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Anyone take Glucosamine?

  • 08-02-2009 2:36pm
    #1
    Registered Users, Registered Users 2 Posts: 310 ✭✭


    I have had a bit of knee pain ever since Dublin last October. I read about Glucosamine is runners world magazine. Seems to have mixed reviews online. Anyone tried it before to help rebuild the knee cartilage faster?


Comments

  • Registered Users, Registered Users 2 Posts: 1,035 ✭✭✭Funkyzeit


    gmurran wrote: »
    I have had a bit of knee pain ever since Dublin last October. I read about Glucosamine is runners world magazine. Seems to have mixed reviews online. Anyone tried it before to help rebuild the knee cartilage faster?

    Yea I've started taking it in Nov after some knee pain post runs. I've been taking that and Cod Liver Oil together.

    IMO to be honest most of the clinical studies on it the effects are questionable but none saying it's bad for you... Cod Liver Oil has shown to have very positive effects so I'd try that first tbh


  • Closed Accounts Posts: 3,983 ✭✭✭TheRoadRunner


    Yeah I take it at the moment but as you say it has mixed reviews online and in some of the scientific literature I've read. I don't know if it is helping or not but the mrs bought me a big supply a coupe of months back so that is why I'm still popping them


  • Closed Accounts Posts: 6,492 ✭✭✭Woddle


    I take glucosamine with chrondoitin and I'll continue to do so as since taking it have had no knee trouble and I always would have been prone to it.


  • Registered Users, Registered Users 2 Posts: 1,145 ✭✭✭baza1976


    I take it with cod liver oil... Hasn't done any harm.


  • Closed Accounts Posts: 7,598 ✭✭✭shels4ever


    Yep been taking it for about a year now, had problems with my knees before and zero problems now, not sure if they helped at all, as giving up footall may have been more help.


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  • Registered Users, Registered Users 2 Posts: 19,550 ✭✭✭✭Krusty_Clown


    Have been taking it since I started longer distance running. Like others, I take a variety that also has chrondoitin, and I also take Cod Liver oil. No knee troubles at all, since I started taking these supplements, but have also been doing more disciplined stretching and taking better care of my limbs.


  • Registered Users, Registered Users 2 Posts: 310 ✭✭gmurran


    Thanks went into town today and got some glucosamine with chrondoitin. Fingers crossed it makes a difference.


  • Registered Users, Registered Users 2 Posts: 19,550 ✭✭✭✭Krusty_Clown


    Don't expect instant gratification! If after a couple of months you say to yourself "I used to have knee pains" then you know it may have worked.


  • Registered Users, Registered Users 2 Posts: 6,463 ✭✭✭run_Forrest_run


    I used to take it a few years ago and I must have stopped taking it somewhere along the line..obviously my knee pain went away.
    I now take Eskimo Oil because I 'heard' it is good but sure maybe it's doing nothing :)


  • Registered Users, Registered Users 2 Posts: 1,395 ✭✭✭eliwallach


    Woddle wrote: »
    I take glucosamine with chrondoitin and I'll continue to do so as since taking it have had no knee trouble and I always would have been prone to it.

    Snap.
    Started experiencing knee pain last May/June - made enquiries in the local health shop and that's what the guy recommended.
    Knee pain disappeared in a few weeks - maybe it was subsiding anyway?
    If nothing else the obecalp (for that is what some doctors prescribe) effect was fantastic.


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  • Closed Accounts Posts: 4,742 ✭✭✭ultraman1


    i take glucosamin for my elbow,motorbike crash and lost my elbow joint.iv been taking it for a few years now and my elbow doesnt feel any worse now.though could b d placebo effect


  • Registered Users, Registered Users 2 Posts: 19,550 ✭✭✭✭Krusty_Clown


    I used to take it a few years ago and I must have stopped taking it somewhere along the line..obviously my knee pain went away.
    I now take Eskimo Oil because I 'heard' it is good but sure maybe it's doing nothing :)
    How do they extract it from the eskimos? Is it painful?
    I hate eskimos. :)


  • Closed Accounts Posts: 3,912 ✭✭✭thirtyfoot


    I take it every day. When I don't I find I wake my wife up in the mornings walking across the wooden floor with my creaking ankles and knees.


