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COVID-19: Vaccine/antidote and testing procedures Megathread [Mod Warning - Post #1]

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  • #6512
    Breaston Plants
    Registered Users, Registered Users 2 Posts: 770 ✭✭✭Breaston Plants


    JTMan wrote: »
    Moncef Slaoui, chief scientific adviser of the US government’s Operation Warp Speed programme has said:
    - Vaccinations likely to begin 11 December or 12 December.
    - US to vaccinate 20 million people in December and another 30 million per month thereafter.
    - Normality to resume by May 2021.

    https://www.google.com/amp/s/amp.theguardian.com/world/2020/nov/22/us-vaccine-expert-life-could-be-back-to-normal-may

    Wow! That's absolutely fantastic news. Very positive.


  • #6513
    WoollyRedHat
    Registered Users, Registered Users 2 Posts: 10,462 ✭✭✭✭WoollyRedHat


    I reckon major universities will play an important role in vaccination distribution, plus a lot of research labs will have freezers that can store it.


  • #6514
    St.Spodo
    Registered Users, Registered Users 2 Posts: 1,027 ✭✭✭St.Spodo


    Thinking back to September time, it was touted on Irish television that a reasonable best case scenario for the country in terms of a vaccine would be that one 70% effective vaccine would be approved by spring time. It was said that this would eventually provide protection to just over half of the population towards the end of 2021. It's looking likely that we'll have two 95% effective vaccines approved by Christmas, likely another 90% effective vaccine approved early in the new year and possibly one or two more by the summer. Amid the relentless misery of the lockdown, I think many people have not quite processed that we are most likely going to see a steady march towards normality right throughout 2021.


  • #6515
    plodder
    Registered Users, Registered Users 2 Posts: 7,769 ✭✭✭plodder


    timsey tiger wrote: »
    "The efficacy was estimated only seven days (Pfizer) or 14 days (Moderna) after the last of two vaccinations."

    I didn't think it was a good article. Take this sentence as an example. If it read "The efficacy was estimated from only..." it would be accurate. It is both inaccurate and given what follows in the article seems to imply the vaccines only give short term immunity.
    Yes, it seems to imply that the trials checked on everyone seven days (or 14 days) after the second vaccination to see who had the disease and who didn't. But, they clearly didn't do that.

    I assume what he meant is that anyone who caught the disease in the one or two week window after the second shot, was just excluded from the results, which is totally reasonable as it takes time to build up the immunity.


  • #6516
    Dickie10
    Registered Users, Registered Users 2 Posts: 4,067 ✭✭✭Dickie10


    St.Spodo wrote: »
    Thinking back to September time, it was touted on Irish television that a reasonable best case scenario for the country in terms of a vaccine would be that one 70% effective vaccine would be approved by spring time. It was said that this would eventually provide protection to just over half of the population towards the end of 2021. It's looking likely that we'll have two 95% effective vaccines approved by Christmas, likely another 90% effective vaccine approved early in the new year and possibly one or two more by the summer. Amid the relentless misery of the lockdown, I think many people have not quite processed that we are most likely going to see a steady march towards normality right throughout 2021.

    Just waiting for king tony with the "were deeply concerned " about safety of these vaccines....


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  • #6517
    Micky 32
    Registered Users, Registered Users 2 Posts: 6,623 ✭✭✭Micky 32


    El Sueño wrote: »
    I don't see many "vaccines won't end the pandemic" articles anymore.

    I take it the general consensus is that vaccines will provide a return to normality in the next 12 months?


    As far as I’m concerned normality will come back in to my life once i get vaccinated along with my family. I’ll have no hesitation hopping back on a plane to visit family.


  • #6518
    JTMan
    Registered Users, Registered Users 2 Posts: 5,575 ✭✭✭JTMan


    The Telegraph are reporting that the UK regulator could give approval to the Pfizer vaccine by 27 November.

    Maybe the UK will start vaccinations before the US start on 11/12 December?

    https://twitter.com/DeItaone/status/1330600991889219585


  • #6519
    lbj666
    Registered Users, Registered Users 2 Posts: 2,027 ✭✭✭lbj666


    JTMan wrote: »
    The Telegraph are reporting that the UK regulator could give approval to the Pfizer vaccine by 27 November.

