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DNA testing

  • 15-01-2015 9:40pm
    #1
    Registered Users, Registered Users 2 Posts: 11,763 ✭✭✭✭


    This post has been deleted.


«1

Comments

  • Registered Users, Registered Users 2 Posts: 11,763 ✭✭✭✭Crann na Beatha


    This post has been deleted.


  • Closed Accounts Posts: 5,995 ✭✭✭Ipso


    Phoenix wrote: »
    Anyone

    Yes, at 23andme and at Family Tree DNA.
    If you want to find relatives you need a good paper trail to help you.


  • Moderators, Society & Culture Moderators Posts: 6,708 Mod ✭✭✭✭pinkypinky


    I did one on my mother with FTDNA - an autosomal test.
    Over 500 matches.

    I have so far managed to connect the closest match only - she turns out to be my third cousin.

    Long chat with someone else who was apparently a close match and we can't connect with records yet but did find a set of people we're both related too.

    Genealogy Forum Mod



  • Registered Users, Registered Users 2 Posts: 738 ✭✭✭hblock21


    I did the basic 12 marker test with FTDNA a couple of years ago. Was very sceptical at first but then thought what the heck i'll give it a go, it only cost something like €20 as on offer.
    The results were very interesting. I was placed into the G Halpogroup, which is very uncommon in Ireland, about 1% of the population.
    I matched with one other person that had done a test. He was living in America and his ancestor had come from a place just 10 or so miles from where my family are based.
    It basically confirmed that the family in the next parish had a common ancestor at one point in time with my family. Very interesting. But of course there will be no written records to find this connection.


  • Closed Accounts Posts: 5,108 ✭✭✭pedroeibar1


    The last time I looked - about a year ago - in all the databases (on those sites that gave them) there was no other individual with my surname! It would however confirm/deny stories in the family of our origins.


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  • Closed Accounts Posts: 5,995 ✭✭✭Ipso


    hblock21 wrote: »
    I did the basic 12 marker test with FTDNA a couple of years ago. Was very sceptical at first but then thought what the heck i'll give it a go, it only cost something like €20 as on offer.
    The results were very interesting. I was placed into the G Halpogroup, which is very uncommon in Ireland, about 1% of the population.
    I matched with one other person that had done a test. He was living in America and his ancestor had come from a place just 10 or so miles from where my family are based.
    It basically confirmed that the family in the next parish had a common ancestor at one point in time with my family. Very interesting. But of course there will be no written records to find this connection.

    G, wow. You could be related to Stalin :)


  • Registered Users, Registered Users 2 Posts: 447 ✭✭dido2


    I've done the autosomal (Family Finder) test with FTDNA, and I'm currently waiting on my dads results too...

    Have found a few groups of matches where we share a common ancestor but we haven't found the yet, the more people you test in your own family, parents ideally first or even grandparents, the more you can sort the matches into different lines..


  • Registered Users, Registered Users 2 Posts: 484 ✭✭RGM


    I've done fairly extensive testing, both autosomal and Y-DNA. Purchased kits from 23andMe, FTDNA and Ancestry.com. I admin a Y-DNA project for my surname at FTDNA.

    It can be extremely helpful, but it can also be incredibly frustrating. It's important to establish what you want out of the test and to make sure you understand how realistic or unrealistic that result can be before going in. Far too many people order these tests without really understanding what they're buying (which I can't understand at all; the tests aren't cheap).


  • Registered Users, Registered Users 2 Posts: 3,284 ✭✭✭dubhthach


    Like RGM I've done extensive testing, though in my case I wasn't particulary interested in it from a genealogical point of view as oppose to looking at deep history.

