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Cancer - good news of a cure at last

13

Comments

  • Hosted Moderators Posts: 7,486 ✭✭✭Red Alert


    Any revolutionary cure takes time to get to general market, an unfortunate fact of life. Take the Linear Accelerator for example - the first machine in Hammersmith Hospital was gigantic, and probably not widely accessible at all. Now radiotherapy is just a routine treatment modality, which has made many cancers illness rather than death sentences. A similar cycle is starting again with the new cyclotron-based proton therapies. Same for chemo.


  • Registered Users, Registered Users 2 Posts: 22,443 ✭✭✭✭endacl


    Pretty much ALL of that companies income comes from public heath service or health plans from the public. And most of the income goes to things like marketing and shareholders. And billions spent on fines.

    Only a small fraction goes on R&D.

    Pharma is a cash cow.
    I'm not saying it's not. If it wasn't, new therapies wouldn't be developed. Governments don't do it.

    Lots of things are cash cows. That's why people do them. Who dafuq would go into accountancy, for example, if it wasn't a potential cash cow? The law might be interesting, but conveyancing? Who'd choose that for the love of it?

    Devil's advocate here. Why shouldn't the profit go to the shareholders? Nothing happens without them. The outlay is massive. With no guarantee of a useful, better than current treatment therapy at the end of a years long process. And then the next years long process of passing regulatory bodies to get approval for the various Stage I and II tests. And then more regulatory approval for purpose. And if it turns out that an unexpected side effect suits some other purpose better, back for more regulatory approval. And then it might be taken up and used. Or not. Or somebody else may have done it better in the meantime. Or technology has moved on. Your state of the art therapy is obsolete before it even starts. Drug/therapy development is a long term, long odds bet.

    In most jurisdictions, this one included, company directors are required by law to maximise the interests of shareholders. That's a fact, and a board who didn't follow this might potentially find themselves open to legal action. A little bizarre, but true. That's something governments could address.

    'Billions spent on fines' is a little disingenuous. Surely not all pharma companies are sued all the time. Some drugs and therapies are relatively inexpensive, work well, and just get on with making people better. Without making headlines better...


  • Registered Users, Registered Users 2 Posts: 10,115 ✭✭✭✭Junkyard Tom


    endacl wrote: »
    Lots of things are cash cows. That's why people do them.

    Pharmaceuticals is an area where we see the inadequacies or even downright immorality of the profit motive. Yes, that capitalist sacred cow, despite all the propaganda to the contrary, has its failings. You're probably aware of Ben Goldacre's excellent talks on how the pharma industry/business manipulates data:
    When a new drug gets tested, the results of the trials should be published for the rest of the medical world - except much of the time, negative or inconclusive findings go unreported, leaving doctors and researchers in the dark.

    ted.com/talks/ben_goldacre

    Also, the profit motive can direct research toward where a good return is likely rather than where it might optimally ameliorate human suffering. Consider male pattern baldness. Lots of dudes out there with this grotesque disfiguring disease would pay big money for a cure so lots of time and resources get directed away from where they might otherwise be employed.


  • Registered Users, Registered Users 2 Posts: 22,443 ✭✭✭✭endacl


    Hey, I'm not defending it.

    What's your alternative?


  • Registered Users, Registered Users 2 Posts: 10,115 ✭✭✭✭Junkyard Tom




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  • Closed Accounts Posts: 2,937 ✭✭✭galljga1



    Also, the profit motive can direct research toward where a good return is likely rather than where it might optimally ameliorate human suffering. Consider male pattern baldness. Lots of dudes out there with this grotesque disfiguring disease would pay big money for a cure so lots of time and resources get directed away from where they might otherwise be employed.

    Thanks Tom, I'll never look in the mirror again.


  • Closed Accounts Posts: 754 ✭✭✭mynameis905


    The pharmaceutical industry in a nutshell.

    "why cure with 1 pill, when we can treat for a lifetime with many pills"

    We have made vast strides in medicine over the past 100 years. Smallpox eradicated, cures/vaccines/treatments discovered for syphilis, TB, polio, tetanus, diptheria et al. Chemo and radiation therapy aimed at slowing down cancer and inducing remission where possible.

    But please, put on your tin-foil hat and tell us more about the big bad pharma industry and their conspiracies.


