Sinepin?

Misticles

I know this is an anti depressant but I know someone who has been prescribed it to treat urticaria.

Apparently one of the side effects is to treat this?

He dosnt break out in mad hives, just gets really hot and breaks out in a rash.

Does anyone have this? Whats your experience with this?



Not looking for advice, just opinions or their own stories about it.

Thanks

sam34

ok folks, no advice or alternative suggestions please, personal experience only.


however op, be careful of personal experiences described on the internet, as people will be more likely to recount bad experiences, whereas those with positive experiences will be less likely to go online and talk about it.

so best bet is to discuss it with the prescribing doctor

locum-motion

Better double check your spelling, Misticles.

Ain't no such thing as Sinepin, AFAIK.

I think I know which drug you meant, but I don't want to put words in your mouth, so I'll let you check and repost.

Misticles

Sinepin (dioxin) its called.

locum-motion

Misticles wrote: »

Sinepin (dioxin) its called.

OK, I reckon what you're probably referring to is Sinequan (R), the active ingredient in which is called doxepin (Dioxin is a completely different type of chemical).
Doxepin is marketed in some other countries under the name Sinepin (R), but not here.

SomeDose

Misticles wrote: »

I know this is an anti depressant but I know someone who has been prescribed it to treat urticaria.

Apparently one of the side effects is to treat this?

He dosnt break out in mad hives, just gets really hot and breaks out in a rash.

Does anyone have this? Whats your experience with this?



Not looking for advice, just opinions or their own stories about it.

Thanks

Doxepin is a Tricyclic Antidepressant (TCA) and, like a lot of TCAs, it has a raft of side-effects due to the fact that it intereferes with several different types of receptors. One of these is to block the action of histamine, so it essentially exerts an anti-histamine effect....so you can see why it might be effective in treating pruritis and urticaria.

It's an unlicensed use, presumably prescribed by a specialist. I've never personally come across it for this indication, actually come to think of it I've never seen it used to treat depression either. I'm not sure if its even still licensed in the UK.

Misticles

Ah right, I can see why it would work.

My bf is just having an awful time with the side effects and I just wanted to know a little more about it.

nesf

SomeDose wrote: »

Doxepin is a Tricyclic Antidepressant (TCA) and, like a lot of TCAs, it has a raft of side-effects due to the fact that it intereferes with several different types of receptors. One of these is to block the action of histamine, so it essentially exerts an anti-histamine effect....so you can see why it might be effective in treating pruritis and urticaria.

It's an unlicensed use, presumably prescribed by a specialist. I've never personally come across it for this indication, actually come to think of it I've never seen it used to treat depression either. I'm not sure if its even still licensed in the UK.

Hmm, probably replaced by Zispin (mirtazapine) by this point due to the difference in side effect profiles? (Only hayfever free years of my life were when I was on Zispin)

martin bren

hi.

Chronic idiopatic urticaria can be treated with Sinepin/Doxepin This was originally developed for treating skin rashers and was later discovered to help depression.

I would describe it as a minor miracle for treating urticaria. The rash does not disappear but the itching goes and eventually the rash burns itself out. Anti Depression tablets are no longer addictive t.g. So this is the answer to many peoples prayers for urticaria hope this helps as I don't know if too many g.ps are aware of this.