What exactly is happening with AstraZeneca?

brickster69 · 14-04-2021 03:16PM

During the announcement in Denmark a woman in her 40's collapsed when she heard the word Astra Zeneca today. health authorites are advising that the word should not be spoken unless wearing a mask.

https://twitter.com/thorsome1/status/1382346818269290497

14-04-2021 03:21PM

brickster69 wrote: »

During the announcement in Denmark a woman in her 40's collapsed when she heard the word Astra Zeneca today. health authorites are advising that the word should not be spoken unless wearing a mask.

https://twitter.com/thorsome1/status/1382346818269290497

No Teresa, Trump lost you utter lunatic.

Melanchthon · 14-04-2021 03:54PM

[URLhttps://www.theguardian.com/society/2021/apr/14/single-pfizer-or-astrazeneca-dose-produces-strong-antibody-response-study-shows[/URL]

Interesting to see the stronger T cell response with Astra Zeneca (only 30%) though.
Has there been any real world trials of Pfizer done yet against the south African variants? (Sorry if this posted not sure if post made last night actually worked)

padjocollins · 14-04-2021 07:21PM

https://www.theguardian.com/society/2021/apr/13/how-uk-doctor-marie-scully-blood-clotting-link-astrazeneca-covid-jab-university-college-london-hospital

14-04-2021 09:34PM

Fauci said recently, the blood clot issues seemed very similar in j&j and az. All people who died in usa were women. Most cases in eu have been women including the one case in ireland.

Surely there is extra risk factor for women getting az.

Maybe in time these vaccines could be given to men only.

lausp · 14-04-2021 10:14PM

My understanding was that when the stats were normalised, that it was found these vaccines have been administered to far more women than men and hence there was no higher risk in women vs men.

Certainly was mentioned on newstalk this morning.

Melanchthon · 15-04-2021 05:55AM

lausp wrote: »

My understanding was that when the stats were normalised, that it was found these vaccines have been administered to far more women than men and hence there was no higher risk in women vs men.

Certainly was mentioned on newstalk this morning.

That makes sense for Astra Zeneca as an explanation, due to health care workers in the EU/UK and so on.

For Johnson and Johnson though that doesn't make sense, medical related staff have been done ages ago in the USA. It should be a fairly even uptake by gender.

dogbert27 · 15-04-2021 06:36AM

brickster69 wrote: »

During the announcement in Denmark a woman in her 40's collapsed when she heard the word Astra Zeneca today. health authorites are advising that the word should not be spoken unless wearing a mask.

https://twitter.com/thorsome1/status/1382346818269290497

You really have to let go of the nationalistic feeling towards Astra Zeneca.

To mock a woman collapsing with a snide dig relating to Astra Zeneca shows the Brexit attitude towards other EU countries.

If Denmark chooses to stop using Astra Zeneca as a company that's their choice as there are other vaccines to use.

Don't get upset about it. They're not stopping using it because it's a "British" vaccine. :rolleyes:

Zipppy · 15-04-2021 07:29AM

Do we know yet what is happening to the under 60s who were scheduled a AZ vaccine this week but that was cancelled?

is_that_so · 15-04-2021 07:31AM

Zipppy wrote: »

Do we know yet what is happening to the under 60s who were scheduled a AZ vaccine this week but that was cancelled?

They will be rescheduled, most probably with Pfizer, unless it's a second jab.

Zipppy · 15-04-2021 07:36AM

is_that_so wrote: »

They will be rescheduled, most probably with Pfizer, unless it's a second jab.

Yes, I heard that on news, but it sounded like 65-69 would be more of priority for now...surely that cant be the case and appointments would be quickly rescheduled?

is_that_so · 15-04-2021 07:40AM

Zipppy wrote: »

Yes, I heard that on news, but it sounded like 65-69 would be more of priority for now...surely that cant be the case and appointments would be quickly rescheduled?

