COVID-19: Vaccine/antidote and testing procedures Megathread [Mod Warning - Post #1]

El Weirdo · 10-11-2020 08:14PM

Cork2021 wrote: »

Looks like good news coming from AstraZeneca..
https://twitter.com/askomartin/status/1326177880586526721?s=21
Youll need to use translate

Boutros Boutros-Ghali. Chris Waddle.

PCeeeee · 10-11-2020 08:21PM

JDD wrote: »

I realise there are some immuno compromised people who can't take the vaccine,

Sorry JJD where are you seeing this?

stephenjmcd · 10-11-2020 08:23PM

Gael23 wrote: »

Apparently the Pfizer vaccine will not be suitable for people with compromised immune systems as it requires T cells to be working correctly.

Any link to this ?

Not seen any commentary on this myself. There will be certain people who can't take it for whatever reason but you can't make such a sweeping statement to all immune compromised individuals.

CIARAN_BOYLE · 10-11-2020 08:26PM

PCeeeee wrote: »

Sorry JJD where are you seeing this?

Its the case with most vaccines. The specific immunocompromised group varies from vaccine to vaccine.

No vaccine can be taken by 100% of the population.

Deeper Blue · 10-11-2020 08:30PM

Gael23 wrote: »

Apparently the Pfizer vaccine will not be suitable for people with compromised immune systems as it requires T cells to be working correctly.

Surely with a statement like that you should provide a source??

PCeeeee · 10-11-2020 08:32PM

CIARAN_BOYLE wrote: »

Its the case with most vaccines. The specific immunocompromised group varies from vaccine to vaccine.

No vaccine can be taken by 100% of the population.

I'm just wondering is there something specific out there about Pfizers, all I can find is that it hasn't been studied in that cohort.

10-11-2020 08:37PM

CIARAN_BOYLE wrote: »

Its the case with most vaccines. The specific immunocompromised group varies from vaccine to vaccine.

No vaccine can be taken by 100% of the population.

It's generally "live" vaccines that can't be taken by immunocompromised. Other vaccines don't work as well, but this can often be remedied by a different vaccine schedule (perhaps an extra dose).

Gael23 · 10-11-2020 08:38PM

El Sueño wrote: »

Surely with a statement like that you should provide a source??

Down at the end it states here people with a weak immune system can’t have the vaccine
https://www.bbc.com/news/explainers-54880084

PCeeeee · 10-11-2020 08:44PM

Gael23 wrote: »

Down at the end it states here people with a weak immune system can’t have the vaccine
https://www.bbc.com/news/explainers-54880084

We'll need to hear a bit more than that Gael, weak immune system means a whole range. People on Biologics/DMARDs (forgive me I assuming that's what you're taking) would be at the safer end of that scale. I certainly wouldn't rule it out until I talk to my consultant.

Gael23 · 10-11-2020 08:44PM

PCeeeee wrote: »

We'll need to hear a bit more than that Gael, weak immune system means a whole range. People on Biologics/DMARDs (forgive me I assuming that's what you're taking) would be at the safer end of that scale. I certainly wouldn't rule it out until I talk to my consultant.

Yes I’m in Biologics.

funnydoggy · 10-11-2020 08:57PM

Gael23 wrote: »

Yes I’m in Biologics.

If that's the case for you, try not tk worry as there are other vaccines right on the heels of this Pfizer one

Gael23 · 10-11-2020 09:03PM

funnydoggy wrote: »

If that's the case for you, try not tk worry as there are other vaccines right on the heels of this Pfizer one

Won’t they all be the same story though?

PCeeeee · 10-11-2020 09:13PM

Gael23 wrote: »

Won’t they all be the same story though?

Not necessarily. There are a number of different mechanisms in development.

But honestly the individual you're paying to manage your care is the person to ask. You won't get an answer you can trust from strangers on Internet.

You probably get the flu vaccine and pneumonia vaccine already? So its not out of the question that this or another one will be suitable for us

stephenjmcd · 10-11-2020 09:18PM

Gael23 wrote: »

Down at the end it states here people with a weak immune system can’t have the vaccine
https://www.bbc.com/news/explainers-54880084

Thats not all people with compromised immune systems so a hell of a difference from the initial post. There are always caveats that some people it won't be suitable for.

Hmmzis · 10-11-2020 09:20PM

Gael23 wrote: »

Won’t they all be the same story though?

Novavax is protein subunit with adjuvant, can be given to just about anyone. It still requires some form of functioning B cells and T helpers.

That said, if you have the above I don't see how the mRNA or viral vector wouldn't work. To a lesser extent sure but completelly ineffective? What you can't take for safety reasons are replication competent viral vectors and attenuated live virus vaccines.

Gael23 · 10-11-2020 09:32PM

PCeeeee wrote: »

Not necessarily. There are a number of different mechanisms in development.

But honestly the individual you're paying to manage your care is the person to ask. You won't get an answer you can trust from strangers on Internet.

You probably get the flu vaccine and pneumonia vaccine already? So its not out of the question that this or another one will be suitable for us

Yes got them both this year, mind I wouldn’t if I wasn’t on Humira.
I’m seeing my gastro in 2 weeks time so will discuss then

dominatinMC · 10-11-2020 10:05PM

I see Prime Time are having a piece on the vaccine, will be interesting to see how much of a negative twist they can put on the story.

