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COVID-19 technical discussion

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    #62
    mandrake04
    Registered Users Posts: 4,435 ✭✭✭mandrake04


    lozenges wrote: »

    It tests positive for bits of SARS -CoV-2 virus particles essentially. (SARS -CoV-2 is the same to me as Covid-19, but anyway)

    SARS -CoV-2 is one of a family of viruses called coronaviruses. The test only tests for that one kind of coronavirus, but not the other kinds in the family.

    Hope that makes sense

    The Randox VRI test for the Vivalytic platform test for the following in one hit, but it’s a POC platform so takes 2.5 hrs to do one sample.

    • SARS-CoV-2 (COVID-19)
    • Sarbecovirus (SARS, SARS like, SARS-CoV-2)
    • Influenza A
    • Coronavirus 229E/NL63
    • Adenovirus A/B/C/D/E
    • Influenza B
    • Coronavirus OC43/HKUI
    • Enterovirus A/B/C
    • Rhinovirus A/B
    • Middle East Respiratory Syndrome Coronavirus (MERS-CoV)

    Most other SARS-CoV-2 tests are specific to that particular virus, and can run a batch of 94 samples plus 2IC in one go.


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    #63
    mandrake04
    Registered Users Posts: 4,435 ✭✭✭mandrake04


    dermob wrote: »
    i disagree with the above based on this https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/naming-the-coronavirus-disease-(covid-2019)-and-the-virus-that-causes-it

    i still dont know what the test actually test for?

    They test for specific sequence or sequences of nucleotides in the SARS-CoV-2 virus RNA.


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    #64
    drunkmonkey
    Registered Users Posts: 28,119 ✭✭✭✭drunkmonkey


    I'm not a scientist but this may be of interest to the discussion, quick summary, the Chinese identified 30 different strains with hugely different viral loads, hit download PDF to get the full report.
    I know it's not peer reviewed but still maybe noteworthy considering it's from China

    https://www.medrxiv.org/content/10.1101/2020.04.14.20060160v1.full.pdf+html

    What's the feeling if correct, does 30 strains make a possible vaccine a lot more difficult to create?


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    #65
    Miike
    Registered Users Posts: 2,021 ✭✭✭Miike


    drunkmonkey wrote: »
    I'm not a scientist but this may be of interest to the discussion, quick summary, the Chinese identified 30 different strains with hugely different viral loads, hit download PDF to get the full report.
    I know it's not peer reviewed but still maybe noteworthy considering it's from China

    https://www.medrxiv.org/content/10.1101/2020.04.14.20060160v1.full.pdf+html

    What's the feeling if correct, does 30 strains make a possible vaccine a lot more difficult to create?

    It would depend largely on what these variations have changed on the virus.

    Related:
    https://nextstrain.org/ncov/global

    Mapped genomic epidemiology of SARS-CoV-2.


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    #66
    Miike
    Registered Users Posts: 2,021 ✭✭✭Miike


    https://www.cdc.go.kr/board/board.es?mid=a30402000000&bid=0030&act=view&list_no=367267&nPage=1

    Very interesting observations here regarding reinfection, repositives and quite interestingly no observation of secondary spread in those cases.

    I would be quite interested to know if this is observed elsewhere.


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    #67
    amandstu
    Registered Users Posts: 3,402 ✭✭✭amandstu


    This is a study posted by someone on the main thread.

    https://www.thelancet.com/journals/l...354-4/fulltext

    Can someone who is au fait with this kind of stuff have a look at it and explain the findings.

    What is defined there as the viral load ?

    Is it the population of infected cells in the individual nasal passage at the time of the test?

    How does that correlate to the amount of virus that individual was initially infected with,?

    And how did morbidity rise as a function of the viral load ?Linearly ?

    Presumably not linearly but what kind of exponential relationship was found?


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    #68
    mandrake04
    Registered Users Posts: 4,435 ✭✭✭mandrake04


    amandstu wrote: »
    This is a study posted by someone on the main thread.

    https://www.thelancet.com/journals/l...354-4/fulltext

    Can someone who is au fait with this kind of stuff have a look at it and explain the findings.

    What is defined there as the viral load ?

    Is it the population of infected cells in the individual nasal passage at the time of the test?

    How does that correlate to the amount of virus that individual was initially infected with,?

    And how did morbidity rise as a function of the viral load ?Linearly ?

    Presumably not linearly but what kind of exponential relationship was found?

    LINK IS BROKEN

    Viral load is the amount of virus particles within you body, the virus then replicates by invading cells damaging them and budding producing more virus.

    If your initial viral load is high then you will have more virus all replicating at the same time, by the time your body starts to fight the infection it can be overwhelmed by cell damage.

    If you have a low initial viral infection then the damage is more limited, if your immune system can kick in to fight the infection before it gets too out of hand.

    Front line workers like Doctors and nurses are at risk of being infected with higher loads as they work in an environment where there is a high level infection by multiple sources (patients).

    PPE does not prevent infection 100% but it helps reduce the risk and the amount of virus they absorb.


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    #69
    amandstu
    Registered Users Posts: 3,402 ✭✭✭amandstu


    mandrake04 wrote: »
    LINK IS BROKEN

    Viral load is the amount of virus particles within you body, the virus then replicates by invading cells damaging them and budding producing more virus.

    If your initial viral load is high then you will have more virus all replicating at the same time, by the time your body starts to fight the infection it can be overwhelmed by cell damage.

    If you have a low initial viral infection then the damage is more limited, if your immune system can kick in to fight the infection before it gets too out of hand.

    Front line workers like Doctors and nurses are at risk of being infected with higher loads as they work in an environment where there is a high level infection by multiple sources (patients).

    PPE does not prevent infection 100% but it helps reduce the risk and the amount of virus they absorb.

    Think this one works
    https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30354-4/fulltext

    Thanks for the explanation in the meanwhile


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    #70
    amandstu
    Registered Users Posts: 3,402 ✭✭✭amandstu


    Here is an interesting hypothesis based on the idea that other coronavirus infections may provide protection against Covid-19

    https://www.bbc.com/news/world-africa-53998374

    Too much hygiene?

    I never get colds.**I am less reassured on that score now.

    **a lie ; I did get an odd cold in Feb.


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