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What exactly is happening with AstraZeneca?

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Comments

  • Registered Users, Registered Users 2 Posts: 1,116 ✭✭✭Melanchthon


    Pete_Cavan wrote: »
    We should just not be using it for women under the age of 50 (or whatever the data suggests is the risk age) at the minute. Very few such people will be vaccinated in the next month or two anyway, and those who are to be would be small enough numbers and make little difference to the overall programme if they are given another. Ignoring the issue* will create more problems than actually addressing it.

    *the issue being the (justifiable) reluctance of women in a particular age group to take the vaccine. For women outside the affected age group, or men who are reluctant, the data doesn't seem to support this and we shouldn't be pandering to unfounded concerns.

    You would hope that the authorities here are drawing up plans for that scenario as it's pretty likely and not going to scramble at the last minute or push ahead and raise vaccine skeptism.


  • Registered Users, Registered Users 2, Paid Member Posts: 17,748 ✭✭✭✭astrofool


    You would hope that the authorities here are drawing up plans for that scenario as it's pretty likely and not going to scramble at the last minute or push ahead and raise vaccine skeptism.

    If the report is correct, then it's a pretty big climbdown by the MHRA, they've been pretty unequivocal in their statements so far, the last thing the world needs is to find issues with the cheapest vaccine (easiest to produce seems not to be a thing anymore).


  • Registered Users, Registered Users 2 Posts: 466 ✭✭Probes


    My old man got the AZ jab 5 weeks ago. He found out last week that he shared a car journey for a prolonged period of time with a person who had COVID (they got tested later that day). He’s tested negative once since then and also hasn’t developed any symptoms. He’d be a very vulnerable person too. He’s not out the woods yet but it’s looking positive. Most other close contacts tested positive currently.


  • Registered Users, Registered Users 2 Posts: 410 ✭✭Icantthinkof1


    Probes wrote: »
    My old man got the AZ jab 5 weeks ago. He found out last week that he shared a car journey for a prolonged period of time with a person who had COVID (they got tested later that day). He’s tested negative once since then and also hasn’t developed any symptoms. He’d be a very vulnerable person too. He’s not out the woods yet but it’s looking positive. Most other close contacts tested positive currently.

    Hopefully he’s in the clear


  • Registered Users, Registered Users 2, Paid Member Posts: 21,277 ✭✭✭✭Stark


    That's really good. Car sharing is one of the highest risk close contact situations. Even for people sharing a house together apparently. Good to see the vaccine doing its thing.


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  • Moderators, Entertainment Moderators, Politics Moderators Posts: 14,568 Mod ✭✭✭✭johnnyskeleton


    Switching to age rather than occupation is the right thing to do.

    4. Spare left over vaccines should be given to the Gardai as they could be at the vaccination point in a short time (they have the blue lights that speed them on their way), and they could be safer vaccinated for everyone (as they come into contact anyone) than any other group. Not only that, as there are only 14,000 or so Gardai while there are 100,000 teachers, they would not be an extra burden on the vaccination scheme - one days list at the current rate.

    I find it hard to see how you can reconcile these two things. When the lists were first produced, it was stated to be based on a number of factors, including the risk of serious illness as well as decreasing transmission (it also includes things like the ordinary functioning of society, but lets leave that aside for now as it isn't directly related to the overall best health outcome). You seem to accept that Gardai or indeed anyone who is obliged through their job to interact with the public ought to be vaccinated, not for their own sake, but because by vaccinating them you reduce the risk of it spreading.

    There are some elderly and vulnerable people who can't or won't get the vaccine and others who will not gain full immunity from it. There are also people who, due to an undiagnosed underlying condition or even, it would seem, for causes unknown, will get covid and suffer awful consequences. These people, albeit limited in number need to be protected but cannot be directly inoculated.

    So, after the most vulnerable people have been inoculated, it becomes important not just to reach the next most vulnerable people, but also to stop the spread of the disease generally. There are clear public health benefits to providing a vaccine to a 24 year old Garda over a 50 year old who is working from home.

    And by the way, it's not like I'm just making this up. It's the advice that our own government originally had, and is the current advice of the CDC, the WHO have included stopping transmission as a SAGE group and sensible other EU countries such as Germany have also prioritised people such as the police, rather than doing it by age.

    There is also an unproven but supported theory that severe symptoms can be linked to a higher level of exposure to virus particles, which certainly makes sense in the context of the disproportionate number of otherwise healthy health care workers who had serious doses
    1. Age is just a number on your passport, driving licence, PSC, PPS number, etc and is not up for discussion.

    I would agree with you that it is a lot easier to verify age as opposed to profession. However, that doesn't mean it can't be done. Healthcare workers have already been identified, with some small amount of slippage, but that seems unavoidable.

