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COVID-19: Vaccine/antidote and testing procedures Megathread [Mod Warning - Post #1]

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    #92
    hmmm
    Registered Users Posts: 11,205 ✭✭✭✭hmmm


    That'd be incredible if they met that timeline. Too good to be true almost. Big decisions for regulators to make, and from the sounds of it AstraZeneca must be manufacturing it before trials are finished.

    There's an interesting political issue here with Brexit due. Would our government offer some sort of concession in return for getting doses before the end of the year, or would the UK ask us to make concessions? Even a few tens of thousands doses offered to front-line health workers/nursing home staff would make a massive difference to how quickly we could safely emerge from lockdowns, and have a massive economic impact.


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    #93
    hmmm
    Registered Users Posts: 11,205 ✭✭✭✭hmmm


    https://twitter.com/OutFrontCNN/status/1261441663706075136


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    #94
    JTMan
    Registered Users Posts: 5,537 ✭✭✭JTMan


    Thanks for sharing that video. Interesting that AstraZeneca/Oxford say they will have "several hundred million" vaccines by the end of the year "but not quite a billion". The UK get the first 100 million doses and who gets the remainder?

    If we are close to a billion by the end of the year, then will AstraZeneca/Oxford have 6 billion doses by mid 2021????
    hmmm wrote: »
    There's an interesting political issue here with Brexit due. Would our government offer some sort of concession in return for getting doses before the end of the year, or would the UK ask us to make concessions?

    AstraZeneca are a global company. Don't think Brexit will have any effect on this.


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    #95
    hmmm
    Registered Users Posts: 11,205 ✭✭✭✭hmmm


    JTMan wrote: »
    AstraZeneca are a global company. Don't think Brexit will have any effect on this.
    It will when it is a UK Headquartered company making a vaccine developed by a UK research team in a UK funded university. I expect the UK will demand that the vaccine is made available to UK citizens first, and every other country will fight to get whatever is left over (this all assumes it works).

    Decisions around vaccine distribution are going to get brutal:
    http://www.rfi.fr/en/france/20200515-macron-to-meet-sanofi-ceo-after-u-turn-on-us-priority-for-covid-19-vaccine


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    #96
    Stheno
    Moderators, Business & Finance Moderators, Science, Health & Environment Moderators, Social & Fun Moderators, Society & Culture Moderators Posts: 51,687 Mod ✭✭✭✭Stheno


    Hmmzis wrote: »
    https://www.cell.com/cell/fulltext/S0092-8674(20)30610-3

    Another paper where the researchers have seen existing CD4+ T cells reacting to SARS-cov-2 in rather large proportions. Could this be the explanation for the asymptomatic cases and/or the curiously low household secondary attack rate of this?

    https://www.medrxiv.org/content/10.1101/2020.04.11.20056010v1
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104686/

    Is this the first paper stating that they've found SARS-cov-2 specific CD8+ T cells? If I recall right those are the ones that can stick around for very long times (decades).

    Would someone mind clarifying the difference between T Cells and antibodies?
    Are T cells basically defence mechanisms in our bodies that fight infection, and due to common cold coronavirus, the research is finding that those same t.cells are effective in fighting Covid19?

    Whereas antibodies are specific to covid19?
    Asking as that study estimates that at least 40% of people who had no exposure to the virus had the t cells to fight it, which added to infections is close to herd ability to fight it

    Sorry just confused


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    #97
    Mike3287
    Closed Accounts Posts: 379 ✭✭Mike3287


    hmmm wrote: »
    https://twitter.com/OutFrontCNN/status/1261441663706075136

    Pretty amazing progesss

    He says we will know in a month if it works

    Ramp up from June to Sept


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    #98
    Hmmzis
    Registered Users Posts: 2,004 ✭✭✭Hmmzis


    Stheno wrote: »
    Would someone mind clarifying the difference between T Cells and antibodies?
    Are T cells basically defence mechanisms in our bodies that fight infection, and due to common cold coronavirus, the research is finding that those same t.cells are effective in fighting Covid19?

    Yes. They're part of your first line of defence against pathogens. They also tend to be more universal in what they can attack and recognise (multiple proteins of a pathogen in contrast to a specific one).
    Stheno wrote: »
    Whereas antibodies are specific to covid19?

    Yes. That's why the serology tests all use IgG and IgM to check for prior exposure to SARS-cov-2.
    Stheno wrote: »
    Asking as that study estimates that at least 40% of people who had no exposure to the virus had the t cells to fight it, which added to infections is close to herd ability to fight it

    Sorry just confused

    Maybe. There are now more papers finding the same results (maybe++).