The 65-69 age group can book on the portal from today. Having AZ almost exclusively for the 60-69s could accelerate their shots. Hard to say what'll happen elsewhere although we are still doing about 6 groups anyway.

15-04-2021 08:14AM

65-69 are only starting to register now. Donnelly said anyone registering today should get a text by the end of next week and an appointment shortly after. The focus for the next week will still be cohort 4 and finishing the over 70s.

Enzokk · 15-04-2021 08:22AM

Zipppy wrote: »

Yes, I heard that on news, but it sounded like 65-69 would be more of priority for now...surely that cant be the case and appointments would be quickly rescheduled?

It is about allocating resources, due to the decision to stop AZ for those under 60 it means there will be a delay for those people to get their vaccination that were due one. Hopefully it will not be a long delay but people will still get vaccinated that were due to get one. The registration portal for today is for the 69 year olds only, then the 68 and 69 year olds tomorrow, then the 67, 68 and 69 year old's Saturday, etc. Remember the Pfizer and Moderna vaccines would have been allocated to people already so finding spots for those that had to miss theirs will take time as well. It's not like the government is sitting on millions of vaccines of Pfizer and not giving them out, while they may fail in execution it is not for the lack of trying to get a workable system in place.

titan18 · 15-04-2021 09:11AM

Are they going to use AZ on the over 70s to speed that up. Not sure what age group they're on with Pfizer there but I'd imagine there's still a bit to go.

Elessar · 15-04-2021 09:13AM

Can anyone post some links around the AZ efficacy against the Brazilian and/or South African variants?

I am trying to reassure someone 60+ who does not want the AZ vaccine and is convinced that its terrible against the variants, and is fearful of the clotting issue, despite their doctor saying they would be better off with it.

forumdedum · 15-04-2021 09:16AM

Elessar wrote: »

Can anyone post some links around the AZ efficacy against the Brazilian and/or South African variants?

I am trying to reassure someone 60+ who does not want the AZ vaccine and is convinced that its terrible against the variants, and is fearful of the clotting issue, despite their doctor saying they would be better off with it.

Twice on TV this week Kingston Mills said 10%. I don't have any other links

robinph · 15-04-2021 09:28AM

Elessar wrote: »

Can anyone post some links around the AZ efficacy against the Brazilian and/or South African variants?

I am trying to reassure someone 60+ who does not want the AZ vaccine and is convinced that its terrible against the variants, and is fearful of the clotting issue, despite their doctor saying they would be better off with it.

Unless they are moving to Brazil or South Africa in the next 6 months it's irrelevant. The only variants to be concerned about at the moment are the ones circulating locally, and the Brazil and South African ones are barely even registering in the numbers compared to the UK/Kent one.

If the others become a big factor next year then the booster vaccine they get next year will be updated to work better against those variants. Worry about today, today and worry about next year, next year.

Banana Republic 1 · 15-04-2021 09:33AM

Doctor Jimbob wrote: »

Varadkar said on the radio this morning that AZ would be given to all over 60s, not just 60-69.

Varadkar s stance of “ I’d jump at an ax vaccine”
It reminds me of a Krusty the clown sketch on the Simpson’s. Krusty ate some Krusty,Os cereal to prove it was not dangerous. After taking a spoonful he fell on the floor riding in agony.

josip · 15-04-2021 09:34AM

Doctor Jimbob wrote: »

Varadkar said on the radio this morning that AZ would be given to all over 60s, not just 60-69.

What percentage of the over 70s haven't yet received a first dose of Pfizer?
I'd have thought it was so low as to be insignificant compared to the entire 60-69 cohort.

Stark · 15-04-2021 09:36AM

josip wrote: »

What percentage of the over 70s haven't yet received a first dose of Pfizer?
I'd have thought it was so low as to be insignificant compared to the entire 60-69 cohort.

Still quite a few left but they're moving through them rapidly. Hopefully that decision gets implemented soon.