  • Registered Users, Registered Users 2 Posts: 16,560 ✭✭✭✭AndyBoBandy


    What about the guy who bought the patent for that AIDS pill and immediately jacked the price up by something like 1,000%

    Money is always more important than people's health.


  • Registered Users, Registered Users 2 Posts: 9,994 ✭✭✭sullivlo


    What about the guy who bought the patent for that AIDS pill and immediately jacked the price up by something like 1,000%

    Money is always more important than people's health.

    Yes. Because one greedy person sums up the entire pharmaceutical industry :rolleyes:


  • Registered Users, Registered Users 2 Posts: 9,994 ✭✭✭sullivlo


    Mr_Muffin wrote: »
    I do think there will be a cure for cancer but not for at least another 100+ years at least.

    I don't think there will ever be a cure for the blanket term of illnesses that fall under the name cancer, however I do think that there will be enough treatments out there that can be targeted to specific types of cancer(such as this immunotherapy, or herceptin for certain forms of breast cancer) that will make cancer a long term illness rather than a death sentence. Similar to HIV. They will never eradicate cancer as there are many genetic factors involved, however huge strides are being made.


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  • Closed Accounts Posts: 1,887 ✭✭✭traprunner


    Hopefully a cure comes from this. However I don't get this big pharma thing. Yes there is money in pharmacuticals but to get a drug to market costs so much money. Profits from previous drugs help to fund this.

    To say that pharmacuticals are not interested in curing cancer is crazy. Do people really believe that others put money ahead of a cure for a disease that has affected the lives of family and friends? Scientists are people too as are management in pharmacutical companies.


  • Registered Users, Registered Users 2 Posts: 9,994 ✭✭✭sullivlo


    cbyrd wrote: »
    There's huge money in cancer, what I'd like to know is why it's become so prevalent in recent years? Billions in research and still nowhere near a cure. A cynical person would wonder if it wasn't being introduced through some method, say for example, an injection or series of injections, that causes the body to develop, over time, abnormal cells. The same cynical person would wonder how much money can be generated from these injections and the fear/guilt factor of not getting them for very young bodies ....
    There's a lot of money to be made from making and keeping people sick ..
    It's a funny business, illness, profitable one too..!

    Ffs :rolleyes: antivaxers find their way everywhere now.


  • Registered Users, Registered Users 2 Posts: 32,634 ✭✭✭✭Graces7


    wakka12 wrote: »
    New diseases will always emerge. Im sure people would have said that back when TB was killing children but now look at all the new diseases we have that still kill many children.

    None in the TB league thankfully. My maternal grandmother gave birth to 7 babies and raised three. All died from TB .When I did my family tree the lists of dead babies and small children buried would break your heart. This was Wigan. They list the length of life...I had tears flowing.


  • Registered Users, Registered Users 2 Posts: 9,994 ✭✭✭sullivlo


    traprunner wrote: »
    Hopefully a cure comes from this. However I don't get this big pharma thing. Yes there is money in pharmacuticals but to get a drug to market costs so much money. Profits from previous drugs help to fund this.

    To say that pharmacuticals are not interested in curing cancer is crazy. Do people really believe that others put money ahead of a cure for a disease that has affected the lives of family and friends? Scientists are people too as are management in pharmacutical companies.

    I'm a scientist. I worked on a very novel drug that is currently in phase 2 clinical trials for the treatment of skin cancer and bladder cancer. My lab developed & patented a method of larger scale production of this drug. I cannot begin to explain the costs involved in any of the process, and that's before the clinical studies (which are showing very positive effects) commenced.

    Drug development is expensive. Cancer isn't the only illness out there. I'm currently working on a therapeutic for psoriasis. However only about 1% (or maybe even less these days) of discoveries made in the lab actually make it to product for whatever reasons - safety, efficacy, cost... So the "profits" made by pharma go into developing new drugs for other illnesses.


  • Closed Accounts Posts: 1,887 ✭✭✭traprunner


    sullivlo wrote: »
    I'm a scientist. I worked on a very novel drug that is currently in phase 2 clinical trials for the treatment of skin cancer and bladder cancer. My lab developed & patented a method of larger scale production of this drug. I cannot begin to explain the costs involved in any of the process, and that's before the clinical studies (which are showing very positive effects) commenced.

    Drug development is expensive. Cancer isn't the only illness out there. I'm currently working on a therapeutic for psoriasis. However only about 1% (or maybe even less these days) of discoveries made in the lab actually make it to product for whatever reasons - safety, efficacy, cost... So the "profits" made by pharma go into developing new drugs for other illnesses.

