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COVID-19: Vaccine and testing procedures Megathread Part 3 - Read OP

Beasty

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Thread 2

No anti-vax stuff in this thread - it's to discuss the various vaccines available and how they are getting rolled out, as well as testing procedures

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stephenjmcd

trellheim wrote: »

heres the numbers I was working from
https://pbs.twimg.com/media/Eu7i-TqXIAArZuF?format=jpg&name=medium

Your supply forecast looks a little off, updated forecast below from last week

https://twitter.com/newschambers/status/1364280979267981312?s=19

Russman

pc7 wrote: »

God I hope the government get this right and hit the targets when the big doses start arriving, finding the last few days tough, really need some light at the end of that tunnel.

There IS light at the end of the tunnel. Its a couple of months away yet, but its coming, and soon.

is_that_so

trellheim wrote: »

heres the numbers I was working from
https://pbs.twimg.com/media/Eu7i-TqXIAArZuF?format=jpg&name=medium

Good to see that tabulated. So, are we really only looking at 60% done by June?

trellheim

heres the numbers I was working from
https://pbs.twimg.com/media/Eu7i-TqXIAArZuF?format=jpg&name=medium

ACitizenErased

Pablo Escobar wrote: »

Is the MTU (CIT) location opening then or at a later date?

operating since early last week

KrustyUCC

Pablo Escobar wrote: »

Is the MTU (CIT) location opening then or at a later date?

Already open

https://www.irishexaminer.com/news/arid-40234868.html

pc7

God I hope the government get this right and hit the targets when the big doses start arriving, finding the last few days tough, really need some light at the end of that tunnel.

Pablo Escobar

ACitizenErased wrote: »

I've heard the two big ones in Cork, City Hall and Pairc Ui Chaoimh, are opening next week.

Is the MTU (CIT) location opening then or at a later date?

Responder XY

josip wrote: »

I can see you dropping in at 4:50 every evening, "eh, any spare vaccines today?"

It wouldn't exactly be out of my way! Don't get me wrong, I wouldn't want to take one from a higher priority person. But given the short shelf life, I'd hope they have a back up plan and they'd find an enthusiastic volunteer here!

stephenjmcd

trellheim wrote: »

Vaccine rollout to be discussed in the Dail tomorrow at 1

It's discussed basically every Thursday when its Q&A with Minister for Health.

HSE press conference on each Thursday gives numbers.

josip

Responder XY wrote: »

Has there been any updates on when the mass vaccination centres are due to open? Once of the announced locations is almost literally on my doorstep, but I haven't seen any sign of it going in yet.

On a related topic - does anyone think they will do back up lists in case they have spare vaccines at the end of any given day?

I can see you dropping in at 4:50 every evening, "eh, any spare vaccines today?"

Tippbhoy1

Responder XY wrote: »

Has there been any updates on when the mass vaccination centres are due to open? Once of the announced locations is almost literally on my doorstep, but I haven't seen any sign of it going in yet.

On a related topic - does anyone think they will do back up lists in case they have spare vaccines at the end of any given day?

Recruitment drive for staffing those centres I have been told is for staff starting the end March, so something like the 1st April I would guess. This would line up with the 1million doses a month from April that the government are forecasting. Right now we don’t need any more people administering, we don’t have the supply until then.

trellheim

Vaccine rollout to be discussed in the Dail tomorrow at 1

ACitizenErased

Responder XY wrote: »

Has there been any updates on when the mass vaccination centres are due to open? Once of the announced locations is almost literally on my doorstep, but I haven't seen any sign of it going in yet.

On a related topic - does anyone think they will do back up lists in case they have spare vaccines at the end of any given day?

I've heard the two big ones in Cork, City Hall and Pairc Ui Chaoimh, are opening next week.

dominatinMC

Hmmzis wrote: »

Some more data on the Brazilian variant (P1):

https://www.biorxiv.org/content/10.1101/2021.03.01.433466v1.full.pdf+html

Way less intimidating than the data for B.1.351 (SA), convalescent serum had ~6.5x drop while vaccine plasma had 2.2x drop for Pfizer/BNT and 2.8x drop for Moderna. The SA variant had lots of convalescent serum KOs and vaccinee serum had 3-8x fold drops.

It's interesting that the vaccinee serum is consistently outperforming convalescent serum in terms of quality of the response. It's very consistent and looks to be somewhat broader. I think the messing with the B cells and germinal center formation by the wild type infection could indeed be blunting the humoral immune response and giving vaccines the edge against this virus.

I didn't understand a lot of what you said, but I liked your closing line!

Responder XY

Has there been any updates on when the mass vaccination centres are due to open? Once of the announced locations is almost literally on my doorstep, but I haven't seen any sign of it going in yet.

On a related topic - does anyone think they will do back up lists in case they have spare vaccines at the end of any given day?