PCeeeee · 10-11-2020 10:06PM

Gael23 wrote: »

Yes got them both this year, mind I wouldn’t if I wasn’t on Humira.
I’m seeing my gastro in 2 weeks time so will discuss then

Good man (woman?). A little optimism is appropriate now I think.:) Stress doesn't do our immune system much good either.

St.Spodo · 10-11-2020 10:16PM

dominatinMC wrote: »

I see Prime Time are having a piece on the vaccine, will be interesting to see how much of a negative twist they can put on the story. Given their previous reports, I'll be avoiding!

A few weeks ago their best case scenario for life returning to normal was what they described as "vaccine plus (social distancing)" whereby we'd have one 70% effective vaccine in 2021. It now looks likely that we'll have 2-3 80-90% effective vaccines with the first doses arriving in 1-2 months :cool:

Gael23 · 10-11-2020 10:36PM

What’s the latest on Novavax which Himmzis mentioned earlier?

Apogee · 10-11-2020 10:40PM

FT wrote:

An attempt to test almost the entire population of Slovakia for coronavirus identified 57,500 new infections, according to official figures from the landmark programme that has been closely watched by other countries.

The central European country tested 3.6m people — two-thirds of its population — on 31 October and 1 November using rapid antigen tests, before testing a further 2m people in the worst-hit regions — some for the second time — last weekend.

Despite long queues at some screening centres during the first weekend, fears that a lack of staff would stymie the project were unfounded. Participation was high with 80-90 per cent of eligible people taking part in the first weekend of testing and some previously unknown hotspots, such as in the district of Puchov, were identified. In total, during the two weekends and a trial run in two badly hit regions a week earlier, 57,462 people tested positive, and were sent into quarantine along with their families, according to official figures. The country’s standard polymerase chain reaction, or PCR, testing has separately found 77,123 cases since the start of the pandemic.

https://www.ft.com/content/6d20007c-25ad-4d1a-b678-591acaa57df9

is_that_so · 10-11-2020 11:08PM

lbj666 wrote: »

I havent a word of spanish so they could be talking about the Argentine Superliga for all i know.

It sounded more like it was a source from a British government meeting and he referred to Hancock a bit.

Hmmzis · 10-11-2020 11:12PM

Gael23 wrote: »

What’s the latest on Novavax which Himmzis mentioned earlier?

Phase 3 in the UK.

Check with your consultant, you're on a TNF antibody treatment, not B cell depletion or some T cell destroying chemo. It should not prevent you from getting an mRNA or viral vector vaccine (J&J or AZ/Oxford). You might need an extra dose of Humira along with the vaccine maybe? The vaccine will induce T cells that secrete TNF (among some other cytokines).

Kewreeuss · 10-11-2020 11:17PM

I read that Pfizer has spent 2 billion developing the vaccine and intend marketing it as a cash cow.
Say they started working on it in March, how could they spend 2 billion in 8 months?

Water John · 10-11-2020 11:24PM

This specific vaccine was developed by BioNTech. Pfizer backed it. I presume they also financed other prospects.
Yes Pfizer will make a lot of money. Sadly, this is now the methodology we use.
I presume Govn'ts could have backed it and I suspect some of the money was public money, though Pfizer were not in the group of the US Govn't. They turned down the $2bn. They bet on the outcome.
https://www.theguardian.com/world/2020/nov/10/ugur-sahin-and-ozlem-tureci-german-dream-team-behind-vaccine

ArmaniJeanss · 10-11-2020 11:27PM

Presumably the development costs includes all the 'failures', the many teams of highly paid staff who burned through money over the last 9 months but didn't come up with a vaccine. That's the nature of these things.

Link for the figure of '2 billion' by the way? You don't even say what currency.

Geuze · 10-11-2020 11:46PM

Water John wrote: »

This specific vaccine was developed by BioNTech. Pfizer backed it. I presume they also financed other prospects.
Yes Pfizer will make a lot of money. Sadly, this is now the methodology we use.

Here are the BionTech accounts:

https://investors.biontech.de/

https://investors.biontech.de/static-files/5fe7c487-7eb9-4ecd-91f8-0a4cb47d8d1c

They will split the gross profits, ex-China, 50:50 with Pfizer.

The USA is paying 19.50 USD per dose for 100m doses.

Geuze · 10-11-2020 11:49PM

Kewreeuss wrote: »

I read that Pfizer has spent 2 billion developing the vaccine and intend marketing it as a cash cow.
Say they started working on it in March, how could they spend 2 billion in 8 months?

From the BionTech publication, about their partnership with Pfizer:

Co-development and Co-commercialization worldwide (ex China) if approved
• Combined upfront payment and equity investment of $185 million to BioNTech received in April
• Capital expenditures to be funded by each party independently
• Companies to share development expenses and gross profits on a 50:50 basis
• BioNTech eligible to receive further development & sales milestones up to $563 million

So Pfizer have paid 185m USD, and must spend on their own manufacturing capacity.

Water John · 10-11-2020 11:49PM

The Oxford vaccine is being offered at $4 and no refridgeration. Results in about a month.

Beanybabog · 11-11-2020 12:04AM

Why does the Pfizer vaccine need to be so cold? I’ve read numerous articles explaining the logistical challenges but not why it needs to be so cold. I read one that suggested the freezers can only be opened for a short amount of time... surely when you’re going to be injected the vaccine can’t be -80 (does it freeze?) so how do they manage to make
It warm enough but not ruin it?

COVID-19: Vaccine/antidote and testing procedures Megathread [Mod Warning - Post #1]

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