Vaccine Megathread - See OP for threadbans

lbj666 · 14-04-2021 11:45AM

Micky 32 wrote: »

https://twitter.com/laoneill111/status/1382259410601410562?s=21

Seasonal affects and getting to the bottom of the wave they had while the vacines were being rolled out are contributing to this along with segregation measures (not the geo political type for once) , but its still an amazing result for just 60% of the population jabbed. They are struggling get more supply to finish everything off by the sounds of it , so it will be curious to see if this is maintained.

Le Bruise · 14-04-2021 11:54AM

Micky 32 wrote: »

https://twitter.com/laoneill111/status/1382259410601410562?s=21

Dare we dream that herd immunity is met at 60% rather than 75/80%??

is_that_so · 14-04-2021 11:55AM

Le Bruise wrote: »

Dare we dream that herd immunity is met at 60% rather than 75/80%??

We're a long way from any of those numbers!

14-04-2021 11:55AM

ACitizenErased wrote: »

Right, you know better.

Exact wording from joint FDA/CDC statement

As of April 12, more than 6.8 million doses of the Johnson & Johnson (Janssen) vaccine have been administered in the U.S. CDC and FDA are reviewing data involving six reported U.S. cases of a rare and severe type of blood clot in individuals after receiving the J&J vaccine. In these cases, a type of blood clot called cerebral venous sinus thrombosis (CVST) was seen in combination with low levels of blood platelets (thrombocytopenia). All six cases occurred among women between the ages of 18 and 48, and symptoms occurred 6 to 13 days after vaccination. Treatment of this specific type of blood clot is different from the treatment that might typically be administered. Usually, an anticoagulant drug called heparin is used to treat blood clots. In this setting, administration of heparin may be dangerous, and alternative treatments need to be given.

No where does it say there are definitely only 6 cases from the 6.8 million doses. For one thing, up to yesterday they were vaccinating large numbers every day, so many of the 6.8 million would have been jabbed in the past 13 days. All reports would not have been compiled by yesterday either.
I dont believe its a massive issue, but it cannot be concluded that there are only 6 cases form all 6.8million doses. May turn out to be 8 10, 12 or even 4 . Dont know yet.

What we do know is once awareness of the potential condition with the AZ vaccine was raised more cases were identified.

In theory though, the J&J vaccine uses a human Adenoviros that it is likely most of us have been previously exposed to. The AZ is a Chimpanzee virus that we haven't - I wonder could this be why the AZ has more adverse immune responses?

Hmmzis · 14-04-2021 11:55AM

Some pre-clinical data on the booster shots from Moderna:

https://www.biorxiv.org/content/10.1101/2021.04.13.439482v1.full.pdf+html

They work well, even the original one works well. The B.1.351 booster works best if primed with the current vaccine, on its own it's less broad than the current one. The multivalent shot seems to work well across all variants.

Given these very preliminary findings (in mice) I guess the best two options might be:

1. Give the multivalent shot to all new vaccinees (good in high prevalence scenarios)
2. Prime with current vaccine, boost later with the B.1.351 version if deemed necessary (better use of existing vaccine doses if prevalence is low).

Le Bruise · 14-04-2021 11:56AM

is_that_so wrote: »

We're a long way from any of those numbers!

I know that....but we'd reach 60% a hell of a lot quicker than 80%

MerlinSouthDub · 14-04-2021 11:57AM

Good news - Pfizer/Biontech to beat EU Q2 delivery target! No specifics on much they might beat the target by, but good to hear something positive.

https://www.bloombergquint.com/business/pfizer-biontech-on-track-to-beat-second-quarter-eu-vaccine-goal

ACitizenErased · 14-04-2021 11:57AM

Le Bruise wrote: »

Dare we dream that herd immunity is met at 60% rather than 75/80%??

Israel's assumption is 15% infected + 60% vaccinated = ~75% immune

SJFly · 14-04-2021 11:58AM

It will be very interesting to watch UK figures compared to Israel, with the different mix of vaccines. Of course there are lots of other variables, be we can certainly learn a lot from the counties coming out of this ahead of us.

ACitizenErased · 14-04-2021 11:58AM

MerlinSouthDub wrote: »

Good news - Pfizer/Biontech to beat EU Q2 delivery target! No specifics on much they might beat the target by, but good to hear something positive.

https://www.bloombergquint.com/business/pfizer-biontech-on-track-to-beat-second-quarter-eu-vaccine-goal

Fantastic. Was expecting this because they announced it in the US yesterday.

Le Bruise · 14-04-2021 11:58AM

MerlinSouthDub wrote: »

Good news - Pfizer/Biontech to beat EU Q2 delivery target! No specifics on much they might beat the target by, but good to hear something positive.

https://www.bloombergquint.com/business/pfizer-biontech-on-track-to-beat-second-quarter-eu-vaccine-goal

Pfizer is the gift that keeps on giving

is_that_so · 14-04-2021 12:00PM

MerlinSouthDub wrote: »

Good news - Pfizer/Biontech to beat EU Q2 delivery target! No specifics on much they might beat the target by, but good to hear something positive.

https://www.bloombergquint.com/business/pfizer-biontech-on-track-to-beat-second-quarter-eu-vaccine-goal

Interesting comment in there on J&J pause by the FDA - a matter of days!

14-04-2021 12:01PM

Le Bruise wrote: »

Dare we dream that herd immunity is met at 60% rather than 75/80%??

