COVID-19: Vaccine/antidote and testing procedures Megathread [Mod Warning - Post #1]

ACitizenErased

Further to what Hmmzis posted
https://twitter.com/afp/status/1319393089249792009?s=21

giveitholly

ACitizenErased wrote: »

Further to what Hmmzis posted
https://twitter.com/afp/status/1319393089249792009?s=21

Will this make much of a difference in the overall treatment of covid?

Kickstart1.3

giveitholly wrote: »

Will this make much of a difference in the overall treatment of covid?

No. Its just part of the b0llsh1t that is Covid

hynesie08

giveitholly wrote: »

Will this make much of a difference in the overall treatment of covid?

Theoretically, and I'm open to correction, it would be the third phase attack after a vaccine and an inhaler. If we end up with all 3 and all 3 are proven to be effective, we'll be in a much better place.

Gael23

My concern is our government seem fixated on case numbers, a vaccine won’t stop new cases so where does that leave us. That why I find it hard to see a way out of this

FishOnABike

Gael23 wrote: »

My concern is our government seem fixated on case numbers, a vaccine won’t stop new cases so where does that leave us. That why I find it hard to see a way out of this

How wouldn't a vaccine stop new cases? Vaccines have been effective against numerous infectious diseases, eliminating or vastly reducing the incidence of what were once very common illnesses in developed countries, smallpox, polio, diphtheria, measles, mumps, rubella, etc...

henke

Gael23 wrote: »

My concern is our government seem fixated on case numbers, a vaccine won’t stop new cases so where does that leave us. That why I find it hard to see a way out of this

In the app it tells you 1) daily case number, 2) current hospitalisations and 3) number in ICU.

When the vaccine starts rolling out to the vulnerable wouldn't the hope be that points 2 and 3 drop off with not a whole lot of importance on point 1. If we had 5,000 daily cases and 5 in hospital and 1 in ICU I don't think there would be a need for restrictions. I'm no expert but aren't 2 and 3 the important ones and its the rate these go up that drive restrictions?

opinionated3

LBC radio reporting that the latest update on the Oxford/ astrazeneca vaccine is highly positive. It basically does exactly what it set out to do: activate a strong immunity to the virus. ( I'm trying to find some positive articles out there rather than getting depressed from RTE😂)

ACitizenErased

opinionated3 wrote: »

LBC radio reporting that the latest update on the Oxford/ astrazeneca vaccine is highly positive. It basically does exactly what it set out to do: activate a strong immunity to the virus. ( I'm trying to find some positive articles out there rather than getting depressed from RTE��)

I'll help you out
Coronavirus: Oxford-AstraZeneca vaccine 'behaves as desired', analysis finds

https://news.sky.com/story/coronavirus-oxford-astrazeneca-vaccine-behaves-as-desired-analysis-finds-12111085

Thierry12

opinionated3 wrote: »

LBC radio reporting that the latest update on the Oxford/ astrazeneca vaccine is highly positive. It basically does exactly what it set out to do: activate a strong immunity to the virus. ( I'm trying to find some positive articles out there rather than getting depressed from RTE😂)

Wonder do they do know if its sterilising yet?

How could they test that without infecting people though or maybe alot of the trialists were close contacts to positive cases and they can draw conclusion on that

It sounds great anyway, hope we get good news regularly with it now until released, will shut the doomers up

Someone should let Pat Kenny know, he's been torture today

opinionated3

ACitizenErased wrote: »

I'll help you out
Coronavirus: Oxford-AstraZeneca vaccine 'behaves as desired', analysis finds

https://news.sky.com/story/coronavirus-oxford-astrazeneca-vaccine-behaves-as-desired-analysis-finds-12111085

Apologies if this has been asked already but are the EU purchasing this vaccine as well as others?

ACitizenErased

opinionated3 wrote: »

Apologies if this has been asked already but are the EU purchasing this vaccine as well as others?

They are yes.

