Advertisement
If you have a new account but are having problems posting or verifying your account, please email us on hello@boards.ie for help. Thanks :)
Hello all! Please ensure that you are posting a new thread or question in the appropriate forum. The Feedback forum is overwhelmed with questions that are having to be moved elsewhere. If you need help to verify your account contact hello@boards.ie

Interesting Stuff Thread

16970727475219

Comments

  • Moderators, Society & Culture Moderators Posts: 24,458 Mod ✭✭✭✭robindch


    Meanwhile, from PNAS, comes news of CD47, a protein that blocks the immune response in fighting tumor and cancer cells.

    http://www.pnas.org/content/early/2012/03/20/1121623109
    CD47, a “don't eat me” signal for phagocytic cells, is expressed on the surface of all human solid tumor cells. Analysis of patient tumor and matched adjacent normal (nontumor) tissue revealed that CD47 is overexpressed on cancer cells. CD47 mRNA expression levels correlated with a decreased probability of survival for multiple types of cancer. CD47 is a ligand for SIRPα, a protein expressed on macrophages and dendritic cells. In vitro, blockade of CD47 signaling using targeted monoclonal antibodies enabled macrophage phagocytosis of tumor cells that were otherwise protected. Administration of anti-CD47 antibodies inhibited tumor growth in orthotopic immunodeficient mouse xenotransplantation models established with patient tumor cells and increased the survival of the mice over time. Anti-CD47 antibody therapy initiated on larger tumors inhibited tumor growth and prevented or treated metastasis, but initiation of the therapy on smaller tumors was potentially curative. The safety and efficacy of targeting CD47 was further tested and validated in immune competent hosts using an orthotopic mouse breast cancer model. These results suggest all human solid tumor cells require CD47 expression to suppress phagocytic innate immune surveillance and elimination. These data, taken together with similar findings with other human neoplasms, show that CD47 is a commonly expressed molecule on all cancers, its function to block phagocytosis is known, and blockade of its function leads to tumor cell phagocytosis and elimination. CD47 is therefore a validated target for cancer therapies.
    God, as usual, was unavailable for comment.


  • Registered Users, Registered Users 2 Posts: 238 ✭✭dmw07


    robindch wrote: »
    Meanwhile, from PNAS, comes news of CD47, a protein that blocks the immune response in fighting tumor and cancer cells.

    http://www.pnas.org/content/early/2012/03/20/1121623109

    God, as usual, was unavailable for comment.

    Looks like Rituximab(antiCD20) has a brother.

    And he strong :D


  • Registered Users, Registered Users 2 Posts: 7,845 ✭✭✭Calibos


    Can't wait for 'The Cure' to arrive hopefully within my lifetime to batter the anti science religionists over the head with. I'd also like to batter the Anti 'Big-Pharma' Alt-Med loopers with it as well :D


  • Registered Users, Registered Users 2 Posts: 238 ✭✭dmw07


    Calibos wrote: »
    Can't wait for 'The Cure' to arrive hopefully within my lifetime to batter the anti science religionists over the head with. I'd also like to batter the Anti 'Big-Pharma' Alt-Med loopers with it as well :D

    Cures.

    About 200 would do ;)


  • Registered Users, Registered Users 2 Posts: 30,746 ✭✭✭✭Galvasean


    Calibos wrote: »
    Can't wait for 'The Cure' to arrive hopefully within my lifetime to batter the anti science religionists over the head with. I'd also like to batter the Anti 'Big-Pharma' Alt-Med loopers with it as well :D

    You do realise when said cure does arrive the religious will take the credit and say it was their prayers wot dunnit, not yer fancy science no siree!


  • Advertisement
  • Moderators Posts: 52,024 ✭✭✭✭Delirium


    This may have been posted when the article originally appeared.

    Scientist creates lifelike cells out of metal
    Scientists trying to create artificial life generally work under the assumption that life must be carbon-based, but what if a living thing could be made from another element?