    Let me see I've done the following:
    • 111 STR's Y-Chromosome: FamilytreeDNA
    • Large scale SNP testing with FTDNA, finally discovered R1b-DF41 (second person in FTDNA database to test positive for it)
    • Full Y-Chromosome sequencing with FGC (Full Genomes Corp)
    • Autosomal testing: 23andme (tranfered to FamilytreeDNA -- familyfinder product)

    It really depends on what you want to get out of it. One of little reaserch projects I'm doing at the moment involves checking various surnames connected to the Uí Briúin of Connacht and seeing if they fall into a specific haplogroup (discovered in last 6 months)


  • Registered Users, Registered Users 2 Posts: 2,547 ✭✭✭Seanachai


    I'm considering getting genetic testing but I've read that once you go back past your grandparents the results are too vague. Has the testing improved so that it is more specific or would I have to pay a grand to get the kind of testing that they did for the 'hairy bikers' for example?


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  • Registered Users, Registered Users 2 Posts: 11,763 ✭✭✭✭Crann na Beatha


    This post has been deleted.


  • Registered Users, Registered Users 2 Posts: 447 ✭✭dido2


    JT26

    This is how my dads Ethnicity is represented on FTDNA


  • Closed Accounts Posts: 5,995 ✭✭✭Ipso


    JT26 wrote: »
    Sorry for the bump but another quick question,doing these tests can they tell what part of Europe your genome came from?or will it be able to tell if there has been history of an ancestor of another race etc?
    Thanks!

    Broadly speaking they can tell you what other populations you are similar too. As far as detecting ancestry from a different population, I think they would have to have been in the last 6 or 8 generations as most likey most subsequent descendants would be Irish (assuming) and the non Irish part would get "diluted" very quickly.


  • Registered Users, Registered Users 2 Posts: 1,943 ✭✭✭tabbey


    dido2 wrote: »
    JT26

    This is how my dads Ethnicity is represented on FTDNA

    When I click on the above, all I see is a blank screen.


  • Closed Accounts Posts: 6,824 ✭✭✭Qualitymark


    tabbey wrote: »
    When I click on the above, all I see is a blank screen.

    Me too. Looks like a jpeg but when you copy the link it's boards.ie/vbulletin/attachment.php?attachmentid=372733&d=1451170617


  • Registered Users, Registered Users 2 Posts: 447 ✭✭dido2


    I'll try again!!!


  • Closed Accounts Posts: 6,824 ✭✭✭Qualitymark


    http://www. boards.ie/vbulletin/attachment.php?attachmentid=372748&d=1451219413

    Nope.

    Hit 'Submit Reply'. Go down to 'Manage attachments' and click it. Choose the jpeg from your hard drive. On the right, click 'Upload'. At the bottom, click 'Close window'. Add whatever text you want, and click 'Submit reply'.

    Now right-click (or ctrl-click on a Mac) the file and choose 'Copy link'.

    Go to 'Edit post'.

    In the post's field, hit the Return button a couple of times to get you down below your reply text. Paste in the link you've copied.

    Type

    [ IMG ] (with no spaces) followed by [ /IMG ] (no spaces again) at the beginning and end of the filename.

    'Submit reply'.

    Now your image should be showing.


  • Registered Users, Registered Users 2 Posts: 447 ✭✭dido2




  • Closed Accounts Posts: 6,824 ✭✭✭Qualitymark


    Ah.

    372748.JPG


  • Registered Users, Registered Users 2 Posts: 447 ✭✭dido2


    372748.JPG


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  • Closed Accounts Posts: 685 ✭✭✭FURET


    I'm thinking of buying the "Comprehensive Genome" product from FTDNA (it's the most expensive product at the bottom of this page).

    I'm completely new to this, so perhaps someone can advise me. Here's what I'd like to get out of the test, in plain English:
    • Information about where my ancestors are from geographically. I'm not very impressed with the images above. I know that mine would look relatively similar already - so why would I pay for a blue blob over Ireland? Instead I would like to see what percentage of me is Arab or African, or Central European etc.
    • Connect with people who share a common ancestor and identify how far back the common ancestor lived. I understand that I could find these people as long as they are FTDNA members, but what about connecting with members of 23andme and similar groups?
    • Be part of a project for people who share my surname and also groups who share the surname of my mother. But what is the purpose of such groups? What information are they able to learn / discover?

