COVID-19: Vaccine/antidote and testing procedures Megathread [Mod Warning - Post #1]

Hmmzis · 07-11-2020 03:50PM

Thierry12 wrote: »

Question

Why can't they release an antibody test that targets T Cell?

We've being listening to this T Cell thing for months now

Are we getting anywhere?

We have one for TB

https://www.ouh.nhs.uk/immunology/diagnostic-tests/tests-catalogue/t-spot-tb.aspx

We sent a man to the moon 50 years ago and supposedly have cars that can drive themselves up the Conor Pass but can't test people for Covid immunity

This whole Covid thing has proven what I always thought

We are full of **** about our technological capabilities

If you read the methods part of said paper it states that they used a similar assay that is used for TB. Instead of us talking about T cells and developing assays for years, it's happening within months. The one thing we can't quite do yet is speed up longitudal followup studies, that might require some fundamental breakthroughs in biology (or time travel).

ACitizenErased · 07-11-2020 04:19PM

Not sure if this was posted here but:

SARS-CoV-2 mink-associated variant strain – Denmark
Initial observations suggest that the clinical presentation, severity and transmission among those infected are similar to that of other circulating SARS-CoV-2 viruses. However, this variant, referred to as the "cluster 5" variant, had a combination of mutations, or changes that have not been previously observed. The implications of the identified changes in this variant are not yet well understood. Preliminary findings indicate that this particular mink-associated variant identified in both minks and the 12 human cases has moderately decreased sensitivity to neutralizing antibodies.
https://www.who.int/csr/don/06-november-2020-mink-associated-sars-cov2-denmark/en/

Thierry12 · 07-11-2020 04:33PM

hmmm wrote: »

Apologies if this has been posted already. This statement is kind of weird, I don't think anyone seriously believed there would be tens of millions of doses available in the UK before year end?

https://www.reuters.com/article/us-health-coronavirus-britain-astrazenec/delivery-timetable-of-oxford-astrazeneca-vaccine-has-slipped-uk-official-says-idUSKBN27K2GQ

"The timetable for delivery of the Oxford University/AstraZeneca COVID-19 vaccine candidate has slipped, the UK’s vaccine chief said, adding Britain will receive just 4 million doses of the shot this year."

These vaccine trials are seriously dragging on

Late September, then October, then November, now saying could be January to finish phase 3 trials

All that's holding up now is not enough people in trials infected

Which I find crazy

They don't have 44 infections out of 30,000 including 10,000 in placebo group

Most countries have exploded with cases and are at 1% positivity rates for whole population

Vaccine trials have set 0.20% for infection

Have they picked out people in New Zealand or WFH people for trials or something?

Surely 60 people out 30,000 trialists would catch the virus in Poland, Belgium or Denmark

For something that's supposedly extremely contagious having 44 people infected should have been easy

XsApollo · 07-11-2020 05:53PM

Voluntary challenge trials.
Should of been done months ago.
This isn’t a normal situation , I’m sure many people would volunteer to be over this ****.
If it’s voluntary pay 30,000 people a nice sum of money each and let them on there way would be cheaper, quicker and a lot less painful.

CIARAN_BOYLE · 07-11-2020 06:57PM

XsApollo wrote: »

Voluntary challenge trials.
Should of been done months ago.
This isn’t a normal situation , I’m sure many people would volunteer to be over this ****.
If it’s voluntary pay 30,000 people a nice sum of money each and let them on there way would be cheaper, quicker and a lot less painful.

1,000 people participating in challenge trials would be enough imo.

XsApollo · 07-11-2020 06:58PM

CIARAN_BOYLE wrote: »

1,000 people participating in challenge trials would be enough imo.

Well i don’t know the numbers needed but the point is still the same.

Hmmzis · 07-11-2020 07:44PM

Speaking of T cells, here is a vaccine candidate focusing on just that:

https://www.medrxiv.org/content/10.1101/2020.11.04.20225417v1.full.pdf+html

The company involved is ImmunityBio and the vaccine would appear to be nearing the end of phase1 human trials.

