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MAO-a

  • 27-01-2012 6:42pm
    #1
    WalterMitty
    Registered Users, Registered Users 2 Posts: 1,582 ✭✭✭


    Anyone know the dose of Tranylcypromine needed to fully inhibit MAO-a in the human/primate brain?


Comments

  • #2
    josey_whale
    Registered Users, Registered Users 2 Posts: 284 ✭✭josey_whale


    WalterMitty wrote: »
    Anyone know the dose of Tranylcypromine needed to fully inhibit MAO-a in the human/primate brain?

    Your question has been bugging me.... Apparently Tranylcypromine irreversibly binds to MAO-a. You could anwser it that way... find out how many MAO-a molecules are in the brain!

    What do you mean by "fully inhibit"?

    I've had a look around for toxicity data on Tranylcypromine (Parnate). Best I can come up with is an LD50 of 30-50 mg/kg in mice and rats. See link http://datasheets.scbt.com/sc-200572.pdf

    I can't find any primate data. Hope this helps.


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