    In addition, could someone explain to me what is meant by a "marker"? This test would identify 111 markers - but what does that mean, exactly? What would it tell me about myself and my ancestry? What does it mean when they claim the test "unlocks up to 300,000 years of history"?

    Also, what else can be learned from doing Y tests and also M tests?

    Sorry for all the questions :)


  • Registered Users, Registered Users 2 Posts: 447 ✭✭dido2


    FURET

    That image I posted is for my dad and he is sll Irish so he's only going to get British Isles along with a tiny bit of European

    That image is from the Family finder test from FTDNA, but he also has about 800 dna matches aswell, some have trees, some have surnames, others have nothing at all, a lot though have uploaded to a free website www.gedmatch.com which takes uploads from all 3 big companies, FTDNA, Ancestry and 23andme..

    I had my dads basic MT Test done and he is the same maternal haplogroup as my mother too so I will have to do the bigger MT Test for both to see which subgroup they are in..

    for someone starting out the Family finder is the best one as it gives matches from within the last 5 to 6 generations whereas Y DNA and MT DNA matches could be from thousands of years ago..


  • Closed Accounts Posts: 6,824 ✭✭✭Qualitymark


    Are these tests related at all to the medical DNA tests that tell you what illnesses you're liable to, what medicines will and won't work on you and so on?


  • Registered Users, Registered Users 2 Posts: 447 ✭✭dido2


    This is how my top matches come up, top 2 are my parents, 3rd one is my half uncle

    372826.JPG


  • Moderators, Society & Culture Moderators Posts: 6,708 Mod ✭✭✭✭pinkypinky


    If you have origins other than the British Isles, FTDNA does break that down for you.

    Here's one for my aunt, which I have arbitrarily decided means I am a Viking.

    Genealogy Forum Mod



  • Registered Users, Registered Users 2 Posts: 447 ✭✭dido2


    23and me is the only one of the 3 that does medical testing aswell which is why it's more expensive than the other 2, FTDNA works out the cheapest from Ireland its about €99 altogether including postage etc, whereas Ancestry is about €160, but with ancestry you can then transfer your results to FTDNA for free, then to unlock all of your matches you need to either get 4 people to use a link from your account to unlock for free or pay $39, so for just under €200 you could have your DNA in 2 databases, the only downside to doing it that way is if you want to order a MT or Y test from FTDNA you will have to submit a new sample, whereas if you test with them originally they hold on to your sample, some people prefer this option if its a test done on older people who they may at some point want to get Y or MT testing done on. FTDNA will also send you swabs and hold them until you can pay for testing if you need to get someone tested but can't afford to pay right now..


  • Closed Accounts Posts: 685 ✭✭✭FURET


    pinkypinky wrote: »
    If you have origins other than the British Isles, FTDNA does break that down for you.

    Here's one for my aunt, which I have arbitrarily decided means I am a Viking.

    Ultimately we all have ancestry outside the British Isles - so how come your aunt's shows more detail than dido2's father's?


  • Moderators, Society & Culture Moderators Posts: 6,708 Mod ✭✭✭✭pinkypinky


    It's just a different screen. Dido2's father probably has a breakdown too but it might be 100% British Isles.

    Genealogy Forum Mod



  • Registered Users, Registered Users 2 Posts: 447 ✭✭dido2


    My dad is 88% British Isles and 12 % western European

    His half brother has a slightly different make up

    372832.JPG


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  • Closed Accounts Posts: 685 ✭✭✭FURET


    pinkypinky wrote: »
    It's just a different screen. Dido2's father probably has a breakdown too but it might be 100% British Isles.

    Granted but I suppose my question is that he can't possibly be 100% British Isles because ultimately people migrated there from the Med, Africa, and continental Europe. I would at least have expected to see some miniscule percentages from other regions. Would the lack of such percentages be because he went for the Y37 test rather than the Y111 test?