  • Registered Users, Registered Users 2 Posts: 2,415 ✭✭✭Racing Flat


    Mixed reports on the internet isn't much good to anyone. I think you'd want to do your reserch before taking anything like this willy-nilly. did a quick search - see below. Could not find anything on the use of glucosamine in prophyslaxis - ie if your knees are okay and you take it can you reduce the risk of getting arthritis. Seems to be a lot of trials into the effect of glucosamine on OA, with conflicting results, some saying it's ineffective for relief of symptoms, others saying there may be a small effect in certain groups of people with knee arthritis. Glucosamin may have an effect at changing (? improving) the structure of the knee, but this probably needs to be researched further. See below, my bold.




    [URL="javascript:AL_get(this, 'jour', 'J Am Acad Nurse Pract.');"]J Am Acad Nurse Pract.[/URL] 2006 Oct;18(10):487-93.http:--www3.interscience.wiley.com-aboutus-images-wiley_interscience_150x34.gif [URL="javascript:PopUpMenu2_Set(Menu16999714);"]Links[/URL]

    Evidence-based practice: review of clinical evidence on the efficacy of glucosamine and chondroitin in the treatment of osteoarthritis.

    Distler J, Anguelouch A.
    Department of Family and Community Health, University of Maryland School of Nursing, Baltimore, Maryland, USA. distler@son.umaryland.edu
    PURPOSE: To evaluate past and current evidence from randomized controlled trials on the efficacy of glucosamine sulfate (GS), glucosamine hydrochloride (GH), and chondroitin sulfate (CS) for the treatment of osteoarthritis (OA). DATA SOURCES: An extensive review of four meta-analyses and a review of the findings of the recently published Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT) funded by the National Institutes of Health. FINDINGS: Review of previous studies on the efficacy of GS, GH, and CS in the treatment of OA showed inconclusive results because of weak research design. The GAIT attempted to provide clarity on the use of GH and CS in treating knee pain from OA by using a rigorous research design to elicit cause and effect. The GAIT results showed that GH and CS were not effective in reducing knee pain in the study group overall; however, these may be effective in combination for patients with moderate-to-severe knee pain. IMPLICATIONS FOR PRACTICE: There is now clinical evidence indicating that recommending GS, GH, and CS for the treatment of mild knee pain from OA is ineffective. Further research needs to be done to identify specific characteristics in patients that results in a positive response. Until the findings of the GAIT undergo further peer review, the results of the research needs to be interpreted with caution. It looks like there may be some evdicence that glucosamine can change (? improve) the structure of the knee, but again, more research is probably needed to clarify this. My bold below.


    [URL="javascript:AL_get(this, 'jour', 'Drugs Aging.');"]Drugs Aging.[/URL] 2007;24(7):573-80. [URL="javascript:PopUpMenu2_Set(Menu17658908);"]Links[/URL]

    Glucosamine and chondroitin sulfate as therapeutic agents for knee and hip osteoarthritis.

    Bruyere O, Reginster JY.
    WHO Collaborating Center for Public Health Aspect of Osteoarticular Disorders, University of Liège, Liege, Belgium. olivier.bruyere@ulg.ac.be
    Osteoarthritis (OA), the most common form of arthritis, is a public health problem throughout the world. Several entities have been carefully investigated for the symptomatic and structural management of OA. This review evaluates published studies of the effect of glucosamine salts and chondroitin sulfate preparations on the progression of knee or hip OA.Despite multiple double-blind, controlled clinical trials of the use of glucosamine and chondroitin sulfate in OA, controversy regarding the efficacy of these agents with respect to symptomatic improvement remains. Several potential confounders, including placebo response, use of prescription medicines versus over-the-counter pills or food supplements, or use of glucosamine sulfate versus glucosamine hydrochloride, may have relevance when attempting to interpret the seemingly contradictory results of different clinical trials. The National Institutes of Health-sponsored GAIT (Glucosamine/chondroitin Arthritis Intervention Trial) compared placebo, glucosamine hydrochloride, chondroitin sulfate, a combination of glucosamine and chondroitin sulfate and celecoxib in a parallel, blinded 6-month multicentre study of patients with knee OA. This trial showed that glucosamine hydrochloride and chondroitin sulfate alone or in combination did not reduce pain effectively in the overall group of patients with OA of the knee. However, exploratory analyses suggest that the combination of glucosamine hydrochloride and chondroitin sulfate may be effective in the subgroup of patients with moderate-to-severe knee pain.For decades, the traditional pharmacological management of OA has been mainly symptomatic. However, in recent years, several randomised controlled studies have assessed the structure-modifying effect of glucosamine sulfate and chondroitin sulfate using plain radiography to measure joint space narrowing over years. There is some evidence to suggest a structure-modifying effect of glucosamine sulfate and chondroitin sulfate.On the basis of the results of recent randomised controlled trials and meta-analyses, we can conclude that glucosamine sulfate (but not glucosamine hydrochloride) and chondroitin sulfate have small-to-moderate symptomatic efficacy in OA, although this is still debated. With respect to the structure-modifying effect, there is compelling evidence that glucosamine sulfate and chondroitin sulfate may interfere with progression of OA.