There are also those previously infected. Would be overlap between the vaccinated and previously infected, but almost 10% of the population have confirmed previous infection, actual could be double

ACitizenErased · 14-04-2021 12:01PM

We're expecting 2,128,000 Pfizer doses this quarter and now they are suggesting exceeding this 'significantly'. Even 10-20% extra (like they are exceeding in the US) would be incredible.

is_that_so · 14-04-2021 12:03PM

ACitizenErased wrote: »

We're expecting 2,128,000 Pfizer doses this quarter and now they are suggesting exceeding this 'significantly'. Even 10-20% extra (like they are exceeding in the US) would be incredible.

A learning moment there for AZ, underpromise and massively overdeliver!

1huge1 · 14-04-2021 12:04PM

Deleted User wrote: »

There are also those previously infected. Would be overlap between the vaccinated and previously infected, but almost 10% of the population have confirmed previous infection, actual could be double

True, but there hasn't been any exemption for people who had previously had covid from getting the vaccine, so makes it more difficult to get an exact picture, but fair to say it is less than the c.75% previously predicted which can only be good news.

ACitizenErased · 14-04-2021 12:04PM

Danish media reporting Denmark to stop using AstraZeneca vaccine entirely

funnydoggy · 14-04-2021 12:05PM

ACitizenErased wrote: »

Danish media reporting Denmark to stop using AstraZeneca vaccine entirely

Feck sake :rolleyes:

noplacehere · 14-04-2021 12:07PM

ACitizenErased wrote: »

Danish media reporting Denmark to stop using AstraZeneca vaccine entirely

Ah Jesus. And what about people part ways through their dose? This is a mess

El Weirdo · 14-04-2021 12:08PM

afatbollix wrote: »

No idea if this has been posted as can't be arsed looking at the same thing over and over saying that vaccines are ****e since this new thread started.

https://www.theguardian.com/society/2021/apr/13/how-uk-doctor-marie-scully-blood-clotting-link-astrazeneca-covid-jab-university-college-london-hospital

They have found a way of finding out what the problem is with the cloting. They have a test to detect it already and have a way of treating it if detected early.

Basically, old-school treatments that were the norm were what was killing these people. The treatments caused more problems than solved. They even have a worldwide what's app group to talk about it and treatments.

Science at work, This took weeks to sort instead of years.

I wonder if it's filled with pictures of black lads with huge wangs?

lbj666 · 14-04-2021 12:09PM

Le Bruise wrote: »

Dare we dream that herd immunity is met at 60% rather than 75/80%??

Given the mix of vacines here I wouldnt bank on 60%, the signs were appearing before this percentage but you must remember that israel hasnt abandoned totally all other mitigations for transmission yet. Herd immunity is really when you can allow a full stadiums, full coppers or a big filthy music festival to happen without anything to worry about.

stephenjmcd · 14-04-2021 12:15PM

is_that_so wrote: »

Interesting comment in there on J&J pause by the FDA - a matter of days!

Yeah they said it during the briefing yesterday when asked how long they expected it for

dominatinMC · 14-04-2021 12:16PM

MerlinSouthDub wrote: »

Good news - Pfizer/Biontech to beat EU Q2 delivery target! No specifics on much they might beat the target by, but good to hear something positive.

https://www.bloombergquint.com/business/pfizer-biontech-on-track-to-beat-second-quarter-eu-vaccine-goal

I presume RTE will be leading with this story today then? :rolleyes:

Danzy · 14-04-2021 12:17PM

If they can reduce cases to 50 a day and a death or two, then that's near enough to herd immunity.

Living with the consequences of it, will come before 80% vaccination.

It'll be treated like a bad flu, which kills steadily each year.

Danzy · 14-04-2021 12:19PM

ACitizenErased wrote: »

Danish media reporting Denmark to stop using AstraZeneca vaccine entirely

We should buy the vaccines that they will not use.

stephenjmcd · 14-04-2021 12:20PM

ACitizenErased wrote: »

Danish media reporting Denmark to stop using AstraZeneca vaccine entirely

I'm sure they'll have no shortage of other EU countries looking to take them off their hands

astrofool · 14-04-2021 12:25PM

rm212 wrote: »

This kind of stuff constantly coming out makes the public confidence in the vaccines (particularly AZ and J&J) drop, second by second almost at this stage. It is 100% clear now that Pfizer and Moderna are considered by health professionals (EMA, FDA etc) to be the best, most effective and most safe vaccines by far. The EU should really have made larger optional orders with all vaccine manufacturers, so that we could just pick up the best couple and decline the rest when the results came out. Hindsight is 20/20, I suppose

That's what we did, we have enough vaccines ordered to vaccinate everyone multiple times, it's not like we could have ordered 900M doses of Pfizer and be done, they don't have that many manufactured, so the rollout needs a variety of all approved vaccines.

The announcement around future contracts is for boosters after the initial rollout (if they're even needed), and it's a signal that Europe is going to fund mRNA vaccines going forward, so we'll see lots of capacity come online for mRNA vaccines to handle that (I wonder will we see an mRNA flu jab soon-ish).

J&J and AZ are still an integral part of the initial rollout (as are Valneva, Curevac and maybe Novavax).

BigMo1 · 14-04-2021 12:27PM

Danzy wrote: »

We should buy the vaccines that they will not use.

I'd say we're much more likely to follow suit in cancelling usage than buy unused doses.

astrofool · 14-04-2021 12:28PM

ACitizenErased wrote: »

We're expecting 2,128,000 Pfizer doses this quarter and now they are suggesting exceeding this 'significantly'. Even 10-20% extra (like they are exceeding in the US) would be incredible.

Don't forget that they were already exceeding supply this quarter.

SJFly · 14-04-2021 12:30PM

On the plus side, after Denmark's move, no-one can say we are the most conservative anymore.

Vaccine Megathread - See OP for threadbans

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