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Covid 19 Part XXXV-956,720 ROI (5,952 deaths) 452,946 NI (3,002 deaths) (08/01) Read OP

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Comments

  • Posts: 9,005 ✭✭✭ [Deleted User]


    The increase in spread amongst the vaccinated was due to the delta variant. If anything, this data suggests that boosters are needed to deal with variants due to evidence of waning protective effects of the vaccine.



  • Posts: 9,005 ✭✭✭ [Deleted User]


    Yet, you are using the same paper to suggest there is no effect on transmission if receiving a vaccine. Strange, that?



  • Registered Users, Registered Users 2 Posts: 133 ✭✭vegandinner




  • Registered Users, Registered Users 2 Posts: 1,501 ✭✭✭floorpie


    I'm afraid that's not how statistics works. You can't just look at the mean rates and say "but look, the numbers are different". The study finds NO statistical evidence that rates of transmission are different based on vaccination status.

    Now...that doesn't mean that they are not different, but this study was not able to find it. If the number of participants was an issue then this can be addressed. However far larger household studies had the exact same findings (see the Netherlands households study).

    I think you are getting confused

    I'm not confused at all



  • Registered Users, Registered Users 2 Posts: 2,442 ✭✭✭Cork2021


    ICU Will hover around those figures for a couple more weeks beofre dropping gradually hopefully!



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  • Registered Users, Registered Users 2 Posts: 1,501 ✭✭✭floorpie


    You posted the study. I'm helping you to understand the findings of the study, i.e., that they find NO evidence of reduced transmission based on vaccination status. Zero. They say this in the abstract even.



  • Registered Users, Registered Users 2 Posts: 18,501 ✭✭✭✭namloc1980


    Eh that's data from July to November last year. We're talking about the 941 in hospital today which is what is relevant. How many of those are unvaccinated, as you claimed they were a disproportionate number? No going back to July, what's the stats now?



  • Registered Users, Registered Users 2 Posts: 828 ✭✭✭Hey boy


    None of this was my point as you no doubt know and covid hospitalisation is not prevented with a single jab either.

    Look if you want to be a pin cushion for pharma with injections every 3-6 months go ahead. However if you are really interested in saving hospitals etc etc then at least be consistent and add obese people to those they “annoy” you and need to be restricted “for their own protection “ of course as Dazzler is recently telling us.

    btw obese people have had almost two years to work on themselves and in fairness many have. Those with medical causes for obesity excepted of course.



  • Registered Users, Registered Users 2 Posts: 858 ✭✭✭jolivmmx


    Basically, most medical research uses a branch of statistics called inferential statistics. What you do, you take a small group of people from the big group (a sample who represent the overall group that you want to study). You then study this smaller group and extrapolate to the wider group. If you were to study the effect of vaccine on the transmission rates, you would divide the smaller group into vaccinated and unvaccinated. You would get a mean difference. However, if you were to take another smaller group from the bigger group, you would see a different mean difference due to randomness (sampling variation). You calculate a thing called the 95% confidence interval. This is a range of numbers. If you took 100 small groups from the big group and repeated the study with them, 95/100 would have a mean difference in your quoted range. The purpose of the stat test is to determine what is the likelihood that the observed difference in your study is due to chance. If something is P<0.05, this means that there is <1/20 chance that the observed difference was due to chance. By convention, in medicine this is often used as an acceptable threshold. However, in some cases, they seek P<0.001, meaning that the difference due to chance is <1/1000.

    Inferential statistics is used because it is just not financially or logistically possible to collect data from every single member of the big group.

    The hard part is to make sure that the little group study actually represents the big group and that the variables (ie known and unknown differences between groups) are accounted for.

    Are there any datasets on transmission rates between vaccinated and unvaccinated in omicron? I think that I read somewhere that the risk is reduced?



  • Registered Users, Registered Users 2 Posts: 11,631 ✭✭✭✭Cluedo Monopoly


    To be fair there will be very few 'unvaccinated' people in Ireland by the end of January.

    Many unvaccinated people will pick up Omicron which will give them natural immunity. Thankfully it is a very mild dose for most of them.

    I would not count people who have recovered from Covid in the "big bad unvaccinated" cohort.

    What are they doing in the Hyacinth House?



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  • Registered Users, Registered Users 2 Posts: 858 ✭✭✭jolivmmx


    That news is super! Fingers crossed the trend continues!



  • Moderators, Business & Finance Moderators, Science, Health & Environment Moderators, Society & Culture Moderators Posts: 51,688 Mod ✭✭✭✭Stheno


    Second highest number of outbreaks (and highest outside of households) was in schools in the second half of last year.





  • Registered Users, Registered Users 2 Posts: 858 ✭✭✭jolivmmx


    I am not a pin-cushion for pharma. That term that you use would suggest a degree of equipoise. We have conclusive evidence that vaccines reduce serious Covid.

    If vaccine means me not getting serious covid, then line me up and I will gladly be jabbed until my risk of catching Covid is a lot less than now!



  • Registered Users, Registered Users 2 Posts: 858 ✭✭✭jolivmmx


    This shows a clearly much higher proportion of hospitalisations amongst the unvaccinated (I cannot find any data from the end of December, but I am sure that it will be released soon):

    https://www.hpsc.ie/a-z/respiratory/coronavirus/novelcoronavirus/surveillance/vaccinationstatusreports/Vaccination%20status%20of%20confirmed%20COVID-19%20cases%20in%20Ireland%20Week%2048.pdf



  • Registered Users, Registered Users 2 Posts: 1,333 ✭✭✭bloopy


    We don't know.

    The last hspc report only goes as far as 4th December. The last CSO report goes to 10th December.