    One British researcher may have proven that theory, potentially rewriting the book of life. Lee Cronin of the University of Glasgow has created lifelike cells from metal — a feat few believed feasible. The discovery opens the door to the possibility that there may be life forms in the universe not based on carbon, reports New Scientist.

    Even more remarkable, Cronin has hinted that the metal-based cells may be replicating themselves and evolving.

    "I am 100 percent positive that we can get evolution to work outside organic biology," he said.

    If you can read this, you're too close!



  • Registered Users, Registered Users 2 Posts: 26,578 ✭✭✭✭Turtwig


    Personally I don't think there are many scientists who doubt non carbon based life is possible. Popular articles try to make it sound like the idea is unique and original but it has been mentioned in papers I've read dating back to the 1940s. It's just that carbon based life is the one we think we have the most information on so it should, in theory, be the optimal one to replicate. However, as most posters here know nature doesn't always choose the smartest path. There may be in fact be another type of life far better optimised for planet Earth's ecosystem that just never developed. Unfortunately we have nothing but theory to go on. So replication of life as we know it will always be given first priority.


  • Registered Users, Registered Users 2 Posts: 3,773 ✭✭✭smokingman


    koth wrote: »
    This may have been posted when the article originally appeared.

    Scientist creates lifelike cells out of metal

    :eek::eek::eek:
    tumblr_kzv2tizLwk1qa7qbyo1_400.jpg


  • Registered Users, Registered Users 2 Posts: 8,034 ✭✭✭Sonics2k


    smokingman wrote: »
    :eek::eek::eek:
    tumblr_kzv2tizLwk1qa7qbyo1_400.jpg

    Combine that with last years news that Microsoft and Skype have joined together

    org-skynet-itler-net_130939160469.gif

    Raisins_Face.jpg


  • Registered Users, Registered Users 2 Posts: 3,862 ✭✭✭mikhail


    There's a blog devoted to reposting George Orwell's diaries day by day +70 years that I've been following since before WWII broke out for its unique left-wing, socially conscious, ex-soldier, current propagandist, man on the ground point of view. Part a note in today's entry is interesting for folks here:
    The Vatican is exchanging diplomatic representatives with Tokio. The Vatican now has diplomatic relations with all the Axis powers and – I think – with none of the Allies. A bad sign and yet in a sense a good one, in that this last step means that they have now definitely decided that the Axis and not we stand for the more reactionary policy.
    http://orwelldiaries.wordpress.com/2012/03/27/27-3-42/


  • Advertisement
  • Registered Users, Registered Users 2 Posts: 677 ✭✭✭Doc_Savage


    Sonics2k wrote: »
    Combine that with last years news that Microsoft and Skype have joined together...............

    have you seen the boston dynamics Petman project?



    all the parts of the puzzle are nearly there...


  • Moderators, Society & Culture Moderators Posts: 24,458 Mod ✭✭✭✭robindch


    ^^^ I'd take that robot a lot more serious if he wasn't wearing red shoes.


  • Closed Accounts Posts: 13,989 ✭✭✭✭recedite


    He changes his shoes for the press-ups routine. Definitely a bit gay.
    Did you see where that drunk wandered over and shoved him, and the robot just walked away? He should have crushed that man like an ant.
    Seriously though, I think the red pinhead is designed to make him appear less intimidating to small-brained humans. :)


  • Registered Users, Registered Users 2 Posts: 4,093 ✭✭✭CiaranMT


    Professor who led the infamous 'faster-than-light' neutrino experiment resigns:

    http://www.irishtimes.com/newspaper/breaking/2012/0330/breaking58.html


  • Registered Users, Registered Users 2 Posts: 26,578 ✭✭✭✭Turtwig


    CiaranMT wrote: »
    Professor who led the infamous 'faster-than-light' neutrino experiment resigns:

    http://www.irishtimes.com/newspaper/breaking/2012/0330/breaking58.html

    How is the experiment "infamous"?:confused:


  • Moderators, Category Moderators, Arts Moderators, Sports Moderators Posts: 52,218 CMod ✭✭✭✭magicbastarder


    CiaranMT wrote: »
    Professor who led the infamous 'faster-than-light' neutrino experiment resigns:

    http://www.irishtimes.com/newspaper/breaking/2012/0330/breaking58.html
    i prefer the irish times headline to yours. an FTL scientist sounds cool. though if he was really FTL, he should have resigned before the experiment was performed.


