Vaccine Megathread - See OP for threadbans

Cole · 11-05-2021 06:03PM

Can anyone point me in the direction of the stats for J and J's efficacy against the UK variant?

Thanks

11-05-2021 06:14PM

Cole wrote: »

Can anyone point me in the direction of the stats for J and J's efficacy against the UK variant?

Thanks

Isnt it the dominant strain in the U.S so 72% overall ?

Lumen · 11-05-2021 06:21PM

Marine Layer wrote: »

Isnt it the dominant strain in the U.S so 72% overall ?

Don't think that was the case during the trials. From what I've read Jannsen is only slightly less effective against the B.1.1.7. variant than the classic variant.

There's this EMA assessment report from 11 March 2021

Assessment report
COVID-19 Vaccine Janssen
Procedure No. EMEA/H/C/005737/0000
https://www.ema.europa.eu/en/documents/assessment-report/covid-19-vaccine-janssen-epar-public-assessment-report_en.pdf

...but I am woefully unqualified to interpret it.

Gile_na_gile · 11-05-2021 06:39PM

Lumen wrote: »

Don't think that was the case during the trials. From what I've read Jannsen is only slightly less effective against the B.1.1.7. variant than the classic variant.

There's this EMA assessment report from 11 March 2021

Assessment report
COVID-19 Vaccine Janssen
Procedure No. EMEA/H/C/005737/0000
https://www.ema.europa.eu/en/documents/assessment-report/covid-19-vaccine-janssen-epar-public-assessment-report_en.pdf

...but I am woefully unqualified to interpret it.

I saw that and am even less qualified to read it! OP, see the realworld efficacy paper too although it also has no data specifically on B.1.1.7
https://www.medrxiv.org/content/10.1101/2021.04.27.21256193v1

Cole · 11-05-2021 06:42PM

Lumen wrote: »

Don't think that was the case during the trials. From what I've read Jannsen is only slightly less effective against the B.1.1.7. variant than the classic variant.

There's this EMA assessment report from 11 March 2021

Assessment report
COVID-19 Vaccine Janssen
Procedure No. EMEA/H/C/005737/0000
https://www.ema.europa.eu/en/documents/assessment-report/covid-19-vaccine-janssen-epar-public-assessment-report_en.pdf

...but I am woefully unqualified to interpret it.

Same here. The only thing I can take from it is...

"Preliminary data showed that neutralising antibodies elicited by Ad26.COV2.S were able to neutralise the B.1.1.7 lineage variant in vitro, although less efficiently than the reference strain. Thus, some protection against this variant too is anticipated"

"Anticipated" is what stood out there. I'm guessing there's been something a bit more definitive reported since this and since its roll out in the US, where the UK variant is the dominant one now I think.

scooby77 · 11-05-2021 06:48PM

I had read that a move to extend 2nd dose of Pfizer to 6 weeks ( or longer) was up for discussion at today's cabinet. Cant find any updates...anyone any insight?

Deeper Blue · 11-05-2021 06:55PM

lastusername wrote: »

Care to address what you feel is nonsense?

I'll answer that one

All of it

iheartpooner · 11-05-2021 06:59PM

scooby77 wrote: »

I had read that a move to extend 2nd dose of Pfizer to 6 weeks ( or longer) was up for discussion at today's cabinet. Cant find any updates...anyone any insight?

The Independent had an article on it but have since rewritten the article with a footnote that they had their information wrong. My account is too new to share links

11-05-2021 07:07PM

scooby77 wrote: »

I had read that a move to extend 2nd dose of Pfizer to 6 weeks ( or longer) was up for discussion at today's cabinet. Cant find any updates...anyone any insight?

Heard Fergal Bowers on the news earlier saying it wasn't up for review.

revelman · 11-05-2021 07:20PM

Flying Fox wrote: »

Heard Fergal Bowers on the news earlier saying it wasn't up for review.

Does anyone know why? Is NIAC still pointing to the manufacturer’s guidance based on the trial data? There is so much real world data now that says a first dose of the vaccines is almost 90% effective. The U.K., Canada etc all moved to significantly lengthen the interval between doses. In my opinion, NIAC are being unjustifiably cautious. Having a bigger space between the doses would speed up things significantly.

Strazdas · 11-05-2021 07:23PM

Got my first dose (AstraZeneca) at the Aviva late this afternoon. Excellent set up they have there, flying through the appointments and super efficient. Got vaccinated within 30 minutes of showing up at the main entrance. Everyone there today looked my age, so it looks like they are literally doing one year at a time (which means if you are 35 or 46 or whatever, expect to see hundreds of 35 or 46 year olds on the same day whenever your time comes).

Six day turnaround between registering on the portal and being vaccinated, that's very good going.