    It wouldn't be too difficult to ask the Garda Commission to identify all serving members of AGS and give them priority shots. It isn't up for discussion if they are a serving member of AGS or not, absent some form of fraud or deceipt (e.g. a retired garda's buddies saying he was still serving). But such things will be few and far between, and it's a lot harder to get away with that than, say, using a fake ID with a fake date of birth.
    2. People in general have been scandalised by the queue jumpers of the privileged, and the entitled who consider themselves more worthy than us.

    Which is terrible, but the fact that such things occurred does not mean we should alter the priority list for vaccines. Instead, we should prosecute people who have jumped the queue.
    3. The older you are the more at risk you are from bad outcomes if you get Covid, so working down the age list is a much better strategy.

    I don't dispute that age increases bad outcomes, specifically death. However, that does not mean that the best strategy to prevent that is to work down the age list. It is an easier strategy, not a better one. The reason being that you can protect people by vaccinating them, but you can also protect people by dramatically reducing the number of overall cases of Covid in a country.

    If we are guaranteed a full supply of vaccines such that we can guarantee that everyone who wants it can be fully vaccinated by e.g. the summer or the end of the year, then by age makes sense. But if we can't guarantee that, then the government should not just look at increased risk, but should also look at risk of transmissibility. And for all those who will call me callous for saying so, we are talking here about how to distribute the vaccines after those groups identified as most at risk have already been vaccinated. Conveniently, those highest risk groups also include a group by reason of their profession who are more at risk rather than by age.
    It appears to me, everyone is shouting 'I should be first - I am more vulnerable, more exposed, more important, richer, etc etc etc'. They should grow up and wait their turn.

    100% agree. But so too the government should say that to them, instead of reacting in a way that they say "rather than say no to people, lets just do it by age instead". Again, politically more expedient, but is it a better option for the vaccine rollout?
    Strazdas wrote: »
    I've heard it suggested that vaccinating by profession would almost certainly be very messy and a bit chaotic. Simply doing it by age seems to have a lot more going for it.

    Fully by profession would be utter madness. But targetting specific people who are at higher risk isn't too difficult. The Gardai is a good example.
    astrofool wrote: »
    It's as simple as asking someone (caveated by it being someone who has living parents):

    "Who should be vaccinated first, your parents, or someone else?"

    This works all the way down.

    Interesting. Well, if my parents were in their 50s and I was asked who should be vaccinated first them or someone in their 70s, I could selfishly say my parents.

    Or if I was vaccine hesistant, I would say that someone else should go first and then my parents.

    I'm not sure that the man on the street, including myself, is sufficiently knowledgable in terms of public health to know whether giving the vaccines directly to the most at risk or seeking to protect them indirectly by stopping it spreading is a better strategy to protect them.

    But ultimately, the correct answer to your question is "I don't know and I don't want to make that decision on overly personal and emotive grounds. I expect the government to take the best approach based on public health expert advice, and not make it a political issue".


  • Registered Users, Registered Users 2 Posts: 21,722 ✭✭✭✭Strazdas


    fly_agaric wrote: »
    That narrative (the "Europeans" have it in for AZ and their vaccine, sour grapes due to Brexit!? etc) has been exposed as ridiculous for a while now.

    We've had India blocking AZ vaccine exports to UK, non EU countries pausing and/or limiting use, the US regulators giving out about AZs use of data and US govt. taking quite un-free-markety actions against AZ to stop them using a contract manufacturer in the US in favour of an American company...

    Comparatively little angst from them about any of that, which tells its own tale really.

    I get the feeling that the English press know full well that everything they write praising AstraZeneca is BS, but they have just been using it to boost their hero Johnson and the Tories and put the boot into the EU. It's a total propaganda job.


  • Registered Users, Registered Users 2 Posts: 1,116 ✭✭✭Melanchthon


    astrofool wrote: »
    If the report is correct, then it's a pretty big climbdown by the MHRA, they've been pretty unequivocal in their statements so far, the last thing the world needs is to find issues with the cheapest vaccine (easiest to produce seems not to be a thing anymore).

    If they are basing the under 30's thing on solid evidence it shouldn't effect the rollout in the west too much anyway hopefully. I imagine they are basing it on vaccine Vs Covid risk calculation with under 30 healthy Covid risk also being so minimal


  • Registered Users, Registered Users 2 Posts: 21,722 ✭✭✭✭Strazdas


    If they are basing the under 30's thing on solid evidence it shouldn't effect the rollout in the west too much anyway hopefully. I imagine they are basing it on vaccine Vs Covid risk calculation with under 30 healthy Covid risk also being so minimal

    Ireland is quite lucky in that virtually nobody under the age of 70 or so from the general population has received AZ.