  • Registered Users, Registered Users 2 Posts: 4,540 ✭✭✭joseph brand


    Strange Computer Code Discovered Concealed In Superstring Equations!


    Since when is nature concerned with embedding a very particular kind of error correction code into the fundamental laws of physics?

    Crazy stuff. We're in the Matrix. Nice one. ;)


  • Registered Users, Registered Users 2 Posts: 7,845 ✭✭✭Calibos


    Now that I think about it, the answer to a theist who asks, what would it take to convince you of the existance of a God would be something like this. I would likely put down any visual or auditory apparition in myself or others as a hallucination. However one couldn't argue with the math (even if I don't understand the math myself. ie. Its a totally different propostion to put faith in what a preacher/priest/theologian/pope says than put 'faith in what a peer reviewed panel of mathematicians/scientists say)

    However, this 'Proof' would at most make me a deist because as far as I am concerned it lends no more credence to human religions' plethora of Gods. ie Confirmation of a creator of the universe 'God' does not allow me to connect the 13 billion years of dots to the ramblings of bronze age Goat Herders from the eastern Medditerrainian circa 3000 years ago no more than it allows me to connect the dots to the ramblings of 12th century Llama Herders on an eastern Pacific Coast in Peru.

    To my mind, this is the only way Dawkins conviction that science could explain the creation of the universe some day could come to pass. Its not that science can ever 'see' 'outside' the universe or 'before' the universe because science is part of the universe, but if science can find hints like this written into the fabric of the universe then although it doesn't help science to see outside or before the universe, its a pretty big clue that there must be something outside or before.

    Not convinced of any of this yet though. Is this not a case of finding error correction code within a theory, but a theory that is nowhere close to being proved yet. ie. the theory could be wrong so what then does an error correction code within mean? Could it simply be a self generating property of the math and does that mean anything philosophically? Or was it unconciously written in by the mathemeticians so the math would work. Then it simply becomes an interesting neurological question. ie. The subconcious can do very high level math :D

    Interestingly, this kind of code written into the fabric of the universe was the premise for the short lived Stargate Universe TV series.

    I am also reminded of a fictional book called Pi

    Basically it was discovered that a picture was coded into the numbers after the decimal point in Pi.

    It was a picture of a Circle :eek:


  • Registered Users, Registered Users 2 Posts: 5,406 ✭✭✭Pompey Magnus


    Strange Computer Code Discovered Concealed In Superstring Equations!





    Crazy stuff. We're in the Matrix. Nice one. ;)

    So basically God has gone from this:

    god.jpg

    to this:

    the-fat-man-at-the-computer-photo-u1.jpg


  • Registered Users, Registered Users 2 Posts: 445 ✭✭muppeteer


    http://www.zmescience.com
    The most complex object on Earth is the human brain. However, even though it’s intertwined by billions of nerve fibers almost in a chaotic fashion, scientists who have used sophisticated mathematical analysis of advanced imaging data found that the neural pathways that carry electrical signals through the brain are arranged in a very simple manner, resembling a grid. This counter-intuitive finding suggests that the neural structure is extremely simple, underlying the complexity of the brain.

    “We found the brain is built from parallel and perpendicular fibers that cross each other in an orderly fashion. Finding this kind of simple organization in the forebrain of higher animals was completely unsuspected,” says Van Wedeen, MD, of the Martinos Center for Biomedical Imaging at Massachusetts General Hospital, who led the study. “Knowing there is a simple plan that, modified by evolution and development, gives rise to all brains has implications for researchers working to build an atlas of brain connections, for pursuing investigation of how the brain develops and for expanding theories of how the brain works.”


