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What exactly is happening with AstraZeneca?

hatrickpatrick

The news has been full of stories about AstraZeneca having slashed their initial vaccine deliveries to the EU by 60% and the knock on fallout from that. But what’s either being buried in all the reporting, or simply hasn’t been reported at all, is what exactly happened? What’s the reason for the delay? Technical, logistical, commercial, etc?

I assumed it was similar to what was happening with Pfizer, which is essentially an issue of manufacturing capacity being reduced by an upgrade to their production facility. But what seems odd about the AstraZeneca situation is the anger directed towards them from officials and leaders, plus public statements that “They must honour their delivery commitments”, indicating that this isn’t an act-of-God type mishap in manufacturing, but an act of incompetence and/or willful reneging on the agreement - perhaps their capacity has remained the same but they’ve “bumped” the EU’s order in priority because others are paying more, or something along these lines?

Does anyone know what exactly the situation is? I can’t seem to find anything beyond extremely vague statements at the moment.

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CIARAN_BOYLE

mick087 wrote: »

When THE organization known as the EU was sitting around the coffee table negotiating, other countries was invested and buying the vaccine.

Signed contract with Astra Zenaca last August after an agreement last June.

I think that's early enough to order.

The eu should have ordered less Sanofi and more Pfizer but we didn't know that last June.

Hurrache

This is a reasonable twitter thread, and he hits the nail firmly on the head which also applies to people on this thread.
https://twitter.com/EmporersNewC/status/1354017769700917249

greyday

https://www.spiegel.de/international/europe/the-planning-disaster-germany-and-europe-could-fall-short-on-vaccine-supplies-a-3db4702d-ae23-4e85-85b7-20145a898abd

Its worth reading just to see how disjointed the EU response has been, does anyone seriously believe Ireland on its own could not have sourced 10 million vaccines by now to vaccinate the whole Country if allowed go its own route?

[Deleted User]

Seth Brundle wrote: »

Apparently No. 10 wanted the vials wrapped in the Union flag...
No 10 wanted union flag on Oxford coronavirus vaccine kits
"Plan hatched by new ‘Union unit’ to counter rise in Scottish nationalism"

I could just imagine some poor GP about to inject you with vaccine, only for you to explode in to fits of rage that it has da butcher's Apron on it.:p

mick087

CIARAN_BOYLE wrote: »

Signed contract with Astra Zenaca last August after an agreement last June.

I think that's early enough to order.

The eu should have ordered less Sanofi and more Pfizer but we didn't know that last June.

Im think im correct in saying some countries bulk ordered all 3.
Why did the EU not do this?

Donald Trump

mick087 wrote: »

Im think im correct in saying some countries bulk ordered all 3.
Why did the EU not do this?

eh................they did

Renault 5

greyday wrote: »

https://www.spiegel.de/international/europe/the-planning-disaster-germany-and-europe-could-fall-short-on-vaccine-supplies-a-3db4702d-ae23-4e85-85b7-20145a898abd

Its worth reading just to see how disjointed the EU response has been, does anyone seriously believe Ireland on its own could not have sourced 10 million vaccines by now to vaccinate the whole Country if allowed go its own route?

Do you think Ireland would be the only ones sourcing its own Vaccines then.

Countries 10 to 15 times bigger then us would have the finances and negotiation skills to relegate us to the bottom of the queue in the distribution of the vaccines.

oharach7

https://twitter.com/Peston/status/1354019140084916225

Probably the best analysis I have read on this today.

Renault 5

mick087 wrote: »

Im think im correct in saying some countries bulk ordered all 3.
Why did the EU not do this?

lol. Why do you think the EU are asking where their millions of Vaccines are stored?

CIARAN_BOYLE

oharach7 wrote: »

https://twitter.com/Peston/status/1354019140084916225

Probably the best analysis I have read on this today.

Except it's wrong.

The uk didnt sign a deal till July. They had the same agreement Astra zenaca had with eu vaccine alliance before that.

May UK have a pre agreement with AZ
June eu (ivc) have a pre agreement with AZ
July UK sign a final agreement with AZ
August EU sign a final agreement with AZ

Hurrache

oharach7 wrote: »

https://twitter.com/Peston/status/1354019140084916225

Probably the best analysis I have read on this today.

What you're reading there, as with most things Peston tweets, is a direct line from the Tory party.

greyday

Renault 5 wrote: »

Do you think Ireland would be the only ones sourcing its own Vaccines then.

Countries 10 to 15 times bigger then us would have the finances and negotiation skills to relegate us to the bottom of the queue in the distribution of the vaccines.

We could pay well over the odds without an issue when you consider what lockdown is costing us, we also have the leverage of having most of the biggest pharma companies in the world having operations in Ireland, there would be no bottom of the queue.

The EU ordered the pfizer vaccine in November while the USA ordered it in July, 5 months later, this was gross incompetence at best.

Seth Brundle

Aegir wrote: »

I could just imagine some poor GP about to inject you with vaccine, only for you to explode in to fits of rage that it has da butcher's Apron on it.:p

Personally (and as a someone who is classed as a vulnerable person), I'd happily take it even if the GP looked like Boris himself. Unfortunately, the UK government were trying to politicise it as part of their campaign of nationalism. So much so that even vulnerable patients were putting themselves at risk...
Elderly patients are ‘refusing the Pfizer vaccine to wait for the English one’

CIARAN_BOYLE

mick087 wrote: »

Im think im correct in saying some countries bulk ordered all 3.
Why did the EU not do this?

