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COVID-19: Vaccine and testing procedures Megathread Part 3 - Read OP

Beasty

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Thread 2

No anti-vax stuff in this thread - it's to discuss the various vaccines available and how they are getting rolled out, as well as testing procedures

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dominatinMC

Micky 32 wrote: »

“Professor Sarah Gilbert said that the only way Sars-Cov2 could escape the current vaccines completely, would be to drop the spike protein. Which makes it practically defunct”

I do hear this quite often.

On RTE?? Can't say I have, but I gave up listening to them to any great extent a long time ago!

stephenjmcd

average_runner wrote: »

We need to source our own and stop depending on the EU. Britain has more than enough so we should reach out to them there and the same with the US.

This line of thought is regularly posted but rarely ever backed up with anything other than wishful thinking.

1) source from where ?? There isn't a surplus to source from, manufacturers deliver what they've produced. Can you imagine Ireland out on its own up against other massive countries trying to haggle for vaccine supply. We all saw the issues with PPE when countries tried it that way. It was a mess.

2) neither of those countries currently have more than enough. Why would they give us some when they have their own vaccine programmes to roll out & have to look after their own first.

brickster69

Aegir wrote: »

So it’s Astra Zeneca’s fault, but the EU should block deliveries of Pfizer to the UK because...?

And considering a company in the UK has the IP rights for 4 ingredients that allow Pfizer to be injected into the body, it may not be too good an idea.

Pablo Escobar

eoinbn wrote: »

The SBO groups. They aren't 100% but they give a decent indicator(ignore timelines, it is from December)
https://twitter.com/rachellavin/status/1341087726385377282

There is roughly 1m people up to and including G7.
AZ are projected to deliver ~675k doses by the end of April. Lets say they deliver 500k. That is 500k first doses(assuming none are held back).
By the end of April we should also have 1.3m+ from the mRNA suppliers and a small number from J&J.
Even if we split the 1.3m into first and a second doses(not realistic, first will be higher than 50%) then that gives 1.15m first doses.

I know you say ignore timelines, but it's difficult. She's miles off and is either not informed or scaremongering. Most people won't be as all over timelines as people on here. She even caveats them as being her own predictions. Bascially, it's based on nothing. Why not just follow what authorities are saying?

ACitizenErased

Apologies if posted already

https://twitter.com/EMA_News/status/1369706348615766025?s=20

stefanovich

ACitizenErased wrote: »

Apologies if posted already

https://twitter.com/EMA_News/status/1369706348615766025?s=20

The way it is worded I'm not sure if it is good or bad news.

Pete_Cavan

Aegir wrote: »

So it’s Astra Zeneca’s fault, but the EU should block deliveries of Pfizer to the UK because...?

Well the AZ CEO certainly made it sound like the UK government told them how it was to be;

https://www.repubblica.it/cronaca/2021/01/26/news/interview_pascal_soriot_ceo_astrazeneca_coronavirus_covid_vaccines-284349628/

As you could imagine, the UK government said the supply coming out of the UK supply chain would go to the UK first. Basically, that's how it is.

But the contract with the UK was signed first and the UK, of course, said “you supply us first”, and this is fair enough.

The claims about when contracts were signed are questionable now. In any case, the fact still remains that their contract made commitments to supply the EU and specifically states that they have no other contracts which impede that.

VG31

Denmark’s national health agency has said it is temporarily suspending inoculations with the AstraZeneca vaccine after blood clots formed in several people who had the jab, one of whom has reportedly died.

The agency said on Thursday that it had not conclusively established a link between the clots and the vaccine, but said it had asked the regional authorities in charge of the vaccination programme to stop using the AstraZeneca shot for the time being.

The agency said it would reassess the situation in consultation with the Danish medicines agency in two weeks’ time, but stressed there was “good evidence that the vaccine is both safe and effective”.

https://www.theguardian.com/society/2021/mar/11/denmark-pauses-astrazeneca-vaccines-to-investigate-blood-clot-reports

A bit concerning to be honest. Even a bad batch rather than an issue with the vaccine itself would severely damage public confidence in it.

seamus

It's good news I think. There have been so many AZ jabs done now, that a widespread thrombosis issue would be well flagged.

A "dodgy batch" is relatively more concerning because if one "dodgy batch" can get through quality control, how do we know that any batches are fit for use?

This is most likely a freak occurrence or perhaps a conflict between the jab and some other drug. If the Danes were in the process of vaccinating a group of individuals who were (e.g.) undergoing a specific kind of cancer treatment, then there may be a previously unknown reaction between Az and that drug.

ACitizenErased

stefanovich wrote: »

The way it is worded I'm not sure if it is good or bad news.

"The information available so far indicates that the number of thromboembolic events in vaccinated people is no higher than that seen in the general population."

ACitizenErased

VG31 wrote: »

https://www.theguardian.com/society/2021/mar/11/denmark-pauses-astrazeneca-vaccines-to-investigate-blood-clot-reports

A bit concerning to be honest.

read above

astrofool

Aegir wrote: »

No. Good enough?

Perfect, so now we know that you are a hypocrite when praising the EU supplied UK rollout while criticising the non UK supplied EU rollout.

As John Bercow would say "UNLOCK!".

astrofool

brickster69 wrote: »

And considering a company in the UK has the IP rights for 4 ingredients that allow Pfizer to be injected into the body, it may not be too good an idea.

To be fair, if the EU wanted to ramp up with like for like responses to what the UK was doing, the UK would fall apart pretty quickly, the EU has shown great restraint in dealing with the UK (enough rope to hang themselves really).