  • Registered Users, Registered Users 2 Posts: 447 ✭✭dido2


    Furet

    My dad is 88% Brithish Isles, 12% Western European, and this is based on the FAMILY FINDER only which is Autosomal, no Y testing has been done yet, his half brother who he shares his mother with has a more varied make up posted in my last message of
    92% British Isles
    6% Eastern European
    3% Western & Central European

    So it does pick different bits, but it's always being said too that this particular part of DNA testing isn't 100% accurate

    I personally don't look at the Origins part I look at the matches


  • Closed Accounts Posts: 685 ✭✭✭FURET


    I placed an order on FTDNA for the Family Finder and Y67 products. If I am impressed by the knowledge gleaned, I'll upgrade to Y111 and the M tests.


  • Closed Accounts Posts: 6,824 ✭✭✭Qualitymark


    Wonder why they can't distinguish between Britain and Ireland. I'd be surprised if the genotype was *that* similar.


  • Registered Users, Registered Users 2 Posts: 3,284 ✭✭✭dubhthach


    AncestryDNA (who are based in Dublin) gave me a free DNA sample back when they launched. They had a sample population for Ireland so it was quite distinct from FTDNA (myorigins) -- note this is purely an Autosomnal test, it doesn't look at Y-DNA or mtDNA

    ancestrydna.png

    In case of FTDNA they are probably using Orcadian sample (eg. from Orkney) for their reference for insular populations, this results in following:

    ftdna-myorigins.png

    The AncestryDNA "Irish" component is probably more reflective of a Insular Northwestern component than specifically Irish, it shows high levels in Wales and Scotland for example. Mike Mulligan who works for Ancestry in Ireland did following blog post:

    http://blogs.ancestry.com/ancestry/2015/03/16/what-does-our-dna-tell-us-about-being-irish/


  • Registered Users, Registered Users 2 Posts: 3,284 ✭✭✭dubhthach


    Furet,

    With regards to DNA testing and FTDNA it depends on what your interst is, the "Comprehensive" product will give you results from three testing arena's (eg. Male lineage on Y, mtDNA lineage (female) and Autosomnal -- eg bit gets mix up each generation). However even after spending that amount of money you might end up spending more over time (say if you want to get more in dept testing on your Y-Chromosome lineage)


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  • Closed Accounts Posts: 685 ✭✭✭FURET


    dubhthach wrote: »
    Furet,

    With regards to DNA testing and FTDNA it depends on what your interst is, the "Comprehensive" product will give you results from three testing arena's (eg. Male lineage on Y, mtDNA lineage (female) and Autosomnal -- eg bit gets mix up each generation). However even after spending that amount of money you might end up spending more over time (say if you want to get more in dept testing on your Y-Chromosome lineage)

    What would be the difference in the detail revealed by a Y67 test versus more advanced Y DNA tests?


  • Registered Users, Registered Users 2 Posts: 3,284 ✭✭✭dubhthach


    FURET wrote: »
    What would be the difference in the detail revealed by a Y67 test versus more advanced Y DNA tests?

    It's all very complicated, ye'd need a couple pints to explain all this ;)

    However video might help


    At basic level with STR's (37,67,111) you get increased resolution when it comes to matches in FTDNA database (think of it like, 480p, 1080p, 4k), often you will have matches at 37 markers who are not matches at higher levels, this is due to lower resolution match been "false positive"

    By default with STR's they only predict your wider Haplogroup, for most Irish men you end up been predicted as R1b-M269 -- which is basically useless as a haplogroup as all western European R1b is basically M269+

    What 67 STR's testing often allows though is to look at matches who've done more testing, so for example if you have matches at 67 STR's who are R1b-M222 than more likely you would be R1b-M222+, obviously there are tests that look specifically at haplogroups.

    I'm probably going into way too much detail :)


  • Closed Accounts Posts: 5,995 ✭✭✭Ipso


    Wonder why they can't distinguish between Britain and Ireland. I'd be surprised if the genotype was *that* similar.