    It's interesting that we don't seem to have heard of blood clot cases or fatalities among healthcare workers (we might just have been lucky so far).


  • Registered Users, Registered Users 2, Paid Member Posts: 15,073 ✭✭✭✭josip


    Strazdas wrote: »
    Ireland is quite lucky in that virtually nobody under the age of 70 or so from the general population has received AZ.

    It's interesting that we don't seem to have heard of blood clot cases or fatalities among healthcare workers (we might just have been lucky so far).


    I thought all of cohort 4 (18-69 High Risk) were getting AZ ?


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  • Registered Users, Registered Users 2 Posts: 21,722 ✭✭✭✭Strazdas


    josip wrote: »
    I thought all of cohort 4 (18-69 High Risk) were getting AZ ?

    I was under the impression that they were getting Pfizer and Moderna and that healthcare staff were getting AZ? I could be wrong though.


  • Registered Users, Registered Users 2 Posts: 347 ✭✭redt0m


    Strazdas wrote: »
    I was under the impression that they were getting Pfizer and Moderna and that healthcare staff were getting AZ? I could be wrong though.

    I heard from a pharmacist last week who got his first shot that Pfizer and Moderna are being held for over-70s. He got AZ, and I think he's 50 years old.


  • Registered Users, Registered Users 2 Posts: 3,041 ✭✭✭Call me Al


    redt0m wrote: »
    I heard from a pharmacist last week who got his first shot that Pfizer and Moderna are being held for over-70s. He got AZ, and I think he's 50 years old.

    When that cohort are done who gets it next?
    We will still receive on-going Pfizer/Moderna supplies . What groups are they for?
    Or is it all random.


  • Registered Users, Registered Users 2 Posts: 19,130 ✭✭✭✭murphaph


    redt0m wrote: »
    I heard from a pharmacist last week who got his first shot that Pfizer and Moderna are being held for over-70s. He got AZ, and I think he's 50 years old.
    High time this was turned on its head like in Germany, France, the Netherlands, Canada. The AZ will go to waste if we don't give it to over 60s before they are all vaccinated.

    If even the UK are talking about halting its use in younger people we can be sure of it.


  • Registered Users, Registered Users 2 Posts: 21,722 ✭✭✭✭Strazdas


    redt0m wrote: »
    I heard from a pharmacist last week who got his first shot that Pfizer and Moderna are being held for over-70s. He got AZ, and I think he's 50 years old.

    Oh right. Maybe we've just been very lucky with the blood clots issue then : we don't seem to have heard of any.


  • Registered Users, Registered Users 2 Posts: 71 ✭✭mista11


    Strazdas wrote: »
    I was under the impression that they were getting Pfizer and Moderna and that healthcare staff were getting AZ? I could be wrong though.

    Yes you are wrong -Cohort 4 getting AZ currently


  • Registered Users, Registered Users 2 Posts: 71 ✭✭mista11


    Strazdas wrote: »
    Oh right. Maybe we've just been very lucky with the blood clots issue then : we don't seem to have heard of any.

    If they are a one in a million occurance and we only have 150k AZ doses then its probably not luck.

    The better thing to say would be we havent been unlucky to have one


  • Registered Users, Registered Users 2 Posts: 21,722 ✭✭✭✭Strazdas


    mista11 wrote: »
    If they are a one in a million occurance and we only have 150k AZ doses then its probably not luck.

    The better thing to say would be we havent been unlucky to have one

    Germany and Netherlands are one in every hundred thousand approx (30 cases in Germany....around 3 million AZ doses given).


  • Registered Users, Registered Users 2 Posts: 19,130 ✭✭✭✭murphaph


    Norway had 6 cases after 120k shots. 1 in 20k risk there. The risk for younger people appears to be far higher than the oft quoted "1 in a million" from the UK. The UK keeps including all the older people in the calculation. Few regulators believe AZ is unsafe in older people though.


  • Registered Users, Registered Users 2 Posts: 5,905 ✭✭✭dogbert27


    Is all the blame with AZ? Did AZ conduct the trials in upscaling the Oxford vaccine or was Oxford responsible for the trials?


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  • Registered Users, Registered Users 2 Posts: 3,041 ✭✭✭Call me Al


    Strazdas wrote: »
    Germany and Netherlands are one in every hundred thousand approx (30 cases in Germany....around 3 million AZ doses given).

    I suppose it depends on the age profile.
    If all 30 are under a certain age and all women then this changes the risk profile for some.

    There comes a point where you have to question the ethics and appropriateness of giving a certain group of people a vaccine that increases this risk when there's an alternative available without this level of risk.