The construct is a viral vector using a modified Ad5 virus. The modifications are done to prevent existing Ad5 antibodies from neutralizing the vector.
The expressed SARS-cov-2 proteins are the standard S, an extra construct to to show more of the RBD and a few of the most prominent N (nucleocapsid) epitopes for T cell recognition. Very impressive genetic and protein engineering. Hope it works as intended.

Gael23 · 07-11-2020 09:26PM

I’m on Anti TNF Injections which I believe reduce T Cell production

mandrake04 · 07-11-2020 09:45PM

Thierry12 wrote: »

Question

Why can't they release an antibody test that targets T Cell?

We've being listening to this T Cell thing for months now

Are we getting anywhere?

We have one for TB

https://www.ouh.nhs.uk/immunology/diagnostic-tests/tests-catalogue/t-spot-tb.aspx

We sent a man to the moon 50 years ago and supposedly have cars that can drive themselves up the Conor Pass but can't test people for Covid immunity

This whole Covid thing has proven what I always thought

We are full of **** about our technological capabilities

Testing for T-cells is not that easy, in saying that the same crowd that developed the T-Spot.TB test have a commercially available RUO for SARS2

http://www.oxfordimmunotec.com/international/news/oxford-immunotec-releases-t-spot-discoverytm-sars-cov-2-kit-research-measuring-t-cell-immune-response-sars-cov-2-may-offer-new-insights-immunity-covid-19/

ACitizenErased · 07-11-2020 10:04PM

No infections among 56,000 people who traveled abroad after receiving Sinopharm-developed COVID-19 vaccine: developer

https://www.globaltimes.cn/content/1206008.shtml

Hmmzis · 07-11-2020 10:10PM

mandrake04 wrote: »

Testing for T-cells is not that easy, in saying that the same crowd that developed the T-Spot.TB test have a commercially available RUO for SARS2

http://www.oxfordimmunotec.com/international/news/oxford-immunotec-releases-t-spot-discoverytm-sars-cov-2-kit-research-measuring-t-cell-immune-response-sars-cov-2-may-offer-new-insights-immunity-covid-19/

That's the exact same they used in anger in that T cell study I linked. Looking forward to that one being used even more.

Marhay70 · 07-11-2020 10:26PM

ACitizenErased wrote: »

No infections among 56,000 people who traveled abroad after receiving Sinopharm-developed COVID-19 vaccine: developer

https://www.globaltimes.cn/content/1206008.shtml

Great news as it stands, but I think I'd be more convinced if it was coming from a slightly more credible source.

Dickie10 · 07-11-2020 11:11PM

Anyone hear Pfizer Irish head guy on Bobby Kerr this morning??

JacksonHeightsOwn · 07-11-2020 11:16PM

Dickie10 wrote: »

Anyone hear Pfizer Irish head guy on Bobby Kerr this morning??

No, what was he saying?

timsey tiger · 07-11-2020 11:23PM

speckle wrote: »

If truly 30% of our population is high risk from covid for ICU and death... how does that (even taking into account that most of them are being careful)... explain our low Icu and death rate?

And the German government saying 89% of the over 80s survive... taking into consideration this will be lower for 80 year olds in nursing homes and higher for 80 year olds who are less fragile and living at home.

And surely more people under 70 then should be dying. Does anybody have stats on how many under 70 fall into high risk catagorys? Something not adding up in my brain, but I am sure somebody here can try and explain it to me.

Maybe 25% of our population is over 70? But then 89%+ are meant ro survive.. How I hate maths.

Or our we just the unhealthist nation in europe?

You got to ask yourself, what is the definition of high risk? Off piste skiing is considered a high risk activity.

Dickie10 · 07-11-2020 11:29PM

chrisbonnie wrote: »

No, what was he saying?

He said that Pfizer were waiting until after the US election before coming out saying thier vaccine is ready to roll in case it could be accused of swaying the vote, so probabaly end of this week it will announce its clear and waiting EU approval which is automatic pretty much, vaccines should be ready to start dosing people from december. He said by February there will be at least 3 -4 different vaccines available to genereal population and by summer cant see thier being any need for restrictions.