I've seen an estimate of 475k for cohort 3, not sure how accurate that is or is it a rough estimate taken from the census that probably includes most people from cohort 1 . 325k first doses given so far. So if the numbers are accurate, that's potentially 300k AZ vs Pfizer doses that can be "saved".

FileNotFound · 15-04-2021 09:44AM

Doctor Jimbob wrote: »

No idea. Anecdotally, my 70 year old mum is getting her vaccine next week, so there must be a few at least.

Same with my 71 year old dad, guess they will only have first shots done in a couple of weeks or so.

The mother is in the 65-69 bracket, wonder given the potential excess of AZ vaccine we will have will they reduce the time between doses for it? Was it not originally meant to be 6 weeks or something similar?

josip · 15-04-2021 09:47AM

FileNotFound wrote: »

Same with my 71 year old dad, guess they will only have first shots done in a couple of weeks or so.

The mother is in the 65-69 bracket, wonder given the potential excess of AZ vaccine we will have will they reduce the time between doses for it? Was it not originally meant to be 6 weeks or something similar?

AZ tried a shorter dosing interval initially but the immune response was too poor, so they lengthened the interval to 12 weeks to get a better response.

FileNotFound · 15-04-2021 09:49AM

josip wrote: »

AZ tried a shorter dosing interval initially but the immune response was too poor, so they lengthened the interval to 12 weeks to get a better response.

Thats fair enough, I thought all the trials had a shorter dosing interval and it was a gov based and post release study that lengthened it to 12 weeks.

In that case it will be 4 more months of sat in the house for the parents.

brickster69 · 15-04-2021 09:52AM

Doctor Jimbob wrote: »

Varadkar said on the radio this morning that AZ would be given to all over 60s, not just 60-69.

Hindsight is a wonderful thing and the decision not to give AZ to older people in the first place never cost Ireland a great loss, but it should of been done in the first place. Impossible to dispute now.

josip · 15-04-2021 09:52AM

FileNotFound wrote: »

Thats fair enough, I thought all the trials had a shorter dosing interval and it was a gov based and post release study that lengthened it to 12 weeks.

In that case it will be 4 more months of sat in the house for the parents.

I think it's only 16 weeks for people under 60 with moderate risk who have already received their first dose.
It's 12 weeks for the 60-69 I thought?

Those aged 60 and older should receive their second dose 12 weeks later as scheduled.

Those aged under 60 years with a very high risk or high-risk medical condition should receive their second dose 12 weeks later as scheduled.

Those aged under 60 years without a very high risk or high-risk medical condition should have the scheduled interval between doses extended to 16 weeks to allow further assessment of the benefits and risks as more evidence becomes available.

titan18 · 15-04-2021 09:57AM

Doctor Jimbob wrote: »

Varadkar said on the radio this morning that AZ would be given to all over 60s, not just 60-69.

Ya, haven't heard of any over 70 getting it, so hopefully they will. Might assure some 60-69 year olds then if it's just not them.

deeperlearning · 15-04-2021 10:08AM

brickster69 wrote: »

Hindsight is a wonderful thing and the decision not to give AZ to older people in the first place never cost Ireland a great loss, but it should of been done in the first place. Impossible to dispute now.

Yeah, they 'should of' (sic).

The number of pontificating illiterates on this thread is bizarre.

Sierra 117 · 15-04-2021 10:51AM

Has there been any furhter word on how AZ works against the South African variant? I know it doesn't prevent mild covid but apparently it should still protect against severe covid?

Widescreen · 15-04-2021 10:55AM

titan18 wrote: »

Ya, haven't heard of any over 70 getting it, so hopefully they will. Might assure some 60-69 year olds then if it's just not them.

I assume all politicians in that cohort 60-69 will be getting AZ, if they don't, unless for some underlying reason, the media should be all over it!

What exactly is happening with AstraZeneca?

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