    In essence what I was saying. :) It's the conspiracy theory that I don't get.


  • Registered Users, Registered Users 2 Posts: 28,956 ✭✭✭✭murpho999


    If we cut out the profits and marketing and share holders then the same research could be done for a quarter of the cost.

    Corporate welfare is one thing when it's money out of our pockets, when it means having to choose which patients are going to die because there are limited health budgets then it's morally indefensible.

    Why would a pharmaceutical company work for no money?

    Do you think marketing outweighs the cost of research.

    Profits are vital for this as it goes back to shareholders who have financed the company in the first place.

    If there were no profits these companies would not exists, research would not get done and advances in medicine would not be found.


  • Registered Users, Registered Users 2 Posts: 1,905 ✭✭✭fret_wimp2


    cbyrd wrote: »
    There's huge money in cancer, what I'd like to know is why it's become so prevalent in recent years?

    It's always been around but now days circumstances are different.

    -were living longer. Ailments which would have killed us are now curable and not such an issue. Hygiene is better, so there's overall less things to kill us or knock us back. Thr longer your about the more likely a form. Of cancer will affect you.

    -there are many more of us. The population has grown from. About 3-4 billion in 1950 to about 9 billion today. Juat by more people existing, more people will get cancer.

    -my own opinion here, I think our diets an lifestyles don't help us. Eating foods with a lot of chemicals, pesticides and things we don't need and are known to be bad for us. They are cheap and side widely available but they are not healthy. Eat junk for 20 or 30 years and your body ends but being made of junk and full of stuff that shouldn't be there.


  • Registered Users, Registered Users 2 Posts: 68,173 ✭✭✭✭seamus


    fret_wimp2 wrote: »
    -my own opinion here, I think our diets an lifestyles don't help us. Eating foods with a lot of chemicals, pesticides and things we don't need and are known to be bad for us. They are cheap and side widely available but they are not healthy. Eat junk for 20 or 30 years and your body ends but being made of junk and full of stuff that shouldn't be there.
    I don't disagree that modern lifestyles have changed and certain aspects are a cancer risk, but it's not like people were living pure and clean lifestyles before 1970. Smoking, infection, excess alcohol, red meat, salt, excessive sun exposure, environmental chemicals, are all things that have been factors for humans for most of our existence and account for a majority of cancers.

    The big one affecting us is obesity which is "new", but it also has a rather bizarre side-element where you're more likely to die from obesity than obesity-related cancer.

    However this increase in obesity is offset by the massive improvements in infection control which have caused a large drop in infection-related cancers.

    Luckily however, obesity-related cancer is an easy issue to solve and one that seems to be on a downward trend in the western world. Hopefully developing countries don't have to re-learn the same mistakes.


  • Registered Users, Registered Users 2 Posts: 6,934 ✭✭✭Wossack


    we've also become a lot better at diagnosing causes of deaths over the years, which may skew figures


  • Registered Users, Registered Users 2 Posts: 32,634 ✭✭✭✭Graces7


    cbyrd wrote: »
    There's huge money in cancer, what I'd like to know is why it's become so prevalent in recent years? Billions in research and still nowhere near a cure. A cynical person would wonder if it wasn't being introduced through some method, say for example, an injection or series of injections, that causes the body to develop, over time, abnormal cells. The same cynical person would wonder how much money can be generated from these injections and the fear/guilt factor of not getting them for very young bodies ....
    There's a lot of money to be made from making and keeping people sick ..
    It's a funny business, illness, profitable one too..!

    Thought provoking post; thank you. Whenever something so new comes out my mind says, "Remember thalidomide..opren.." Agree too re processed foods. There was a US study a few years ago, comparing cancer and altzheimers rates among A the general population and B women in enclosed religious orders who ate simple wholesome food. The results were very telling; less cancer and less dementia. When the women started eating modern foods a the order shrank the rates changed to match the general population. Do not get me started re vaccination...


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  • Closed Accounts Posts: 14,949 ✭✭✭✭IvyTheTerrible


    Graces7 wrote: »
    Thought provoking post; thank you. Whenever something so new comes out my mind says, "Remember thalidomide..opren.." Agree too re processed foods. There was a US study a few years ago, comparing cancer and altzheimers rates among A the general population and B women in enclosed religious orders who ate simple wholesome food. The results were very telling; less cancer and less dementia. When the women started eating modern foods a the order shrank the rates changed to match the general population. Do not get me started re vaccination...
    What's the problem with vaccination?


