COVID-19: Vaccine and testing procedures Megathread Part 3 - Read OP

Wolf359f wrote: »

1.7 mil vaccinated in May based off a supply of 1.25mil in May.
Something doesn't add up there.

Likely that he's may and June mixed up, ah he's a tryer
Am I right in saying we are getting similar amount of Jansen in July and Jun like 400k. With the rest having a similar sustained supply in July. So whatever slippage in targets by end of June would be mopped up quiet fast in July.

I ask nearly every week but is there any sign of Pfizer updating the dosage interval based on UK data? whatever about at risk, it's overkill for any non risk groups that end up getting it with a 4 week gap.

astrofool

lbj666 wrote: »

Likely that he's may and June mixed up, ah he's a tryer
Am I right in saying we are getting similar amount of Jansen in July and Jun like 400k. With the rest having a similar sustained supply in July. So whatever slippage in targets by end of June would be mopped up quiet fast in July.

I ask nearly every week but is there any sign of Pfizer updating the dosage interval based on UK data? whatever about at risk, it's overkill for any non risk groups that end up getting it with a 4 week gap.

I haven't heard any update on the Pfizer schedule, which data are you referring to specifically? Anything I've seen from the UK so far tended to be from a mix of vaccines, so was hard to draw any conclusions from (other than vaccines work great).

Champagne Sally

How long to folks reckon each 5 yr group will take? I see 65-69yr olds, portal opening 19th April so I'm just trying to work through the numbers. Two weeks for that group would that be too short do you reckon?

I suppose it depends on how many are in each group.

Russman

Champagne Sally wrote: »

How long to folks reckon each 5 yr group will take? I see 65-69yr olds, portal opening 19th April so I'm just trying to work through the numbers. Two weeks for that group would that be too short do you reckon?

I suppose it depends on how many are in each group.

There was a piece at the weekend by someone in the Sunday Business Post (think it was quoted on here a few pages back) where she reckoned that the 45-55 year old group would have their first dose by end of May.
I was a little surprised it would be that soon tbh but great if it is.

https://twitter.com/mark_coughlan/status/1379772733513474048?s=21

dominatinMC

ACitizenErased wrote: »

https://twitter.com/mark_coughlan/status/1379772733513474048?s=21

Good to see BioNTech as the workhorse, who would have thought it back in December. That in itself kind of epitomises how dynamic the whole situation is. I know all vaccines are great, and the one you are offered is the best one for you, but BioNTech really is the gold standard at the moment. Studies show it reduces transmission, works against "variants of concern", etc.

Micky 32

https://twitter.com/sailorrooscout/status/1379756117262209026?s=21

PhoenixParker

Champagne Sally wrote: »

How long to folks reckon each 5 yr group will take? I see 65-69yr olds, portal opening 19th April so I'm just trying to work through the numbers. Two weeks for that group would that be too short do you reckon?

I suppose it depends on how many are in each group.

Very quick.

They’ll be using AZ.
Up to end March we had received 340k doses.
To date we’ve used 205k.
There are 135k doses in the country and another 224k due by month end.

To date, AZ is mostly for cohort 4 which is really tough to identify people in.
No second doses of AZ will be due until May.

The whole of 65-69 is 200-225k people. Looks like plan is to mostly use MVCs which will be quick.

If a 65+ year old wants it, they should have it by end of April, maybe week 1 May.

Champagne Sally

ACitizenErased wrote: »

https://twitter.com/mark_coughlan/status/1379772733513474048?s=21

Thanks for that ACE, I've done the maths and the difference between the two estimates is 133,875 with Mark's original being overstated by this amount. The main reason is Astra Zenaca he says deliveries of 958,550 vs Governments estimate of 813,000. Are the Government just being cautious? We shall see.

[Deleted User]

There's been a report in Germany today that some of their April delivery of Moderna has been cancelled, can't be sure there's any truth to it yet or if it may also impact other EU countries

https://www.businessinsider.de/politik/deutschland/moderna-lieferung-von-bis-zu-878-000-impfstoff-dosen-geplatzt/

patnor1011

And nobody knows if AZ will be still used as this vaccine only have emergency use approval and EMA is starting to crack.

https://www.reuters.com/article/us-health-coronavirus-astrazeneca-vaccin-idUSKBN2BT1ER

Behind paywall but full article can be found on other sites.
https://www.wsj.com/articles/oxford-pauses-dosing-in-trial-of-astrazeneca-covid-19-vaccine-in-children-teenagers-11617729303

astrofool wrote: »

I haven't heard any update on the Pfizer schedule, which data are you referring to specifically? Anything I've seen from the UK so far tended to be from a mix of vaccines, so was hard to draw any conclusions from (other than vaccines work great).