ShineOn7 · 11-05-2021 07:25PM

I'm hearing from family members that more GPs are telling Cohort 7 patients to go to the HSE portal and wait till their age comes up or to try another GP

What happens if they decide to take their chances on the portal and get Janssen, when people in Cohort 7 are in fact largely supposed to get Pfizer

Today's updated figures

Vaccination Numbers - Up to Sunday 9th May

Total doses: 1,848,747 (+21,137)
First dose: 1,347,561 (+19,740)
Second dose: 501,186 (+1,397)
Fully vaccinated (Second +J&J): 501,351 (+1,422)

Vaccine Type

Pfizer: 1,247,493 (+3,731) - 18% of total
Moderna: 89,399 (+267) - 1% of total
AZ: 511,690 (+17,114) - 81% of total
Janssen: 165 (+25) - 0.1% of total

Cohort Breakdown

Cohort 1 (Residents aged 65+ in LTCF)

Total in group: ~105,000
Total vaccines: 195,830 (+62)
Total with first vaccine: 110,970 (+56)
Total with second vaccine: 84,860 (+6)
106% of total half vaccinated (+0%)
81% of total fully vaccinated (+0%)

Cohort 2 (Frontline Healthcare Workers)

Total in group: ~250,000
Total vaccines: 357,523(+357)
Total with first vaccine: 259,792 (+282)
Total with second vaccine: 97,731 (+75)
104% of total half vaccinated (+0%)
39% of total fully vaccinated (+0%)

Cohort 3 (People 70+)

Total in group: 482,327
Total vaccines: 767,789 (+1,541)
Total with first vaccine: 459,133 (+375)
Total with second vaccine: 308,676 (+1,166)
95% of total half vaccinated (+0%)
64% of total fully vaccinated (+0%)

Cohort 4 (People aged 16-69 and at very high risk of severe Covid-19)

Total in group: ~250,000
Total vaccines: 268,030 (+2,339)
Total with first vaccine: 258,244 (+2,193)
Total with second vaccine: 9,786 (+146)
103% of total half vaccinated (+1%)
3.9% of total fully vaccinated (+0%)

Cohort 5 (All aged 60-69)

Total in group: 417,000
Total vaccines: 253,722 (+16,267)
Total with first vaccine: 253,642 (+16,262)
Total with second vaccine: 80 (+5)
61% of total half vaccinated (+4%)
0% of total fully vaccinated

Cohort 7 (People aged 16-69 who have an underlying conditions that puts them at high risk of severe disease and death)

Total in group: ~350,000
Total vaccines: 2,785 (+12)
Total with first vaccine: 2,782 (+12)
Total with second vaccine: 3 (+0)
0.8% of total half vaccinated (+0%)
0% of total fully vaccinated (+0%)

Other "Uncoded" Cohort

Total: 3,068
First Dose: 3,018
Second Dose: 50

(Majority of these in "Uncoded" will be assigned to the correct Cohort in tomorrow's numbers)

Evil_g · 11-05-2021 07:33PM

ShineOn7 wrote: »

What happens if they decide to take their chances on the portal and get Janssen, when people in Cohort 7 are in fact largely supposed to get Pfizer

Nothing. Nothing happens.

Tyrone212 · 11-05-2021 07:42PM

In France all over 18s can now book an appointment the night before for any free slots that haven’t been booked for the following day.

A really good idea IMO.

wtd2008 · 11-05-2021 07:45PM

Anyone give a guestimate when 48 yr olds might be realistically vaccinated?
Thanks

Lumen · 11-05-2021 07:47PM

wtd2008 wrote: »

Anyone give a guestimate when 48 yr olds might be realistically vaccinated?
Thanks

Last week in May/first week in June, hopefully.

11-05-2021 07:47PM

revelman wrote: »

Does anyone know why? Is NIAC still pointing to the manufacturer’s guidance based on the trial data? There is so much real world data now that says a first dose of the vaccines is almost 90% effective. The U.K., Canada etc all moved to significantly lengthen the interval between doses. In my opinion, NIAC are being unjustifiably cautious. Having a bigger space between the doses would speed up things significantly.

I think the question was asked a few weeks ago so presumably they would expect the same answer.

I agree, even a small change to 6 weeks instead of 4 would help, and it's within the manufacturer's guidelines. I find it strange that they haven't allowed that at least.