    In general the closer the countries are geographically, the closer they are genetically. Eastern British people tend to pull a bit towards the North Sea Region.


  • Closed Accounts Posts: 6,824 ✭✭✭Qualitymark


    Interesting piece about Irish DNA - the Elizabethan English were right; they insisted we were Scythians - the Annalists were right; they said we were Tuatha De Danaan, Firbolg, Milesians, etc

    http://www.bbc.com/news/science-environment-35179269


  • Registered Users, Registered Users 2 Posts: 3,284 ✭✭✭dubhthach


    Interesting piece about Irish DNA - the Elizabethan English were right; they insisted we were Scythians - the Annalists were right; they said we were Tuatha De Danaan, Firbolg, Milesians, etc

    http://www.bbc.com/news/science-environment-35179269

    Not really the people of Steppe (Yamnaya) weren't Scythians, Scythians are an Iranic speaking group from 2,000+ years later

    The Yamnaya were probably Proto-IE speakers in comparison.


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  • Registered Users, Registered Users 2 Posts: 447 ✭✭dido2


    I just thought of it that my mother is the one I've tested on ancestry and then transferred to FTDNA and this is how her Origins show up

    ANCESTRY
    REGION APPROXIMATE AMOUNT

    Europe 100%

    Ireland 84%
    Great Britain 10%
    Europe West 6%



    FTDNA

    European 100%

    British Isles 96%
    Western & Central Europe 4%

    So it looks like Ancestry is more detailed in their Origins


  • Registered Users, Registered Users 2 Posts: 447 ✭✭dido2


    There are 3 Companies that offer Autosomal testing,
    FTDNA https://www.familytreedna.com/family-finder-compare.aspx
    Ancestry http://dna.ancestry.co.uk/
    23andme https://www.23andme.com/en-eu/

    results from any of these tests will go back about 5 to 6 generations for both sides.. FTDNA is the only one to offer MT DNA and Y DNA testing, and 23andme offer medical testing aswell...

    the cost of dna testing from any of the 3 websites depends on who you order from and where in the world you are, ordering from Ireland FTDNA is the cheapest option at the moment at about €99 euro, ancestry is about €160 and 23andme is about €169


  • Moderators, Society & Culture Moderators Posts: 6,708 Mod ✭✭✭✭pinkypinky


    Threads on DNA testing merged

    Genealogy Forum Mod



  • Registered Users, Registered Users 2 Posts: 447 ✭✭dido2


    I thought I was going crazy there for a moment Pinky!


  • Closed Accounts Posts: 6,824 ✭✭✭Qualitymark




  • Registered Users, Registered Users 2 Posts: 3,284 ✭✭✭dubhthach



    For Allergies? Or for Neanderthal admixture? 23andme will give you a breakdown of your "Neanderthal admixture", in my own case they peg me at 2.8% -- the Otherhalf whose from Philippines is 2.7% in comparison.


  • Registered Users, Registered Users 2 Posts: 565 ✭✭✭justagirl


    Interesting thread :) I'm a female and and was interested in getting a DNA test - so from reading here, my test will only show up the female results - is that right? Thanks :)


  • Moderators, Society & Culture Moderators Posts: 6,708 Mod ✭✭✭✭pinkypinky


    No: there's 2 types of test you can do: mitochondrial will show female lines only but autosomal will show XY cousin matches in the 1 - 6th range.

    Genealogy Forum Mod



  • Registered Users, Registered Users 2 Posts: 2,547 ✭✭✭Seanachai


    pinkypinky wrote: »
    No: there's 2 types of test you can do: mitochondrial will show female lines only but autosomal will show XY cousin matches in the 1 - 6th range.

    Are they matching to a database of people with similar markers and tracing your origins this way or from ancient human remains?


  • Moderators, Society & Culture Moderators Posts: 6,708 Mod ✭✭✭✭pinkypinky


    The former. Best database of Irish people is with FTDNA at the moment but I expect Ancestry will catch up fast, given all their advertising.

    Genealogy Forum Mod



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