient for them to say that lol.

Look at all the international data relating to serious illness in vaccinated people. Not everything revolves around Ireland.

They are still doing serial testing in nursing homes.
Last round started April 26th. 19 cases out of 17,550. Doesn't that not show you how effective vaccines are.
I would be curious to know how many of the 19 cases were vaccinated and if there was more than 1 case per nursing home etc...

But yeah... Vaccines are not effective and we hide that information by not testing. Weirdest conspiracy theory I've heard yet.

robinph · 08-05-2021 05:05AM

What type of test were they using when those 19 positives appeared?

With a very low number of cases in the wild, if they were using the Lateral Flow Tests then will have been a good portion of them showing false positive. Have seen varying numbers of up to 50 false results per 10,000 tests.

Agent Avenger · 08-05-2021 09:22AM

A person in my nan's nursing home tested positive in the past month however that was because they were a new resident of the home and had just been released from hospital and had not been fully vaccinated as far as I'm aware. They were being kept in isolation for the two weeks and there was no spread to other residents. I'd say other positive cases in nursing homes may have come from a similar situation.

is_that_so · 09-05-2021 07:45AM

robinph wrote: »

What type of test were they using when those 19 positives appeared?

With a very low number of cases in the wild, if they were using the Lateral Flow Tests then will have been a good portion of them showing false positive. Have seen varying numbers of up to 50 false results per 10,000 tests.

In nursing homes it would be PCR but they are now planning to phase out that serial testing programme.

volchitsa · 09-05-2021 07:48AM

is_that_so wrote: »

In nursing homes it would be PCR but they are now planning to phase out that serial testing programme.

Half measures are why this whole thing got to the level it did. It's madness to stop testing so soon.
Testing is far more useful when numbers are low, because it's feasible to isolate the small number of positives. That wasn't always possible at the height of the wave, there were just so many, and testing itself does nothing. It only allows you to identify who needs to be treated/isolated.

is_that_so · 09-05-2021 07:59AM

volchitsa wrote: »

Half measures are why this whole thing got to the level it did. It's madness to stop testing so soon.
Testing is far more useful when numbers are low, because it's feasible to isolate the small number of positives. That wasn't always possible at the height of the wave, there were just so many, and testing itself does nothing. It only allows you to identify who needs to be treated/isolated.

Deaths have been virtually been eliminated is the CMO quote and vaccinations have done their job.

Donald Trump · 09-05-2021 11:44AM

EU not renewing orders for AZ

https://www.rte.ie/news/world/2021/0509/1217846-europe-vaccines/

is_that_so · 09-05-2021 02:36PM

Donald Trump wrote: »

EU not renewing orders for AZ

https://www.rte.ie/news/world/2021/0509/1217846-europe-vaccines/

Didn't think it was quite so soon, same for J&J when that contract finishes at the end of the year.

tina1040 · 15-05-2021 10:03AM

What's the latest on 2nd dose of Astrazenica? Have people who got the first dose 3 months ago been called back?

trashcan · 16-05-2021 08:19PM

tina1040 wrote: »

What's the latest on 2nd dose of Astrazenica? Have people who got the first dose 3 months ago been called back?

I got my first dose today and was told it will be 16 weeks until the second. It’s 12 weeks for the over sixties seemingly.

Igotadose · 17-05-2021 09:05AM

trashcan wrote: »

I got my first dose today and was told it will be 16 weeks until the second. It’s 12 weeks for the over sixties seemingly.

Yep, 12 weeks, can personally confirm that.

Rumor has it the UK is pulling in that date to 8 weeks to stem the Indian variant tide.

robinph · 17-05-2021 09:17AM

Igotadose wrote: »

Yep, 12 weeks, can personally confirm that.

Rumor has it the UK is pulling in that date to 8 weeks to stem the Indian variant tide.

They released a statement that clinically vulnerable and those over 50 would be getting their 2nd jabs sooner... Only thing is the people in those groups have already had their 2nd jabs last week or are due it in the next two weeks anyway, mine is due in 8 days.

It was a pointless statement to make it sound like they are doing something in response, but without actually having to do anything. It would take longer to rearrange the appointments than to just wait another week and a bit and most of those groups will have had their second dose. I'm sure a couple of people will have been brought in sooner by their GPs, but most having booked via the main NHS vaccine website don't have any way to rebook or be contacted to get the appointment moved... I've checked.

astrofool · 17-05-2021 02:22PM

robinph wrote: »

They released a statement that clinically vulnerable and those over 50 would be getting their 2nd jabs sooner... Only thing is the people in those groups have already had their 2nd jabs last week or are due it in the next two weeks anyway, mine is due in 8 days.

It was a pointless statement to make it sound like they are doing something in response, but without actually having to do anything. It would take longer to rearrange the appointments than to just wait another week and a bit and most of those groups will have had their second dose. I'm sure a couple of people will have been brought in sooner by their GPs, but most having booked via the main NHS vaccine website don't have any way to rebook or be contacted to get the appointment moved... I've checked.

It's actually been a really good way to increase vaccine uptake, I wonder if we'll have a similar scare here in July/August to get the numbers up, or maybe I'm being cynical

Wompa1 · 18-05-2021 02:50PM

Igotadose wrote: »

Yep, 12 weeks, can personally confirm that.

Rumor has it the UK is pulling in that date to 8 weeks to stem the Indian variant tide.

The only people I know who got AZ in Ireland, all told it's 12 weeks for dose 2. Including some frontline worked in their 30s. Only country I have heard about doing 16 weeks for AZ is the UK and it didn't seem to be a planned strategy, just something they pivoted to when the AZ supply slowed.

trashcan · 18-05-2021 04:09PM

Wompa1 wrote: »

The only people I know who got AZ in Ireland, all told it's 12 weeks for dose 2. Including some frontline worked in their 30s. Only country I have heard about doing 16 weeks for AZ is the UK and it didn't seem to be a planned strategy, just something they pivoted to when the AZ supply slowed.

Well I was definitely told on Sunday that the second dose would be 16 weeks.

Call me Al · 18-05-2021 06:08PM

trashcan wrote: »

Well I was definitely told on Sunday that the second dose would be 16 weeks.

Guidance on the HSE website says 16 weeks for those under 60 with no underlying conditions.

deeperlearning · 18-05-2021 06:43PM

Wompa1 wrote: »

The only people I know who got AZ in Ireland, all told it's 12 weeks for dose 2. Including some frontline worked in their 30s. Only country I have heard about doing 16 weeks for AZ is the UK and it didn't seem to be a planned strategy, just something they pivoted to when the AZ supply slowed.

Spain have also extended the AstraZeneca interval to 16 weeks for under 60s.

brickster69 · 18-05-2021 07:01PM

deeperlearning wrote: »

Spain have also extended the AstraZeneca interval to 16 weeks for under 60s.

Canada the same

brickster69 · 19-05-2021 02:34PM

Malawi destroys 20K does that have expired. Fair enough but why let them expire or at least send them somewhere else in time.

https://twitter.com/BBCAfrica/status/1394974870145019906

is_that_so · 21-05-2021 09:08AM

Now planned to be reduced to 12 weeks from May 24th.

https://www.irishtimes.com/news/health/gap-between-astrazeneca-doses-to-be-reduced-to-12-weeks-1.4570846

Also Reid has said

AstraZeneca "is not a choice vaccine" as it will be used for second doses so a strong signal that it will have little part to play down the line apart from that.

What exactly is happening with AstraZeneca?

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