  • Advertisement
  • Registered Users, Registered Users 2 Posts: 445 ✭✭muppeteer


    And something more worrying.

    http://www.reuters.com/article/2012/03/28/us-science-cancer-idUSBRE82R12P20120328
    A former researcher at Amgen Inc has found that many basic studies on cancer -- a high proportion of them from university labs -- are unreliable, with grim consequences for producing new medicines in the future.

    During a decade as head of global cancer research at Amgen, C. Glenn Begley identified 53 "landmark" publications -- papers in top journals, from reputable labs -- for his team to reproduce. Begley sought to double-check the findings before trying to build on them for drug development.

    Result: 47 of the 53 could not be replicated. He described his findings in a commentary piece published on Wednesday in the journal Nature.


  • Registered Users, Registered Users 2 Posts: 26,578 ✭✭✭✭Turtwig


    muppeteer wrote: »

    Not at all surprising. Lots of peer reviewed papers published are in fact rubbish.


  • Moderators, Society & Culture Moderators Posts: 25,583 Mod ✭✭✭✭Dades


    Calibos wrote: »
    I am also reminded of a fictional book called Pi

    Basically it was discovered that a picture was coded into the numbers after the decimal point in Pi.

    It was a picture of a Circle :eek:
    That sounds oddly like the reveal at the end of another fantastic book by a favourite writer around these parts that I won't mention.

    Odd!


  • Registered Users, Registered Users 2 Posts: 445 ✭✭muppeteer


    Dades wrote: »
    That sounds oddly like the reveal at the end of another fantastic book by a favourite writer around these parts that I won't mention.

    Odd!
    Given that it is supposed to be infinite then all possible pictures would be encoded too, no?


    And if that end reveal is from the favourite writer I'm thinking of and currently reading then,
    may your dreams be made into appropriate nightmares, you spoiler making poopie head!!!!!!1


  • Moderators, Society & Culture Moderators Posts: 25,583 Mod ✭✭✭✭Dades


    muppeteer wrote: »
    Given that it is supposed to be infinite then all possible pictures would be encoded too, no?
    In theory... but now I'm afraid to elaborate!
    muppeteer wrote: »
    And if that end reveal is from the favourite writer I'm thinking of and currently reading then,
    may your dreams be made into appropriate nightmares, you spoiler making poopie head!!!!!!1
    I went out of my way to not mention it (or even tempt people with spoiler tags!)

    Also, the pi thing is almost a footnote in the book I'm thinking of, rather than a big Crying Game twist. :pac:


  • Registered Users, Registered Users 2 Posts: 4,718 ✭✭✭The Mad Hatter


    mikhail wrote: »
    There's a blog devoted to reposting George Orwell's diaries day by day +70 years that I've been following since before WWII broke out for its unique left-wing, socially conscious, ex-soldier, current propagandist, man on the ground point of view. Part a note in today's entry is interesting for folks here:

    http://orwelldiaries.wordpress.com/2012/03/27/27-3-42/

    *subscribes*


  • Registered Users, Registered Users 2 Posts: 4,718 ✭✭✭The Mad Hatter


    Strange Computer Code Discovered Concealed In Superstring Equations!





    Crazy stuff. We're in the Matrix. Nice one. ;)

    o.O I can't say I understood most of that, but skeptical Hatter is skeptical.


  • Moderators, Society & Culture Moderators Posts: 24,458 Mod ✭✭✭✭robindch


    skeptical Hatter is skeptical.
    I'm mildly familiar with error-correcting codes and until he shows up with the loot, I'm keeping my hands in my pockets on this one(*)

    (*) Poster is expert metaphor-handler and can say things like this with a straight face.


  • Registered Users, Registered Users 2 Posts: 4,093 ✭✭✭CiaranMT


    Saw this in Cool Vids, thought I'd share:



  • Advertisement
  • Registered Users, Registered Users 2 Posts: 3,862 ✭✭✭mikhail


    *subscribes*
    Sadly, it runs out some time this year.


Advertisement