Today, the European Commission has reached a first agreement with the pharmaceutical company AstraZeneca to purchase a potential vaccine against COVID-19 as well as to donate to lower and middle income countries or re-direct to other European countries. This is following the positive steps regarding the conclusion of exploratory talks with Sanofi-GSK announced on 31 July and with Johnson & Johnson on 13 August. Once the vaccine has proven to be safe and effective against COVID-19, the Commission now has agreed the basis for a contractual framework for the purchase of 300 million doses of the AstraZeneca vaccine, with an option to purchase 100 million more, on behalf of EU Member States. The Commission continues discussing similar agreements with other vaccine manufacturers.

https://ec.europa.eu/commission/presscorner/detail/en/ip_20_1438

Le Bruise

ACitizenErased wrote: »

I'll help you out
Coronavirus: Oxford-AstraZeneca vaccine 'behaves as desired', analysis finds

https://news.sky.com/story/coronavirus-oxford-astrazeneca-vaccine-behaves-as-desired-analysis-finds-12111085

But, but, but all those opinion pieces told me not to get my hopes up and live in a bubble of anxiety until at least 2023????;)

CIARAN_BOYLE

Gael23 wrote: »

My concern is our government seem fixated on case numbers, a vaccine won’t stop new cases so where does that leave us. That why I find it hard to see a way out of this

They are fixated on care numbers because the relationship between cases, hospitalizations and deaths are well established.

They can say if theres 1k cases today x of those will be admitted in the next week.

If the relationship changes their modeling will change.

mandrake04

ACitizenErased wrote: »

I'll help you out
Coronavirus: Oxford-AstraZeneca vaccine 'behaves as desired', analysis finds

https://news.sky.com/story/coronavirus-oxford-astrazeneca-vaccine-behaves-as-desired-analysis-finds-12111085

This is very reassuring thankfully, I heard that the Pfizer vaccine didn’t really reach the expectations of immune response in older patients.

Le Bruise

mandrake04 wrote: »

This is very reassuring thankfully, I heard that the Pfizer vaccine didn’t really reach the expectations of immune response in older patients.

Where did you hear that (not being smart, just interested)?

iguana

mandrake04 wrote: »

This is very reassuring thankfully, I heard that the Pfizer vaccine didn’t really reach the expectations of immune response in older patients.

It's not coming quite as fast but I seem to recall something about Moderna working quite well in older patients.

mandrake04

Le Bruise wrote: »

Where did you hear that (not being smart, just interested)?

Heard it on radio the other day, over 56s wasn’t as good as 18-55. It’s early days yet.

mandrake04

iguana wrote: »

It's not coming quite as fast but I seem to recall something about Moderna working quite well in older patients.

I did read something about that, so you are right.

Hmmzis

mandrake04 wrote: »

Heard it on radio the other day, over 56s wasn’t as good as 18-55. It’s early days yet.

The only data available to the public is the phase 1 set, the overall binding titers are not significantly different. The IC50 values are, maybe that's the source of those comments?

https://www.medrxiv.org/content/10.1101/2020.08.17.20176651v1.full.pdf

If anyone has any links for the BNT162b2 version with data past 28 days, it might show a better picture?

hmmm

Germany planning to start vaccinations before the end of the year
https://uk.reuters.com/article/uk-health-coronavirus-germany-vaccine-idUKKBN277342

"The health ministry plans to create 60 special vaccination centres to ensure the vaccines can be stored at the proper temperature and has asked the country’s 16 federal states to provide addresses for them by Nov. 10, Bild reported without citing its sources."

hmmm

Convalescent plasma is ineffective. Very disappointing, and in fact it looks like it may even be slightly harmful for some.

https://www.bmj.com/content/371/bmj.m4072

"The desperation engendered by covid-19 demands that we strongly resist the urge to succumb to pandemic research exceptionalism.13 High quality clinical research must be an integral part of a coordinated international response.13 Specifically, scientific validity is a necessary component of ethical research.14 Low quality research not only wastes scarce resources, it is also inherently unethical.14"

stephenjmcd

hmmm wrote: »

Germany planning to start vaccinations before the end of the year
https://uk.reuters.com/article/uk-health-coronavirus-germany-vaccine-idUKKBN277342

"The health ministry plans to create 60 special vaccination centres to ensure the vaccines can be stored at the proper temperature and has asked the country’s 16 federal states to provide addresses for them by Nov. 10, Bild reported without citing its sources."