I thought there were phase 4 studies in the UK specifically for Pfizer.

patnor1011 wrote: »

And nobody knows if AZ will be still used as this vaccine only have emergency use approval and EMA is starting to crack.

https://www.reuters.com/article/us-health-coronavirus-astrazeneca-vaccin-idUSKBN2BT1ER

Behind paywall but full article can be found on other sites.
https://www.wsj.com/articles/oxford-pauses-dosing-in-trial-of-astrazeneca-covid-19-vaccine-in-children-teenagers-11617729303

It has emergency approval in the UK, full approval by the EMA.

stephenjmcd

Wolf359f wrote: »

1.7 mil vaccinated in May based off a supply of 1.25mil in May.
Something doesn't add up there.

Journalist has corrected himself

https://twitter.com/PTHosford/status/1379793842652774405?s=19

https://twitter.com/DarrenGBNews/status/1379795796057542660?s=20

https://www.youtube.com/watch?v=R44xKGOZ0kQ

Live:

stephenjmcd

EMA’s safety committee (PRAC) has concluded today that unusual blood clots with low blood platelets should be listed as very rare side effects of Vaxzevria (formerly COVID-19 Vaccine AstraZeneca).

https://twitter.com/EMA_News/status/1379794539456688137?s=19

169 cases in EU reporting database of the clots out of 34 million doses administered

UK MHRA have announced they are offering vaccines other than AstraZeneca to Under-30s.

freddie_

Was it not meant to be 1 million monthly average for April, May and june yet the latest estimates show us receiving 4m over 3 months? Or have I got it wrong!

stephenjmcd

ACitizenErased wrote: »

UK MHRA have announced they are offering vaccines other than AstraZeneca to Under-30s.

Interesting point in their statement is "where possible".

It can still be used in the age group.

seamus

Great to have those numbers.

Based on deliveries and vaccination rates, we have been pretty consistently at a place where we've used 80-85% of all of the vaccines we've received. That 15-20% is whatever has just been recently delivered.

Rough calculation suggests then that based on a cumulative total of receiving 5.1m doses into the country by the end of June, we will have administered about 4.1m doses.

I think a dose 1 / dose 2 breakdown of that number is probably a lot of work because there's a mix of Janssen (1 shot), AZ (12 weeks) and Pfizer/Moderna (4 weeks) in there.

But nevertheless 80% of 3.8m people having been offered their first dose by the end of June seems like a soft target given those numbers. If there are few delivery hiccups, then this is all really positive stuff.

stephenjmcd wrote: »

EMA’s safety committee (PRAC) has concluded today that unusual blood clots with low blood platelets should be listed as very rare side effects of Vaxzevria (formerly COVID-19 Vaccine AstraZeneca).

https://twitter.com/EMA_News/status/1379794539456688137?s=19

Its not the end of it , they dont have enough age stratified data yet.

stephenjmcd wrote: »

EMA’s safety committee (PRAC) has concluded today that unusual blood clots with low blood platelets should be listed as very rare side effects of Vaxzevria (formerly COVID-19 Vaccine AstraZeneca).

https://twitter.com/EMA_News/status/1379794539456688137?s=19

Good that it is to be listed as rare side effect , and that vaccination clearly recommended to be continued by EMA .
Much better information and will be easier for those involved in vaccination to explain risks/ benefits to patients now .

Similar immune response to aypical Heparin Induced Thrombocytopenia which can occur rarely , but more often in dialysis patients receiving continuous heparin infusion.
This as discussed before , triggers an antibody reaction causing platelet clumping and clot formation , in these cases in one of the major blood vessels in the brain , the sagiital sinus .

Signs and symptoms may include severe headache or neurological changes like stroke , bruising or petechia ( small purple marks on skin) , within a few days of receiving the vaccine .
Most normal side effects of vaccine wear off within 24 to 48 hours .
Anybody with persisting problems or side effects post vaccination should report this to their GP or health care provider and seek advice .

lbj666 wrote: »

Its not the end of it , they dont have enough age stratified data yet.

And they only have data on those particular side effects reported .
I in 100, 000 in EU , 1 in 600, 000 in UK .
That is just incidents reported

Also if this is an immune response , I wonder if the patients involved had a previous Covid infection , and so were already sensitised to the immune response ?
They haven't answered that ..yet .

trellheim

The numbers ( planned deliveries) were published - I presume after todays mini-Cabinet because the Minister for Health said in the Dail last week he'd try and publish them but strongly cautioned.

IN FAIRNESS he has absolutely no control over those numbers but will no doubt be vilified if AZ go potty again so I can see why they'd be so reluctant to publish.

GLaDOS

Goldengirl wrote: »

Also if this is an immune response , I wonder if the patients involved had a previous Covid infection , and so were already sensitised to the immune response ?
They haven't answered that ..yet .

If that's the case, you might expect to see it more often in 2nd doses of AZ. Given the large time frame between doses there probably isn't enough data on that yet.

PTH2009

Numbers getting moved around again

Mentioned that J&J also have noted a similar side effect , but in very low numbers.

No connection with Oestrogen according to them , so don't understand the MRHA recommending restriction of use to women under 30 ..

The data available in EU not sufficient to determine any criteria for restricting administration according to age as yet, so further to come on this.