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    #99
    Hmmzis
    Registered Users Posts: 2,004 ✭✭✭Hmmzis


    Interesting attack pattern and could be quite useful when considering what places to open up and what places to keep shut:

    https://wwwnc.cdc.gov/eid/article/26/8/20-0633_article

    It needs ideal conditions to spread like mad, take that away and it rather sharply nosedives the attack rate.

    Sort of makes sense, it's a bat virus, adapted to bats and their environment and how they live. Close contact crowded enclosed environments (bat caves) is all it needs to keep spreading among them. Same for us now, since it managed to jump across to us.


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    #100
    stephenjmcd
    Registered Users Posts: 15,199 ✭✭✭✭stephenjmcd


    Early positive signs from Moderna

    https://www.businesswire.com/news/home/20200518005348/en/Moderna-Announces-Positive-Interim-Phase-1-Data


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    #101
    is_that_so
    Registered Users Posts: 32,136 ✭✭✭✭is_that_so


    Hmmzis wrote: »
    Interesting attack pattern and could be quite useful when considering what places to open up and what places to keep shut:

    https://wwwnc.cdc.gov/eid/article/26/8/20-0633_article

    It needs ideal conditions to spread like mad, take that away and it rather sharply nosedives the attack rate.

    Sort of makes sense, it's a bat virus, adapted to bats and their environment and how they live. Close contact crowded enclosed environments (bat caves) is all it needs to keep spreading among them. Same for us now, since it managed to jump across to us.

    The other factor there is how high levels of exercise can also weaken the immune system.


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    #102
    hmmm
    Registered Users Posts: 11,205 ✭✭✭✭hmmm


    stephenjmcd wrote: »
    Early positive signs from Moderna

    https://www.businesswire.com/news/home/20200518005348/en/Moderna-Announces-Positive-Interim-Phase-1-Data
    https://www.youtube.com/watch?v=t-zwecJ9qxk


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    #103
    hmmm
    Registered Users Posts: 11,205 ✭✭✭✭hmmm


    https://www.biocentury.com/article/305211

    Just to dampen enthusiasm a bit


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    #104
    Hmmzis
    Registered Users Posts: 2,004 ✭✭✭Hmmzis


    hmmm wrote: »
    https://www.biocentury.com/article/305211

    Just to dampen enthusiasm a bit

    Will be interesting to see if the booster addition changes things. From the sounds of it the antibody titres are bit on the low side from the single dose alone. The question for the booster shots is, did the immune system develop antibodies against the vector or not. If there are antibodies against the vector, the booster won't work. Then the only other way is to increase the initial dose and maybe an adjuvant to spark a more robust immune response.

    Still, if it's safe, jab everyone! A bout of the sniffles is way more preferable than a full blown pneumonia and a lengthy hospital stay.


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    #105
    Mike3287
    Closed Accounts Posts: 379 ✭✭Mike3287


    hmmm wrote: »
    https://www.biocentury.com/article/305211

    Just to dampen enthusiasm a bit

    Its still excellent news

    At worst its a treatment that turns it into a cold and from reading it seems incrediblely safe, a really basic approach

    If they have it by September it will be life changing


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    #106
    JTMan
    Registered Users Posts: 5,537 ✭✭✭JTMan


    WSJ update on the vaccine front-runners here (paywall).

    - 100+ efforts globally
    - 8 are at human trial stage including Moderna Inc., Pfizer Inc, Johnson & Johnson, JNJ, AstraZeneca PLC and Sanofi SA.
    - Some, like vaccines from Pfizer and Moderna, are based on relatively new technologies that haven’t been approved previously.
    - FDA in the US expected to give rapid approval after successful trials.
    - Whilst some might reach the finishing line this year, fuller supply to vaccinate the general population might not become available until well into 2021.
    - US to use existing network of state agencies that run childhood vaccination programs at public clinics.
    - Johnson & Johnson expects to have some batches of its vaccine ready by early 2021.
    - Moderna to make tens of millions of doses a month by the end of this year, and eventually as many as one billion doses a year.


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    #107
    patnor1011
    Registered Users Posts: 2,956 ✭✭✭patnor1011


    It is quite likely that there is already treatment to covid we just need to figure out what it is. There are some things positive and some other may be found. Like this:
    Researchers claim 100 percent cure rate vs. covid-19 in 100+ patient trial conducted in Ecuador, using intravenous chlorine dioxide.

    Perhaps more resources should be turned to looking to identify effective tratment and not looking for something new like new vaccine - which btw looks mora and more difficult to create.


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    #108
    Szero
    Registered Users Posts: 162 ✭✭Szero


    Really impressive to see how quick things are happening in the vaccine space.

    In an optimistic scenario:
    • Several vaccine trials succeed as seems likely to happen.
    • Vaccine for some this year.
    • Vaccine for most in early 2021.
    • Vaccine available to all that want it during 2021.