    Hspc report unvaccinated from 7 November to 4 December:

    15% cases

    21% hospitalisations

    45% icu

    16% deaths.

    Still higher than percentage of population unvaccinated but had been dropping.

    Was expecting updated report last week but has not arrived yet.

    What the current stats are for the omicron wave is unknown so far.

    Cases over Christmas unlikely to be known until near the end of the month if the new style reports continue the two week release schedule.



  • Registered Users, Registered Users 2 Posts: 1,501 ✭✭✭floorpie


    Are there any datasets on transmission rates between vaccinated and unvaccinated in omicron? I think that I read somewhere that the risk is reduced?

    There are preliminary studies (e.g., SARS-CoV-2 Omicron VOC Transmission in Danish Households | medRxiv) that show what you're saying. I.e. rates of transmission overall are lower when compared to Delta. Susceptibility to infection of Omicron is the same for fully vaccinated and unvaccinated, however succeptibility is lower in the period after booster. In odds ratios it's 0.54 compared to fully vaccinated. This table shows all the above:

    image.png




  • Registered Users, Registered Users 2 Posts: 713 ✭✭✭cheezums


    Surprise surprise. And covid doesnt suddenly appear in households either. It probably came from freely mixing kids in playgrounds and classrooms, like most other respiratory viruses.

    Does anyone still doubt schools were the main driver of this thing all along?



  • Registered Users, Registered Users 2 Posts: 858 ✭✭✭jolivmmx


    Thanks a million for that!

    It is a pretty convincing odds ratio for the booster cohort versus even the fully vaccinated



  • Registered Users, Registered Users 2 Posts: 7,641 ✭✭✭timmyntc


    Give it 3 months and you'll need another or be just as much at risk of infection as the rest.

    Besides, I thought the goal of the vaccines was to stop serious disease and not infection rates?



  • Registered Users, Registered Users 2 Posts: 858 ✭✭✭jolivmmx


    And hopefully in 3 months, the daily infections rate will have fallen right down! I can only deal with the here and now. Now, my risk is high. Therefore, I got the booster



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  • Registered Users, Registered Users 2 Posts: 7,641 ✭✭✭timmyntc


    Do you have any evidence that the vaccinated are at risk of serious disease from covid? Sounds like an anti-vaxxer talking point from you.

    The vaccines work to protect you from serious disease and death - there is very little waning from that.



  • Registered Users, Registered Users 2 Posts: 8,162 ✭✭✭Jinglejangle69


    And isn't that now proving to be a good thing as we are heading towards herd immunity and all the numbers are dropping.


    Leaving schools open has accelerated are way out of this.


    Closing them would have just prolonged it.



  • Registered Users, Registered Users 2 Posts: 858 ✭✭✭jolivmmx


    I fail to understand you? I love the vaccine! I am triple dosed. My point was about the data suggesting boosters reduce transmission

    I was responding to somebody who questioned the study I thanked, stating that transmission rates are lower amongst the booster cohort. They told me that in 3 months I will be in the same boat as everybody else.

    vaccines are effective at reducing serious Covid AND there is preliminary data to suggest that the transmission rates are lower in the booster than even the doubly vaccinated. Boosters are our best chance, especially now with Covid at large



  • Registered Users, Registered Users 2 Posts: 7,641 ✭✭✭timmyntc


    Boosters are our best chance, especially now with Covid at large

    Best chance at what? We already have population wide protection against illness and death, hospitals are coping, why do we need boosters for everyone?



  • Registered Users, Registered Users 2 Posts: 858 ✭✭✭jolivmmx


    Because boosters confer ongoing protection against serious illness (I.e. requiring oxygen) AND there is preliminary data (see earlier in thread) that boosters reduce transmission, even compared to those with two doses.


    1,000 hospitalisations is a lot of pressure. We are coping. But we need to ensure that it doesn’t get worse.



  • Posts: 12,836 ✭✭✭✭ [Deleted User]


    I seriously struggle to believe any study saying these vaccines reduce transmission in any material way at this point. The real world stats surely outweigh them.

    And with that any serious argument for these vaccine passes should go out the window. But instead we will double down on what was flawed logic to begin with



  • Registered Users, Registered Users 2 Posts: 858 ✭✭✭jolivmmx


    What is your relative comparator. You are simply looking at the society as a whole.


    But you have to compare transmission rates in vaccinated and unvaccinated to know if there is a difference in transmission rates.

    Also, given the risk of serious disease in unvaccinated and the pressure that puts our health service under, surely we need to help reduce the risk of unvaccinated catching Covid



  • Registered Users, Registered Users 2 Posts: 1,893 ✭✭✭the kelt


    Maybe you should campaign to have their driving licences revoked forcing them to walk everywhere, problem solved!!



  • Registered Users, Registered Users 2 Posts: 858 ✭✭✭jolivmmx


    You really don’t understand analogies. God help you if you ever have to attend an ethics lecture!

    Usually, I would laugh and like your point. But by making me the arse of your jokes, you make me into a figure of ridicule. Therefore, no matter what I say, even if it is valid, you can just dismiss it as nonsense. It is easier to laugh than listen



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  • Posts: 12,836 ✭✭✭✭ [Deleted User]


    Look at countries with high vaccination rates versus low? The rate vaccinated people are getting it in this country is off the charts, so not sure how a comparison is even useful.

    Also the rate of spread here is so high right now, it seems incredibly evident they're doing nothing. My argument isn't about severity, of course the vaccines are useful. Its just seems completely nuts to me, not a scientist, that we're still claiming they impact transmission when the basic statistics seem to show otherwise.



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