Hmmzis

Some more data on the Brazilian variant (P1):

https://www.biorxiv.org/content/10.1101/2021.03.01.433466v1.full.pdf+html

Way less intimidating than the data for B.1.351 (SA), convalescent serum had ~6.5x drop while vaccine plasma had 2.2x drop for Pfizer/BNT and 2.8x drop for Moderna. The SA variant had lots of convalescent serum KOs and vaccinee serum had 3-8x fold drops.

It's interesting that the vaccinee serum is consistently outperforming convalescent serum in terms of quality of the response. It's very consistent and looks to be somewhat broader. I think the messing with the B cells and germinal center formation by the wild type infection could indeed be blunting the humoral immune response and giving vaccines the edge against this virus.

seamus

Thelonious Monk wrote: »

This year I suppose

You'll likely be offered your first dose by the end of June, otherwise shortly afterwards.

Van.Bosch

Thelonious Monk wrote: »

This year I suppose

You’ll be done by September I’d say at the latest

is_that_so

Thelonious Monk wrote: »

My brother, and a friend of mine who both live in Malta are getting their vaccines next week. Both healthy and young enough. I assume someone like myself, 40 and healthy, wont be getting a vax any time soon in Ireland?

June or so based on the "projections". That's where most of the adult population are.

Thelonious Monk

josip wrote: »

What kind of timeframe would you consider 'any time soon' ?

This year I suppose

josip

Thelonious Monk wrote: »

My brother, and a friend of mine who both live in Malta are getting their vaccines next week. Both healthy and young enough. I assume someone like myself, 40 and healthy, wont be getting a vax any time soon in Ireland?

What kind of timeframe would you consider 'any time soon' ?

padjocollins

https://www.theguardian.com/world/2021/mar/02/covid-germany-and-france-under-pressure-to-shift-oxford-vaccine

Thelonious Monk

My brother, and a friend of mine who both live in Malta are getting their vaccines next week. Both healthy and young enough. I assume someone like myself, 40 and healthy, wont be getting a vax any time soon in Ireland?

seamus

Apogee wrote: »

There are currently 435,895 doses administered as of Sat 27th. If 500,000 administered by Sun 7th, that comes to 64,005 for Sun 28th-Sun 7th. Seems low, even allowing for AZ 25,000 shortfall.

Tbh, I would take any figures that Donnelly throws out as being quite loose. He is very poor at speaking clearly and concisely.

He very likely meant to say we will have administered more than 500k or will have administered 520k by the end of the week.

The 25k AZ doses that were missed last week were supposed to be delivered this week. Has that not happened?

IrishStuff09

So that's 81,843 doses last week then, with a rise of 2,462 on Sunday 28th Feb.

https://www.hse.ie/eng/services/news/newsfeatures/covid19-updates/vaccination-programme-dashboard-as-of-28-february-2021.pdf

speckle

Mickey 32....re above link...Found a good analysis of the findings here..good news for those who have been already infected
Does this mean we might be able to save vaccine doses for those who really need it and does it potentially mean unless the virus undergoes very significant changes we wont need an injection every year... those people previously infected seem to be holding up amazingly well to the new variants with a very very low chance out of the hundreds if millions infected? Anybody what are your thoughts?

https://mobile.twitter.com/sailorrooscout/status/1366742151351132168

ixoy

Wow, even RTE are starting to feel optimistic about the vaccinations - one of the headlines on the front page of the news is:

'Reasons to be hopeful' as Covid hospital numbers fall

If they can start to see it, that's a sign in itself.

funnydoggy

Saw a video online last night, of some guy following Luke O'Neill down the street with a microphone and presumably he asked about long term side effects from the vaccine, to which Luke started to talk about stage 4 trials.

The poster of this video tried to spin it as a "they're experimenting on the population" conspiracy.

I'm going to go weep for humanity now.

is_that_so

eoinbn wrote: »

The EMA being slightly slower isn't a major issue. They approved Moderna in early Jan yet we still have hardly any doses. It took the US over 3 weeks to approve J&J . The EMA will do it on the same timeframe - maybe a day faster. The EMA aren't the reason why AZ has missed every target that they themselves set.
What the EU has done poorly is that it didn't take enough risks with manufacturing. The US handed over billions to ramp up production - some of this was in the form of higher prices. The EU didn't. AFAIK the only real investment in manufacturing was by German and even that was in the form of a loan to BioNtech last September. We will start to see benefits of that next month.

There's a bit of Captain Hindsight in that. The EU mistake, if you can call it that, was to spread the risk over a wide range of vaccines, a good number of which are still in trials. Moderna was always known to be a supply issue for most of the year but they got thrown sideways firstly by Pfizer and then the far bigger mess of AZ. People would have more readily accepted the slower rate for these months had supplies, as promised or agreed, arrived.