    After we get a vaccine, will we be given an immunity passport? Are the Irish government planning this?


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    #109
    hmmm
    Registered Users Posts: 11,205 ✭✭✭✭hmmm


    patnor1011 wrote: »
    It is quite likely that there is already treatment to covid we just need to figure out what it is. There are some things positive and some other may be found. Like this:
    Researchers claim 100 percent cure rate vs. covid-19 in 100+ patient trial conducted in Ecuador, using intravenous chlorine dioxide.
    Dangerous bull****. There's plenty of other threads for this sort of thing.
    https://www.fda.gov/news-events/press-announcements/fda-warns-consumers-about-dangerous-and-potentially-life-threatening-side-effects-miracle-mineral


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    #110
    4068ac1elhodqr
    Closed Accounts Posts: 9,586 ✭✭✭4068ac1elhodqr


    • Vaccine available to all that want it during 2021.
    The bigger question is not 'want', but might it be 'require' instead?
    Szero wrote: »
    After we get a vaccine, will we be given an immunity passport? Are the Irish government planning this?
    Needless to say, some sort of record will be needed.

    The exact form it will take hasn't been considered much by anyone.

    Paper cert, or plastic card inside of a passport? A simple generic visa stamp on a passport page wouldn't suffice (easy to forge, can't update and passports can expire or get lost).
    Maybe a digital-only image (unique QRCode) stored on a smartphone/laptop that can be cloud-verified (updated) and linked to biometric data matching.

    Even better, what about a small scanable tattoo with unique serial number identifier, at the same time as the vaccine?


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    #111
    Mike3287
    Closed Accounts Posts: 379 ✭✭Mike3287


    hmmm wrote: »
    Dangerous bull****. There's plenty of other threads for this sort of thing.
    https://www.fda.gov/news-events/press-announcements/fda-warns-consumers-about-dangerous-and-potentially-life-threatening-side-effects-miracle-mineral

    How's is it dangerous bull?

    Most scientists are in agreement a drug cocktail is out there as a viable treatment, they just haven't found the cocktail yet

    Alot of work is being done on these cocktails like antiviral, antibiotic, haemoglobin type medication working together as a treatment

    Remdesivir is being trialed with many drugs right now and they will find a treatment


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    #112
    [Deleted User]
    Posts: 0 ✭ [Deleted User]


    CNN are reporting today that Moderna will have covid19 vaccine ready by January


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    #113
    [Deleted User]
    Posts: 0 ✭ [Deleted User]


    Ready as in available to the public


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    #114
    Stheno
    Moderators, Business & Finance Moderators, Science, Health & Environment Moderators, Social & Fun Moderators, Society & Culture Moderators Posts: 51,687 Mod ✭✭✭✭Stheno


    [Deleted User] wrote: »
    Ready as in available to the public

    For the US only though?


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    #115
    [Deleted User]
    Posts: 0 ✭ [Deleted User]


    UK are saying bu September. https://www.cnbc.com/2020/05/18/coronavirus-astrazeneca-aims-to-distribute-vaccine-in-uk-by-september.html


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    #116
    [Deleted User]
    Posts: 0 ✭ [Deleted User]


    Stheno wrote: »
    For the US only though?

    Im not sure. Maybe uk will throw us a few million in Sept


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    #117
    Blueshoe
    Banned (with Prison Access) Posts: 3,964 ✭✭✭Blueshoe


    Buy bio pharma stock. Quidel and Therapeutic giants Crispr are among some of the attractive options


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    #118
    Stheno
    Moderators, Business & Finance Moderators, Science, Health & Environment Moderators, Social & Fun Moderators, Society & Culture Moderators Posts: 51,687 Mod ✭✭✭✭Stheno


    [Deleted User] wrote: »
    Im not sure. Maybe uk will throw us a few million in Sept

    Results from the UK.are not as positive not negative though


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    #119
    stephenjmcd
    Registered Users Posts: 15,199 ✭✭✭✭stephenjmcd


    https://www.rte.ie/news/coronavirus/2020/0519/1139228-cornavirus-drug-china/


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    #120
    Hmmzis
    Registered Users Posts: 2,004 ✭✭✭Hmmzis


    Good article about what our T cells do and how they can and do cross-react with different types and strains of viruses.

    https://www.frontiersin.org/articles/10.3389/fimmu.2012.00357/full

    The Spanish Flu to Swine Flu analysis and results are very interesting.


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    #121
    hmmm
    Registered Users Posts: 11,205 ✭✭✭✭hmmm


    Moderna results being questioned
    https://www.statnews.com/2020/05/19/vaccine-experts-say-moderna-didnt-produce-data-critical-to-assessing-covid-19-vaccine/

    There's also questions being raised about their financial activity.
    https://www.youtube.com/watch?v=nPgm1nfH1HQ


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