    Maybe the UK will start vaccinations before the US start on 11/12 December?

    https://twitter.com/DeItaone/status/1330600991889219585

    Better bring foward that task force meeting to Tuesday.


  • #6520
    ACitizenErased
    Registered Users, Registered Users 2 Posts: 11,750 ✭✭✭✭ACitizenErased


    JTMan wrote: »
    The Telegraph are reporting that the UK regulator could give approval to the Pfizer vaccine by 27 November.

    Maybe the UK will start vaccinations before the US start on 11/12 December?

    https://twitter.com/DeItaone/status/1330600991889219585
    If the UK are doing that then the EU EMA could be even closer...


  • #6521
    ACitizenErased
    Registered Users, Registered Users 2 Posts: 11,750 ✭✭✭✭ACitizenErased


    News circulating that the UK may approve Pfizer's vaccine by Friday. Massive news.


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  • #6522
    Russman
    Registered Users, Registered Users 2 Posts: 5,977 ✭✭✭Russman


    ACitizenErased wrote: »
    If the UK are doing that then the EU EMA could be even closer...

    Was there an announcement saying they had applied to the EMA ? I remember seeing the FDA application alright but didn’t know they had applied in the EU & UK already.


  • #6523
    ACitizenErased
    Registered Users, Registered Users 2 Posts: 11,750 ✭✭✭✭ACitizenErased


    Russman wrote: »
    Was there an announcement saying they had applied to the EMA ? I remember seeing the FDA application alright but didn’t know they had applied in the EU & UK already.
    EMA commenced rolling reviews for approval weeks ago


  • #6524
    Russman
    Registered Users, Registered Users 2 Posts: 5,977 ✭✭✭Russman


    ACitizenErased wrote: »
    EMA commenced rolling reviews for approval weeks ago

    Yeah I’d seen that alright. Think the FDA were doing that also. Just didn’t realise a formal application had been made in Europe tbh. Great news if true.


  • #6525
    [Deleted User]
    Posts: 0 ✭ [Deleted User]


    I assume the UK can start using the vaccine whenever either approval comes through.


  • #6526
    Russman
    Registered Users, Registered Users 2 Posts: 5,977 ✭✭✭Russman


    Deleted User wrote: »
    I assume the UK can start using the vaccine whenever either approval comes through.

    I’d guess so, if it’s before 31st Dec as they’d still be in the transition phase.


  • #6527
    [Deleted User]
    Posts: 0 ✭ [Deleted User]


    Russman wrote: »
    I’d guess so, if it’s before 31st Dec as they’d still be in the transition phase.

    I'm a little sceptical of the Telegraph, very biased paper. If you look at any of the right wing papers recently they've been desperately trying to spin bad Covid news as "it's not that bad, look cases only increased 14% compared with the same day last week".

    Looking at the case numbers in the last month, unfortunately the UK will be facing into December with death numbers possibly approaching 1,000 a day.

    They might be hoping pumping the positive vaccine stories will distract from the grim situation.

    In any event, hopefully we see approval by early December.


  • #6528
    Thierry12
    Closed Accounts Posts: 979 ✭✭✭Thierry12


    ACitizenErased wrote: »
    News circulating that the UK may approve Pfizer's vaccine by Friday. Massive news.

    Strange they are all taking so long anyway

    Its not as if the regulatories are testing the vaccine in vitro in a lab or anything for efficacy, safety etc?

    They are just reading through paperwork?

    What could they possibly find in the paperwork to fail it?

    Pfizer will have double checked and triple checked everything

    They might as well just sign it.


  • #6529
    billybonkers
    Registered Users, Registered Users 2 Posts: 2,293 ✭✭✭billybonkers


    Thierry12 wrote: »
    Strange they are all taking so long anyway

    Its not as if the regulatories are testing the vaccine in vitro in a lab or anything for efficacy, safety etc?

    They are just reading through paperwork?

    What could they possibly find in the paperwork to fail it?

    Pfizer will have double checked and triple checked everything

    They might as well just sign it.

    That's not how this works


  • #6530
    ACitizenErased
    Registered Users, Registered Users 2 Posts: 11,750 ✭✭✭✭ACitizenErased


    billybonkers wrote: »
    That's not how this works
    All they're doing is reviewing the paperwork and getting independent thoughts. There's no testing per se.