ACitizenErased

Hungary has disclosed that it is paying €17 per full dose of Sputnik and €63 per Sinopharm.

CIARAN_BOYLE

seamus wrote: »

It's good news I think. There have been so many AZ jabs done now, that a widespread thrombosis issue would be well flagged.

A "dodgy batch" is relatively more concerning because if one "dodgy batch" can get through quality control, how do we know that any batches are fit for use?

This is most likely a freak occurrence or perhaps a conflict between the jab and some other drug. If the Danes were in the process of vaccinating a group of individuals who were (e.g.) undergoing a specific kind of cancer treatment, then there may be a previously unknown reaction between Az and that drug.

I wonder if the uk approval process (emergency approval only individual approval for each batch) compared to the European approval process (conditional marketing approval, no separate for each batch) might come out on top here.

trellheim

Vaccine rollout questions just answered in the Dail. Text should be up soon. first bits up now

https://www.oireachtas.ie/en/debates/debate/dail/2021-03-11/2/

[Deleted User]

CIARAN_BOYLE wrote: »

I wonder if the uk approval process (emergency approval only individual approval for each batch) compared to the European approval process (conditional marketing approval, no separate for each batch) might come out on top here.

No. Batch approval is essentially is - "here is our batch release data for this batch". CMA is "here is our batch release controls details that are applied to every batch, manufacturing control data and all associated details showing the safety and efficacy of our product"

eoinbn

Pablo Escobar wrote: »

I know you say ignore timelines, but it's difficult. She's miles off and is either not informed or scaremongering. Most people won't be as all over timelines as people on here. She even caveats them as being her own predictions. Bascially, it's based on nothing. Why not just follow what authorities are saying?

The poster wanted to know how many people were in each group, that is why I posted the link. Granted - their numbers for front line health care works and nursing homes was a fair bit off but the other numbers are close.
Can you post some official figures that aren't nonsense? If you believe official figures we will get 50k doses of J&J and 180k of Pfizer in the first week of April(week starting the 5th). I have been saying for weeks that all the projected figures for April are way over inflated based on stupid math. J&J have confirmed that now by stating only a small amount will arrive in April and only in the 2nd half. Our delivers in April won't be much more than for March. That is what I am basing my predictions on. Hopefully I am wrong.

josip

ACitizenErased wrote: »

Hungary has disclosed that it is paying €17 per full dose of Sputnik and €63 per Sinopharm.

€63 for Sinopharm :eek:
Jinping must have seen Orban coming.

VonLuck

I'm sure this has been asked a hundred times, but where can I access the current vaccine rollout programme based on the expected vaccine supply as it stands?

Just looking to know when each group is targeted for partial or full vaccination.

Mark1916

https://twitter.com/deitaone/status/1369977791459000323?s=21

Could be fantastic news.

Rebelbrowser

Mark1916 wrote: »

https://twitter.com/deitaone/status/1369977791459000323?s=21

Could be fantastic news.

That's the beginning of the end of covid if true. Thank f*** if so

Mark1916

https://twitter.com/business/status/1369985196821450752?s=21

Full report

funnydoggy

This could well mean the same for the other vaccines too. Unreal.

[Deleted User]

astrofool wrote: »

Perfect, so now we know that you are a hypocrite when praising the EU supplied UK rollout while criticising the non UK supplied EU rollout.

As John Bercow would say "UNLOCK!".

editing someone's post to make a point is pretty pathetic to be honest.

Now, care to answer my question, as you are so keen on people answering questions.

big syke

Mark1916 wrote: »

https://twitter.com/business/status/1369985196821450752?s=21

Full report

I like this part:

Israel’s use of the Pfizer-BioNTech vaccine coincided with broad spread of the more infectious virus variant first identified in the U.K., meaning that the efficacy observed in the country indicates the vaccine also works well against that mutant strain

CIARAN_BOYLE

J&J decision expected today.

I don't think we will be getting many doses til q2 though whether its approved or not.

ACitizenErased

BioNTech are just incredible. The fact they had that vaccine made not even 3 months into the pandemic is insanity.

noserider

Irish Examiner Thu, 11 Mar, 2021 - 08:04
Jane Kirby, PA Health Editor

A monoclonal antibody drug reduces hospital admission or death from Covid-19 by 85%, the pharmaceutical giant GlaxoSmithKline (GSK) has announced.
The drug, called VIR-7831, is a new treatment for people with mild to moderate illness, and the study has been so successful that it has been stopped early.
GSK and its partner, Vir Biotechnology, plan to immediately seek an emergency use authorisation in the United States and approval in other countries, including potentially in the UK.
Monoclonal antibodies are laboratory-produced molecules that mimic human antibodies.
The global phase 3 clinical trial based its initial analysis on data from 583 patients at risk of hospital admission.
GSK said VIR-7831 works in two ways – by blocking the virus’s entry into healthy cells and also clearing infected cells.
A separate laboratory study has found that VIR-7831 is effective against the main current Covid-19 variants, including the Kent, South African and Brazilian variants, the firm said.
VIR-7831 is designed to be given as a single intravenous (IV) infusion.
Dr Hal Barron, chief scientific officer at GSK, said: “We are pleased that this unique monoclonal antibody was able to bring such a profound benefit to patients.
“We look forward to the possibility of making VIR-7831 available to patients as soon as possible and to further exploring its potential in other settings.”
A trial using the drug in very sick patients in hospital was stopped last week owing to lack of benefit.

hynesie08

https://twitter.com/COVID19DataIE/status/1369991502752059392?s=20

Is that a Monday record?