JacksonHeightsOwn · 07-11-2020 11:31PM

Dickie10 wrote: »

He said that Pfizer were waiting until after the US election before coming out saying thier vaccine is ready to roll in case it could be accused of swaying the vote, so probabaly end of this week it will announce its clear and waiting EU approval which is automatic pretty much, vaccines should be ready to start dosing people from december. He said by February there will be at least 3 -4 different vaccines available to genereal population and by summer cant see thier being any need for restrictions.

Wow, super news!!!

Fingers crossed he's right.

ACitizenErased · 07-11-2020 11:33PM

Dickie10 wrote: »

He said that Pfizer were waiting until after the US election before coming out saying thier vaccine is ready to roll in case it could be accused of swaying the vote, so probabaly end of this week it will announce its clear and waiting EU approval which is automatic pretty much, vaccines should be ready to start dosing people from december. He said by February there will be at least 3 -4 different vaccines available to genereal population and by summer cant see thier being any need for restrictions.

Any link for this? Would love to listen

Dickie10 · 07-11-2020 11:39PM

newstalk player maybe ? it was around 11:20-11:45 i think it was on.

ACitizenErased · 07-11-2020 11:43PM

Newstalk haven't got that interview up from the show today. Shame.

mandrake04 · 07-11-2020 11:44PM

Hmmzis wrote: »

That's the exact same they used in anger in that T cell study I linked. Looking forward to that one being used even more.

T-spot I believe involves a lot of manual lab work and some of the equipment used is not common, it’s not an easy process like CLIA immunoassay uses to detect antibodies.

Dickie10 · 07-11-2020 11:46PM

https://www.newstalk.com/listen-back

0:54 - 0:57

Dickie10 · 07-11-2020 11:46PM

Bobby Kerr show 7th Nov.

FintanMcluskey · 07-11-2020 11:49PM

Dickie10 wrote: »

He said that Pfizer were waiting until after the US election before coming out saying thier vaccine is ready to roll in case it could be accused of swaying the vote, so probabaly end of this week it will announce its clear and waiting EU approval which is automatic pretty much, vaccines should be ready to start dosing people from december. He said by February there will be at least 3 -4 different vaccines available to genereal population and by summer cant see thier being any need for restrictions.

Surely that news should be on a loop throughout the day?

ACitizenErased · 07-11-2020 11:50PM

It wasn't the head of Pfizer, unfortunately. It was Cathal Friel, head of Open Orphan. They run challenge trials for vaccines.

timsey tiger · 07-11-2020 11:57PM

ACitizenErased wrote: »

It wasn't the head of Pfizer, unfortunately. It was Cathal Friel, head of Open Orphan. They run challenge trials for vaccines.

Figures, if he were a pfizer employee and said that on air, we wouldn't even get a chance to clear out his desk on Monday.

ACitizenErased · 07-11-2020 11:58PM

timsey tiger wrote: »

Figures, if he were a pfizer employee and said that on air, we wouldn't even get a chance to clear out his desk on Monday.

It's not wrong though? Pfizer are widely believed to be filing for approval the week after next.

Leftwaffe · 08-11-2020 12:17AM

ACitizenErased wrote: »

No infections among 56,000 people who traveled abroad after receiving Sinopharm-developed COVID-19 vaccine: developer

https://www.globaltimes.cn/content/1206008.shtml

First time I've seen a figure like that high associated with good news in long time.

mean gene · 08-11-2020 10:55AM

Dickie10 wrote: »

He said that Pfizer were waiting until after the US election before coming out saying thier vaccine is ready to roll in case it could be accused of swaying the vote, so probabaly end of this week it will announce its clear and waiting EU approval which is automatic pretty much, vaccines should be ready to start dosing people from december. He said by February there will be at least 3 -4 different vaccines available to genereal population and by summer cant see thier being any need for restrictions.

that's huge news funny theres no mention of it on rte with their thrash scaremongering agenda;)

ILoveYourVibes · 08-11-2020 11:48AM

New strain of vaccine has put a vaccine back in its box me thinks.

Thank mink farmers ..the only farmers whose farming methods couldn't stop an outbreak among their animals for some reason.

COVID-19: Vaccine/antidote and testing procedures Megathread [Mod Warning - Post #1]

Comments