EU made large orders with (I think) 6 different vaccines manufacturers.

mick087

Donald Trump wrote: »

eh................they did

Yes but after other countries and ordered the EU was still negotiating.

brickster69

greyday wrote: »

https://www.spiegel.de/international/europe/the-planning-disaster-germany-and-europe-could-fall-short-on-vaccine-supplies-a-3db4702d-ae23-4e85-85b7-20145a898abd

Its worth reading just to see how disjointed the EU response has been, does anyone seriously believe Ireland on its own could not have sourced 10 million vaccines by now to vaccinate the whole Country if allowed go its own route?

What do you expect when you give the job to someone who was responsible for kitting out the German army with broomsticks instead of rifles.

mick087

CIARAN_BOYLE wrote: »

EU made large orders with (I think) 6 different vaccines manufacturers.

Yes i know that but my point is why did they not order before other countries did? They was negotiating as others was paying

Is this a case we got it cheaper and you get what you pay for?

ElJaguar

oharach7 wrote: »

I have read reports of Israel opportunistically "borrowing" supplies meant for other countries who hadn't approved yet, on the basis that they would make it up to the other country once approval was granted.

Source for this?

Donald Trump

mick087 wrote: »

Yes but after other countries and ordered the EU was still negotiating.

As of 8th Jan this was the status:

https://ec.europa.eu/commission/presscorner/detail/en/qanda_20_2467

With which companies have you concluded COVID-19 vaccine agreements?

The Commission is negotiating intensely to build a diversified portfolio of vaccines for EU citizens at fair prices. Contracts have been concluded with AstraZeneca (400 million doses), Sanofi-GSK (300 million doses), Johnson and Johnson (400 million doses ), BioNTech-Pfizer 600 million doses, CureVac (405 million doses) and Moderna (160 million doses). The Commission has concluded exploratory talks with the pharmaceutical company Novavax with a view to purchasing up to 200 million doses.

This means that the Commission has secured a portfolio of more than 2 billion doses. For the Commission it was important from the beginning to build a diversified portfolio of vaccines based on different technologies, to increase the chances that one or more of the vaccine candidates are approved by EMA. Should all vaccines candidates turn out to be safe and effective, Member States have the possibility to donate part of their doses to lower and middle income countries.

Donald Trump

mick087 wrote: »

Yes i know that but my point is why did they not order before other countries did? They was negotiating as others was paying

Is this a case we got it cheaper and you get what you pay for?

I think that perhaps you may not really understand the concept of a contract?

mick087

greyday wrote: »

https://www.spiegel.de/international/europe/the-planning-disaster-germany-and-europe-could-fall-short-on-vaccine-supplies-a-3db4702d-ae23-4e85-85b7-20145a898abd

Its worth reading just to see how disjointed the EU response has been, does anyone seriously believe Ireland on its own could not have sourced 10 million vaccines by now to vaccinate the whole Country if allowed go its own route?

what you expect when dealing with an organization and not a elected government

mick087

Donald Trump wrote: »

I think that perhaps you may not really understand the concept of a contract?

Is the contract even worth the paper its written on?

I find a contract for a vaccine shocking.
This should be a world wide roll out

ypres5

are we going to get the proper amount of vaccines as promised off as or are we going to get whatever amount they're saying now? if it's the latter it's heartbreaking

HalfAndHalf

is_that_so wrote: »

That they agreed/contracted to supply so many doses in Q1 and are now saying that will be 60% lower.

So did Pfizer and they’re falling short, due to the same reasons stated by AZ. Do you only pick out the bits of posts that meet your narrative?

greyday

ypres5 wrote: »

are we going to get the proper amount of vaccines as promised off as or are we going to get whatever amount they're saying now? if it's the latter it's heartbreaking

We will get them over a longer time period.

Donald Trump

mick087 wrote: »

Is the contract even worth the paper its written on?

I find a contract for a vaccine shocking.
This should be a world wide roll out

The vaccines are produced by private companies who might decide not to take the risk to invest in ramping up production capability if they think they might not have a market at the end of it. That is why they would want a contract.

We could of course try to do it through the public sector. There are a few lads I know who work in the local council who haven't had much to do since the lockdowns because they aren't able to refurbish the vacated council properties.
Perhaps we should get them onto doing up an oul' vaccine for us?

ypres5

CIARAN_BOYLE wrote: »

It looks like we will be receiving a cut down amount of Astra zenaca vaccine.

is there anything the EU can do to get them to honour their contract? that's ridiculous

[Deleted User]

oharach7 wrote: »

https://twitter.com/Peston/status/1354019140084916225

Probably the best analysis I have read on this today.

when you read that and the Spiegal article, it looks like the EU have made a complete balls of this and seem to think that stamping their foot and banging tables is miraculously going to make vaccines materialise. A vaccine that they still haven't actually approved for use and have told member states that under no circumstances are they to take pre deliveries of.

Renault 5

mick087 wrote: »

Yes i know that but my point is why did they not order like other countries did. They was negotiating as others was paying

Is this a case we got it cheaper and you get what you pay for?

They are not getting what they paid for.

They paid for X amount of doses to be made and stored until approval as highlighted in the contract.

AZ agreed that they would make and store the doses so they will be ready for roll out once approved.

Now that the EU is ready to approve they are asking where the amount if Initial doses are.

The response from AZ is

mick087

ypres5 wrote: »

are we going to get the proper amount of vaccines as promised off as or are we going to get whatever amount they're saying now? if it's the latter it's heartbreaking

Yes but they will be delayed.
To me it looks like we was slow of the mark and other coutries ordered before us.