Germany preparing to roll out Pfizer then.

You can be dam sure these vaccination centres will be unbelievable well set up and run. Everyone could learn something from the Germans organisation.

We can only hope that the HSE & Dept of Health have some sort of plan

Level 42

stephenjmcd wrote: »

Germany preparing to roll out Pfizer then.

You can be dam sure these vaccination centres will be unbelievable well set up and run. Everyone could learn something from the Germans organisation.

We can only hope that the HSE & Dept of Health have some sort of plan

The HSE lads can't even organize hand sanatizer for the schools no faith in them

eigrod

stephenjmcd wrote: »

Germany preparing to roll out Pfizer then.

You can be dam sure these vaccination centres will be unbelievable well set up and run. Everyone could learn something from the Germans organisation.

We can only hope that the HSE & Dept of Health have some sort of plan

Outsource it to the Germans?

lbj666

henke wrote: »

In the app it tells you 1) daily case number, 2) current hospitalisations and 3) number in ICU.

When the vaccine starts rolling out to the vulnerable wouldn't the hope be that points 2 and 3 drop off with not a whole lot of importance on point 1. If we had 5,000 daily cases and 5 in hospital and 1 in ICU I don't think there would be a need for restrictions. I'm no expert but aren't 2 and 3 the important ones and its the rate these go up that drive restrictions?

You would still need restrictions to sustain the virus at 5,000 cases at day, otherwise it is would spread at R0=6 like it was early march.
Also 5,000 cases a day is 1,000,000 cases in 6months even if that's among the normally healthy but unvacinated, thats still a lot of people who will develop long covid symptom or even die from it.

Add to the fact that a vacine will not have 100% efficacy among the vulverable who first get it and the people not in good enough health to take a vacine, you can see experts are saying its not a silver bullet and why Meehole said to expect restrictions to continue well into 2021 (now he didnt phrase is very well or in the best tone)

Best we can hope for is get over this level 5, get over a post xmas spike in feb-march. Vaccine rollout in Q2 wait for the actual efficacy to show in the statistics and perhaps sustain level 1- 2 restrictions til vaccines roll out amongst the rest of the population and/or more effective treatments at the onset and reliable rapid testing.

Away With The Fairies

I hope the Oxford vaccine helps when it comes out. But when do people see normal back again? We're almost at the end of 2020, soon into 2021 and I still don't see any normal for 2021 yet. Maybe the end of next year but is that too optimistic at this stage?

funnydoggy

Away With The Fairies wrote: »

I hope the Oxford vaccine helps when it comes out. But when do people see normal back again? We're almost at the end of 2020, soon into 2021 and I still don't see any normal for 2021 yet. Maybe the end of next year but is that too optimistic at this stage?

Once the vulnerable are vaccinated, I can see some restrictions being lifted. Spring maybe?

According to historians, pandemics typically have two types of endings: the medical, which occurs when the incidence and death rates plummet, and the social, when the epidemic of fear about the disease wanes.

NYTimes.com



I feel the social end is going to happen much sooner than the medical end.

plodder

hmmm wrote: »

Convalescent plasma is ineffective. Very disappointing, and in fact it looks like it may even be slightly harmful for some.

https://www.bmj.com/content/371/bmj.m4072

"The desperation engendered by covid-19 demands that we strongly resist the urge to succumb to pandemic research exceptionalism.13 High quality clinical research must be an integral part of a coordinated international response.13 Specifically, scientific validity is a necessary component of ethical research.14 Low quality research not only wastes scarce resources, it is also inherently unethical.14"

Disappointing. I wonder does this have implications for the Regeneron artificial antibody product?

tayto lover

Level 42 wrote: »

The HSE lads can't even organize hand sanatizer for the schools no faith in them

In fairness it’s hardly their fault if the manufacturers put Methylene into their product instead of Ethylene.
Just to be fair minded about it.