  • Registered Users, Registered Users 2 Posts: 351 ✭✭Dimithy


    What's the problem with vaccination?

    You'll probably regret asking that.


  • Registered Users, Registered Users 2 Posts: 9,994 ✭✭✭sullivlo


    Graces7 wrote: »
    Thought provoking post; thank you. Whenever something so new comes out my mind says, "Remember thalidomide..opren.." Agree too re processed foods. There was a US study a few years ago, comparing cancer and altzheimers rates among A the general population and B women in enclosed religious orders who ate simple wholesome food. The results were very telling; less cancer and less dementia. When the women started eating modern foods a the order shrank the rates changed to match the general population. Do not get me started re vaccination...

    Thread about cancer. Please don't derail with antivaxers mumbo jumbo.


  • Registered Users, Registered Users 2 Posts: 9,786 ✭✭✭wakka12


    Why do so many people think pharma companies are out to kill you? Why is this such a common opinion? If they really didnt care about peoples health then why is there injections for MMR, TB, bubonic plague , all of these deadly diseases killed hundreds of millions of people for as long as humanity has been around. Why not just create an expensive pill we have to take everyday to keep us safe from these diseases if theyre so evil?

    Yes pharma companies make profits, big profits even, but how can you blame a company for wanting to make profits. Big pharma companies have done a lot more good for society than bad.


  • Registered Users, Registered Users 2 Posts: 19,801 ✭✭✭✭suicide_circus


    ^^^^ they're not "evil" but they're also not doing it for altruistic reasons.


  • Registered Users, Registered Users 2 Posts: 9,994 ✭✭✭sullivlo


    ^^^^ they're not "evil" but they're also not doing it for altruistic reasons.

    And what big companies that benefit the health of the world, DO do it for altruistic reasons?


  • Registered Users, Registered Users 2 Posts: 68,173 ✭✭✭✭seamus


    wakka12 wrote: »
    Yes pharma companies make profits, big profits even, but how can you blame a company for wanting to make profits. Big pharma companies have done a lot more good for society than bad.
    Because some people have this misguided notion that if you're doing something good, you should also be doing it out of the goodness of your heart.

    People who work for charities can heavily relate to this - management and supporters constantly attacking them for taking any kind of salary and expecting them to give more and more of their time for no pay because "it's a charity".


  • Moderators, Society & Culture Moderators Posts: 24,476 Mod ✭✭✭✭robindch


    cbyrd wrote: »
    There's huge money in cancer, what I'd like to know is why it's become so prevalent in recent years?
    Because up to fairly recently, people used to die of diseases which can be cured by antibiotics and better medical care. So people now live much older than they used to be, and if you live a long time, then you're much more likely to die from cancer as it's primarily a disease of old age (cigarette smoke and other preventibles notwithstanding).
    cbyrd wrote: »
    Billions in research and still nowhere near a cure. [...] A cynical person would wonder if it wasn't being introduced through some method, say for example, an injection or series of injections, that causes the body to develop, over time, abnormal cells.
    We've a scientist in the family who's been working for over twenty years on a gene-based cure for a class of certain debilitating diseases. Progress during this time is slow and painstaking, but steady and showing promise.

    I wonder would you have the bravery to tell her to her face that her colleagues over in cancer research are actively working to murder the people they're in fact working day and night to cure?

    Do you also believe that the people who made hangover cures are also poisoning your beer, or more likely, cider?


  • Moderators, Society & Culture Moderators Posts: 24,476 Mod ✭✭✭✭robindch


    wakka12 wrote: »
    Why do so many people think pharma companies are out to kill you? Why is this such a common opinion?
    Because it's easy.

    Most, and probably all, of the haters do not comprehend science or the scientific process or the regulatory environment or medicine and certainly have no overview of how all the players interact with each other and with reality - and instead prefer to dream up simplistic, grand, dramatic, shadowy - but complete unproveable - conspiracy theories to explain away what they do not understand.

    One doesn't need to look further than the social-network hatchet-job which is Monsanto to see the level of scientific rigour and honesty that the haters bring to a topic - all belly and no head.


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  • Registered Users, Registered Users 2 Posts: 816 ✭✭✭padraig.od


    time to start smoking again


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