We all knew it... the secret to long life

Terodil · 05-10-2009 7:06pm #1

http://www.nature.com/ncb/journal/vaop/ncurrent/abs/ncb1975.html

Article abstract
Nature Cell Biology
Published online: 4 October 2009 | doi:10.1038/ncb1975

Induction of autophagy by spermidine promotes longevity
Tobias Eisenberg1, Heide Knauer1, Alexandra Schauer1, Sabrina Büttner1, Christoph Ruckenstuhl1, Didac Carmona-Gutierrez1, Julia Ring1, Sabrina Schroeder1, Christoph Magnes2, Lucia Antonacci1, Heike Fussi1, Luiza Deszcz3,4, Regina Hartl3,4, Elisabeth Schraml5, Alfredo Criollo6,7,8, Evgenia Megalou9, Daniela Weiskopf10, Peter Laun11, Gino Heeren11, Michael Breitenbach11, Beatrix Grubeck-Loebenstein10, Eva Herker12, Birthe Fahrenkrog13, Kai-Uwe Fröhlich1, Frank Sinner2, Nektarios Tavernarakis9, Nadege Minois3,4,14, Guido Kroemer6,7,8 & Frank Madeo1

Abstract
Ageing results from complex genetically and epigenetically programmed processes that are elicited in part by noxious or stressful events that cause programmed cell death. Here, we report that administration of spermidine, a natural polyamine whose intracellular concentration declines during human ageing, markedly extended the lifespan of yeast, flies and worms, and human immune cells. In addition, spermidine administration potently inhibited oxidative stress in ageing mice. In ageing yeast, spermidine treatment triggered epigenetic deacetylation of histone H3 through inhibition of histone acetyltransferases (HAT), suppressing oxidative stress and necrosis. Conversely, depletion of endogenous polyamines led to hyperacetylation, generation of reactive oxygen species, early necrotic death and decreased lifespan. The altered acetylation status of the chromatin led to significant upregulation of various autophagy-related transcripts, triggering autophagy in yeast, flies, worms and human cells. Finally, we found that enhanced autophagy is crucial for polyamine-induced suppression of necrosis and enhanced longevity.

So here we go. No more spitting.

Conor108 · 05-10-2009 7:08pm

Spare me the medical mumbo-jumbo doc, I can take it!

EDIT: OK now I read the big words and get it

mikom · 05-10-2009 7:10pm

What do they say about snowballing?

jumpguy · 05-10-2009 7:14pm

Here, we report that administration of spermidine, a natural polyamine whose intracellular concentration declines during human ageing, markedly extended the lifespan of yeast, flies and worms, and human immune cells.

Unless your yeast, flies, worms or a human immune cell you're not gonna live much longer than you already wood.

Spermidine is not sperm made by the testes, it's a chemical.

Thread fail.