nitric oxide containing products

Transform

lost that thread that was up earlier today as wanted to add the following -

Potentially fatal new trend in performance enhancement: a cautionary note on nitrite
Andrea Petroczi and Declan P Naughton

Journal of the International Society of Sports Nutrition 2010, 7:25doi:10.1186/1550-2783-7-25


Published: 29 June 2010

Abstract (provisional)

Background
Considerable interest has been shown by athletes and scientists in the potential for nitric oxide and associated vasodilators to enhance performance. This study aims to explore potential misuse of vasodilators by the athletes, and to highlight the growing concern over these agents.

Methods
Retrospective analyses of anonymous inquiries recorded in the Drug Information DatabaseTM (DIDTM) between January 2006 and June 2008 (inclusive). In this 30-month period, the DIDTM recorded 198,023 inquiries, of which 118,724 were UK Licensed Pharmaceutical products with a further 79,299 inquiries made for substance not found in the database.

Results
Phosphodiesterase type 5 (PDE-5) inhibitors, dominated by Viagra(R), ranked 16th among the substance groups. The proportion of the inquiries made regarding PDE-5 inhibitors, especially in comparison to antibiotics, painkillers or alcohol, appears to be above the level that would normally be expected from medical need. No significant change in the months leading up to the Beijing Olympics was observed. On the contrary, the Nitric/Nitrate group showed a notable increase between 2006-2007 and 2008, suggesting a potential increase in interest in using nitric oxide among athletes.

Conclusions
With patents which have recently been filed for the use of agents containing sodium nitrite/nitrate to enhance blood flow for performance enhancement in sport, coupled with anecdotal evidence from internet athlete forums and media, there is a concern that athletes may endanger their health by using vasodilators to enhance athletic performance. PDE-5 inhibitors or chemicals in the nitrate/nitrate group are currently not prohibited or tested for by the doping control agencies but some are highly dangerous to health and can lead to cardiovascular collapse, coma and death. Its promotion among athletes as a performance enhancing supplement is ethically and medically questionable.

kevpants

Transform wrote: »

.... anecdotal evidence from internet athlete forums and media...[/B]

It was all going so well until this point.

Transform

yes that did not sit well with me also but this can help -

Comparison of pre-workout nitric oxide stimulating dietary supplements on skeletal muscle oxygen saturation, blood nitrate/nitrite, lipid peroxidation, and upper body exercise performance in resistance trained men
Richard J Bloomer1 , Tyler M Farney1 , John F Trepanowski1 , Cameron G McCarthy1 , Robert E Canale1 and Brian K Schilling2

1 Cardiorespiratory/Metabolic Laboratory, Department of Health and Sport Sciences, The University of Memphis, Memphis, TN 38152, USA

2 Exercise Neuromechanics Laboratory, Department of Health and Sport Sciences, The University of Memphis, Memphis, TN 38152, USA

author email corresponding author email

Journal of the International Society of Sports Nutrition 2010, 7:16doi:10.1186/1550-2783-7-16


Published: 6 May 2010

Abstract
Background
We compared Glycine Propionyl-L-Carnitine (GlycoCarn®) and three different pre-workout nutritional supplements on measures of skeletal muscle oxygen saturation (StO2), blood nitrate/nitrite (NOx), lactate (HLa), malondialdehyde (MDA), and exercise performance in men.

Methods
Using a randomized, double-blind, cross-over design, 19 resistance trained men performed tests of muscular power (bench press throws) and endurance (10 sets of bench press to muscular failure). A placebo, GlycoCarn®, or one of three dietary supplements (SUPP1, SUPP2, SUPP3) was consumed prior to exercise, with one week separating conditions. Blood was collected before receiving the condition and immediately after exercise. StO2 was measured during the endurance test using Near Infrared Spectroscopy. Heart rate (HR) and rating of perceived exertion (RPE) were determined at the end of each set.

Results
A condition effect was noted for StO2 at the start of exercise (p = 0.02), with GlycoCarn® higher than SUPP2. A condition effect was also noted for StO2 at the end of exercise (p = 0.003), with SUPP1 lower than all other conditions. No statistically significant interaction, condition, or time effects were noted for NOx or MDA (p > 0.05); however, MDA decreased 13.7% with GlycoCarn® and increased in all other conditions. Only a time effect was noted for HLa (p < 0.0001), with values increasing from pre- to post-exercise. No effects were noted for HR, RPE, or for any exercise performance variables (p > 0.05); however, GlycoCarn® resulted in a statistically insignificant greater total volume load compared to the placebo (3.3%), SUPP1 (4.2%), SUPP2 (2.5%), and SUPP3 (4.6%).

Conclusion
None of the products tested resulted in favorable changes in our chosen outcome measures, with the exception of GlycoCarn® in terms of higher StO2 at the start of exercise. GlycoCarn® resulted in a 13.7% decrease in MDA from pre- to post-exercise and yielded a non-significant but greater total volume load compared to all other conditions. These data indicate that 1) a single ingredient (GlycoCarn®) can provide similar practical benefit than finished products containing multiple ingredients, and 2) while we do not have data in relation to post-exercise recovery parameters, the tested products are ineffective in terms of increasing blood flow and improving acute upper body exercise performance.

ragg

I used no xplode a few times with my mate who gets it in the UK.
I thought it was awesome and I'm still alive

Brian?

ragg wrote: »

I used no xplode a few times with my mate who gets it in the UK.
I thought it was awesome and I'm still alive

It could be due to this effect.

Transform

briankeating wrote: »

It could be due to this effect.

exactly - cant understand people who take stuff like this for one workout as there are farrrrr better products that would help with recovery so people could get back in for more frequent sessions.

ragg i am surprised you would need something like that seeing as you are quite a motivated person already and attack the workouts