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Sickle Cell genetics

  • 20-09-2009 5:15pm
    #1
    Edible
    Registered Users, Registered Users 2 Posts: 93 ✭✭


    Can someone please tell me whether sickle cell disease is an example of incomplete dominance or co-dominance? i.e. in people with sickle cell trait, are the HbA and HbS genes equally expressed or is the HbS gene incompletely dominant to the HbA gene?
    I've read so many different things in books and the internet, no one seems to know for sure....


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  • #2
    liberal
    Closed Accounts Posts: 291 ✭✭liberal


    Edible wrote: »
    Can someone please tell me whether sickle cell disease is an example of incomplete dominance or co-dominance? i.e. in people with sickle cell trait, are the HbA and HbS genes equally expressed or is the HbS gene incompletely dominant to the HbA gene?
    I've read so many different things in books and the internet, no one seems to know for sure....


    HbS is autosomal incomplete dominant....

    In the areas where HbS is prevalent, the hetrozygous form is fitter than the both the homo forms as it gives immuntiy to malaria! If it was recessive it wouldn't be of any use or if it were dominant it would have died out, thats why its evolved to be incompletely dominant


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