    Certainly if the medical authorities want to maintain confidence in this vaccine amongst younger women (after all they need everyone to be on board with this rollout) they need to be seen to address this.


  • Registered Users, Registered Users 2 Posts: 5,518 ✭✭✭fly_agaric


    Strazdas wrote: »
    I get the feeling that the English press know full well that everything they write praising AstraZeneca is BS, but they have just been using it to boost their hero Johnson and the Tories and put the boot into the EU. It's a total propaganda job.

    In fairness, the company has a good Covid-19 vaccine and it has mostly delivered for the UK (in terms of quantity of vaccine it provided, even if the company was not meeting UK production targets). I can understand to an extent why the media there would be firmly on their side in a dispute between the company and the EU. That's putting aside support for Johnson/the Tories and dislike of the EU etc.

    Idea that the decisions of regulators/health authorities around Europe about vaccine use might have had political influence or be connected to disputes between the EU and the company over their production shortfall + how they favoured the UK (let alone to Brexit) was completely irrational.


  • Registered Users, Registered Users 2 Posts: 1,993 ✭✭✭FileNotFound


    dogbert27 wrote: »
    Is all the blame with AZ? Did AZ conduct the trials in upscaling the Oxford vaccine or was Oxford responsible for the trials?


    Well considering its the AZ vaccine - and oxford were a research support group really. Then its all on AZ.

    The UK just like calling it the Oxford vaccine.


    FDA has still not approved??


  • Registered Users, Registered Users 2 Posts: 1,993 ✭✭✭FileNotFound


    Ignoring the current environment.


    If any new to market drug was killing patients (say a cancer med) it would go on hold and be dealt with just the same way the AZ vaccine is.

    I personally think Health Authorities following there standard protocols is a good thing, it gives me confidence that anything put in my arm will be as safe as can reasonably be.

    The % impacted is quite small, but the rules for the HA's would have existed pre covid and I have no issue with their application during Covid.


  • Closed Accounts Posts: 4,105 ✭✭✭Kivaro


    Strazdas wrote: »
    Ireland is quite lucky in that virtually nobody under the age of 70 or so from the general population has received AZ.

    It's interesting that we don't seem to have heard of blood clot cases or fatalities among healthcare workers (we might just have been lucky so far).
    You are wrong.


  • Registered Users, Registered Users 2 Posts: 1,993 ✭✭✭FileNotFound


    You got it backwards, it was developed by scientists at Jenner Institute in Oxford, AZ was chosen by then as manufacturer

    There is a good history here as well as breakdown of who funded research and this institute and why AZ was chosen (basically cronyism)

    https://medicineslawandpolicy.org/wp-content/uploads/2020/10/How-the-Oxford-Covid-19-Vaccine-became-the-AstraZeneca-Covid-19-Vaccine-Final.pdf

    Regardless Astra Zeneca have made complete balls of production as that’s not their area of expertise.

    UK government then tried to take credit for everything related to this vaccine to distract from disastrous Covid death toll and Brexit disaster occurring concurrently

    Tho notice the rhetoric will now shift and they and their media propaganda papers will try to put as much distance between themselves and the Astra Zeneca/Oxford/UK/Brexit vaccine

    Thanks for the correction.


  • Registered Users, Registered Users 2 Posts: 71 ✭✭mista11


    Strazdas wrote: »
    Germany and Netherlands are one in every hundred thousand approx (30 cases in Germany....around 3 million AZ doses given).


    I am referencing Serious complications & Deaths


    As usual you have been very selective of your data as well so i will do the same. The rate of clotting complications on the contraceptive pill is 1 in 1000, do women still take it...absoloutly


  • Registered Users, Registered Users 2 Posts: 6,015 ✭✭✭Russman


    Strazdas wrote: »
    Ireland is quite lucky in that virtually nobody under the age of 70 or so from the general population has received AZ.

    I know some nurses got the AZ, whether they'd be called general population is another thing I guess. Two I know in their 30s/40s got it end of Jan/early Feb and are due second shots at the start of May.
    I'd say you're right though, the incidence of these events is rare enough that Ireland probably hasn't done enough people yet to find/expose some.


  • Posts: 5,853 ✭✭✭ [Deleted User]


    Thanks for the correction.

    I suggest before you thank the poster, you read what they linked to rather than take their word for what it says.


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  • Registered Users, Registered Users 2 Posts: 6,699 ✭✭✭thecretinhop


    i dont give a monkeys fk what or who said wat about AZ its a damn good vacine and im happy out to have got vaccinated. btw every female i know is getting az and taking it. women are not autotron idiots lol they know risk.


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