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How severe are anti-cholinergic side effects??

  • 14-07-2016 10:48pm
    #1
    Under_Graduate
    Banned (with Prison Access) Posts: 621 ✭✭✭


    I've been going over a bunch of lectures on neurotransmission, mechanism of action etc.

    A lot of these lectures go into more depth regarding the group of reuptake inhibitors that are tricyclics.
    In terms of the effect on the adrenergic and 5-HT neurons, maintenance of the chemical in the synaptic cleft, and eventual reuptake and resynthesis.

    But the side effects were interesting also.
    Hypotension, being one.
    But anti-cholinergic.... wow!

    So neurons control the bladder and sphincter muscle, thus, they can often cause their non-relaxation compliance, inciting urinary retention?
    Sounds nasty!!

    Dry mouth, blurred vision.

    But despite other classes of reuptake inhibitors that effectively act with a tricyclic mechanism, such as venlafaxine or duloxatine (acting on serotonine and noradrenaline and dopamine), they do not incite these issues.

    So what's up with that?

    The material I reviewed also seemed to think that, Desipramine, yielded the least severe side effects of that class.

    I'm just curious, perhaps some here have more experience or knowledge, but why is that the case?


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