  • #6531
    Russman
    Registered Users, Registered Users 2 Posts: 5,977 ✭✭✭Russman


    Thierry12 wrote: »
    Strange they are all taking so long anyway

    Its not as if the regulatories are testing the vaccine in vitro in a lab or anything for efficacy, safety etc?

    They are just reading through paperwork?

    What could they possibly find in the paperwork to fail it?

    Pfizer will have double checked and triple checked everything

    They might as well just sign it.

    Always thoroughly read anything you’re putting your name to.
    Plus there’d be an element of setting a precedent for future approvals.

    In reality though, as you say, Pfizer will have checked everything.


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  • #6532
    hmmm
    Registered Users, Registered Users 2 Posts: 11,203 ✭✭✭✭hmmm


    Thierry12 wrote: »
    What could they possibly find in the paperwork to fail it?

    Pfizer will have double checked and triple checked everything

    They might as well just sign it.
    "Trust but verify" as we say. They trust the data they've been given is correct, but their job is to double-check. Apparently applications like this can run into thousands of pages so it takes time even to read it all.


  • #6533
    Gael23
    Registered Users, Registered Users 2 Posts: 12,147 ✭✭✭✭Gael23


    I’m glad to see the rollout being an aged by someone not employed within the HSE


  • #6534
    Thierry12
    Closed Accounts Posts: 979 ✭✭✭Thierry12


    ACitizenErased wrote: »
    All they're doing is reviewing the paperwork and getting independent thoughts. There's no testing per se.

    Exactly

    They can read later

    People are dieing, just put it out there

    Pfizer will have that paperwork A1


  • #6535
    billybonkers
    Registered Users, Registered Users 2 Posts: 2,293 ✭✭✭billybonkers


    ACitizenErased wrote: »
    All they're doing is reviewing the paperwork and getting independent thoughts. There's no testing per se.

    Exactly, they can't just "sign" it


  • #6536
    Thierry12
    Closed Accounts Posts: 979 ✭✭✭Thierry12


    hmmm wrote: »
    "Trust but verify" as we say. They trust the data they've been given is correct, but their job is to double-check. Apparently applications like this can run into thousands of pages so it takes time even to read it all.

    True

    While people are dieing?

    They are 99.999999999% going to clear it for use anyway

    Just wasting valuable time imo


  • #6537
    ACitizenErased
    Registered Users, Registered Users 2 Posts: 11,750 ✭✭✭✭ACitizenErased


    billybonkers wrote: »
    Exactly, they can't just "sign" it
    But there likely shouldn't be any reason for them to be taking extra time than what is necessary.


  • #6538
    Thierry12
    Closed Accounts Posts: 979 ✭✭✭Thierry12


    billybonkers wrote: »
    Exactly, they can't just "sign" it

    If UK have it out on 27th

    They just did.;-)


  • #6539
    Le Bruise
    Registered Users, Registered Users 2 Posts: 1,344 ✭✭✭Le Bruise


    Thierry12 wrote: »
    True

    While people are dieing?

    They are 99.999999999% going to clear it for use anyway

    Just wasting valuable time imo

    They’re cancelling out the 0.000000001% of doubt....can’t be too careful when vaccinating a large portion of the population


  • #6540
    [Deleted User]
    Posts: 0 ✭ [Deleted User]


    Thierry12 wrote: »
    Strange they are all taking so long anyway

    Its not as if the regulatories are testing the vaccine in vitro in a lab or anything for efficacy, safety etc?

    They are just reading through paperwork?

    What could they possibly find in the paperwork to fail it?

    Pfizer will have double checked and triple checked everything

    They might as well just sign it.

    If you look at the Russian vaccine some scientists noticed inconsistencies in the published data

    https://www.sciencealert.com/researchers-raise-concerns-over-russia-s-vaccine-trial-s-data-inconsistencies

    I'm not suggesting Pfizer would be anything like this, but I'd much rather a process where all the available data is assessed by the regulators prior to giving it to the public


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  • #6541
    hmmm
    Registered Users, Registered Users 2 Posts: 11,203 ✭✭✭✭hmmm


    Thierry12 wrote: »
    Exactly

    They can read later

    People are dieing, just put it out there

    Pfizer will have that paperwork A1
    A week or two of a delay will be better than listening to endless anti-vax youtube videos about how it was not properly reviewed by regulators :) It's important to be able to say all the safety and regulatory steps were taken to give people confidence.


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