    1: [URL="javascript:AL_get(this, 'jour', 'Clin Sports Med.');"]Clin Sports Med.[/URL] 2005 Jan;24(1):71-82.http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif [URL="javascript:PopUpMenu2_Set(Menu15636778);"]Links[/URL]

    The use of NSAIDs and nutritional supplements in athletes with osteoarthritis: prevalence, benefits, and consequences.

    Gorsline RT, Kaeding CC.
    Department of Orthopaedics, The Ohio State University Medical Center, 2050 Kenny Road, Columbus, OH 43221-3502, USA.
    The use of nonsteroidal antiinflammatory medications (NSAIDs) and nutraceuticals, such as glucosamine and chondroitin, is common among athletes at all ages and levels of participation. The use of these drugs has significant effects on pain and swelling associated with injury; however, this use does have significant risks to the gastrointestinal, hepatic, and renal organ systems. In the athlete with degenerative changes in the joints, the use of these medications can become chronic and lead to an increased risk of adverse effects. The purpose of this article is to examine the incidence of injury in sports, the prevalence of osteoarthritis in athletes, and the use of common over-the-counter medications and supplements. In addition, the mechanism of action, adverse side effects, and behavioral patterns for use of these medications will be analyzed.
    PMID: 15636778 [PubMed - indexed for MEDLINE]


  • Registered Users, Registered Users 2 Posts: 2,623 ✭✭✭dna_leri


    1: Clin Sports Med. 2005 Jan;24(1):71-82.http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Links

    The use of NSAIDs and nutritional supplements in athletes with osteoarthritis: prevalence, benefits, and consequences.

    Gorsline RT, Kaeding CC.
    Department of Orthopaedics, The Ohio State University Medical Center, 2050 Kenny Road, Columbus, OH 43221-3502, USA.
    The use of nonsteroidal antiinflammatory medications (NSAIDs) and nutraceuticals, such as glucosamine and chondroitin, is common among athletes at all ages and levels of participation. The use of these drugs has significant effects on pain and swelling associated with injury; however, this use does have significant risks to the gastrointestinal, hepatic, and renal organ systems. In the athlete with degenerative changes in the joints, the use of these medications can become chronic and lead to an increased risk of adverse effects. The purpose of this article is to examine the incidence of injury in sports, the prevalence of osteoarthritis in athletes, and the use of common over-the-counter medications and supplements. In addition, the mechanism of action, adverse side effects, and behavioral patterns for use of these medications will be analyzed.
    PMID: 15636778 [PubMed - indexed for MEDLINE]

    Thanks for the detailed information, useful considering so many runners use Glucosamine regularly.

    The use of these drugs has significant effects on pain and swelling associated with injury; however, this use does have significant risks to the gastrointestinal, hepatic, and renal organ systems.

    With reference to the quoted section above, does the highlighted
    sentence about risks actually refer to Glucosamine and Chondroitin or to the NSAIDs?

    I can not access the original article to verify but my understanding is that
    Glucosamine sulfate has been used safely in human studies lasting up to three years and that glucosamine may be less risky than NSAIDs, which can cause stomach bleeding and even liver or kidney damage with long-term use.


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