Wolf359f · 11-05-2021 07:48PM

ShineOn7 wrote: »

I'm hearing from family members that more GPs are telling Cohort 7 patients to go to the HSE portal and wait till their age comes up or to try another GP

What happens if they decide to take their chances on the portal and get Janssen, when people in Cohort 7 are in fact largely supposed to get Pfizer

The most at risk would be those with certain autoimmune conditions or taking certain immune suppressants. Some would not make or make very little antibodies, so having the highest efficiency or highest antibody response vaccine would be extremely important. At least going through a GP, they can choose or refer you for the most appropriate vaccine, where the MVC is what's ever on the menu that day.

revelman · 11-05-2021 07:51PM

wtd2008 wrote: »

Anyone give a guestimate when 48 yr olds might be realistically vaccinated?
Thanks

Who knows? But if I was to guess I’d say that you might be able to register from the middle of next week and you might get a vaccination before the end of the month. That is if things are going well!

muckisluck · 11-05-2021 07:51PM

wtd2008 wrote: »

Anyone give a guestimate when 48 yr olds might be realistically vaccinated?
Thanks

If you live in Louth Id guess October 2022

embraer170 · 11-05-2021 07:53PM

ShineOn7 wrote: »

I'm hearing from family members that more GPs are telling Cohort 7 patients to go to the HSE portal and wait till their age comes up or to try another GP

What happens if they decide to take their chances on the portal and get Janssen, when people in Cohort 7 are in fact largely supposed to get Pfizer

Today's updated figures

Cohort 7 (People aged 16-69 who have an underlying conditions that puts them at high risk of severe disease and death)
Total in group: ~350,000

Total vaccines: 2,785 (+12)

Total with first vaccine: 2,782 (+12)

Total with second vaccine: 3 (+0)

0.8% of total half vaccinated (+0%)

0% of total fully vaccinated (+0%)

Quite shocking.

WoollyRedHat · 11-05-2021 07:57PM

USA holding up the show again, this time Curevac. EU need to redirect some of their ire held for AZ to the USA.

https://www.reuters.com/business/healthcare-pharmaceuticals/curevac-says-mass-vaccine-rollout-thrown-into-doubt-by-us-restrictions-2021-05-04

Strazdas · 11-05-2021 07:59PM

wtd2008 wrote: »

Anyone give a guestimate when 48 yr olds might be realistically vaccinated?
Thanks

At the pace they are going at the moment, it could easily before the end of this month. Wouldn't be a surprise if they throw open the portal for you early next week.

PopePalpatine · 11-05-2021 08:00PM

Tyrone212 wrote: »

In France all over 18s can now book an appointment the night before for any free slots that haven’t been booked for the following day.

A really good idea IMO.

I'm just waiting for...
1) the site to collapse under the massive amount of people logging on to book a spot.
2) people to code bots to snatch up all those empty spots like console/PC component scalpers.

Rebelbrowser · 11-05-2021 08:05PM

eoinbn wrote: »

There is a lot of flawed logic in that.

Not all over 60s are done.
Not all age groups are the same size - they keep getting bigger until the 20s.

Your end result for 50s and 40s probably isn't that far off. It could take longer for the 30s and 20s.

Bizarrely 40s are biggest age group....

Bubbaclaus · 11-05-2021 08:06PM

Tyrone212 wrote: »

In France all over 18s can now book an appointment the night before for any free slots that haven’t been booked for the following day.

A really good idea IMO.

Sounds a bit chaotic to me. Potentially up to 30 million odd people logging on to fight over a few free slots online?

pc7 · 11-05-2021 08:11PM

Bubbaclaus wrote: »

Sounds a bit chaotic to me. Potentially up to 30 million odd people logging on to fight over a few free slots online?

Be interesting to see how it works and if vaccine hesitancy is going to be an issue in France.

Gen.Zhukov · 11-05-2021 08:16PM

Strazdas wrote: »

Got my first dose (AstraZeneca) at the Aviva late this afternoon. Excellent set up they have there, flying through the appointments and super efficient. Got vaccinated within 30 minutes of showing up at the main entrance. Everyone there today looked my age, so it looks like they are literally doing one year at a time (which means if you are 35 or 46 or whatever, expect to see hundreds of 35 or 46 year olds on the same day whenever your time comes).

Six day turnaround between registering on the portal and being vaccinated, that's very good going.

I had the same experience but at CityWest and Pfizer. Very impressed.

The mens hair grooming stall was very quiet:pac:

Strazdas · 11-05-2021 08:26PM

Gen.Zhukov wrote: »

I had the same experience but at CityWest and Pfizer. Very impressed.

The mens hair grooming stall was very quiet:pac:

Yes, the queues hardly stop moving for even a moment. Looks like it's all going like clockwork, they're doing a great job. Also, means people are leaving the place with a spring in their step having not being messed around.

Voguementol · 11-05-2021 08:43PM

Anyone get Pfizer in the Avia this week or is it all astra this past week?

Vaccine Megathread - See OP for threadbans

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